(Re)Discovering Civitas: The L.A.gora

The purpose of this study was the development of an architectural methodology capable of re-establishing polycentric civitas in the City of Los Angeles. To establish a new civic design framework for the city of Los Angeles, research and analysis was conducted in many fields using several different methods. A review of literature pertaining to the historic establishment of civitas serves an analysis of the different forms of public space in Western civilization. An analysis of urbanism in Los Angeles was conducted using existing literature related to the topic, while an analysis of the neighborhood chosen as the site for the “execution” of the methodology was performed through first-hand research and field study. This information was then synthesized, producing a building program customized to the Miracle Mile in Los Angeles. The final stage of the study was the design of this new civic core. In the context of the Miracle Mile—defined by the presence of the Los Angeles County Museum of Art—the proposed civic core took the form of an artist commune. The study concludes that the re-establishment of polycentrism in Los Angeles, as a means for (re)discovering civitas, requires the development of several new alternative civic cores, dispersed throughout the urban fabric of the Los Angeles Basin. In order to effectively operate as sites of critical civic engagement, however, each core must be developed independently of the other, responding to specific micro-cultures. This study advocates choosing sites based on the presence of existing civic potentials. In this way, the alienating effects of tabula rasa city planning are avoided. The architectural project presented at the end of this study, should therefore be understood, not as an architectural prototype to be universally replicated across the city, but as a prototype for an architectural research method. In order to (re)discover civitas in Los Angeles, architects and urban planners must recognize the limitations of universal models and accept that the architectural spaces that define the civic realm must reflect the needs of the specific societies who will ultimately activate them

3,3′-Bis(quinolin-8-yl)-1,1′-[4,4′-methyl­enebis(4,1-phenyl­ene)]diurea

The title compound, C33H26N6O2, contains two 3-(quinolin-8-yl)urea groups linked to a diphenyl­methane. The asymmetric unit contains two mol­ecules, A and B. Each quinoline plane is essentially parallel to the attached urea unit [dihedral angles = 8.97 (18) and 8.81 (19) in molecule A and 18.47 (18) and 4.09 (19)° in molecule B]. The two benzene rings are twisted, making dihedral angles of 81.36 (8)° in A and 87.20 (9)° in B. The molecular structures are stabilized by intramolecular N—H⋯N hydrogen bonds. In the crystal, each urea O atom is involved in two N—H⋯O hydrogen bonds, generating two inter­penetrating three-dimensional sets of mol­ecules

Polarized Radio Sources: A Study of Luminosity, Redshift and Infrared Colors

The Dominion Radio Astrophysical Observatory Deep Field polarization study has been matched with the Spitzer Wide-Area Infrared Extragalactic survey of the European Large Area Infrared Space Observatory Survey North 1 field. We have used VLA observations with a total intensity rms of 87 microJy beam^-1 to match SWIRE counterparts to the radio sources. Infrared color analysis of our radio sample shows that the majority of polarized sources are elliptical galaxies with an embedded active galactic nucleus. Using available redshift catalogs, we found 429 radio sources of which 69 are polarized with redshifts in the range of 0.04 < z <3.2. We find no correlation between redshift and percentage polarization for our sample. However, for polarized radio sources, we find a weak correlation between increasing percentage polarization and decreasing luminosity.Comment: 35 pages, 12 figures, accepted for publication in The Astrophysical Journa

Post-Capillary Pulmonary Hypertension: Clinical Review

Pulmonary hypertension (PH) caused by left heart disease, also known as post-capillary PH, is the most common etiology of PH. Left heart disease due to systolic dysfunction or heart failure with preserved ejection fraction, valvular heart disease, and left atrial myopathy due to atrial fibrillation are causes of post-capillary PH. Elevated left-sided filling pressures cause pulmonary venous congestion due to backward transmission of pressures and post-capillary PH. In advanced left-sided heart disease or valvular heart disease, chronic uncontrolled venous congestion may lead to remodeling of the pulmonary arterial system, causing combined pre-capillary and post-capillary PH. The hemodynamic definition of post-capillary PH includes a mean pulmonary arterial pressure \u3e 20 mmHg, pulmonary vascular resistance \u3c 3 Wood units, and pulmonary capillary wedge pressure \u3e 15 mmHg. Echocardiography is important in the identification and management of the underlying cause of post-capillary PH. Management of post-capillary PH is focused on the treatment of the underlying condition. Strategies are geared towards pharmacotherapy and guideline-directed medical therapy for heart failure, surgical or percutaneous management of valvular disorders, and control of modifiable risk factors and comorbid conditions. Referral to centers with advanced heart and pulmonary teams has shown to improve morbidity and mortality. There is emerging interest in the use of targeted agents classically used in pulmonary arterial hypertension, but current data remain limited and conflicting. This review aims to serve as a comprehensive summary of postcapillary PH and its etiologies, pathophysiology, diagnosis, and management, particularly as it pertains to advanced heart failure

