Urotensin II in cardiovascular regulation

Cardiovascular function is modulated by neuronal transmitters, circulating hormones, and factors that are released locally from tissues. Urotensin II (UII) is an 11 amino acid peptide that stimulates its’ obligatory G protein coupled urotensin II receptors (UT) to modulate cardiovascular function in humans and in other animal species, and has been implicated in both vasculoprotective and vasculopathic effects. For example, tissue and circulating concentrations of UII have been reported to increase in some studies involving patients with atherosclerosis, heart failure, hypertension, preeclampsia, diabetes, renal disease and liver disease, raising the possibility that the UT receptor system is involved in the development and/or progression of these conditions. Consistent with this hypothesis, administration of UT receptor antagonists to animal models of cardiovascular disease have revealed improvements in cardiovascular remodelling and hemodynamics. However, recent studies have questioned this contributory role of UII in disease, and have instead postulated a protective effect on the cardiovascular system. For example, high concentrations of circulating UII correlated with improved clinical outcomes in patients with renal disease or myocardial infarction. The purpose of this review is to consider the regulation of the cardiovascular system by UII, giving consideration to methodologies for measurement of plasma concentrations, sites of synthesis and triggers for release

System and method for monitoring cellular activity

A system and method for monitoring cellular activity in a cellular specimen. According to one embodiment, a plurality of excitable markers are applied to the specimen. A multi-photon laser microscope is provided to excite a region of the specimen and cause fluorescence to be radiated from the region. The radiating fluorescence is processed by a spectral analyzer to separate the fluorescence into respective wavelength bands. The respective bands of fluorescence are then collected by an array of detectors, with each detector receiving a corresponding one of the wavelength bands

Does autonomous macrophage-driven inflammation promote alveolar damage in COVID-19?

SARS-CoV-2 has caused devastating effects with over 550 million infections by July 2022 and approximately 6.4 million deaths [1]. Societal and economic impacts will reverberate for years, with continuous evolution of SARS-CoV-2 as it persistently spreads through the human population as exemplified by reduced activity of vaccines and monoclonals against Omicron BA.4 or BA.5 subvariants [2]. A greater understanding of pathogenesis and more tailored therapeutic approaches are therefore essential

Multiwavelength monitoring of a very active dwarf nova AX J1549.8-5416 with an unusually high duty cycle

We present new optical, UV and X-ray observations of a highly variable dwarf nova(DN) AX J1549.8-5416. The multiwavelength analysis of three mini-outbursts and one normal outburst represent one of the most complete multiwavelength studies of a DN and help to refine the relationship between the X-ray, UV and optical emission in this system. We find that the UV emission is delayed the optical (1.0-5.4 days) during the rising phase of the outburst. The X-ray emission is suppressed during the peak of the optical outburst and recovers during the end of the outburst. We also analyse archival Swift, Chandra and XMM-Newton observations of the source. Our estimated high duty cycle suggests the X-ray luminosity of this source should be larger than 10E32 erg/s in quiescence. We find a roughly anti-correlation between X-ray and UV flux. The X-ray spectra of XMM-Newton and Chandra can be well described either by a single temperature thermal plasma model or by an isobaric cooling flow model when its X-ray flux is high.Fil: Zhang, Guobao. New York University Abu Dhabi; Emiratos Arabes UnidosFil: Gelfand, Joseph D.. New York University Abu Dhabi; Emiratos Arabes UnidosFil: Russell, David M.. New York University Abu Dhabi; Emiratos Arabes UnidosFil: Lewis, Fraser. Cardiff University; Reino UnidoFil: Masetti, Nicola. Istituto Nazionale di Astrofisica; ItaliaFil: Bernardini, Federico. New York University Abu Dhabi; Emiratos Arabes UnidosFil: Andruchow, Ileana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Zibecchi, Lorena Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaThe X-ray Universe 2017RomaItaliaEuropean Space AgencyXMM Newton Science CenterNational Institute for AstrophysicsItalian Space AgencyUniversity Roma TreLa Sapienza Universit

Seven reflares, a mini-outburst and an outburst : High amplitude optical variations in the black hole X-ray binary Swift J1910.2-0546

We present long-term (2012-2022) optical monitoring of the candidate black hole X-ray binary Swift J1910.2-0546 with the Faulkes Telescopes and Las Cumbres Observatory (LCO) network. Following its initial bright 2012 outburst, we find that the source displayed a series of at least 7 quasi-periodic, high amplitude (~3 mags) optical reflares in 2013, with a recurrence time increasing from ~42 days to ~49 days. In 2014, the source experienced a mini-outburst with two peaks in the optical. We also study the recent 2022 outburst of the source at optical wavelengths, and perform a comparative analysis with the earlier rebrightenings. A single X-ray detection and only two radio detections were obtained during the 2013 reflaring period, and only optical detections were acquired in 2014. During the reflaring in both 2013 and 2014, the source showed bluer-when-brighter behavior, having optical colors consistent with a blackbody heating and cooling between 4500 and 9500 K, i.e. the temperature range in which hydrogen starts to ionize. Finally, we compare the flaring behavior of the source to re-brightening events in other X-ray binaries. We show that the repeated reflarings of Swift J1910.2-0546 are highly unusual, and propose that they arise from a sequence of repetitive heating and cooling front reflections travelling through the accretion disk.Comment: Accepted for publication in ApJ, appendix will appear at the published version of the pape

Multiwavelength monitoring of a very active dwarf nova AX J1549.8-5416 with an unusually high duty cycle

