454 research outputs found
SIDS & Infant Sleep Ecology
Sudden infant death syndrome (SIDS) is the designation given to the unexpected death of an infant that remains unexplained following post-mortem, death scene investigation and review of clinical history [1]. The search for mechanisms underlying such deaths has been largely unsuccessful; brainstem anomalies are thought to be involved. Although rare SIDS is the leading category of non-accidental deaths between 1 month and 1 year of age, annually affecting one in 3000 babies in the UK and one in 2000 in USA. Key associations with SIDS are identified using retrospective studies of SIDS-cases and matched controls. Three key
Use of large-diameter, cast-in situ concrete pipe piles for embankment over soft clay
Article originally submitted as "Soil improvement using large diameter, cast-in-situ, thin-wall concrete pipe piles"A new method of using large-diameter, castâin situ concrete pipe (PCC) piles for embankments over soft clay is introduced in this paper. This PCC pile method offers a relatively quick and cost-effective way for soil improvement as compared with other existing soil improvement methods. The principles and construction techniques involved in this method are described. Full-scale model tests were conducted to evaluate the quality and performance of piles and the responses of the surrounding soils. Methods that can be used to check the quality of the pipe piles are elaborated. A case study that illustrates the application of this method in a piled embankment over soft clay is presented.Han-Long Liu, Jian Chu, and An Den
Investigating an unusually large 28-day oscillation in mesospheric temperature over Antarctica using ground-based and satellite measurements
The Utah State University (USU) Advanced Mesospheric Temperature Mapper (AMTM) was deployed at the AmundsenâScott South Pole Station in 2010 to measure OH temperature at ~87 km as part of an international network to study the mesospheric dynamics over Antarctica. During the austral winter of 2014, an unusually large amplitude ~28âday oscillation in mesospheric temperature was observed for ~100 days from the South Pole Station. This study investigates the characteristics and global structure of this exceptional planetaryâscale wave event utilizing groundâbased mesospheric OH temperature measurements from two Antarctic stations (South Pole and Rothera) together with satellite temperature measurements from the Microwave Limb Sounder (MLS) on the Aura satellite, and the Solar Occultation For Ice Experiment (SOFIE) on the Aeronomy of Ice in the Mesosphere (AIM) satellite. Our analyses have revealed that this large oscillation is a winter time, high latitude phenomenon, exhibiting a coherent zonal wave #1 structure below 80 km altitude. At higher altitudes, the wave was confined in longitude between 180â360°E. The amplitude of this oscillation reached ~15 K at 85 km and it was observed to grow with altitude as it extended from the stratosphere into the lower thermosphere in the southern hemisphere. The satellite data further established the existence of this oscillation in the northern hemisphere during the boreal winter time. The main characteristics and global structure of this event as observed in temperature are consistent with the predicted 28âday Rossby Wave (1,4) mode
Residual cognitive deficits 50 years after lead poisoning during childhood
The long term neurobehavioural consequences of childhood lead poisoning are not known. In this study adult subjects with a documented history of lead poisoning before age 4 and matched controls were examined with an abbreviated battery of neuropsychological tests including measures of attention, reasoning, memory, motor speed, and current mood. The subjects exposed to lead were inferior to controls on almost all of the cognitive tasks. This pattern of widespread deficits resembles that found in children evaluated at the time of acute exposure to lead rather than the more circumscribed pattern typically seen in adults exposed to lead. Despite having completed as many years of schooling as controls, the subjects exposed to lead were lower in lifetime occupational status. Within the exposed group, performance on the neuropsychological battery and occupational status were related, consistent with the presumed impact of limitations in neuropsychological functioning on everyday life. The results suggest that many subjects exposed to lead suffered acute encephalopathy in childhood which resolved into a chronic subclinical encephalopathy with associated cognitive dysfunction still evident in adulthood. These findings lend support to efforts to limit exposure to lead in childhood
Radio emission and jets from microquasars
To some extent, all Galactic binary systems hosting a compact object are
potential `microquasars', so much as all galactic nuclei may have been quasars,
once upon a time. The necessary ingredients for a compact object of stellar
mass to qualify as a microquasar seem to be: accretion, rotation and magnetic
field. The presence of a black hole may help, but is not strictly required,