The Building Blocks of Interoperability. A Multisite Analysis of Patient Demographic Attributes Available for Matching.

BackgroundPatient matching is a key barrier to achieving interoperability. Patient demographic elements must be consistently collected over time and region to be valuable elements for patient matching.ObjectivesWe sought to determine what patient demographic attributes are collected at multiple institutions in the United States and see how their availability changes over time and across clinical sites.MethodsWe compiled a list of 36 demographic elements that stakeholders previously identified as essential patient demographic attributes that should be collected for the purpose of linking patient records. We studied a convenience sample of 9 health care systems from geographically distinct sites around the country. We identified changes in the availability of individual patient demographic attributes over time and across clinical sites.ResultsSeveral attributes were consistently available over the study period (2005-2014) including last name (99.96%), first name (99.95%), date of birth (98.82%), gender/sex (99.73%), postal code (94.71%), and full street address (94.65%). Other attributes changed significantly from 2005-2014: Social security number (SSN) availability declined from 83.3% to 50.44% (p&lt;0.0001). Email address availability increased from 8.94% up to 54% availability (p&lt;0.0001). Work phone number increased from 20.61% to 52.33% (p&lt;0.0001).ConclusionsOverall, first name, last name, date of birth, gender/sex and address were widely collected across institutional sites and over time. Availability of emerging attributes such as email and phone numbers are increasing while SSN use is declining. Understanding the relative availability of patient attributes can inform strategies for optimal matching in healthcare

Paleomagnetism of Middle Tertiary Volcanic-Rocks from the Western Cascade Series, Northern California

The Western Cascade Series (WCS) is a 3.5-km-thick, crudely homoclinal (east dipping) calcalkaline volcanic sequence of mid-Oligocene to early Miocene age that crops out near the southern tip of the Cascade Range in northern California. The mean direction of remanent magnetization in the WCS is D, 4.9°; I, 57.6° (N, 53; k, 14.4; α95 , 5.3°). When compared to a reference direction for the North American cration, the WCS direction indicates that the southern Cascade Range has rotated 14.0° +/- 9.0° since the WCS accumulated. A difference in mean direction between the lower and upper halves of the WCS suggests that much of this rotation occurred during the late Oligocene. Six other paleomagnetic studies of rock units of an age roughly comparable to the WCS also are available from western Oregon, northwestern California, and southwestern Washington. All show statistically significant clockwise rotation (inclination of all but one are concordant). Comparison of directions indicates that the Pacific Northwest did not rotate as a rigid body, but neither did it behave as a collection of small, independently rotating domains. The amount of rotation found throughout the area increases to the west or northwest, suggesting a driving force for rotation operating at the continental margin

Tumor Doubling Time of Pulmonary Carcinoid Tumors Measured by CT

Introduction: Pulmonary carcinoid tumor (PCT) is a rare neuroendocrine lung cancer that is known clinically to be a slow-growing neoplasm. Few studies have established the true growth rate of these tumors when followed over time by radiography. Therefore, we sought to determine PCT tumor doubling time using longitudinal Computed Tomography (CT) scans. Nodule guidelines may misclassify early PCT nodules with a small diameter as benign if tumor growth is too slow to be appreciable on follow up radiographic scans completed between six months and two years after initial detection. Methods: We performed a retrospective analysis of available CT imaging of all PCTs treated at Thomas Jefferson University Hospital between 2006-2020 where radiographic follow up occurred prior to biopsy or resection. Nodule dimensions were measured manually using Phillips Intellispace PACS or retrieved from radiology reports. Tumor doubling time was calculated for all tumors demonstrating definitive growth (an increase in average diameter ≥ 2 mm) over a follow up interval of at least two years. Results: Fifteen patients had pathologically proven PCT with pre-resection observation times exceeding two years. 12/15 (80%) were typical carcinoids and 3/15 were atypical. 11/12 of the typical PCTs demonstrated definitive growth with a median doubling time of 140 weeks (mean = 161 ± 105 weeks). Discussion: The median doubling time of typical PCT was 141 weeks, or almost three years. It is conceivable that PCTs detected early with small diameter may be mistaken for benign non-growing lesions when followed for less than two years in low-risk patients