We present the results of our analysis of new optical, ultraviolet (UV) and X-ray observations of a highly variable source − AX J1549.8−5416. Both the detection of several fast rise, exponential decay outbursts in the optical light curve and the lack of He II emission lines in the optical spectra suggest AX J1549.8−5416 is a cataclysmic variable of the dwarf nova (DN) type. The multiwavelength analysis of three mini-outbursts and one normal outburst represent one of the most complete multiwavelength studies of a DN and help to refine the relationship between the X-ray, UV and optical emission in this system. We find that the UV emission is delayed with respect to the optical by 1.0–5.4 d during the rising phase of the outburst. The X-ray emission is suppressed during the peak of the optical outburst and recovers during the end of the outburst. From our analysis of archival Swift, Chandra and XMM–Newton observations of AX J1549.8−5416, we estimate this DN has a high duty cycle (∼50 per cent), suggesting a quiescent X-ray luminosity larger than 1032 erg/s. We also find the X-ray and UV flux are roughly anticorrelated. Furthermore, we find that, at low X-ray fluxes, the X-ray spectrum is well described by a single temperature thermal plasma model, while at high X-ray fluxes, an isobaric cooling flow model also works. We find that the maximum temperature of the plasma in quiescence is significantly higher than that in outburst.Instituto de Astrofísica de La Plat

Multiwavelength monitoring of a very active dwarf nova AX J1549.8-5416 with an unusually high duty cycle

We present the results of our analysis of new optical, ultraviolet (UV) and X-ray observations of a highly variable source − AX J1549.8−5416. Both the detection of several fast rise, exponential decay outbursts in the optical light curve and the lack of He II emission lines in the optical spectra suggest AX J1549.8−5416 is a cataclysmic variable of the dwarf nova (DN) type. The multiwavelength analysis of three mini-outbursts and one normal outburst represent one of the most complete multiwavelength studies of a DN and help to refine the relationship between the X-ray, UV and optical emission in this system. We find that the UV emission is delayed with respect to the optical by 1.0–5.4 d during the rising phase of the outburst. The X-ray emission is suppressed during the peak of the optical outburst and recovers during the end of the outburst. From our analysis of archival Swift, Chandra and XMM–Newton observations of AX J1549.8−5416, we estimate this DN has a high duty cycle (∼50 per cent), suggesting a quiescent X-ray luminosity larger than 1032 erg/s. We also find the X-ray and UV flux are roughly anticorrelated. Furthermore, we find that, at low X-ray fluxes, the X-ray spectrum is well described by a single temperature thermal plasma model, while at high X-ray fluxes, an isobaric cooling flow model also works. We find that the maximum temperature of the plasma in quiescence is significantly higher than that in outburst.Instituto de Astrofísica de La Plat

Encephalitis caused by a Lyssavirus in fruit bats in Australia.

This report describes the first pathologic and immunohistochemical recognition in Australia of a rabies-like disease in a native mammal, a fruit bat, the black flying fox (Pteropus alecto). A virus with close serologic and genetic relationships to members of the Lyssavirus genus of the family Rhabdoviridae was isolated in mice from the tissue homogenates of a sick juvenile animal

Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects

Elucidating the causes of congenital heart defects is made difficult by the complex morphogenesis of the mammalian heart, which takes place early in development, involves contributions from multiple germ layers, and is controlled by many genes. Here, we use a conditional/invertible genetic strategy to identify the cell lineage(s) responsible for the development of heart defects in a Nipbl-deficient mouse model of Cornelia de Lange Syndrome, in which global yet subtle transcriptional dysregulation leads to development of atrial septal defects (ASDs) at high frequency. Using an approach that allows for recombinase-mediated creation or rescue of Nipbl deficiency in different lineages, we uncover complex interactions between the cardiac mesoderm, endoderm, and the rest of the embryo, whereby the risk conferred by genetic abnormality in any one lineage is modified, in a surprisingly non-additive way, by the status of others. We argue that these results are best understood in the context of a model in which the risk of heart defects is associated with the adequacy of early progenitor cell populations relative to the sizes of the structures they must eventually form

Ice chemistry in massive Young Stellar Objects: the role of metallicity

We present the comparison of the three most important ice constituents (water, CO and CO2) in the envelopes of massive Young Stellar Objects (YSOs), in environments of different metallicities: the Galaxy, the Large Magellanic Cloud (LMC) and, for the first time, the Small Magellanic Cloud (SMC). We present observations of water, CO and CO2 ice in 4 SMC and 3 LMC YSOs (obtained with Spitzer-IRS and VLT/ISAAC). While water and CO2 ice are detected in all Magellanic YSOs, CO ice is not detected in the SMC objects. Both CO and CO2 ice abundances are enhanced in the LMC when compared to high-luminosity Galactic YSOs. Based on the fact that both species appear to be enhanced in a consistent way, this effect is unlikely to be the result of enhanced CO2 production in hotter YSO envelopes as previously thought. Instead we propose that this results from a reduced water column density in the envelopes of LMC YSOs, a direct consequence of both the stronger UV radiation field and the reduced dust-to-gas ratio at lower metallicity. In the SMC the environmental conditions are harsher, and we observe a reduction in CO2 column density. Furthermore, the low gas-phase CO density and higher dust temperature in YSO envelopes in the SMC seem to inhibit CO freeze-out. The scenario we propose can be tested with further observations.Comment: accepted by MNRAS Letters; 5 pages, 3 figures, 1 tabl