since neutron star X-ray binaries and dwarf novae can be powerful jet sources
as well. The above issues are broadly discussed throughout this Chapter, with a
a rather trivial question in mind: why do we care? In other words: are jets a
negligible phenomenon in terms of accretion power, or do they contribute
significantly to dissipating gravitational potential energy? How do they
influence their surroundings? The latter point is especially relevant in a
broader context, as there is mounting evidence that outflows powered by
super-massive black holes in external galaxies may play a crucial role in
regulating the evolution of cosmic structures. Microquasars can also be thought
of as a form of quasars for the impatient: what makes them appealing, despite
their low number statistics with respect to quasars, are the fast variability
time-scales. In the first approximation, the physics of the jet-accretion
coupling in the innermost regions should be set by the mass/size of the
accretor: stellar mass objects vary on 10^5-10^8 times shorter time-scales,
making it possible to study variable accretion modes and related ejection
phenomena over average Ph.D. time-scales. [Abridged]Comment: 28 pages, 13 figures, To appear in Belloni, T. (ed.): The Jet
Paradigm - From Microquasars to Quasars, Lect. Notes Phys. 794 (2009
Abundances of the elements in the solar system
A review of the abundances and condensation temperatures of the elements and
their nuclides in the solar nebula and in chondritic meteorites. Abundances of
the elements in some neighboring stars are also discussed.Comment: 42 pages, 11 tables, 8 figures, chapter, In Landolt- B\"ornstein, New
Series, Vol. VI/4B, Chap. 4.4, J.E. Tr\"umper (ed.), Berlin, Heidelberg, New
York: Springer-Verlag, p. 560-63
Integrating group Delphi, fuzzy logic and expert systems for marketing strategy development:the hybridisation and its effectiveness
A hybrid approach for integrating group Delphi, fuzzy logic and expert systems for developing marketing strategies is proposed in this paper. Within this approach, the group Delphi method is employed to help groups of managers undertake SWOT analysis. Fuzzy logic is applied to fuzzify the results of SWOT analysis. Expert systems are utilised to formulate marketing strategies based upon the fuzzified strategic inputs. In addition, guidelines are also provided to help users link the hybrid approach with managerial judgement and intuition. The effectiveness of the hybrid approach has been validated with MBA and MA marketing students. It is concluded that the hybrid approach is more effective in terms of decision confidence, group consensus, helping to understand strategic factors, helping strategic thinking, and coupling analysis with judgement, etc
Compensatory growth of Malaysian prawns reared at high densities during the nursery phase
Measurement of the Charged Multiplicities in b, c and Light Quark Events from Z0 Decays
Average charged multiplicities have been measured separately in , and
light quark () events from decays measured in the SLD experiment.
Impact parameters of charged tracks were used to select enriched samples of
and light quark events, and reconstructed charmed mesons were used to select
quark events. We measured the charged multiplicities:
,
, from
which we derived the differences between the total average charged
multiplicities of or quark events and light quark events: and . We compared
these measurements with those at lower center-of-mass energies and with
perturbative QCD predictions. These combined results are in agreement with the
QCD expectations and disfavor the hypothesis of flavor-independent
fragmentation.Comment: 19 pages LaTex, 4 EPS figures, to appear in Physics Letters
Virus-specific T cells engineered to coexpress tumor-specific receptors: Persistence and antitumor activity in individuals with neuroblastoma
Cytotoxic T lymphocytes (CTLs) directed to nonviral tumor-associated antigens do not survive long term and have limited antitumor activity in vivo, in part because such tumor cells typically lack the appropriate costimulatory molecules. We therefore engineered Epstein-Barr virus (EBV)-specific CTLs to express a chimeric antigen receptor directed to the diasialoganglioside GD2, a nonviral tumor-associated antigen expressed by human neuroblastoma cells. We reasoned that these genetically engineered lymphocytes would receive optimal costimulation after engagement of their native receptors, enhancing survival and antitumor activity mediated through their chimeric receptors. Here we show in individuals with neuroblastoma that EBV-specific CTLs expressing a chimeric GD2-specific receptor indeed survive longer than T cells activated by the CD3-specific antibody OKT3 and expressing the same chimeric receptor but lacking virus specificity. Infusion of these genetically modified cells seemed safe and was associated with tumor regression or necrosis in half of the subjects tested. Hence, virus-specific CTLs can be modified to function as tumor-directed effector cells
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