A Supersymmetric Model for Dark Matter and Baryogenesis Motivated by the Recent CDMS Result

We discuss a supersymmetric model for cogenesis of dark and baryonic matter where the dark matter (DM) has mass in the 8-10 GeV range as indicated by several direct detection searches including most recently the CDMS experiment with the desired cross section. The DM candidate is a real scalar filed. Two key distinguishing features of the model are the following: (i) in contrast with the conventional WIMP dark matter scenarios where thermal freeze-out is responsible for the observed relic density, our model uses non-thermal production of dark matter after reheating of the universe caused by moduli decay at temperatures below the QCD phase transition, a feature which alleviates the relic over-abundance problem caused by small annihilation cross section of light DM particles; (ii) baryogenesis occurs also at similar low temperatures from the decay of TeV scale mediator particles arising from moduli decay. A possible test of this model is the existence of colored particles with TeV masses accessible at the LHC.Comment: 5 pages, 1 figur

Criticality and oscillatory behavior in non-Markovian Contact Process

A Non-Markovian generalization of one-dimensional Contact Process (CP) is being introduced in which every particle has an age and will be annihilated at its maximum age $\tau$. There is an absorbing state phase transition which is controlled by this parameter. The model can demonstrate oscillatory behavior in its approach to the stationary state. These oscillations are also present in the mean-field approximation which is a first-order differential equation with time-delay. Studying dynamical critical exponents suggests that the model belongs to the DP universlity class.Comment: 4 pages, 5 figures, to be published in Phys. Rev.

Schizophrenic Neutrinos and ν\nu-less Double Beta Decay

We point out a novel possibility for neutrinos where all neutrino flavors can be part Dirac and part Majorana. Our primary motivation for this model comes from an attempt to use supersymmetric see-saw models to tie inflation, baryon asymmetry of the Universe and dark matter to the neutrino sector. The idea however could stand on its own, with or without supersymmetry. We present a realization of this possibility within an $S_3$ family symmetry for neutrino masses, where we obtain tri-bi-maximal mixing for neutrinos to the leading order. The model predicts that for the case of inverted hierarchy, the lower limit on the neutrino mass measured in neutrinoless double beta decay experiments is about a factor of two larger than the usual case.Comment: 6 pages, 1 figure. Extended discussion on the pseudo-Dirac mass splitting due to loop correction

Identifying the curvaton within MSSM

We consider inflaton couplings to MSSM flat directions and the thermalization of the inflaton decay products, taking into account gauge symmetry breaking due to flat direction condensates. We then search for a suitable curvaton candidate among the flat directions, requiring an early thermally induced start for the flat direction oscillations to facilitate the necessary curvaton energy density dominance. We demonstrate that the supersymmetry breaking $A$-term is crucial for achieving a successful curvaton scenario. Among the many possible candidates, we identify the ${\bf u_1dd}$ flat direction as a viable MSSM curvaton.Comment: 9 pages. Discussion on the evaporation of condensate added, final version published in JCA

Cosmological bounds on large extra dimensions from non-thermal production of Kaluza-Klein modes

The existing cosmological constraints on theories with large extra dimensions rely on the thermal production of the Kaluza-Klein modes of gravitons and radions in the early Universe. Successful inflation and reheating, as well as baryogenesis, typically requires the existence of a TeV-scale field in the bulk, most notably the inflaton. The non-thermal production of KK modes with masses of order 100 GeV accompanying the inflaton decay sets the lower bounds on the fundamental scale M_*. For a 1 TeV inflaton, the late decay of these modes distort the successful predictions of Big Bang Nucleosynthesis unless M_*> 35, 13, 7, 5 and 3 TeV for 2, 3, 4, 5 and 6 extra dimensions, respectively. This improves the existing bounds from cosmology on M_* for 4, 5 and 6 extra dimensions. Even more stringent bounds are derived for a heavier inflaton.Comment: 17 pages, latex, 4 figure

