1,966 research outputs found

    Digital Signal Processing

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    Contains reports on three research projects.U. S. Navy Office of Naval Research (Contract N00014-67-A-0204-0064)National Science Foundation (Grant GK-31353

    Perceived mental effort correlates with changes in tonic arousal during attentional tasks

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    <p>Abstract</p> <p>Background</p> <p>It has been suggested that perceived mental effort reflects changes in arousal during tasks of attention. Such changes in arousal may be tonic or phasic, and may be mediated by the locus-coeruleus norepinephrine (LC-NE) system. We hypothesized that perceived mental effort during attentional tasks would correlate with tonic changes in cortical arousal, as assessed by relative electroencephalogram (EEG) band power and theta/beta ratio, and not with phasic changes in cortical arousal, assessed by P300 amplitude and latency.</p> <p>Methods</p> <p>Forty-six healthy individuals completed tasks that engage the anterior and posterior attention networks (continuous performance task, go/no-go task, and cued target detection task). During completion of the three attentional tasks a continuous record of tonic and phasic arousal was taken. Cortical measures of arousal included frequency band power, theta/beta ratios over frontal and parietal cortices, and P300 amplitude and latency over parietal cortices. Peripheral measures of arousal included skin conductance responses, heart rate and heart rate variance. Participants reported their perceived mental effort during each of the three attentional tasks.</p> <p>Results</p> <p>First, changes in arousal were seen from rest to completion of the three attentional tasks and between the attentional tasks. Changes seen between the attentional tasks being related to the task design and the attentional network activated. Second, perceived mental effort increased when demands of the task increased and correlated with left parietal beta band power during the three tasks of attention. Third, increased mental effort during the go/no-go task and the cued target detection task was inversely related to theta/beta ratios.</p> <p>Conclusion</p> <p>These results indicate that perceived mental effort reflects tonic rather than phasic changes in arousal during tasks of attention. We suggest that perceived mental effort may reflect in part tonic activity of the LC-NE system in healthy individuals.</p

    Heavy Dark Matter Through the Higgs Portal

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    Motivated by Higgs Portal and Hidden Valley models, heavy particle dark matter that communicates with the supersymmetric Standard Model via pure Higgs sector interactions is considered. We show that a thermal relic abundance consistent with the measured density of dark matter is possible for masses up to \sim 30\tev. For dark matter masses above \sim 1\tev, non-perturbative Sommerfeld corrections to the annihilation rate are large, and have the potential to greatly affect indirect detection signals. For large dark matter masses, the Higgs-dark-matter-sector couplings are large and we show how such models may be given a UV completion within the context of so-called "Fat-Higgs" models. Higgs Portal dark matter provides an example of an attractive alternative to conventional MSSM neutralino dark matter that may evade discovery at the LHC, while still being within the reach of current and upcoming indirect detection experiments.Comment: LaTex, 21 pages, 9 figures. Discussion improved, comments and references adde

    Deep Big Simple Neural Nets Excel on Handwritten Digit Recognition

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    Good old on-line back-propagation for plain multi-layer perceptrons yields a very low 0.35% error rate on the famous MNIST handwritten digits benchmark. All we need to achieve this best result so far are many hidden layers, many neurons per layer, numerous deformed training images, and graphics cards to greatly speed up learning.Comment: 14 pages, 2 figures, 4 listing

    Changes with Age in the Moisture Content of Human Skin

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    A technique to measure the dynamic mechanical properties of human skin in vivo is described. The technique measures the propagation and attenuation of shear waves in skin tissue over a range of frequencies (8–1016 Hz). Results show that both the propagation velocity and attenuation of shear waves in skin are highly dependent upon the water content of the stratum corneum. The technique was used to measure the dynamic mechanical properties of the skin on the back of the left hand for a group of 16 men ranging in age from 24–63 years. The results suggest that aged skin has a lower water content than the skin of younger men

    Heavy dark matter through the Higgs portal

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    Abstract Motivated by Higgs Portal and Hidden Valley models, heavy particle dark matter that communicates with the supersymmetric Standard Model via pure Higgs sector interactions is considered. We show that a thermal relic abundance consistent with the measured density of dark matter is possible for masses up to ∼ 30 TeV. For dark matter masses above ∼ 1 TeV, non-perturbative Sommerfeld corrections to the annihilation rate are large, and have the potential to greatly affect indirect detection signals. For large dark matter masses, the Higgs-dark matter sector couplings are large and we show how such models may be given a UV completion within the context of so-called &quot;Fat-Higgs&quot; models. Higgs Portal dark matter provides an example of an attractive alternative to conventional MSSM neutralino dark matter that may evade discovery at the LHC, while still being within the reach of current and upcoming indirect detection experiments

