Análisis del coste-efectividad y coste-utilidad del tratamiento cognitivo-conductual de los desórdenes emocionales en atención primaria frente a tratamiento convencional

Los trastornos emocionales de tipo ansioso, depresivo o somatomorfo son los trastornos mentales más prevalentes en Atención Primaria (AP) en España y causan importantes costes económicos tanto directos como indirectos, así como una disminución de la calidad de vida. Los tratamientos habituales aplicados en AP para el manejo de dichos trastornos no se ajustan a los recomendados en las guías de práctica clínica más importantes.Objetivo. Los objetivos de este estudio se centran en analizar las relaciones de coste-efectividad y coste-utilidad de un tratamiento psicológico cognitivo-conductual transdiagnóstico grupal, frente al tratamiento habitual de AP, para el tratamiento de los trastornos emocionales. Además, se analiza la evolución de estas ratios al cabo de 6 y 12 meses después del tratamiento..

Intellectual structure of international new venture research: a bibliometric analysis and suggestions for a future research agenda

We examine the intellectual structure of the international new venture (INV) literature using bibliometric citation and co-citation analysis. We aim to identify the most influential papers/authors, publication outlets, and key research topics. We focus on the top 100 most-cited papers in this field published between 1994 and 2015. In the post-hoc reading, we supplement our main bibliometric techniques with the qualitative content analysis method to shed light on a number of theoretical and empirical issues. We find that the literature has grown significantly in the past two decades. However, the main factors that hinder the field are the diversity of applicable theoretical perspectives and the inconsistencies between theoretical concepts and measurements of variables in empirics. We outline a detailed future research agenda to address these inconsistencies and recommend using new lenses from international business to examine the INV phenomenon

Functional characterization of two enhancers located downstream FOXP2

Background: Mutations in the coding region of FOXP2 are known to cause speech and language impairment. However, it is not clear how dysregulation of the gene contributes to language deficit. Interestingly, microdeletions of the region downstream the gene have been associated with cognitive deficits. Methods: Here, we investigate changes in FOXP2 expression in the SK-N-MC neuroblastoma human cell line after deletion by CRISPR-Cas9 of two enhancers located downstream of the gene. Results: Deletion of any of these two functional enhancers downregulates FOXP2, but also upregulates the closest 3′ gene MDFIC. Because this effect is not statistically significant in a HEK 293 cell line, derived from the human kidney, both enhancers might confer a tissue specific regulation to both genes. We have also found that the deletion of any of these enhancers downregulates six well-known FOXP2 target genes in the SK-N-MC cell line. Conclusions: We expect these findings contribute to a deeper understanding of how FOXP2 and MDFIC are regulated to pace neuronal development supporting cognition, speech and language.Spanish National Research and Development Plan PI14/01884Instituto de Salud Carlos III PI14/01884FEDER PI14/0188

Center-of-mass momentum dependence of short-range correlations with the coarse-grained Granada potential

This work was partially supported by Grant No. PID2020-114767GB-I00 funded by MCIN/AEI/10.13039/ 501100011033, by FEDER/Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades/A-FQM-390-UGR20, and by Junta de Andalucía (Grant No. FQM-225).The effect of the center-of-mass motion on the high-momentum distributions of correlated nucleon pairs is studied by solving the Bethe-Goldstone equation in nuclear matter with the Granada nucleon-nucleon potential. We show that this coarse-grained potential reduces the problem to an algebraic linear system of five (ten) equations for uncoupled (coupled) partial waves that can be easily solved. The corresponding relative wave functions of correlated pn, pp, and nn pairs are computed for different values of their center-of-mass (CM) momentum. We find that the pn pairs dominate the high-momentum tail of the relative momentum distribution, and that this only depends marginally on center-of-mass momentum. Our results provide further justification and agreement for the factorization approximation commonly used in the literature. This approximation assumes that the momentum distribution of nucleon pairs can be factorized as the product of the center-of-mass momentum distribution and the relative momentum distribution.MCIN/AEI/10.13039/ 501100011033: PID2020-114767GB-I00FEDER/Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades/A-FQM-390-UGR20Junta de Andalucía FQM-22

Acciones Formativas para el Fomento del Emprendimiento de Base Tecnológica de los Alumnos de los Grados de Comercio y Turismo

Depto. de Organización de EmpresasFac. de Comercio y TurismoFac. de Ciencias Económicas y EmpresarialesFALSEsubmitte

An orthogonal synthetic approach to nonsymmetrical bisazolyl 2,4,6-trisubstituted pyridines

