An exact fluid model for relativistic electron beams: The many moments case

An interesting and satisfactory fluid model has been proposed in literature for the the description of relativistic electron beams. It was obtained with 14 independent variables by imposing the entropy principle and the relativity principle. Here the case is considered with an arbitrary number of independent variables, still satisfying the above mentioned two principles; these lead to conditions whose general solution is here found. We think that the results satisfy also a certain ordering with respect to a smallness parameter $\epsilon$ measuring the dispersion of the velocity about the mean; this ordering generalizes that appearing in literature for the 14 moments case

Penetration of Air Jets Issuing from Circular, Square, and Elliptical Orifices Directed Perpendicularly to an Air Stream

An experimental investigation was conducted to determine the penetration of air jets d.irected perpendicularlY to an air stream. Jets Issuing from circular, square, and. elliptical orifices were investigated. and. the jet penetration at a position downstream of the orifice was determined- as a function of jet density, jet velocity, air-stream d.enaity, air-stream velocity, effective jet diameter, and. orifice flow coeffIcient. The jet penetrations were determined for nearly constant values of air-stream density at three tunnel-air velocities arid for a large range of Jet velocities and. densities. The results were correlated in terms of dimensionless parameters and the penetrations of the various shapes were compared. Greater penetration was obtained. with the square orifices and the elliptical orifices having an axis ratio of 4:1 at low tunnel-air velocities and low jet pressures than for the other orifices investigated. The square orifices gave the best penetrations at the higher values of tunnel-air velocity and jet total pressure

Shock structure in extended thermodynamics with second-order maximum entropy principle closure

An investigation on the features of the shock structure solution of the 13-moment system of extended thermodynamics with a second-order closure based on the maximum entropy principle is presented. The results are compared to those obtained by means of the traditional first-order closure and to those obtained in the framework of kinetic theory by solving the Boltzmann equation with a BGK model for the collision term. It is seen that when adopting a second-order closure, the strength of the subshock that appears in the shock structure profile for large enough Mach numbers is remarkably reduced with respect to what is found with the first-order closure, and the overall profile of the shock structure solution is in better agreement with the results obtained with the kinetic theory approach. The analysis is extended to the case of the 14-moment system of a polyatomic gas, and some preliminary results are presented also for this case

Space station contamination control study: Internal combustion, phase 1

Contamination inside Space Station modules was studied to determine the best methods of controlling contamination. The work was conducted in five tasks that identified existing contamination control requirements, analyzed contamination levels, developed outgassing specification for materials, wrote a contamination control plan, and evaluated current materials of offgassing tests used by NASA. It is concluded that current contamination control methods can be made to function on the Space Station for up to 1000 days, but that current methods are deficient for periods longer than about 1000 days

Counterbalancing, Spatial Dependence, and Peer Group Effects

Previous studies identified several domestic factors that may influence a country?s level of structural coup-proofing, i.e., counterbalancing strategies that shall prevent internal groups from seizing power via a coup d?�tat. We suggest that a country?s level of counterbalancing is also affected by such policies in what we term countries? ?peer groups.? When deciding the appropriate level of counterbalancing, rulers may be affected by external information flows from a ?peer group? with similar structural coup-risk characteristics (institutions) or a similar coup-risk experience (coup history). Using maximum likelihood spatial lag models and data in 1976?2005, we find that leaders learn from and emulate counterbalancing in other states, but rather only through an ?experiential peer group.

Identification of an average temperature and a dynamical pressure in a multitemperature mixture of fluids

We present a classical approach of a mixture of compressible fluids when each constituent has its own temperature. The introduction of an average temperature together with the entropy principle dictates the classical Fick law for diffusion and also novel constitutive equations associated with the difference of temperatures between the components. The constitutive equations fit with results recently obtained through Maxwellian iteration procedure in extended thermodynamics theory of multitemperature mixtures. The differences of temperatures between the constituents imply the existence of a new dynamical pressure even if the fluids have a zero bulk viscosity. The nonequilibrium dynamical pressure can be measured and may be convenient in several physical situations as for example in cosmological circumstances where - as many authors assert - a dynamical pressure played a major role in the evolution of the early universe.Comment: 16 page

First-line erlotinib and fixed dose-rate gemcitabine for advanced pancreatic cancer

AIM: To investigate activity, toxicity, and prognostic factors for survival of erlotinib and fixed dose-rate gemcitabine (FDR-Gem) in advanced pancreatic cancer. METHODS: We designed a single-arm prospective, multicentre, open-label phase II study to evaluate the combination of erlotinib (100 mg/d, orally) and weekly FDR-Gem (1000 mg/m2, infused at 10 mg/m2per minute) in a population of previously untreated patients with locally advanced, inoperable, or metastatic pancreatic cancer. Primary endpoint was the rate of progression-free survival at 6 mo (PFS-6); secondary endpoints were overall response rate (ORR), response duration, tolerability, overall survival (OS), and clinical benefit. Treatment was not considered to be of further interest if the PFS-6 was < 20% (p0 = 20%), while a PFS-6 > 40% would be of considerable interest (p1 = 40%); with a 5% rejection error (α = 5%) and a power of 80%, 35 fully evaluable patients with metastatic disease were required to be enrolled in order to complete the study. Analysis of prognostic factors for survival was also carried out. RESULTS: From May 2007 to September 2009, 46 patients were enrolled (male/female: 25/21; median age: 64 years; median baseline carbohydrate antigen 19-9 (CA 19-9): 897 U/mL; locally advanced/metastatic disease: 5/41). PFS-6 and median PFS were 30.4% and 14 wk (95%CI: 10-19), respectively; 1-year and median OS were 20.2% and 26 wk (95%CI: 8-43). Five patients achieved an objective response (ORR: 10.9%, 95%CI: 1.9-19.9); disease control rate was 56.5% (95%CI: 42.2-70.8); clinical benefit rate was 43.5% (95%CI: 29.1-57.8). CA 19-9 serum levels were decreased by > 25% as compared to baseline in 14/23 evaluable patients (63.6%). Treatment was well-tolerated, with skin rash being the most powerful predictor of both longer PFS (P < 0.0001) and OS (P = 0.01) at multivariate analysis (median OS for patients with or without rash: 42 wk vs 15 wk, respectively, Log-rank P = 0.03). Additional predictors of better outcome were: CA 19-9 reduction, female sex (for PFS), and good performance status (for OS). CONCLUSION: Primary study endpoint was not met. However, skin rash strongly predicted erlotinib efficacy, suggesting that a pharmacodynamic-based strategy for patient selection deserves further investigation