Exciton-polaritons in a two-dimensional Lieb lattice with spin-orbit coupling

We study exciton-polaritons in a two-dimensional Lieb lattice of micropillars. The energy spectrum of the system features two flat bands formed from $S$ and $P_{x,y}$ photonic orbitals, into which we trigger bosonic condensation under high power excitation. The symmetry of the orbital wave functions combined with photonic spin-orbit coupling gives rise to emission patterns with pseudospin texture in the flat band condensates. Our work shows the potential of polariton lattices for emulating flat band Hamiltonians with spin-orbit coupling, orbital degrees of freedom and interactions

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Optical and magnetic control of orbital flat bands in a polariton Lieb lattice

We study the magneto-optical response of exciton polaritons in p-orbital flat bands in a two-dimensional Lieb lattice of semiconductor microcavity pillars. At low excitation density, we detail the influence of an external magnetic field on the exciton component, which enables magnetic tuning of the flat-band states. In the high-density regime, one can induce a spin population imbalance by circularly polarized pumping leading to an effective nonlinear Zeeman splitting. We show how the interplay between the symmetry of the orbital wave function, photonic spin-orbit coupling, and real and effective Zeeman splittings gives rise to real-space flat-band patterns with tilted orbital wave functions in the regime of dynamical polariton condensation. These results demonstrate the ability to optically and magnetically manipulate the spatial, spectral, and polarization properties of polariton condensates in the flat energy bands of a Lieb lattice