A three-step synthetic route giving access to nonsymmetrical bisazolyl 2,4,6-trisubstituted pyridines with different substituents on the pyrazole, indazole, and pyridine heterocycles is described. From the readily available 4-bromo-2,6-difluoropyridine, both fluorine atoms allow for easy selective stepwise substitution, and the bromine atom provides easy access to additional functionalities through both Suzuki and Sonogashira Pd(0) cross-coupling reactions. These synthons represent optimal structures as building blocks in complexation and metalloorganic structures for the tuning of their chelating and photophysical propertie

Salud y Sostenibilidad: los Objetivos de Desarrollos Sostenible como herramienta pedagógica en el Grado de Biología Sanitaria con implicaciones profesionales y sociales

Los futuros graduados en Biología Sanitaria pueden mejorar su impacto profesional en salud pública incorporando como referencia el avance hacia los Objetivos de Desarrollo Sostenible (ODS). Se llevó a cabo un proyecto de innovación docente en la asignatura de Ecología y Bienestar Humano con el objetivo de que los alumnos profundizasen en la gestión de la salud considerando los ODS y la dimensión del medio ambiente. Se utilizaron las metodologías de “Aprendizaje Basado en Retos y Aprendizaje Basado en Investigación” en las prácticas y seminarios a través de dos casos de estudio. La adquisición de competencias se evaluó a través de una encuesta estructurada que pretendía medir la opinión de los estudiantes respecto a la importancia de los ODS en la salud y en su futuro profesional. Los resultados muestran un aumento en la importancia que los alumnos dieron a la relación entre salud y ecología tras la asignatura, a la vez que un aumento en su motivación

Improved Superscaling in Quasielastic Electron Scattering with Relativistic Effective Mass

Superscaling in electron scattering from nuclei is re-examined, paying special attention to the definition of the averaged single-nucleon responses. The validity of the extrapolation of nucleon responses in the Fermi gas has been examined, which previously lacked a theoretical foundation. To address this issue, we introduce new averaged responses with a momentum distribution smeared around the Fermi surface, allowing for momenta above the Fermi momentum. This approach solves the problem of negativity in the extrapolation away from the scaling region and, at the same time, validates its use in the scaling analysis. This work has important implications for the interpretation of scaling data and contributes to the development of a more complete understanding of the scaling approach.MCIN/AEI PID2020-114767GB-I00FEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades A-FQM-390-UGR20Junta de Andalucia FQM-22

Differences in Dietary Habits, Physical Exercise, and Quality of Life between Patients with Obesity and Overweight

Background: Overweight and obesity differ in their repercussions on the health and health-related quality of life (HRQoL) of patients. The objective of this study was to compare physical activity levels and dietary habits before admission and HRQoL at discharge between patients with obesity and overweight. Methods: A cross-sectional study was undertaken among participants in a clinical trial on education for healthy eating and physical activity, enrolling non-diabetic patients admitted to Internal Medicine Departments. These were classified by body mass index (BMI) as having overweight (25-29.9 Kg/m2) or obesity (≥30 kg/m2). Data were gathered on sociodemographic characteristics, clinical variables (medication for anxiety/depression, Charlson Comorbidity Index, length of hospital stay), physical exercise and diet (International Physical Activity and Pardo Questionnaires), and HRQoL (EQ-5D-5L). The study included 98 patients with overweight (58.2% males) and 177 with obesity (52% males). Results: In comparison to patients with obesity, those with overweight obtained better results for regular physical exercise (p = 0.007), healthy diet (p = 0.004), and "emotional eating" (p = 0.017). No between-group difference was found in HqoL scores. Conclusion: Patients with overweight and obesity differ in healthy dietary and physical exercise behaviors. Greater efforts are warranted to prevent an increase in the BMI of patients, paying special attention to their state of mind.This research was funded by Carlos III Health Institute and The European Regional Development Fund (ERDF), grant nº PI17/00419.S

Using aequorin probes to measure Ca2+ in intracellular organelles

Producción CientíficaAequorins are excellent tools for measuring intra-organellar Ca2+ and assessing its role in physiological and pathological functions. Here we review targeting strategies to express aequorins in various organelles. We address critical topics such as probe affinity tuning as well as normalization and calibration of the signal. We also focus on bioluminescent Ca2+ imaging in nucleus or mitochondria of living cells. Finally, recent advances with a new chimeric GFP-aequorin protein (GAP), which can be used either as luminescent or fluorescent Ca2+ probe, are presented. GAP is robustly expressed in transgenic flies and mice, where it has proven to be a suitable Ca2+ indicator for monitoring physiological Ca2+ signaling ex vivo and in vivo.Ministerio de Economía, Industria y Competitividad (Project BFU2014-53469P)Instituto de Salud Carlos III (TerCel, RD16/0011/0003