MIBG avidity correlates with clinical features, tumor biology, and outcomes in neuroblastoma: A report from the Children’s Oncology Group

BackgroundPrior studies suggest that neuroblastomas that do not accumulate metaiodobenzylguanidine (MIBG) on diagnostic imaging (MIBG non‐avid) may have more favorable features compared with MIBG avid tumors. We compared clinical features, biologic features, and clinical outcomes between patients with MIBG nonavid and MIBG avid neuroblastoma.ProcedurePatients had metastatic high‐ or intermediate‐risk neuroblastoma and were treated on Children’s Oncology Group protocols A3973 or A3961. Comparisons of clinical and biologic features according to MIBG avidity were made with chi‐squared or Fisher exact tests. Event‐free (EFS) and overall (OS) survival compared using log–rank tests and modeled using Cox models.ResultsThirty of 343 patients (8.7%) had MIBG nonavid disease. Patients with nonavid tumors were less likely to have adrenal primary tumors (34.5 vs. 57.2%; P = 0.019), bone metastases (36.7 vs. 61.7%; P = 0.008), or positive urine catecholamines (66.7 vs. 91.0%; P < 0.001) compared with patients with MIBG avid tumors. Nonavid tumors were more likely to be MYCN amplified (53.8 vs. 32.6%; P = 0.030) and had lower norepinephrine transporter expression. Patients with MIBG nonavid disease had a 5‐year EFS of 50.0% compared with 38.7% for patients with MIBG avid disease (P = 0.028). On multivariate testing in high‐risk patients, MIBG avidity was the sole adverse prognostic factor for EFS identified (hazard ratio 1.77; 95% confidence interval 1.04–2.99; P = 0.034).ConclusionsPatients with MIBG nonavid neuroblastoma have lower rates of adrenal primary tumors, bone metastasis, and catecholamine secretion. Despite being more likely to have MYCN‐amplified tumors, these patients have superior outcomes compared with patients with MIBG avid disease.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138438/1/pbc26545_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138438/2/pbc26545.pd

Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies.

IntroductionQuantitative in vivo measurement of brain amyloid burden is important for both research and clinical purposes. However, the existence of multiple imaging tracers presents challenges to the interpretation of such measurements. This study presents a direct comparison of Pittsburgh compound B-based and florbetapir-based amyloid imaging in the same participants from two independent cohorts using a crossover design.MethodsPittsburgh compound B and florbetapir amyloid PET imaging data from three different cohorts were analyzed using previously established pipelines to obtain global amyloid burden measurements. These measurements were converted to the Centiloid scale to allow fair comparison between the two tracers. The mean and inter-individual variability of the two tracers were compared using multivariate linear models both cross-sectionally and longitudinally.ResultsGlobal amyloid burden measured using the two tracers were strongly correlated in both cohorts. However, higher variability was observed when florbetapir was used as the imaging tracer. The variability may be partially caused by white matter signal as partial volume correction reduces the variability and improves the correlations between the two tracers. Amyloid burden measured using both tracers was found to be in association with clinical and psychometric measurements. Longitudinal comparison of the two tracers was also performed in similar but separate cohorts whose baseline amyloid load was considered elevated (i.e., amyloid positive). No significant difference was detected in the average annualized rate of change measurements made with these two tracers.DiscussionAlthough the amyloid burden measurements were quite similar using these two tracers as expected, difference was observable even after conversion into the Centiloid scale. Further investigation is warranted to identify optimal strategies to harmonize amyloid imaging data acquired using different tracers