A-term inflation and the smallness of the neutrino masses

The smallness of the neutrino masses may be related to inflation. The minimal supersymmetric Standard Model (MSSM) with small Dirac neutrino masses already has all the necessary ingredients for a successful inflation. In this model the inflaton is a gauge-invariant combination of the right-handed sneutrino, the slepton, and the Higgs field, which generate a flat direction suitable for inflation if the Yukawa coupling is small enough. In a class of models, the observed microwave background anisotropy and the tilted power spectrum are related to the neutrino masses.Comment: 13 pages, 1 figure, uses JHEP3.cls, minor modifications, final version accepted for publication in JCA

Supersymmetric Thermalization and Quasi-Thermal Universe: Consequences for Gravitinos and Leptogenesis

Motivated by our earlier paper \cite{am}, we discuss how the infamous gravitino problem has a natural built in solution within supersymmetry. Supersymmetry allows a large number of flat directions made up of {\it gauge invariant} combinations of squarks and sleptons. Out of many at least {\it one} generically obtains a large vacuum expectation value during inflation. Gauge bosons and Gauginos then obtain large masses by virtue of the Higgs mechanism. This makes the rate of thermalization after the end of inflation very small and as a result the Universe enters a {\it quasi-thermal phase} after the inflaton has completely decayed. A full thermal equilibrium is generically established much later on when the flat direction expectation value has substantially decareased. This results in low reheat temperatures, i.e., $T_{\rm R}\sim {\cal O}({\rm TeV})$, which are compatible with the stringent bounds arising from the big bang nucleosynthesis. There are two very important implications: the production of gravitinos and generation of a baryonic asymmetry via leptogenesis during the quasi-thermal phase. In both the cases the abundances depend not only on an effective temperature of the quasi-thermal phase (which could be higher, i.e., $T\gg T_{\rm R}$), but also on the state of equilibrium in the reheat plasma. We show that there is no ``thermal gravitino problem'' at all within supersymmetry and we stress on a need of a new paradigm based on a ``quasi-thermal leptogenesis'', because in the bulk of the parameter space the {\it old} thermal leptogenesis cannot account for the observed baryon asymmetry.Comment: 53 pages. Final version published in JCA

Glioblastomas with primitive neuronal component harbor a distinct methylation and copy‑number profle with inactivation of TP53, PTEN, and RB1

Glioblastoma IDH-wildtype presents with a wide histological spectrum. Some features are so distinctive that they are considered as separate histological variants or patterns for the purpose of classification. However, these usually lack defined (epi-)genetic alterations or profiles correlating with this histology. Here, we describe a molecular subtype with overlap to the unique histological pattern of glioblastoma with primitive neuronal component. Our cohort consists of 63 IDH-wildtype glioblastomas that harbor a characteristic DNA methylation profile. Median age at diagnosis was 59.5 years. Copy-number variations and genetic sequencing revealed frequent alterations in TP53, RB1 and PTEN, with fewer gains of chromosome 7 and homozygous CDKN2A/B deletions than usually described for IDH-wildtype glioblastoma. Gains of chromosome 1 were detected in more than half of the cases. A poorly differentiated phenotype with frequent absence of GFAP expression, high proliferation index and strong staining for p53 and TTF1 often caused misleading histological classification as carcinoma metastasis or primitive neuroectodermal tumor. Clinically, many patients presented with leptomeningeal dissemination and spinal metastasis. Outcome was poor with a median overall survival of only 12 months. Overall, we describe a new molecular subtype of IDH-wildtype glioblastoma with a distinct histological appearance and genetic signature.publishedVersio

Scenarios of modulated perturbations

In an alternative mechanism recently proposed, adiabatic cosmological perturbations are generated at the decay of the inflaton field due to small fluctuations of its coupling to matter. This happens whenever the coupling is governed by the vacuum expectation value of another field, which acquires fluctuations during inflation. We discuss generalization and various possible implementations of this mechansim, and present some specific particle physics examples. In many cases the second field can start oscillating before perturbations are imprinted, or survive long enough so to dominate over the decay products of the inflaton. The primordial perturbations will then be modified accordingly in each case.Comment: 12 pages, 3 figures. Final version to appear in Phys. Rev.

AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery