A versatile trigger and synchronization module with IEEE1588 capabilities and EPICS support.

Event timing and synchronization are two key aspects to improve in the implementation of distributed data acquisition (dDAQ) systems such as the ones used in fusion experiments. It is also of great importance the integration of dDAQ in control and measurement networks. This paper analyzes the applicability of the IEEE1588 and EPICS standards to solve these problems, and presents a hardware module implementation based in both of them that allow adding these functionalities to any DAQ. The IEEE1588 standard facilitates the integration of event timing and synchronization mechanisms in distributed data acquisition systems based on IEEE 803.3 (Ethernet). An optimal implementation of such system requires the use of network interface devices which include specific hardware resources devoted to the IEE1588 functionalities. Unfortunately, this is not the approach followed in most of the large number of applications available nowadays. Therefore, most solutions are based in software and use standard hardware network interfaces. This paper presents the development of a hardware module (GI2E) with IEEE1588 capabilities which includes USB, RS232, RS485 and CAN interfaces. This permits to integrate any DAQ element that uses these interfaces in dDAQ systems in an efficient and simple way. The module has been developed with Motorola's Coldfire MCF5234 processor and National Semiconductors's PHY DP83640T, providing it with the possibility to implement the PTP protocol of IEEE1588 by hardware, and therefore increasing its performance over other implementations based in software. To facilitate the integration of the dDAQ system in control and measurement networks the module includes a basic Input/Output Controller (IOC) functionality of the Experimental Physics and Industrial Control System (EPICS) architecture. The paper discusses the implementation details of this module and presents its applications in advanced dDAQ applications in the fusion community

Analysis of breakfast in a population of school of 3rd cycle Primary, a resource training in Health Education

El desayuno es básico en el óptimo desarrollo en las etapas infantil y adolescente, asociándose a un mayor rendimiento físico e intelectual. A pesar de la gran importancia de un desayuno saludable, la falta de tiempo y los nuevos estilos de vida han afectado principalmente al hábito del desayuno completo, con una tendencia mayoritaria a realizar desayunos muy ligeros e incluso a llegar a eliminarlos. Nuestro objetivo fue iniciar el análisis del desayuno en una población escolar, alumnos de 3er Ciclo de Primaria de la Provincia de Badajoz. Para ello se recogió la información del Desayuno mediante Cuestionario-Recordatorio y análisis nutricional mediante Programa DIAL Los resultados iniciales indican que, en el ámbito urbano tan solo el 23,25 % de los escolares tomaron un desayuno saludable, dicho porcentaje se incrementa ligeramente para el ámbito rural, siendo de 39,13%. En conclusión se debe promocionar, en dicha población escolar, un proceso de enseñanza- aprendizaje significativo, de intervención educativa del Desayuno SaludableBreakfast is basic in the optimal development in the child and adolescent stages and is associated with increased physical and intellectual performance. Despite the great importance of a healthy breakfast, lack of time and changing lifestyles have affected mainly full breakfast habit, with a majority tendency to make very light breakfast and even get to remove them Our goal was to begin the analysis of the breakfast in a population Elementary school students in the province of Badajoz This information was collected by Questionnaire-Reminder Breakfast. And nutritional analysis by DIAL Program The results, initials, indicate that in urban areas as only 23.25% of the students took a healthy breakfast. And this percentage slightly increases for rural areas, being 39.13%. In conclusion it should be promoted in this school population, a process of teaching and learning meaningful educational intervention Healthy Breakfast- Diputación de Badajoz - Gobierno de Extremadura - Fondos FEDER - Universidad de ExtremadurapeerReviewe

Los ostrácodos como trazadores ambientales en medios contaminados: el río Odiel (SO España)

In this paper, ostracods are used as tracers of the environmental changes observed in the lower estuary of the Odiel River during the last decades. These microorganisms have a differential behaviour according to the sedimentary environment studied (ebb-end channels, distributaries, main channels). In the ebb-end channels draining the salt marsh bodies, the subaerial exposure is the main factor controlling the evolution of the ostracod assemblages. In the deeper distributaries and the main channel, the acid wastes derived from two industrial concentrations cause the disappearance of these microcrustaceans between 1966 and 1985. In the distributaries, a recovery was observed in the present-day sediments, whereas no individuals were collected in the main channel. The ostracod carapace is a good indicator of water pollution. Percentages of SO3, FeO and CuO are higher in the valves belonging to the pre-industrial (before 1966) and industrial periods. These components may be derived from the industrial wastes, with a latter tidal redistribution along the estuary.En este trabajo, los ostrácodos son usados como trazadores de los cambios ambientales detectados en el estuario bajo del río Odiel durante las últimas décadas. Estos microorganismos tienen un comportamiento diferencial dependiendo del medio sedimentario estudiado (canales finalizadores, distribuidores, principales). En los canales finalizadores, la exposición subaérea es el principal factor que controla la evolución de las asociaciones de ostrácodos. En los distributarios más profundos y en el canal principal, los desechos ácidos procedentes de dos concentraciones industriales causaron la desaparición de estos microcrustáceos entre 1966 y 1985. En los distributarios, se ha apreciado una parcial recuperación en los sedimentos actuales, en tanto que los primeros centímetros del canal principal no contenían valvas o caparazones de ostrácodos. El caparazón de los ostrácodos es un buen indicador de la contaminación del agua. Los porcentajes de SO3, FeO y CuO son mayores en las valvas obtenidas en sedimentos depositados durante el período pre-industrial (antes de 1965) e industrial. Estos componentes podrían proceder de los efluentes industriales, con una redistribución mareal posterior a lo largo del estuario

