A survey of nearby galaxies for CO

We have made a survey of the nuclei of 81 galaxies for the 1-) line of CO. 38 of the galaxies are from a complete sample with recession velocity ≦400 km s-1 and 21-cm line strength ≧10-27 Wm-2, and the remainder represent nearby galaxies with weaker or no HI, early-type galaxies (E/SO/Sa) with detected HI and active/infrared galaxies. Galaxies with strong CO lines like M82, NGC253 and IC342 are exceedingly rare: all the galaxies we observed are weaker than 0/2K except the irregular galaxy DDO133 with T*A=0.22K. We have new, confirmed detections of two other irregular galaxies, IC10 and Pegasus, at a weaker level, and unconfirmed detections of the irregular NGC3109 and the nearest Type I Seyfert galaxy NGC4051. We have confirmed the existence of CO in the nucleus of NGC6946 and obtained spectra of new positions in M82 and NGC253

Thermodynamics and phase behavior of the lamellar Zwanzig model

Binary mixtures of lamellar colloids represented by hard platelets are studied within a generalization of the Zwanzig model for rods, whereby the square cuboids can take only three orientations along the $x$, $y$ or $z$ axes. The free energy is calculated within Rosenfeld's ''Fundamental Measure Theory'' (FMT) adapted to the present model. In the one-component limit, the model exhibits the expected isotropic to nematic phase transition, which narrows as the aspect ratio $\zeta=L/D$ ($D$ is the width and $L$ the thickness of the platelets) increases. In the binary case the competition between nematic ordering and depletion-induced segregation leads to rich phase behaviour.Comment: 9 pages, 6 figure

Suramin inhibits the early effects of PLA(2) neurotoxins at mouse neuromuscular junctions: a twitch tension study

Several phospholipase A(2) (PLA(2)) neurotoxins from snake venoms can affect acetylcholine release at the neuromuscular junction. In isolated nerve-muscle preparations three distinct phases have been described for this phenomenon: An initial transient decrease in twitch tension; a second facilitatory phase during which twitch height is greater than control twitch height; and the last phase which causes a reduction in twitch height that finally results in paralysis. Suramin has been reported to inhibit the toxic effects of β-bungarotoxin and another PLA(2) neurotoxin, crotoxin in vitro and in vivo. We have further examined the effects of suramin on the three phases of the effects of the presynaptic PLA(2) neurotoxins β-bungarotoxin, taipoxin and ammodytoxin on mouse phrenic nerve-hemidiaphragm preparations. When preparations were pre-treated with suramin (0.3mM), the early biphasic effects (depression followed by facilitation) were abolished, and the time taken for final blockade induced by β-bungarotoxin, taipoxin and ammodytoxin A was significantly prolonged. In contrast, suramin did not significantly affect the facilitation induced by the potassium channel blocking toxin dendrotoxin I when applied under the same conditions. In addition, application of 0.3mM suramin did not prevent the facilitatory actions of 3,4-diaminopyridine (3,4-DAP) and tetraethylammonium chloride (TEA). Overall, the mechanism whereby suramin reduces the effects of PLA(2) neurotoxins remains elusive. Since suramin reduces both enzyme-dependent and enzyme-independent effects of the toxins, suramin is not acting as a simple enzyme inhibitor. Furthermore, the observation that suramin does not affect actions of standard K(+) channel blockers suggests that suramin does not stabilise nerve terminals

Evaporation of microdroplets of azeotropic liquids

This work reports data showing the evolution of contact angle with time for mixtures of water and 1-propanol at room temperature on poly(methyl methacrylate) (PMMA). The composition range investigated spans the azeotropic composition, thus encompassing systems containing excess water and excess 1-propanol. A discontinuity in the contact angle behavior is observed and it is suggested that this enables the identification of the azeotropic composition as 0.39 mole fraction of 1-propanol. This suggestion is supported by boiling point measurements made at around 20 mmHg. The discontinuity is associated with the presence of an instability, which causes a distortion around the droplet perimeter. It is suggested that the distortion is caused by competing effects of local surface tension maxima and minima

Screened electrostatic interactions between clay platelets

An effective pair potential for systems of uniformly charged lamellar colloids in the presence of an electrolytic solution of microscopic co- and counterions is derived. The charge distribution on the discs is expressed as a collection of multipole moments, and the tensors which determine the interactions between these multipoles are derived from a screened Coulomb potential. Unlike previous studies of such systems, the interaction energy may now be expressed for discs at arbitrary mutual orientation. The potential is shown to be exactly equivalent to the use of linearized Poisson-Boltzmann theory.Comment: 23 pages, 10 figures, created with Revtex. To appear in Molecular Physic

A comprehensive model to determine the effects of temperature and species fluctuations on reaction rates in turbulent reacting flows

The use of probability theory to determine the effects of turbulent fluctuations on reaction rates in turbulent combustion systems is briefly reviewed. Results are presented for the effect of species fluctuations in particular. It is found that turbulent fluctuations of species act to reduce the reaction rates, in contrast with the temperature fluctuations previously determined to increase Arrhenius reaction rate constants. For the temperature fluctuations, a criterion is set forth for determining if, in a given region of a turbulent flow field, the temperature can be expected to exhibit ramp like fluctuations. Using the above results, along with results previously obtained, a model is described for testing the effects of turbulent fluctuations of temperature and species on reaction rates in computer programs dealing with turbulent reacting flows. An alternative model which employs three variable probability density functions (temperature and two species) and is currently being formulated is discussed as well

