238 research outputs found
PREVALENCE OF CORONARY ARTERY DISEASE DETECTED ON ROUTINE ECG-GATED COMPUTED TOMOGRAPHY EVALUATION OF CONGENITAL THORACIC AORTIC ANEURYSMS
Experimental results for nulling the effective thermal expansion coefficient of fused silica fibres under a static stress
We have experimentally demonstrated that the effective thermal expansion coefficient of a fused silica fibre can be nulled by placing the fibre under a particular level of stress. Our technique involves heating the fibre and measuring how the fibre length changes with temperature as the stress on the fibre was systematically varied. This nulling of the effective thermal expansion coefficient should allow for the complete elimination of thermoelastic noise and is essential for allowing second generation gravitational wave detectors to reach their target sensitivity. To our knowledge this is the first time that the cancelation of the thermal expansion coefficient with stress has been experimentally observed
Timeline analysis and wavelet multiscale analysis of the AKARI All-Sky Survey at 90 micron
We present a careful analysis of the point source detection limit of the
AKARI All-Sky Survey in the WIDE-S 90 m band near the North Ecliptic Pole
(NEP). Timeline Analysis is used to detect IRAS sources and then a conversion
factor is derived to transform the peak timeline signal to the interpolated 90
m flux of a source. Combined with a robust noise measurement, the point
source flux detection limit at S/N for a single detector row is
Jy which corresponds to a point source detection limit of the
survey of 0.4 Jy.
Wavelet transform offers a multiscale representation of the Time Series Data
(TSD). We calculate the continuous wavelet transform of the TSD and then search
for significant wavelet coefficients considered as potential source detections.
To discriminate real sources from spurious or moving objects, only sources with
confirmation are selected. In our multiscale analysis, IRAS sources selected
above can be identified as the only real sources at the Point Source
Scales. We also investigate the correlation between the non-IRAS sources
detected in Timeline Analysis and cirrus emission using wavelet transform and
contour plots of wavelet power spectrum. It is shown that the non-IRAS sources
are most likely to be caused by excessive noise over a large range of spatial
scales rather than real extended structures such as cirrus clouds.Comment: 16 pages, 19 figures, 5 tables, accepted for publication in MNRA
A deep ATCA 20cm radio survey of the AKARI Deep Field South near the South Ecliptic Pole
The results of a deep 20 cm radio survey at 20 cm are reported of the AKARI
Deep Field South (ADF-S) near the South Ecliptic Pole (SEP), using the
Australia Telescope Compact Array telescope, ATCA. The survey has 1 sigma
detection limits ranging from 18.7--50 microJy per beam over an area of ~1.1 sq
degrees, and ~2.5 sq degrees to lower sensitivity. The observations, data
reduction and source count analysis are presented, along with a description of
the overall scientific objectives, and a catalogue containing 530 radio sources
detected with a resolution of 6.2" x 4.9". The derived differential source
counts show a pronounced excess of sources fainter than ~1 mJy, consistent with
an emerging population of star forming galaxies. Cross-correlating the radio
with AKARI sources and archival data we find 95 cross matches, with most
galaxies having optical R-magnitudes in the range 18-24 mag, and 52 components
lying within 1" of a radio position in at least one further catalogue (either
IR or optical). We have reported redshifts for a sub-sample of our catalogue
finding that they vary between galaxies in the local universe to those having
redshifts of up to 0.825. Associating the radio sources with the Spitzer
catalogue at 24 microns, we find 173 matches within one Spitzer pixel, of which
a small sample of the identifications are clearly radio loud compared to the
bulk of the galaxies. The radio luminosity plot and a colour-colour analysis
suggest that the majority of the radio sources are in fact luminous star
forming galaxies, rather than radio-loud AGN. There are additionally five cross
matches between ASTE or BLAST submillimetre galaxies and radio sources from
this survey, two of which are also detected at 90 microns, and 41 cross-matches
with submillimetre sources detected in the Herschel HerMES survey Public Data
release.Comment: MNRAS accepted and in press 9 July 2012: 28 pages, 15 Figures, 17
Table
The Far-Infrared Spectral Energy Distributions of X-ray-selected Active Galaxies
[Abridged] We present ISO far-infrared (IR) observations of 21 hard X-ray
selected AGN from the HEAO-1 A2 sample. We compare the far-IR to X-ray spectral
energy distributions (SEDs) of this sample with various radio and optically
selected AGN samples. The hard-X-ray selected sample shows a wider range of
optical/UV shapes extending to redder near-IR colors. The bluer objects are
Seyfert 1s, while the redder AGN are mostly intermediate or type 2 Seyferts.
