Numerical analysis of run-up oscillations under dissipative conditions

This paper presents laboratory and numerical simulations of run-up induced by irregular waves breaking on a gentle-sloping planar beach. The experimental data are well reproduced by a numerical model based on the nonlinear shallow water equations. By extending the incoming wave conditions considered in the laboratory experiments, the model is applied to study the run-up variability under highly energetic incoming conditions. The numerical results support the idea that, for cases characterized by the same incident peak frequency, infragravity run-up increases almost linearly with the offshore significant wave height. Moreover, the most energetic conditions lead to an upper limit of the swash similarity parameter of about 1.8. © 2014 Elsevier B.V

A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial

Multi-element interventions for first-episode psychosis (FEP) are promising, but have mostly been conducted in non-epidemiologically representative samples, thereby raising the risk of underestimating the complexities involved in treating FEP in 'real-world' services

Reynolds averaged Navier-Stokes modelling of long waves induced by a transient wave group on a beach

This paper presents the numerical modelling of the cross shore propagation of infragravity waves induced by a transient focused short wave group over a sloping bottom. A dataset obtained through new laboratory experiments in the wave flume of the University of Cantabria is used to validate the Reynolds averaged Navier-Stokes type model IH- 2VOF. A new boundary condition based on the wave maker movement used in the experiments is implemented in the model. Shoaling and breaking of short waves as well as the enhancement of long waves and the energy transfer to low-frequency motion are well addressed by the model, proving the high accuracy in the reproduction of surf zone hydrodynamics. Under the steep slope regime, a long wave trough is radiated offshore from the breakpoint. Numerical simulations conducted for different bottom slopes and short wave steepness suggest that this low-frequency breakpoint generated wave is controlled by both the bed slope parameter and the Iribarren number. Moreover, the numerical model is used to investigate the influence that a large flat bottom induces on the propagation pattern of long waves. © 2010 The Royal Society

Radiation stress and low-frequency energy balance within the surf zone: A numerical approach

This paper evaluates the energy transfer between short and long waves resulting from nonlinear interactions of the radiation stress with the low-frequency motion in the nearshore. Shoaling and breaking of irregular waves over different slopes are investigated by means of numerical simulations with the Reynolds Averaged Navier-Stokes model IH-2VOF. The low-frequency energy flux is enhanced up to the outer surf zone where dissipation starts. Seaward of the inner surf zone, the rate of work done by the radiation stress roughly balances the low-frequency energy flux gradients, indicating that nonlinear interactions with sea-swell waves are responsible for both the enhancement and the damping of low-frequency energy. In the inner surf zone, interactions between short- and long-wave fields are weak and the low-frequency energy loss appears to be largely due to self-self nonlinear interactions. © 2012 Elsevier B.V

Combining standardized uptake value of FDG-PET and apparent diffusion coefficient of DW-MRI improves risk stratification in head and neck squamous cell carcinoma

Objectives: To assess the independent prognostic value of standardized uptake value (SUV) and apparent diffusion coefficient (ADC), separately and combined, in order to evaluate if the combination of these two variables allows further prognostic stratification of patients with head and neck squamous cell carcinomas (HNSCC). Methods: Pretreatment SUV and ADC were calculated in 57 patients with HNSCC. Mean follow-up was 21.3\ua0months. Semiquantitative analysis of primary tumours was performed using SUVmaxT/B, ADCmean, ADCmin and ADCmax. The prognostic value of SUVmaxT/B, ADCmean, ADCmin and ADCmax in predicting disease-free survival (DFS) was evaluated with log-rank test and Cox regression models. Results: Patients with SUVmaxT/B 655.75 had an overall worse prognosis (p = 0.003). After adjusting for lymph node status and diameter, SUVmaxT/B and ADCmin were both significant predictors of DFS with hazard ratio (HR) = 10.37 (95\ua0% CI 1.22\u201387.95) and 3.26 (95\ua0% CI 1.20\u20138.85) for SUVmaxT/B 655.75 and ADCmin 650.58 7 10 123 mm2/s, respectively. When the analysis was restricted to subjects with SUVmaxT/B 655.75, high ADCmin significantly predicted a worse prognosis, with adjusted HR = 3.11 (95\ua0% CI 1.13\u20138.55). Conclusions: The combination of SUVmaxT/B and ADCmin improves the prognostic role of the two separate parameters; patients with high SUVmaxT/B and high ADCmin are associated with a poor prognosis. Key Points: \u2022 High SUVmaxT/Bis a poor prognostic factor in HNSCC \u2022 High ADCminis a poor prognostic factor in HNSCC \u2022 In patients with high SUVmaxT/B, high ADCminidentified those with worse prognosi