RF and digital signal processing for software-defined radio: a multi-standard multi-mode approach

Software-defined radio (SDR) is the hottest area of RF/wireless design, and this title describes SDR concepts, theory, and design principles from the perspective of the signal processing (both on transmission and reception) performed by a SDR system. After an introductory overview of essential SDR concepts, this book examines waveform creation, analog signal processing, digital signal processing, data conversion, phase-locked loops, SDR algorithms, and SDR hardware design. The various trade-offs at each of these design stages are discussed in detail. *Offers readers a powerful set of analytical and design tools *Details real world designs *Comprehensive coverage makes this a must have in the RF/Wireless industry.Software-defined radio (SDR) is the hottest area of RF/wireless design, and this title describes SDR concepts, theory, and design principles from the perspective of the signal processing (both on transmission and reception) performed by a SDR system. After an introductory overview of essential SDR concepts, this book examines waveform creation, analog signal processing, digital signal processing, data conversion, phase-locked loops, SDR algorithms, and SDR hardware design. The various trade-offs at each of these design stages are discussed in detail. *Offers readers a powerful set of analytical and design tools *Details real world designs *Comprehensive coverage makes this a must have in the RF/Wireless industry.Chapter 1: Introduction -- Chapter 2: Common Analog Modulation and Pulse Shaping Methods -- Chapter 3: Common Digital Modulation Methods -- Chapter 4: High-Level Requirements and Link Budget Analysis -- Chapter 5: Memoryless Non-Linearity and Distortion -- Chapter 6: Transceiver System Analysis and Design Parameters -- Chapter 7: Uniform Sampling of Signals and Automatic Gain Control -- Chapter 8: Nyquist-Rate Data Conversion -- Chapter 9: AO Modulators for Data Conversion -- Chapter 10: Multirate Digital Signal Processing.Includes bibliographical references and index.Print version record.Elsevie

Do marine protected areas in the Red Sea afford protection to dugongs and sea turtles?

Dugongs (Dugong dugon) and most sea turtles are threatened by gill nets and other human activities worldwide. In the Red Sea these animals are potentially isolated from populations in other areas of the world. This isolation would make recovery following major population decline in the Red Sea unlikely. Protected areas are promoted as a management tool to safeguard these animals from human activities. Elba National Park, Egypt, supports populations of dugongs and sea turtles, as well as a growing fishing industry. We undertook a survey of fishers to determine if dugongs and sea turtles formed bycatch in Elba National Park. Specifically, we quantified the proportion of fishers operating in Elba National Park who had caught these animals as bycatch in fishing nets and the proportion of fishers who perceived that sea turtle eggs were still collected. This study indicates that at least one protected area in the Red Sea is not achieving conservation objectives relating to these animals. Nine and eighty percent of fishers reported having caught dugongs and sea turtles in nets, respectively. Seven percent of fishers perceived that people still collected turtle eggs. Elba National Park is failing to protect these animals for reasons including: it is managed solely as an IUCN Category VI Protected Area; fishers lack awareness of laws pertaining to these animals; and fishers are highly resource dependent. Potential management strategies to reduce bycatch include the establishment of IUCN Category 1a Protected Areas in important dugong and sea turtle habitat, encouraging fishers to adopt fishing gear that poses less risk to megafauna and raising awareness among fishers of the protected status of dugongs and sea turtles

Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients : a randomised controlled trial

Background: Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) in preventing PA nosocomial pneumonia was assessed in PA-colonised mechanically ventilated subjects. Methods: EVADE (NCT02696902) was a phase 2, randomised, parallel-group, double-blind, placebo-controlled study in Europe, Turkey, Israel, and the USA. Subjects ≥ 18 years old, mechanically ventilated, tracheally colonised with PA, and without new-onset pneumonia, were randomised (1:1:1) to MEDI3902 500, 1500 mg (single intravenous dose), or placebo. The primary efficacy endpoint was the incidence of nosocomial PA pneumonia through 21 days post-dose in MEDI3902 1500 mg versus placebo, determined by an independent adjudication committee. Results: Even if the initial sample size was not reached because of low recruitment, 188 subjects were randomised (MEDI3902 500/1500 mg: n = 16/87; placebo: n = 85) between 13 April 2016 and 17 October 2019. Out of these, 184 were dosed (MEDI3902 500/1500 mg: n = 16/85; placebo: n = 83), comprising the modified intent-to-treat set. Enrolment in the 500 mg arm was discontinued due to pharmacokinetic data demonstrating low MEDI3902 serum concentrations. Subsequently, enrolled subjects were randomised (1:1) to MEDI3902 1500 mg or placebo. PA pneumonia was confirmed in 22.4% (n = 19/85) of MEDI3902 1500 mg recipients and in 18.1% (n = 15/83) of placebo recipients (relative risk reduction [RRR]: − 23.7%; 80% confidence interval [CI] − 83.8%, 16.8%; p = 0.49). At 21 days post-1500 mg dose, the mean (standard deviation) serum MEDI3902 concentration was 9.46 (7.91) μg/mL, with 80.6% (n = 58/72) subjects achieving concentration