This is consistent with a modified unification model in which the amount of
obscuring material increases with viewing angle and may be clumpy. Such a
scenario, already suggested by differing optical/near-IR spectroscopic and
X-ray AGN classifications, allows for different amounts of obscuration of the
continuum emission in different wavebands and of the broad emission line region
which results in a mixture of behaviors for AGN with similar optical emission
line classifications. The resulting limits on the column density of obscuring
material through which we are viewing the redder AGN are 100 times lower than
for the standard optically thick torus models. The resulting decrease in
optical depth of the obscuring material allows the AGN to heat more dust at
larger radial distances. We show that an AGN-heated, flared, dusty disk with
mass 10^9 solar and size of few hundred pc is able to generate optical-far-IR
SEDs which reproduce the wide range of SEDs present in our sample with no need
for an additional starburst component to generate the long-wavelength, cooler
part of the IR continuum.Comment: 40 pages, 14 figures, accepted for publication in Astrophysical
Journal, V. 590, June 10, 200
Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib
New targeted approaches to ovarian clear cell carcinomas (OCCC) are needed, given the limited treatment options in this disease and the poor response to standard chemotherapy. Using a series of high-throughput cell-based drug screens in OCCC tumor cell models, we have identified a synthetic lethal (SL) interaction between the kinase inhibitor dasatinib and a key driver in OCCC, ARID1A mutation. Imposing ARID1A deficiency upon a variety of human or mouse cells induced dasatinib sensitivity, both in vitro and in vivo, suggesting that this is a robust synthetic lethal interaction. The sensitivity of ARID1A-deficient cells to dasatinib was associated with G1 -S cell-cycle arrest and was dependent upon both p21 and Rb. Using focused siRNA screens and kinase profiling, we showed that ARID1A-mutant OCCC tumor cells are addicted to the dasatinib target YES1. This suggests that dasatinib merits investigation for the treatment of patients with ARID1Amutant OCCC. Mol Cancer Ther; 15(7); 1472-84. Ó2016 AACR.</p
Maintaining independence in individuals with dementia at home after a fall:a protocol for the UK pilot cluster randomised controlled trial MAINTAIN
Introduction: Individuals with dementia face an increased risk of falls. Falls can cause a decline in the individual’s overall functionality. All types of falls, including those that do not result in injury, can lead to psychosocial consequences, such as diminished confidence and a fear of falling. Projections indicate a rising trend in dementia diagnoses, implying an increase in fall incidents. Yet, there is a lack of evidence to support interventions for people living with dementia who have fallen. Our objective is to test the feasibility of a falls intervention trial for people with dementia. Method and analysis: This is a UK-based two-arm pilot cluster randomised controlled trial. In this study, six collaborating sites, which form the clusters, will be randomly allocated to either the intervention arm or the control arm (receiving treatment as usual) at a 1:1 ratio. During the 6 month recruitment phase, each cluster will enrol 10 dyads, comprising 10 individuals with dementia and their respective carers, leading to a total sample size of 60 dyads. The primary outcomes are the feasibility parameters for a full trial (ie, percentage consented, follow-up rate and cost framework). Secondary outcomes include activities of daily living, quality of life, fall efficacy, mobility, goal attainment, cognitive status, occurrence of falls, carer burden and healthcare service utilisation. Outcome measures will be collected at baseline and 28 weeks, with an additional assessment scheduled at 12 weeks for the healthcare service utilisation questionnaire. An embedded process evaluation, consisting of interviews and observations with participants and healthcare professionals, will explore how the intervention operates and the fidelity of study processes. Ethics and dissemination: The study was approved by the NHS and local authority research governance and research ethics committees (NHS REC reference: 23/WA/0126). The results will be shared at meetings and conferences and will be published in peer-reviewed journals. Trial registration number: ISRCTN16413728
The Subaru/XMM-Newton Deep Field - II. The 37 brightest radio sources
We study the 37 brightest radio sources in the Subaru/XMM-Newton Deep Field
(SXDF). We have spectroscopic redshifts for 24 of 37 objects and photometric
redshifts for the remainder, yielding a median redshift z_med for the whole
sample of z_med ~= 1.1 and a median radio luminosity close to the `FRI/FRII'
luminosity divide. Using mid-IR (Spitzer MIPS 24 um) data we expect to trace
nuclear accretion activity, even if it is obscured at optical wavelengths,
unless the obscuring column is extreme. Our results suggest that above the
FRI/FRII radio luminosity break most of the radio sources are associated with
objects that have excess mid-IR emission, only some of which are broad-line
objects, although there is one clear low-accretion-rate object with an FRI
radio structure. For extended steep-spectrum radio sources, the fraction of
objects with mid-IR excess drops dramatically below the FRI/FRII luminosity
break, although there exists at least one high-accretion-rate `radio-quiet'
QSO. We have therefore shown that the strong link between radio luminosity (or
radio structure) and accretion properties, well known at z ~ 0.1, persists to z
~ 1. Investigation of mid-IR and blue excesses shows that they are correlated
as predicted by a model in which, when significant accretion exists, a torus of
dust absorbs ~30% of the light, and the dust above and below the torus scatters
>~1% of the light.Comment: Accepted for publication by MNRAS; 39 pages, 7 figures, 4 table
The Far-Infrared Surveyor (FIS) for AKARI
The Far-Infrared Surveyor (FIS) is one of two focal plane instruments on the
AKARI satellite. FIS has four photometric bands at 65, 90, 140, and 160 um, and
uses two kinds of array detectors. The FIS arrays and optics are designed to
sweep the sky with high spatial resolution and redundancy. The actual scan
width is more than eight arcmin, and the pixel pitch is matches the diffraction
limit of the telescope. Derived point spread functions (PSFs) from observations
of asteroids are similar to the optical model. Significant excesses, however,
are clearly seen around tails of the PSFs, whose contributions are about 30% of
the total power. All FIS functions are operating well in orbit, and its
performance meets the laboratory characterizations, except for the two longer
wavelength bands, which are not performing as well as characterized.
Furthermore, the FIS has a spectroscopic capability using a Fourier transform
spectrometer (FTS). Because the FTS takes advantage of the optics and detectors
of the photometer, it can simultaneously make a spectral map. This paper
summarizes the in-flight technical and operational performance of the FIS.Comment: 23 pages, 10 figures, and 2 tables. Accepted for publication in the
AKARI special issue of the Publications of the Astronomical Society of Japa
Coronary Atherosclerosis in Indigenous South American Tsimane: A Cross-Sectional Cohort Study
Background—Conventional coronary artery disease risk factors might potentially explain at least 90% of the attributable risk of coronary artery disease. To better understand the association between the pre-industrial lifestyle and low prevalence of coronary artery disease risk factors, we examined the Tsimane, a Bolivian population living a subsistence lifestyle of hunting, gathering, fishing, and farming with few cardiovascular risk factors, but high infectious inflammatory burden.
Methods—We did a cross-sectional cohort study including all individuals who self-identified as Tsimane and who were aged 40 years or older. Coronary atherosclerosis was assessed by coronary artery calcium (CAC) scoring done with non-contrast CT in Tsimane adults. We assessed the difference between the Tsimane and 6814 participants from the Multi-Ethnic Study of Atherosclerosis (MESA). CAC scores higher than 100 were considered representative of significant atherosclerotic disease. Tsimane blood lipid and inflammatory biomarkers were obtained at the time of scanning, and in some patients, longitudinally.
Findings—Between July 2, 2014, and Sept 10, 2015, 705 individuals, who had data available for analysis, were included in this study. 596 (85%) of 705 Tsimane had no CAC, 89 (13%) had CAC scores of 1–100, and 20 (3%) had CAC scores higher than 100. For individuals older than age 75 years, 31 (65%) Tsimane presented with a CAC score of 0, and only four (8%) had CAC scores of 100 or more, a five-fold lower prevalence than industrialised populations (p≤0-0001 for all age categories of MESA). Mean LDL and HDL cholesterol concentrations were 2.35 mmol/L (91 mg/dL) and 1.0 mmol/L (39.5 mg/dL), respectively; obesity, hypertension, high blood sugar, and regular cigarette smoking were rare. High- sensitivity C-reactive protein was elevated beyond the clinical cutoff of 3.0 mg/dL in 360 (51%) Tsimane participants.
Interpretation—Despite a high infectious inflammatory burden, the Tsimane, a forager-horticulturalist population of the Bolivian Amazon with few coronary artery disease risk factors, have the lowest reported levels of coronary artery disease of any population recorded to date. These findings suggest that coronary atherosclerosis can be avoided in most people by achieving a lifetime with very low LDL, low blood pressure, low glucose, normal body-mass index, no smoking, and plenty of physical activity. The relative contributions of each are still to be determined
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