Early Condylectomy: Biological Considerations

Objective: To describe the early treatment of two patients with unilateral condylar hyperplasia (UCH) diagnosis and therapeutic surgical protocol (early condylectomy) supported by the current biological knowledge about the development and repair of mandibular condyle cartilage (MCC). Methods: Review of the literature and two case description of the treatment. The two patients were girls, 12 and 13 year old. The follow up period was of 3 years. SPECT diagnostic, radiographic, photographic and tomographic images are presented. Results: The literature summarized provides biological basis favoring the early treatment of UCH. The two cases were treated with the same surgical protocol obtaining good esthetic and functional stable results. Discussion: The present literature review and clinical results provide biological basis to justify the practice of early condylectomy. Early intervention appears to be able to produce a successful outcome in terms of esthetic facial symmetry, avoiding dentoalveolar orthodontic compensations or additional orthognathic surgeries

El soroban, ábaco japonés un instrumento mágico para desarrollar la habilidad mental

El trabajo con el soroban surge como una alternativa para poder facilitar el trabajo con las matemáticas en el aula, por consiguiente desde la introducción para cada niño(a) se cuida que sea muy gratificante, para iniciar el trabajo de soroban los estudiantes primeramente trabajan en el mini computador de Dennis Papim que tiene como objetivo que ellos puedan descomponer y componer cantidades y luego aprenden el valor posicional de las fichas en el soroban, para iniciar el desarrollo de talleres escritos de suma y resta sencilla pasando a la multiplicación, división, potencia, radiación,etc

Estudio del consumo de opioides en la Comunidad de Madrid entre 2004 y 2014

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina. Fecha de lectura: 18-09-201

A bacterial acetyltransferase targets the protein kinase ZIP1, a positive regulator of plant immunity

Pseudomonas syringae is a model bacterial pathogen that penetrates the leaf to reach the plant apoplast, where it replicates causing disease. In order to do that, the pathogen must interfere and suppress a two-tiered plant defense response: PTI (PAMP-Triggered Immunity, or basal resistance) and ETI (Effector-Triggered Immunity). P. syringae uses a type III secretion system to directly deliver effector proteins inside the plant cell cytosol, many of which are known to suppress PTI, some of which are known to trigger ETI, and a handful of which are known to suppress ETI. Bacterial infection can also trigger a systemic plant defense response that protects the plant against additional pathogen attacks known as SAR (Systemic Acquired Resistance). We are particularly interested in the molecular and cellular mechanisms involved in effector-mediated defense evasion by P. syringae, in particular those involved in the suppression of ETI and SAR, and/or mediation of hormone signaling. Here we present data describing effector-mediated interference with plant immunity, by means of acetylation of a key positive regulator of local and systemic responses. Our work identifies a novel plant target for effector function, and characterizes its function. This work illustrates how analyzing the means by which a given effector interferes with its target can provide novel information regarding eukaryotic molecular mechanisms.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. MINECO BIO2015-64391R y FEDE

The bacterial effector HopZ1a acetylates ZIP1 kinase to suppress Arabidopsis defence responses

During the plant-pathogen interaction, disease or resistance are determined in the plant by a series of molecular events. The plant detects Pathogen-Associated Molecular Patterns (PAMPs), such as flagellin, triggering a defence response called PTI (PAMP-Triggered Immunity). Bacterial pathogens can in turn suppress such defence response through the translocation into the plant cell cytosol of virulence proteins, called effectors, via a Type Three Secretion System (T3SS). In resistant plants, intracellular receptors known as R proteins recognize these effectors, triggering a second line of defence, more specific and intense, called ETI (Effector-Triggered Immunity), which usually leads to programmed cell death known as HR (Hypersensitive Response). Pseudomonas syringae is a phytopathogenic bacterium whose virulence depends on a T3SS and its effector repertoire. Some strains include HopZ1a, an unusual effector which is able to suppress in Arabidopsis both local (PTI and ETI), and systemic (SAR, for Systemic Acquired Resistance) defences, by means of its acetyltransferase activity. In resistant Arabidopsis plants, HopZ1a acetylates the ZED1 pseudokinase, which is proposed to function as a decoy mimicking HopZ1a target in the plant: ZED1 modification activates an R-protein (ZAR1) to trigger HopZ1a-dependent ETI. None of the Arabidopsis proteins proposed to date as HopZ1a targets is a kinase, nor fully explains the effector´s defence suppression abilities. In this work we identify an Arabidopsis kinase that functions as a positive regulator of PTI, ETI and SAR, which interacts with HopZ1a and is acetylated by this effector in lysine residues essential for its kinase activity. Further, HopZ1a can specifically suppress the defence phenotypes resulting from ZIP1 expression in Arabidopsis. We propose that ZIP1 acetylation by HopZ1a interferes with its kinase activity, and consequently with positive defence signalling.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

