21,239 research outputs found

    The impact of job complexity and study design on situational and behavior description interview validity

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    The primary purpose of this investigation was to test two key characteristics hypothesized to influence the validity of situational (SI) and behavior description (BDI) structured interviews. A meta-analysis of 54 studies with a total sample size of 5536 suggested that job complexity influences the validity of SIs, with decreased validity for high-complexity jobs, but does not influence the validity of BDIs. And, results indicated a main effect for study design across both SIs and BDIs, with predictive studies having 0.10 lower validity on average than concurrent studies. Directions for future research are discussed

    Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10.

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    The mechanism by which the mammalian mother accepts the implanting fetus as an allograft remains unexplained, but is likely to be the result of a combination of factors. Mononuclear cytotrophoblasts, the specialized fetal cells of the placenta that invade the uterus, play an important role. These cells express HLA-G, an unusual major histocompatibility complex class I-B molecule, and secrete cytokines and pregnancy-specific proteins that can regulate immune function. We investigated whether cytotrophoblasts secrete interleukin 10 (IL-10), a cytokine that potently inhibits alloresponses in mixed lymphocyte reactions. Cytotrophoblasts from all stages of pregnancy produced IL-10 in vitro, but neither placental fibroblasts nor choriocarcinoma (malignant trophoblast) cell lines did so. Spontaneous IL-10 production averaged 650, 853, and 992 pg/10(6) cells in the first, second, and third trimesters of pregnancy, respectively. IL-10 secretion dropped approximately 10-fold after the first 24 h of culture, and was paralleled by a decrease in messenger RNA. IL-10 messenger RNA was detected in biopsies of the placenta and the portion of the uterus that contains invasive cytotrophoblasts, suggesting that this cytokine is also produced in vivo. IL-10 secreted by cytotrophoblasts in vitro is bioactive, as determined by its ability to suppress interferon gamma production in an allogeneic mixed lymphocyte reaction. We conclude that human cytotrophoblast IL-10 may be an important factor that contributes to maternal tolerance of the allogeneic fetus

    A likelihood method to cross-calibrate air-shower detectors

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    We present a detailed statistical treatment of the energy calibration of hybrid air-shower detectors, which combine a surface detector array and a fluorescence detector, to obtain an unbiased estimate of the calibration curve. The special features of calibration data from air showers prevent unbiased results, if a standard least-squares fit is applied to the problem. We develop a general maximum-likelihood approach, based on the detailed statistical model, to solve the problem. Our approach was developed for the Pierre Auger Observatory, but the applied principles are general and can be transferred to other air-shower experiments, even to the cross-calibration of other observables. Since our general likelihood function is expensive to compute, we derive two approximations with significantly smaller computational cost. In the recent years both have been used to calibrate data of the Pierre Auger Observatory. We demonstrate that these approximations introduce negligible bias when they are applied to simulated toy experiments, which mimic realistic experimental conditions.Comment: 10 pages, 7 figure

    Glass Ceiling Commission - The Impact of the Glass Ceiling and Structural Change on Minorities and Women

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    Glass Ceiling ReportGlassCeilingBackground12StructuralChange.pdf: 9391 downloads, before Oct. 1, 2020

    Manipulation Strategies for the Rank Maximal Matching Problem

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    We consider manipulation strategies for the rank-maximal matching problem. In the rank-maximal matching problem we are given a bipartite graph G=(AP,E)G = (A \cup P, E) such that AA denotes a set of applicants and PP a set of posts. Each applicant aAa \in A has a preference list over the set of his neighbours in GG, possibly involving ties. Preference lists are represented by ranks on the edges - an edge (a,p)(a,p) has rank ii, denoted as rank(a,p)=irank(a,p)=i, if post pp belongs to one of aa's ii-th choices. A rank-maximal matching is one in which the maximum number of applicants is matched to their rank one posts and subject to this condition, the maximum number of applicants is matched to their rank two posts, and so on. A rank-maximal matching can be computed in O(min(cn,n)m)O(\min(c \sqrt{n},n) m) time, where nn denotes the number of applicants, mm the number of edges and cc the maximum rank of an edge in an optimal solution. A central authority matches applicants to posts. It does so using one of the rank-maximal matchings. Since there may be more than one rank- maximal matching of GG, we assume that the central authority chooses any one of them randomly. Let a1a_1 be a manipulative applicant, who knows the preference lists of all the other applicants and wants to falsify his preference list so that he has a chance of getting better posts than if he were truthful. In the first problem addressed in this paper the manipulative applicant a1a_1 wants to ensure that he is never matched to any post worse than the most preferred among those of rank greater than one and obtainable when he is truthful. In the second problem the manipulator wants to construct such a preference list that the worst post he can become matched to by the central authority is best possible or in other words, a1a_1 wants to minimize the maximal rank of a post he can become matched to

    Donor binding energy and thermally activated persistent photoconductivity in high mobility (001) AlAs quantum wells

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    A doping series of AlAs (001) quantum wells with Si delta-modulation doping on both sides reveals different dark and post-illumination saturation densities, as well as temperature dependent photoconductivity. The lower dark two-dimensional electron density saturation is explained assuming deep binding energy of Delta_DK = 65.2 meV for Si-donors in the dark. Persistent photoconductivity (PPC) is observed upon illumination, with higher saturation density indicating shallow post-illumination donor binding energy. The photoconductivity is thermally activated, with 4 K illumination requiring post-illumination annealing to T = 30 K to saturate the PPC. Dark and post-illumination doping efficiencies are reported.Comment: The values of binding energy changed from previous versions because of a better understanding for the dielectric permittivity. Also, the Gamma - X donor states are better explaine

    Paired and altruistic kidney donation in the UK: algorithms and experimentation

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    We study the computational problem of identifying optimal sets of kidney exchanges in the UK. We show how to expand an integer programming-based formulation [1, 19] in order to model the criteria that constitute the UK definition of optimality. The software arising from this work has been used by the National Health Service Blood and Transplant to find optimal sets of kidney exchanges for their National Living Donor Kidney Sharing Schemes since July 2008.We report on the characteristics of the solutions that have been obtained in matching runs of the scheme since this time. We then present empirical results arising from the real datasets that stem from these matching runs, with the aim of establishing the extent to which the particular optimality criteria that are present in the UK influence the structure of the solutions that are ultimately computed. A key observation is that allowing 4-way exchanges would be likely to lead to a significant number of additional transplants

    Experimentally exploring compressed sensing quantum tomography

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    In the light of the progress in quantum technologies, the task of verifying the correct functioning of processes and obtaining accurate tomographic information about quantum states becomes increasingly important. Compressed sensing, a machinery derived from the theory of signal processing, has emerged as a feasible tool to perform robust and significantly more resource-economical quantum state tomography for intermediate-sized quantum systems. In this work, we provide a comprehensive analysis of compressed sensing tomography in the regime in which tomographically complete data is available with reliable statistics from experimental observations of a multi-mode photonic architecture. Due to the fact that the data is known with high statistical significance, we are in a position to systematically explore the quality of reconstruction depending on the number of employed measurement settings, randomly selected from the complete set of data, and on different model assumptions. We present and test a complete prescription to perform efficient compressed sensing and are able to reliably use notions of model selection and cross-validation to account for experimental imperfections and finite counting statistics. Thus, we establish compressed sensing as an effective tool for quantum state tomography, specifically suited for photonic systems.Comment: 12 pages, 5 figure
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