Real-world data of fulvestrant as first-line treatment of postmenopausal women with estrogen receptor-positive metastatic breast cancer

Goals of endocrine therapy for advanced breast cancer (ABC) include prolonging survival rates, maintaining the quality of life, and delaying the initiation of chemotherapy. We evaluated the effectiveness of fulvestrant as first-line in patients with estrogen receptor (ER)-positive ABC with relapse during or after adjuvant anti-estrogenic therapy in real-world settings. Retrospective, observational study involving 171 postmenopausal women with ER-positive ABC who received fulvestrant as first-line between January 2011 and May 2018 in Spanish hospitals. With a median follow-up of 31.4 months, the progression-free survival (PFS) with fulvestrant was 14.6 months. No differences were seen in the visceral metastatic (14.3 months) versus non-visceral (14.6 months) metastatic subgroup for PFS. Overall response rate and clinical benefit rate were 35.2% and 82.8%. Overall survival was 43.1 months. The duration of the clinical benefit was 19.2 months. Patients with ECOG performance status 0 at the start of treatment showed a significant greater clinical benefit rate and overall survival than with ECOG 1-2. Results in real-world settings are in concordance with randomized clinical trials. Fulvestrant continues to demonstrate clinical benefits in real-world settings and appears be well tolerated as first-line for the treatment of postmenopausal women with ER-positive ABC

Metodologías para el desarrollo de prácticas docentes en Psicología aplicada a Ciencias de la Salud

La Psicología, como disciplina científica, se encuentra recogida en el plan de estudios de diferentes grados de formación universitaria en Ciencias de la Salud. A pesar de que el contenido teórico de la materia ha recibido una adecuada atención, las actividades prácticas de la asignatura nos parecen mejorables para su aplicación a la profesión de Nutrición. El objetivo de este trabajo fue diseñar y aplicar nuevas estrategias docentes que faciliten una mejor y mayor adecuación profesional. La metodología llevada a cabo fue el diseño y aplicación de materiales docentes con aplicaciones prácticas de la Psicología en el ámbito de Ciencias de la Salud. Así mismo se ha evaluado el grado de satisfacción de los estudiantes con estas estrategias docentes mediante un cuestionario elaborado ad hoc. Los resultados esperados han mostrado el grado de adecuación de las nuevas actividades y materiales docentes para la aplicación de los procesos psicológicos a la práctica profesional en Ciencias de la Salud

Renovación de Prácticas Docentes de Psicología para Ciencias de la Salud

La presente memoria recoge los principales resultados obtenidos en el proyecto desarrollado por la Red Docente: “Renovación de Prácticas Docentes de Psicología para Ciencias de la Salud”. El propósito principal de esta Red Docente fue diseñar, desarrollar y aplicar las prácticas docentes en escenarios de innovación curricular con el uso de metodologías más activas, diversificadas y motivadoras. Asimismo, se crearon espacios reflexivos y colaborativos, entre el profesorado de las distintas asignaturas, para avanzar hacia una práctica docente más adecuada a las necesidades profesionales del alumnado. Por último se pretendió elaborar instrumentos de evaluación que permitieran valorar los procesos de innovación docente desarrollados. La metodología de trabajo se ha desarrollado mediante la generación de espacios reflexivos y colaborativos, entre el profesorado de las distintas asignaturas, para avanzar hacia una práctica docente más adecuada a las necesidades profesionales del alumnado. Los resultados han mostrado el grado de adecuación de las nuevas actividades y materiales docentes para la aplicación de los procesos psicológicos a la práctica profesional en Ciencias de la Salud

Influence of the ripening chamber's geographical location on dry-cured Iberian ham's key odorants

