The association between internet addiction, sleep quality, and health-related quality of life among Iranian medical students

Due to the increasing use of the internet in Iranian society, especially among students, and the importance of sleep quality (SQ) and quality of life (QOL), the present study examined the relationship between QOL, SQ, and internet addiction (IA) among medical science students. In the present descriptive-analytical study, the sample comprised Saveh University of Medical Sciences students who were studying in 2019. The survey included demographic information (i.e., age, gender, place of residence, field of study, semester, marital status, smoking status, daily exercise) and the 20-item Internet Addiction Test. From 285 distributed questionnaires, 279 individuals with a mean age of 21.01 years (SD ± 3.17) completed the survey. Findings indicated that students with IA had higher mean scores on (i) all physical dimensions concerning QOL (except for the physical pain) and (ii) all psychological dimensions of QOL. The findings will help national health authorities and planners in Iran design appropriate and effective interventions to improve student health and prevent IA

Monoolein Lipid Phases as Incorporation and Enrichment Materials for Membrane Protein Crystallization

The crystallization of membrane proteins in amphiphile-rich materials such as lipidic cubic phases is an established methodology in many structural biology laboratories. The standard procedure employed with this methodology requires the generation of a highly viscous lipidic material by mixing lipid, for instance monoolein, with a solution of the detergent solubilized membrane protein. This preparation is often carried out with specialized mixing tools that allow handling of the highly viscous materials while minimizing dead volume to save precious membrane protein sample. The processes that occur during the initial mixing of the lipid with the membrane protein are not well understood. Here we show that the formation of the lipidic phases and the incorporation of the membrane protein into such materials can be separated experimentally. Specifically, we have investigated the effect of different initial monoolein-based lipid phase states on the crystallization behavior of the colored photosynthetic reaction center from Rhodobacter sphaeroides. We find that the detergent solubilized photosynthetic reaction center spontaneously inserts into and concentrates in the lipid matrix without any mixing, and that the initial lipid material phase state is irrelevant for productive crystallization. A substantial in-situ enrichment of the membrane protein to concentration levels that are otherwise unobtainable occurs in a thin layer on the surface of the lipidic material. These results have important practical applications and hence we suggest a simplified protocol for membrane protein crystallization within amphiphile rich materials, eliminating any specialized mixing tools to prepare crystallization experiments within lipidic cubic phases. Furthermore, by virtue of sampling a membrane protein concentration gradient within a single crystallization experiment, this crystallization technique is more robust and increases the efficiency of identifying productive crystallization parameters. Finally, we provide a model that explains the incorporation of the membrane protein from solution into the lipid phase via a portal lamellar phase

Root Canal Anatomy of Maxillary and Mandibular Teeth

It is a common knowledge that a comprehensive understanding of the complexity of the internal anatomy of teeth is imperative to ensure successful root canal treatment. The significance of canal anatomy has been emphasized by studies demonstrating that variations in canal geometry before cleaning, shaping, and obturation procedures had a greater effect on the outcome than the techniques themselves. In recent years, significant technological advances for imaging teeth, such as CBCT and micro-CT, respectively, have been introduced. Their noninvasive nature allows to perform in vivo anatomical studies using large populations to address the influence of several variables such as ethnicity, aging, gender, and others, on the root canal anatomy, as well as to evaluate, quantitatively and/or qualitatively, specific and fine anatomical features of a tooth group. The purpose of this chapter is to summarize the morphological aspects of the root canal anatomy published in the literature of all groups of teeth and illustrate with three-dimensional images acquired from micro-CT technology.info:eu-repo/semantics/publishedVersio

Religious Attitude Associated with General Health and Smoking in Iranian Students

Abstract Given the university students’ model role in the society and the importance of period of university education in selecting behavioral methods and lifestyles in the future have made it necessary to study the smoking pattern and its associated factors and complications among students. The aim of this study was to compare religious attitude and mental health between smoking and non-smoking students. In this research, religious attitude and mental health was studied in 1065 smoking and non-smoking students of Kerman University of Medical Sciences. In this study, three questionnaires were used (Demographic Questionnaire, General Health Questionnaire and Religious Attitude Scale Questionnaire) which were completed by the students voluntarily. The data were analyzed by descriptive statistic methods, multivariate analysis of variance (MANOVA), t-test, Pearson correlation, and regression coefficient. The mean age of smokers was 20 years and most of the smokers were male (78.9%), single (86.5%) and in BS or BA degree (52.5%). Most of them smoked a cigarette or more in the past month. The average age of start of smoking was 18 years. There was no significant difference between religious attitude and mental health in smoking students in terms of gender but in non-smoking students there was a significant difference in this regard. Smoking students had lower mental health status and religious attitude in comparison with non-smoking students. Between religious attitude and general health in smoking and non-smoking students was also a direct association. Due to psychological and physiological consequences of cigarette smoking, promoting smoking prevention by religious missionaries and university professors, and helping the students to quit smoking by counselors, psychologists and psychiatrics are necessary