    UVUDF: Ultraviolet Imaging of the Hubble Ultradeep Field with Wide-field Camera 3

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    We present an overview of a 90-orbit Hubble Space Telescope treasury program to obtain near ultraviolet imaging of the Hubble Ultra Deep Field using the Wide Field Camera 3 UVIS detector with the F225W, F275W, and F336W filters. This survey is designed to: (i) Investigate the episode of peak star formation activity in galaxies at 1<z<2.5; (ii) Probe the evolution of massive galaxies by resolving sub-galactic units (clumps); (iii) Examine the escape fraction of ionizing radiation from galaxies at z~2-3; (iv) Greatly improve the reliability of photometric redshift estimates; and (v) Measure the star formation rate efficiency of neutral atomic-dominated hydrogen gas at z~1-3. In this overview paper, we describe the survey details and data reduction challenges, including both the necessity of specialized calibrations and the effects of charge transfer inefficiency. We provide a stark demonstration of the effects of charge transfer inefficiency on resultant data products, which when uncorrected, result in uncertain photometry, elongation of morphology in the readout direction, and loss of faint sources far from the readout. We agree with the STScI recommendation that future UVIS observations that require very sensitive measurements use the instrument's capability to add background light through a "post-flash". Preliminary results on number counts of UV-selected galaxies and morphology of galaxies at z~1 are presented. We find that the number density of UV dropouts at redshifts 1.7, 2.1, and 2.7 is largely consistent with the number predicted by published luminosity functions. We also confirm that the image mosaics have sufficient sensitivity and resolution to support the analysis of the evolution of star-forming clumps, reaching 28-29th magnitude depth at 5 sigma in a 0.2 arcsecond radius aperture depending on filter and observing epoch.Comment: Accepted A

    Agmatidine, a modified cytidine in the anticodon of archaeal tRNA\u3csup\u3eIle\u3c/sup\u3e, base pairs with adenosine but not with guanosine

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    Modification of the cytidine in the first anticodon position of the AUA decoding tRNAIle (tRNAIle 2 ) of bacteria and archaea is essential for this tRNA to read the isoleucine codon AUA and to differentiate between AUA and the methionine codon AUG. To identify the modified cytidine in archaea, we have purified this tRNA species from Haloarcula marismortui, established its codon reading properties, used liquid chromatography–mass spectrometry (LC-MS) to map RNase A and T1 digestion products onto the tRNA, and used LC-MS/MS to sequence the oligonucleotides in RNase A digests. These analyses revealed that the modification of cytidine in the anticodon of tRNAIle 2 adds 112 mass units to its molecular mass and makes the glycosidic bond unusually labile during mass spectral analyses. Accurate mass LC-MS and LC-MS/MS analysis of total nucleoside digests of the tRNAIle 2 demonstrated the absence in the modified cytidine of the C2-oxo group and its replacement by agmatine (decarboxy-arginine) through a secondary amine linkage. We propose the name agmatidine, abbreviation C+, for this modified cytidine. Agmatidine is also present in Methanococcus maripaludis tRNAIle 2 and in Sulfolobus solfataricus total tRNA, indicating its probable occurrence in the AUA decoding tRNAIle of euryarchaea and crenarchaea. The identification of agmatidine shows that bacteria and archaea have developed very similar strategies for reading the isoleucine codon AUA while discriminating against the methionine codon AUG

    Homophily and Contagion Are Generically Confounded in Observational Social Network Studies

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    We consider processes on social networks that can potentially involve three factors: homophily, or the formation of social ties due to matching individual traits; social contagion, also known as social influence; and the causal effect of an individual's covariates on their behavior or other measurable responses. We show that, generically, all of these are confounded with each other. Distinguishing them from one another requires strong assumptions on the parametrization of the social process or on the adequacy of the covariates used (or both). In particular we demonstrate, with simple examples, that asymmetries in regression coefficients cannot identify causal effects, and that very simple models of imitation (a form of social contagion) can produce substantial correlations between an individual's enduring traits and their choices, even when there is no intrinsic affinity between them. We also suggest some possible constructive responses to these results.Comment: 27 pages, 9 figures. V2: Revised in response to referees. V3: Ditt
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