Olfactometric and sensory analyses have been applied to study the possible influence of the ripening chamber’s geographical location on the aroma sensory profiles and key odorants of Iberian ham. Dry-cured Iberian ham was obtained from 3 acorn-fed pigs and, for the first time, both of the participating production facilities, located in two different Andalusian municipalities with different altitudes above mean sea level, processed one of the two hind legs from each pig. The descriptive sensory profile of orthonasal and retronasal odours was determined by trained panellists, while odour-active compounds were determined by gas chromatography/mass spectrometry-olfactometry (GC/MS-O). The results obtained showed that, separately, both techniques enable Iberian ham samples to be differentiated by their ripening chamber’s geographical location. For sensory analysis, retronasal sensory analysis appeared to be the most suitable for this goal, highlighting the “meat broth odour” and “roasted nuts odour” descriptors which presented significant differences between geographical locations for samples from all pigs. Moreover, ripening chamber’s geographical location characteristics and the initial composition of the raw material seemed to influence the content of some odour-active compounds. The odour-active compound identified as octane/acetone and isobutanol were conditioned by the ripening chamber’s geographical location, while decanal/2-ethyl-1-hexanol, 1-undecanol, 2-furanmethanol and cis-2-nonenal were also influenced by the individual pig itself. This study showed that slight climatological differences due to the location of the ripening chamber seem to have somewhat of an influence on the aromatic profile.Universidad de Sevilla VIPPIT-2019-I

Prognostic ability of EndoPredict compared to research-based versions of the PAM50 risk of recurrence (ROR) scores in node-positive, estrogen receptor-positive, and HER2-negative breast cancer. A GEICAM/9906 sub-study

There are several prognostic multigene-based tests for managing breast cancer (BC), but limited data comparing them in the same cohort. We compared the prognostic performance of the EndoPredict (EP) test (standardized for pathology laboratory) with the research-based PAM50 non-standardized qRT-PCR assay in node-positive estrogen receptor-positive (ER+) and HER2-negative (HER2−) BC patients receiving adjuvant chemotherapy followed by endocrine therapy (ET) in the GEICAM/9906 trial. EP and PAM50 risk of recurrence (ROR) scores [based on subtype (ROR-S) and on subtype and proliferation (ROR-P)] were compared in 536 ER+/HER2− patients. Scores combined with clinical information were evaluated: ROR-T (ROR-S, tumor size), ROR-PT (ROR-P, tumor size), and EPclin (EP, tumor size, nodal status). Patients were assigned to risk-categories according to prespecified cutoffs. Distant metastasis-free survival (MFS) was analyzed by Kaplan–Meier. ROR-S, ROR-P, and EP scores identified a low-risk group with a relative better outcome (10-year MFS: ROR-S 87%; ROR-P 89%; EP 93%). There was no significant difference between tests. Predictors including clinical information showed superior prognostic performance compared to molecular scores alone (10-year MFS, low-risk group: ROR-T 88%; ROR-PT 92%; EPclin 100%). The EPclin-based risk stratification achieved a significantly improved prediction of MFS compared to ROR-T, but not ROR-PT. All signatures added prognostic information to common clinical parameters. EPclin provided independent prognostic information beyond ROR-T and ROR-PT. ROR and EP can reliably predict risk of distant metastasis in node-positive ER+/HER2− BC patients treated with chemotherapy and ET. Addition of clinical parameters into risk scores improves their prognostic ability.Electronic supplementary materialThe online version of this article (doi:10.1007/s10549-016-3725-z) contains supplementary material, which is available to authorized users

Exome sequencing reveals a high genetic heterogeneity on familial Hirschsprung disease

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Application of reflectance parameters in the estimation of the structural order of coals and carbonaceous materials. Precision and bias of measurements derived from the ICCP structural working group

Optical reflectance of vitrinite is one of the fundamental physical properties that have been used for the study of coal and carbonaceous materials. Organic matter in coals and carbonaceous matter consists mainly of aromatic lamellae, whose dimensions and spatial orientation define its internal structure. Various reflectance parameters describe well the average degree of order of the molecular structure of organic matter. Moreover, reflectance parameters are numerical values which characterize the samples unambiguously, facilitating the comparison of the optical properties of different carbonaceous materials as well as comparison between optical parameters and other physical or chemical factors. The focus of this study is the evaluation of the precision and bias of reflectance measurements (R and R) performed by various analysts in different laboratories in order to check the applicability of reflectance parameters to the estimation of the structural order of coals and carbonaceous materials. Additionally, it was desirable to compare reflectance parameters with other parameters obtained by different analytical methods able to provide structural information. The consistency and repeatability of the reflectance measurements obtained by different participants turned out to enable the drawing of similar conclusions regarding the structural transformation of anthracite during heating. Good correlations were found between the reflectance parameters studied and structural factors obtained by comparative methods. The reflectance parameters examined proved to be very sensitive to any changes of the structural order of coals and carbonaceous materials and seem to be a perfect complement to structural studies made by X-ray diffraction or Raman spectroscopy