Motivation of R and D enterpreneurs - Determinants of company success

Human performance related to motivations of achievement, power, and company affiliations for determining leadership qualitie

Structural basis of template-boundary definition in Tetrahymena telomerase.

Telomerase is required to maintain repetitive G-rich telomeric DNA sequences at chromosome ends. To do so, the telomerase reverse transcriptase (TERT) subunit reiteratively uses a small region of the integral telomerase RNA (TER) as a template. An essential feature of telomerase catalysis is the strict definition of the template boundary to determine the precise TER nucleotides to be reverse transcribed by TERT. We report the 3-Å crystal structure of the Tetrahymena TERT RNA-binding domain (tTRBD) bound to the template boundary element (TBE) of TER. tTRBD is wedged into the base of the TBE RNA stem-loop, and each of the flanking RNA strands wraps around opposite sides of the protein domain. The structure illustrates how the tTRBD establishes the template boundary by positioning the TBE at the correct distance from the TERT active site to prohibit copying of nontemplate nucleotides

Polar orbit electrostatic charging of objects in shuttle wake

A survey of DMSP data has uncovered several cases where precipitating auroral electron fluxes are both sufficiently intense and energetic to charge spacecraft materials such as teflon to very large potentials in the absence of ambient ion currents. Analytical bounds are provided which show that these measured environments can cause surface potentials in excess of several hundred volts to develop on objects in the orbiter wake for particular vehicle orientations

Gravitational Wave Bursts from Collisions of Primordial Black Holes in Clusters

The rate of gravitational wave bursts from the mergers of massive primordial black holes in clusters is calculated. Such clusters of black holes can be formed through phase transitions in the early Universe. The central black holes in clusters can serve as the seeds of supermassive black holes in galactic nuclei. The expected burst detection rate by the LISA gravitational wave detector is estimated.Comment: 10 pages, 2 figure

Solar Carboreduction of Alumina under Vacuum

AbstractMain requirements for successful production of aluminum via carboreduction of alumina using solar vacuum reactors are sufficiently high reaction temperature, suitable low partial pressure of the product gases, fast heating and quenching at temperature low enough to prevent backward reaction. Based on these requests a batch solar reactor was modeled, designed, built and tested. Experimental results of the solar tests under different vacuum levels and temperature conditions will be presented. It will be shown that for reaction temperature, which is above the minimal temperature required for full conversion as predicted by thermodynamic calculations for appropriate pressure, the alumina to aluminum conversion is above 90%. Not reaching the full conversion can be explained by the byproducts formation during the initial preheating. At lower reaction temperatures and higher CO partial pressure by products can also be formed when reaching steady state condition both in the forward and backward reactions. This formation in the forward reaction is confirmed by the discovery of larger amounts of Al4C3, Al4CO4 solids as the residual byproducts in the reactants holder and higher alumina content in the deposits on the cold parts of the reactor that originated from the volatile Al2O produced in the forward reaction which during the deposition converts to alumina and aluminum. Decreasing the reaction temperature is accompanied by decreasing the temperature in the hot zone that causes the increasing of the deposit mass there with higher amount of Al4C3 and Al4CO4 produced in the backward reaction. Nano crystalline and amorphous morphology of the deposits in the cold zone caused by fast cooling will also be discussed

Three-dimensional calculation of shuttle charging in polar orbit

The charged particles environment in polar orbit can be of sufficient intensity to cause spacecraft charging. In order to gain a quantitative understanding of such effects, the Air Force is developing POLAR, a computer code which simulates in three dimensions the electrical interaction of large space vehicles with the polar ionospheric plasma. It models the physical processes of wake generation, ambient ion collection, precipitating auroral electron fluxes, and surface interactions, including secondary electron generation and backscattering, which lead to vehicle charging. These processes may be followed dynamically on a subsecond timescale so that the rapid passage through intense auroral arcs can be simulated. POLAR models the ambient plasma as isotropic Maxwellian electrons and ions (0+, H+), and allows for simultaneous precipitation of power-law, energetic Maxwellian, and accelerated Gaussian distributions of electrons. Magnetic field effects will be modeled in POLAR but are currently ignored

Jet substructure as a new Higgs search channel at the LHC

It is widely considered that, for Higgs boson searches at the Large Hadron Collider, WH and ZH production where the Higgs boson decays to b anti-b are poor search channels due to large backgrounds. We show that at high transverse momenta, employing state-of-the-art jet reconstruction and decomposition techniques, these processes can be recovered as promising search channels for the standard model Higgs boson around 120 GeV in mass.Comment: 4 pages, 3 figure

Mechanism for the Suppression of Intermediate-Mass Black Holes

A model for the formation of supermassive primordial black holes in galactic nuclei with the simultaneous suppression of the formation of intermediate-mass black holes is presented. A bimodal mass function for black holes formed through phase transitions in a model with a "Mexican hat" potential has been found. The classical motion of the phase of a complex scalar field during inflation has been taken into account. Possible observational manifestations of primordial black holes in galaxies and constraints on their number are discussed.Comment: 12 pages, 2 figure

Organics in comet 67P – a first comparative analysis of mass spectra from ROSINA–DFMS, COSAC and Ptolemy

The ESA Rosetta spacecraft followed comet 67P at a close distance for more than 2 yr. In addition, it deployed the lander Philae on to the surface of the comet. The (surface) composition of the comet is of great interest to understand the origin and evolution of comets. By combining measurements made on the comet itself and in the coma, we probe the nature of this surface material and compare it to remote sensing observations. We compare data from the double focusing mass spectrometer (DFMS) of the ROSINA experiment on ESA's Rosetta mission and previously published data from the two mass spectrometers COSAC (COmetary Sampling And Composition) and Ptolemy on the lander. The mass spectra of all three instruments show very similar patterns of mainly CHO-bearing molecules that sublimate at temperatures of 275 K. The DFMS data also show a great variety of CH-, CHN-, CHS-, CHO2- and CHNO-bearing saturated and unsaturated species. Methyl isocyanate, propanal and glycol aldehyde suggested by the earlier analysis of the measured COSAC spectrum could not be confirmed. The presence of polyoxymethylene in the Ptolemy spectrum was found to be unlikely. However, the signature of the aromatic compound toluene was identified in DFMS and Ptolemy data. Comparison with remote sensing instruments confirms the complex nature of the organics on the surface of 67P, which is much more diverse than anticipated