miRNA/phasiRNA mediated regulation of plant defense response against P. syringae

Gene silencing is a mechanism of regulation of gene expression where the small RNAs (sRNAs) are key components for giving specificity to the system. In plants, two main types of noncoding small RNA molecules have been found: microRNAs (miRNAs) and small interfering RNAs (siRNAs). DCL proteins acting on large RNA precursors produce the mature forms of sRNAs (20-24nt) that can act as negative regulators of gene expression. In recent years, the role of miRNAs in regulation of gene expression in plant responses against bacterial pathogens is becoming clearer. Comparisons carried out in our lab between expression profiles of different Arabidopsis thaliana mutants affected in gene silencing, and plants challenged with Pseudomonas syringae pathovar tomato DC3000, led us to identify a set of uncharacterized R genes, belonging to the TIR-NBS-LRR gene family, as differentially expressed in these conditions. Through the use of bioinformatics tools, we found a miRNA* of 22 nt putatively responsible for down-regulating expression of these R genes. We have validated this regulation, and have also established that the corresponding pri-miRNA is down-regulated upon PAMPs or bacteria perception. Using GUS reporters, we have characterized the expression pattern of both pri-miRNA and its best target R genes. We demonstrate that plants with altered levels of miRNA* (knockdown or overexpression lines) exhibit altered PTI-associated phenotypes, supporting a role for this miRNA* in the defence response against this bacterial pathogen. Finally, we identify phasiRNAs that arise from the transcript of one of the R target genes in a miRNA*-RDR6-DCL4-dependent manner.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

New communication technologies for inclusive education in and outside the classroom

This chapter explores new communication technologies and methods for avoiding accessibility and communication barriers in the educational environment. It is focused on providing real-time captions so students with hearing disabilities and foreign students, among others, could participate in an inclusive way in and outside the classroom. The inclusive proposals are based on the APEINTA educational project, which aims for accessible education for all. The research work proposes the use of mobile devices for teacher and students in order to provide more flexibility using the APEINTA real-time captioning service. This allows using this service from anywhere and at anytime, not only in the classroom.APEINTA is the result of collaboration among the Department of Computer Science and the Department of Electronic Technology, Universidad Carlos III, and the Spanish Centre of Captioning and Audiodescription (CESyA)1. This project was initially supported by the Ministry of Science and Innovation (2007 I+D projects - EA2008-0312) within the program of Studies and Analyses - Actions to Improve the Quality of Higher Education and the Activity of University Professors. Currently, the research presented in this chapter is being partially supported by France Telecom España S.A. and the MA2VICMR (S2009/TIC-1542), GEMMA (TSI-020302-2010-141) and SAGAS (TSI-020100-2010-184) research projects.Publicad

El soroban, ábaco japones un instrumento mágico para desarrollar la habilidad mental

Spa: El trabajo con el soroban surge como una alternativa para poder facilitar el trabajo con las matemáticas en el aula, por consiguiente desde la introducción para cada niño(a) se cuida que sea muy gratificante, para iniciar el trabajo de soroban los estudiantes primeramente trabajan en el mini computador de Dennis Papim que tiene como objetivo que ellos puedan descomponer y componer cantidades y luego aprenden el valor posicional de las fichas en el soroban, para iniciar el desarrollo de talleres escritos de suma y resta sencilla pasando a la multiplicación, división, potencia, radicación, etc. PALABRAS CLAVES Abaco japonés cerrado Cálculo mental Aprendizaje de la matemática Experiencia agradable 18 años de trabaj

El acumulador Arquímedes

El objetivo de este proyecto es dar a conocer la innovación que supone el Acumulador Arquímedes, una máquina que tiene el fin de acumular anillos de rodamientos interiores de todo tipo y exteriores de primera generación. El proyecto nace de la necesidad de la fábrica SKF ESPAÑOLA (situada en carretera de Corella, km 3,5 Tudela (Navarra) 31500) en mejorar la gestión de espacio en planta. Actualmente es capaz de solucionar problemas de invasión de pasillos de paso (aplicación al acumulador del CH3 IR´s), desahogue de espacios de trabajo, mejorar la seguridad (reduce riesgo de atrapamientos / enganchones) y compactación de los equipos. Su principal característica es que se aprovecha el 100% del espacio, a diferencia de los actuales en los que solo se puede utilizar un 40% del espacio en planta (menor con cadena arrastrador). Otra ventaja es la posibilidad de hacerlo escalable radialmente, teniendo en cuenta el dimensionado necesario para un correcto funcionamiento. La estructura del proyecto consta de una parte principal donde se da a conocer el funcionamiento de la máquina y tres ANEXOS. El ANEXO III es una aplicación concreta de esta máquina para la fábrica SKF española, Tudela