Force Sensing in an Optomechanical System with Feedback-Controlled In-Loop Light

Quantum control techniques applied at macroscopic scales provide us with opportunities in fundamental physics and practical applications. Among them, measurement-based feedback allows efficient control of optomechanical systems and quantum-enhanced sensing. In this paper, we propose a near-resonant narrow-band force sensor with extremely low optically added noise in a membrane in the middle optomechanical system subject to a feedback-controlled in-loop light. The membrane's intrinsic motion consisting of zero-point motion and thermal motion is affected by the added noise of measurement due to the backaction noise and imprecision noise. We show that, in the optimal low-noise regime, the system is analogous to an optomechanical system containing a near quantum-limited optical parametric amplifier coupled to an engineered reservoir interacting with the cavity. Therefore, the feedback loop enhances the mechanical response of the system to the input while keeping the optically added noise of measurement below the standard quantum limit. Moreover, the system based on feedback offers a much larger amplification bandwidth than the same system with no feedback. Without the need to hybridize it with other quantum systems or introduce nonlinearities, our force sensor may have broad applications ranging from biology and medicine to gravitational wave detection and tests of fundamental physics

Probing Color Response - Wakes in a Color Plasma

The wake induced in a hot QCD medium by a high momentum parton (jet precursor) is calculated in the framework of linear response theory. Two different scenarios are discussed: a weakly coupled quark gluon plasma (pQGP) as described by hard-thermal loop (HTL) perturbation theory and a strongly cupled QGP (sQGP) with the properties of a quantum liquid. In the latter case the wake could exhibit a pronounced Mach cone structure. This physical mechanism could be important for the understanding of preliminary data from the PHENIX and STAR experiments at RHIC on the angular distribution of low-pt secondaries stemming from the away-side jet which indicate maxima at $\Delta\phi=\pi \pm 1.1$.Comment: Prepared for: Workshop on Correlations and Fluctuations in Relativistic Nuclear Collisions, MIT, Cambridge, Massachusetts, USA, 21-23 April 200

Cotranslational N-degron masking by acetylation promotes proteome stability in plants

N-terminal protein acetylation (NTA) is a prevalent protein modification essential for viability in animals and plants. The dominant executor of NTA is the ribosome tethered N-alpha-acetyltransferase A (NatA) complex. However, the impact of NatA on protein fate is still enigmatic. Here, we demonstrate that depletion of NatA activity leads to a 4-fold increase in global protein turnover via the ubiquitin-proteasome system in Arabidopsis. Surprisingly, a concomitant increase in translation, actioned via enhanced Target-of-Rapamycin activity, is also observed, implying that defective NTA triggers feedback mechanisms to maintain steady-state protein abundance. Quantitative analysis of the proteome, the translatome, and the ubiquitome reveals that NatA substrates account for the bulk of this enhanced turnover. A targeted analysis of NatA substrate stability uncovers that NTA absence triggers protein destabilization via a previously undescribed and widely conserved nonAc/N-degron in plants. Hence, the imprinting of the proteome with acetylation marks is essential for coordinating proteome stability. N-terminal protein acetylation is required for plant viability. Here the authors show that reducing N-terminal acetylation by NatA leads to an increase in global protein turnover that is facilitated by absent masking of a novel N-degro

Dissecting and modeling photic and melanopsin effects to predict sleep disturbances induced by irregular light exposure in mice.

Artificial lighting, day-length changes, shift work, and transmeridian travel all lead to sleep-wake disturbances. The nychthemeral sleep-wake cycle (SWc) is known to be controlled by output from the central circadian clock in the suprachiasmatic nuclei (SCN), which is entrained to the light-dark cycle. Additionally, via intrinsically photosensitive retinal ganglion cells containing the photopigment melanopsin (Opn4), short-term light-dark alternations exert direct and acute influences on sleep and waking. However, the extent to which longer exposures typically experienced across the 24-h day exert such an effect has never been clarified or quantified, as disentangling sustained direct light effects (SDLE) from circadian effects is difficult. Recording sleep in mice lacking a circadian pacemaker, either through transgenesis (Syt10 <sup>cre/cre</sup> Bmal1 <sup>fl/-</sup> ) or SCN lesioning and/or melanopsin-based phototransduction (Opn4 <sup>-/-</sup> ), we uncovered, contrary to prevailing assumptions, that the contribution of SDLE is as important as circadian-driven input in determining SWc amplitude. Specifically, SDLE were primarily mediated (>80%) through melanopsin, of which half were then relayed through the SCN, revealing an ancillary purpose for this structure, independent of its clock function in organizing SWc. Based on these findings, we designed a model to estimate the effect of atypical light-dark cycles on SWc. This model predicted SWc amplitude in mice exposed to simulated transequatorial or transmeridian paradigms. Taken together, we demonstrate this SDLE is a crucial mechanism influencing behavior on par with the circadian system. In a broader context, these findings mandate considering SDLE, in addition to circadian drive, for coping with health consequences of atypical light exposure in our society

Chiral symmetry restoration in linear sigma models with different numbers of quark flavors