Fainting Spells

Audience: The target audience for this simulation is 4th year medical students, emergency medicine residents, pediatric residents, and family medicine residents. Introduction: Brugada syndrome is defined as the combination of specific electrocardiogram (ECG) changes and clinical manifestations of a ventricular arrhythmia, including syncope and sudden cardiac arrest.1 Brugada syndrome is caused by a mutation in the phase-0 cardiac sodium channel. This mutation can be inherited in an autosomal dominant fashion or it can also occur spontaneously.1,2 This syndrome occurs most frequently in men and is one of the most common causes of sudden cardiac death in Southeast Asian males under the age of 50 with structurally normal hearts.3,4 The classic type I Brugada ECG findings are defined as down-sloping ST segment elevation of >2mm in more than one lead in V1-3, with an associated incomplete or complete right bundle branch block. This mutation can lead to ventricular arrhythmias, most often polymorphic ventricular tachycardia and ventricular fibrillation, resulting in syncope and sudden cardiac death.1,2,3,4,5 These ECG changes are often transient, but can be provoked by a number of factors, including fever and infection, medications, and illicit drugs.6 The treatment for this syndrome is placement of an implanted cardiac cardioverter-defibrillator (ICD) to prevent malignant arrhythmias, treatment of any obvious precipitant, and avoidance of specific medications that are associated with inducing arrhythmias.3 Objectives: By the end of this simulation and debriefing, the learning will be able to: 1) Identify Brugada pattern on ECG; 2) Define Brugada syndrome; 3) Discuss the clinical presentation of Brugada syndrome; 4) List provoking factors that can often precipitate arrhythmia; 5) Review management of adult cardiac arrest; 6) Discuss treatment of Brugada syndrome. Method: High-fidelity medical simulation Topics: Brugada syndrome, syncope, sudden cardiac arrest, ACLS, simulation

Reducing Covid-19 Health Inequities Through Identification of Health-Related Social Needs and Clinical Deterioration in Patients Discharged from the Emergency Department

Introduction The decision to discharge a patient from the hospital with confirmed or suspected COVID-19 is fraught with challenges. Patients who are discharged home must be both medically stable and able to safely isolate to prevent disease spread. Socioeconomically disadvantaged patient populations in particular may lack resources to safely quarantine and are at high risk for COVID-19 morbidity. Methods We developed a telehealth follow-up program for emergency department (ED) patients who received testing for COVID-19 from April 24 to June 29, 2020 and were discharged home. Patients who were discharged with a pending COVID-19 test received follow up calls on Days 1, 4 and 8. The objective of our program was to screen and provide referrals for health-related social needs (HRSNs); conduct clinical screening for worsening symptoms; and deliver risk-reduction strategies for vulnerable individuals. Retrospective chart review was conducted on all patients in this cohort to collect demographic information, testing results, and outcomes of clinical symptom and HRSN screening. Our primary outcome measurement was the need for clinical reassessment and referral for an unmet HRSN. Results From April 24th to June 29th, 2020, we made calls to 1,468 patients tested for COVID-19 and discharged home. On Day 4, we reached 67.0% of the 1,468 patients called. Of these, 15.9% were referred to a PA out of concern for clinical worsening and 12.4% were referred to an ED Patient Navigator for HRSNs. On Day 8, we reached 81.8% of the 122 patients called. Of these, 19.7% were referred to a PA for clinical reassessment and 14.0% of patients were referred to an ED Patient Navigator for HRSNs. Our intervention reached 1,069 patients, of which 12.6% required referral for HRSNs and 1.3% (n=14) were referred to the ED or Respiratory Illness Clinic due to concern for worsening clinical symptoms. Conclusion In this patient population, the demand for interventions to address social needs was as high as the need for clinical reassessment. Similar ED-based programs should be considered to help support patients’ interdependent social and health needs, beyond those related to COVID-19.&nbsp

Substrate size effects in the modeling of molecular grafting: Case of organo-silane chains on silica

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