The Global Star Formation Rate from the 1.4 GHz Luminosity Function

The decimetric luminosity of many galaxies appears to be dominated by synchrotron emission excited by supernova explosions. Simple models suggest that the luminosity is directly proportional to the rate of supernova explosions of massive stars averaged over the past 30 Myr. The proportionality may be used together with models of the evolving 1.4 GHz luminosity function to estimate the global star formation rate density in the era z < 1. The local value is estimated to be 0.026 solar masses per year per cubic megaparsec, some 50% larger than the value inferred from the Halpha luminosity density. The value at z ~ 1 is found to be 0.30 solar masses per year per cubic megaparsec. The 10-fold increase in star formation rate density is consistent with the increase inferred from mm-wave, far-infrared, ultra-violet and Halpha observations.Comment: 10 pages, 2 figures, Astrophysical Journal Letters (in press); new PS version has improved figure placemen

The star-formation history of the universe - an infrared perspective

A simple and versatile parameterized approach to the star formation history allows a quantitative investigation of the constraints from far infrared and submillimetre counts and background intensity measurements. The models include four spectral components: infrared cirrus (emission from interstellar dust), an M82-like starburst, an Arp220-like starburst and an AGN dust torus. The 60 $\mu$m luminosity function is determined for each chosen rate of evolution using the PSCz redshift data for 15000 galaxies. The proportions of each spectral type as a function of 60 $\mu$m luminosity are chosen for consistency with IRAS and SCUBA colour-luminosity relations, and with the fraction of AGN as a function of luminosity found in 12 $\mu$m samples. The luminosity function for each component at any wavelength can then be calculated from the assumed spectral energy distributions. With assumptions about the optical seds corresponding to each component and, for the AGN component, the optical and near infrared counts can be accurately modelled. A good fit to the observed counts at 0.44, 2.2, 15, 60, 90, 175 and 850 $\mu$m can be found with pure luminosity evolution in all 3 cosmological models investigated: $\Omega_o$ = 1, $\Omega_o$ = 0.3 ($\Lambda$ = 0), and $\Omega_o$ = 0.3, $\Lambda$ = 0.7. All 3 models also give an acceptable fit to the integrated background spectrum. Selected predictions of the models, for example redshift distributions for each component at selected wavelengths and fluxes, are shown. The total mass-density of stars generated is consistent with that observed, in all 3 cosmological models.Comment: 20 pages, 25 figures. Accepted for publication in ApJ. Full details of models can be found at http://astro.ic.ac.uk/~mrr/countmodel

Real-Time Risk Analysis and Hazard Management

Safety remains a critical priority for the Australian mineral resource industry and will receive increased focus in the future. This is particularly evident in underground coal mines where reserves are becoming deeper and more hazardous to extract. The CSIRO, through its Exploration and Mining Division, have recently delivered on two projects aimed at providing step-change capabilities in real-time risk management and hazard control. This paper describes the key outcomes of these projects

Clinical Importance of the Drug interaction Between Statins and CYP3A4 Inhibitors

Statins reduce the risk of major coronary outcomes and all cause mortality. They are generally well tolerated, but are associated with uncommon but serious adverse events. Pharmacokinetic studies show statins metabolized by the CYP3A4 isoenzyme (statin 3A4 substrates) are susceptible to drug interactions when concomitantly administered with drugs that inhibit the CYP3A4 isoenzyme (CYP3A4 inhibitors) - potentially increasing the risk for adverse events. Studies to evaluate the clinical importance of the statin-CYP3A4 inhibitor interaction are limited to anecdotal findings. This research endeavored to evaluate the clinical importance of the statin-CYP3A4 inhibitor drug interaction in two empiric investigations and a methodologic study. The preliminary empiric study was an analysis of spontaneous rhabdomyolysis reports. It showed an increased rhabdomyolysis reporting rate for simvastatin (a statin 3A4 substrate) but not for pravastatin (a statin non-3A4 substrate) with a concomitant CYP3A4 inhibitor. Substantial internal validity limitations, inherent in spontaneous reporting analyses, warranted additional research. To further assess the clinical importance of this drug interaction, we evaluated the validity of the multinomial propensity score as a confounding adjustment method in a simulated drug interaction study. The results from the simulation study provided support for using the multinomial propensity score in the second empiric study. The results showed the multinomial propensity score reduced bias, had greater coverage probability, and increased precision compared to binary propensity score methods. Investigators studying multinomial exposures, such as drug interactions, should consider the multinomial propensity score for confounding adjustment. The second empiric study was a large retrospective cohort study. The objective was to evaluate the hazard of muscle toxicity, renal dysfunction, and hepatic dysfunction among patients exposed to statin 3A4 substrates (atorvastatin and simvastatin) compared to statin non-3A4 substrates (fluvastatin, pravastatin, and rosuvastatin) with and without CYP3A4 inhibitor concomitancy. We found no overall increased hazard of muscle toxicity, renal dysfunction, or hepatic dysfunction associated with statin 3A4 substrates compared to statin non-3A4 substrates with versus without a concomitant CYP3A4 inhibitor. Given the magnitude and validity of this investigation, the drug interaction between statins and CYP3A4 inhibitors therefore does not represent a substantial public health concern