Chiral symmetry restoration at nonzero temperature is studied in the framework of the O(4) linear sigma model and the U(N_f)_r x U(N_f)_l linear sigma model with N_f=2,3, and 4 quark flavors. We investigate the temperature dependence of the masses of the scalar and pseudoscalar mesons, and the non-strange, strange, and charm condensates within the Hartree approximation as derived from the Cornwall-Jackiw-Tomboulis formalism. We find that the masses of the non-strange and strange mesons at nonzero temperature depend sensitively on the particular symmetry of the model and the number of light quark flavors N_f. On the other hand, due to the large charm quark mass, neither do charmed mesons significantly affect the properties of the other mesons, nor do their masses change appreciably in the temperature range around the chiral symmetry restoration temperature. In the chiral limit, the transition temperatures for chiral symmetry restoration are surprisingly close to those found in lattice QCD.Comment: 28 pages, 8 figure

OC-057 PREVENTION OF INCISIONAL HERNIAS BY PROPHYLACTIC MESH-AUGMENTED REINFORCEMENT OF MIDLINE LAPAROTOMIES FOR ABDOMINAL AORTIC ANEURYSM TREATMENT. 5-YEAR FOLLOW-UP OF A RANDOMIZED CONTROLLED TRIAL

peer reviewedAbstract Introduction The incidence of incisional hernias (IHs) after open repair of an abdominal aortic aneurysm (AAA) is high. Several randomized controlled trials have reported favorable results with the use of prophylactic mesh to prevent IHs, without increasing complications. In this analysis we report on the results of the 60-month follow-up of the PRIMAAT trial (Ann Surg 2016; 263(4): 638–45). Methods In a prospective, multicenter, open label, randomized design, patients were randomized between prophylactic retrorectus mesh reinforcement (MESH group), and primary closure of their midline laparotomy after open AAA repair (NOMESH group). This article reports on the results of clinical follow-up after 60 months. If performed, ultrasonography or computed tomography were used for the diagnosis of IHs. Results Of the 120 randomized patients, 114 were included in the intention-to-treat analysis. Thirty-three patients in the NOMESH group (33/58–56.9%) and 34 patients in the MESH group (34/56–60.7%) were evaluated after 5 years. The cumulative incidence of IHs in the NOMESH group was 32.9% after 24 months and 49.2% after 60 months. No incisional hernias were diagnosed in the MESH group. In the NOMESH group, 21.7% (5/23) underwent reoperation within 5 years due to an IH. Conclusion Prophylactic retrorectus mesh reinforcement after midline laparotomy for the treatment of AAAs safely and effectively decreases the rate of IHs. The cumulative incidence of IHs after open AAA repair, when no mesh is used, continues to increase during the first 5 years after surgery, which leads to a substantial rate of hernia repairs

Shift invariant preduals of ℓ₁(ℤ)

The Banach space ℓ<sub>1</sub>(ℤ) admits many non-isomorphic preduals, for example, C(K) for any compact countable space K, along with many more exotic Banach spaces. In this paper, we impose an extra condition: the predual must make the bilateral shift on ℓ<sub>1</sub>(ℤ) weak<sup>*</sup>-continuous. This is equivalent to making the natural convolution multiplication on ℓ<sub>1</sub>(ℤ) separately weak*-continuous and so turning ℓ<sub>1</sub>(ℤ) into a dual Banach algebra. We call such preduals <i>shift-invariant</i>. It is known that the only shift-invariant predual arising from the standard duality between C<sub>0</sub>(K) (for countable locally compact K) and ℓ<sub>1</sub>(ℤ) is c<sub>0</sub>(ℤ). We provide an explicit construction of an uncountable family of distinct preduals which do make the bilateral shift weak<sup>*</sup>-continuous. Using Szlenk index arguments, we show that merely as Banach spaces, these are all isomorphic to c<sub>0</sub>. We then build some theory to study such preduals, showing that they arise from certain semigroup compactifications of ℤ. This allows us to produce a large number of other examples, including non-isometric preduals, and preduals which are not Banach space isomorphic to c<sub>0</sub>

Variational tetrahedral meshing

In this paper, a novel Delaunay-based variational approach to isotropic tetrahedral meshing is presented. To achieve both robustness and efficiency, we minimize a simple mesh-dependent energy through global updates of both vertex positions and connectivity. As this energy is known to be the ∠1 distance between an isotropic quadratic function and its linear interpolation on the mesh, our minimization procedure generates well-shaped tetrahedra. Mesh design is controlled through a gradation smoothness parameter and selection of the desired number of vertices. We provide the foundations of our approach by explaining both the underlying variational principle and its geometric interpretation. We demonstrate the quality of the resulting meshes through a series of examples

Closed-Time Path Integral Formalism and Medium Effects of Non-Equilibrium QCD Matter

We apply the closed-time path integral formalism to study the medium effects of non-equilibrium gluon matter. We derive the medium modified resummed gluon propagator to the one loop level in non-equilibrium in the covariant gauge. The gluon propagator we derive can be used to remove the infrared divergences in the secondary parton collisions to study thermalization of minijet parton plasma at RHIC and LHC.Comment: Final version, To appear in Physical Review D, Minor modification, reference adde