Design for a Darwinian Brain: Part 1. Philosophy and Neuroscience

Physical symbol systems are needed for open-ended cognition. A good way to understand physical symbol systems is by comparison of thought to chemistry. Both have systematicity, productivity and compositionality. The state of the art in cognitive architectures for open-ended cognition is critically assessed. I conclude that a cognitive architecture that evolves symbol structures in the brain is a promising candidate to explain open-ended cognition. Part 2 of the paper presents such a cognitive architecture.Comment: Darwinian Neurodynamics. Submitted as a two part paper to Living Machines 2013 Natural History Museum, Londo

Prognostic factors for tumour response, progression-free survival and toxicity in metastatic colorectal cancer patients given irinotecan (CPT-11) as second-line chemotherapy after 5FU failure

Our purpose was to determine, in patients with metastatic colorectal carcinoma treated with irinotecan single-agent after 5-FU failure, the most significant predictive parameters for tumour response, progression-free survival and toxicity. Between October 1992 and April 1995, 455 patients with 5-FU resistant metastatic colorectal carcinoma entered four consecutive phase II trials. The first two studies assessed tumour response, the other two were randomized studies which assessed the efficacy of racecadotril to prevent irinotecan-induced diarrhoea. Due to homogeneous main eligibility criterias, data from those studies could be pooled for statistical analysis. Potential clinical and biological predictive factors (PF) for toxicity, tumour growth control, e.g. response or stabilization and progression-free survival (PFS), were studied in multivariate analysis. 363 patients were evaluable for response, 432 were evaluable for PFS, 368 for neutropenia and 416 for delayed diarrhoea, respectively. Normal baseline haemoglobin level (Hb), time since diagnosis of colorectal carcinoma, grade 3 or 4 neutropenia or diarrhoea at first cycle and a low number of organs involved were the most PF for tumour growth control (P< 0.05). Significant prognostic variables for PFS were WHO Performance Status, liver and lymph-node involvement, time since diagnosis, age and CEA value (P≤ 0.02). Six groups of patients based on the number of unfavourable prognostic factors are presented. Baseline bilirubin, haemoglobin level, number of organs involved and time from diagnosis were PF for neutropenia; PS, serum creatinine, leukocyte count, time from 5-FU progression and prior abdominopelvic irradiation were PF for delayed diarrhoea (P≤ 0.05). These PF should help clinicians to anticipate for a given patient the probability to observe a response/stabilization or a toxicity. These results should also be prospectively confirmed in ongoing or future trials using irinotecan, both as a single agent and in combination with other drugs. © 2000 Cancer Research Campaig

Promoting adaptation to changing coasts - Work Package T.2.4.1: Methodology for Engagement and Involvement of End Users and Key Stakeholders in Coastal Climate Adaptation Schemes. Executive Summary

This is the final versionPebblebed Heaths Conservation TrustEuropean Regional Development Fund (ERDF

Promoting adaptation to changing coasts - Work Package T.2.4.1: Methodology for Engagement and Involvement of End Users and Key Stakeholders in Coastal Climate Adaptation Schemes. Report 2: Stakeholder Interviews, Resident Workshops, and Model for Engagement in Coastal Adaptation and Landscape Change

This is the final version.Pebblebed Heaths Conservation TrustEuropean Regional Development Fund (ERDF

Promoting adaptation to changing coasts - Work Package T.2.4.1: Methodology for Engagement and Involvement of End Users and Key Stakeholders in Coastal Climate Adaptation Schemes. Report 1: Documentary Analysis

This is the final version.Pebblebed Heaths Conservation TrustEuropean Regional Development Fund (ERDF

Biomarkers in disk-averaged near-UV to near-IR Earth spectra using Earthshine observations

We analyse the detectability of vegetation on a global scale on Earth's surface. Considering its specific reflectance spectrum showing a sharp edge around 700 nm, vegetation can be considered as a potential global biomarker. This work, based on observational data, aims to characterise and to quantify this signature in the disk-averaged Earth's spectrum. Earthshine spectra have been used to test the detectability of the "Vegetation Red Edge" (VRE) in the Earth spectrum. We obtained reflectance spectra from near UV (320 nm) to near IR (1020 nm) for different Earth phases (continents or oceans seen from the Moon) with EMMI on the NTT at ESO/La Silla, Chile. We accurately correct the sky background and take into account the phase-dependent colour of the Moon. VRE measurements require a correction of the ozone Chappuis absorption band and Rayleigh plus aerosol scattering. Results : The near-UV spectrum shows a dark Earth below 350 nm due to the ozone absorption. The Vegetation Red Edge is observed when forests are present (4.0% for Africa and Europe), and is lower when clouds and oceans are mainly visible (1.3% for the Pacific Ocean). Errors are typically $\pm0.5$, and $\pm1.5$ in the worst case. We discuss the different sources of errors and bias and suggest possible improvements. We showed that measuring the VRE or an analog on an Earth-like planet remains very difficult (photometric relative accuracy of 1% or better). It remains a small feature compared to atmospheric absorption lines. A direct monitoring from space of the global (disk-averaged) Earth's spectrum would provide the best VRE follow-up.Comment: Accepted for publication in A&A. 9 pages, 8 figure