21,239 research outputs found
Learning in Extensive Form Games: Experimental Data and Simple Dynamic Models in the Intermediate Run
The impact of job complexity and study design on situational and behavior description interview validity
The primary purpose of this investigation was to test two key characteristics hypothesized to influence the validity of situational (SI) and behavior description (BDI) structured interviews. A meta-analysis of 54 studies with a total sample size of 5536 suggested that job complexity influences the validity of SIs, with decreased validity for high-complexity jobs, but does not influence the validity of BDIs. And, results indicated a main effect for study design across both SIs and BDIs, with predictive studies having 0.10 lower validity on average than concurrent studies. Directions for future research are discussed
Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10.
The mechanism by which the mammalian mother accepts the implanting fetus as an allograft remains unexplained, but is likely to be the result of a combination of factors. Mononuclear cytotrophoblasts, the specialized fetal cells of the placenta that invade the uterus, play an important role. These cells express HLA-G, an unusual major histocompatibility complex class I-B molecule, and secrete cytokines and pregnancy-specific proteins that can regulate immune function. We investigated whether cytotrophoblasts secrete interleukin 10 (IL-10), a cytokine that potently inhibits alloresponses in mixed lymphocyte reactions. Cytotrophoblasts from all stages of pregnancy produced IL-10 in vitro, but neither placental fibroblasts nor choriocarcinoma (malignant trophoblast) cell lines did so. Spontaneous IL-10 production averaged 650, 853, and 992 pg/10(6) cells in the first, second, and third trimesters of pregnancy, respectively. IL-10 secretion dropped approximately 10-fold after the first 24 h of culture, and was paralleled by a decrease in messenger RNA. IL-10 messenger RNA was detected in biopsies of the placenta and the portion of the uterus that contains invasive cytotrophoblasts, suggesting that this cytokine is also produced in vivo. IL-10 secreted by cytotrophoblasts in vitro is bioactive, as determined by its ability to suppress interferon gamma production in an allogeneic mixed lymphocyte reaction. We conclude that human cytotrophoblast IL-10 may be an important factor that contributes to maternal tolerance of the allogeneic fetus
A likelihood method to cross-calibrate air-shower detectors
We present a detailed statistical treatment of the energy calibration of
hybrid air-shower detectors, which combine a surface detector array and a
fluorescence detector, to obtain an unbiased estimate of the calibration curve.
The special features of calibration data from air showers prevent unbiased
results, if a standard least-squares fit is applied to the problem. We develop
a general maximum-likelihood approach, based on the detailed statistical model,
to solve the problem. Our approach was developed for the Pierre Auger
Observatory, but the applied principles are general and can be transferred to
other air-shower experiments, even to the cross-calibration of other
observables. Since our general likelihood function is expensive to compute, we
derive two approximations with significantly smaller computational cost. In the
recent years both have been used to calibrate data of the Pierre Auger
Observatory. We demonstrate that these approximations introduce negligible bias
when they are applied to simulated toy experiments, which mimic realistic
experimental conditions.Comment: 10 pages, 7 figure
Glass Ceiling Commission - The Impact of the Glass Ceiling and Structural Change on Minorities and Women
Glass Ceiling ReportGlassCeilingBackground12StructuralChange.pdf: 9391 downloads, before Oct. 1, 2020
Manipulation Strategies for the Rank Maximal Matching Problem
We consider manipulation strategies for the rank-maximal matching problem. In
the rank-maximal matching problem we are given a bipartite graph  such that  denotes a set of applicants and  a set of posts. Each
applicant  has a preference list over the set of his neighbours in
, possibly involving ties. Preference lists are represented by ranks on the
edges - an edge  has rank , denoted as , if post 
belongs to one of 's -th choices. A rank-maximal matching is one in which
the maximum number of applicants is matched to their rank one posts and subject
to this condition, the maximum number of applicants is matched to their rank
two posts, and so on. A rank-maximal matching can be computed in  time, where  denotes the number of applicants,  the
number of edges and  the maximum rank of an edge in an optimal solution.
  A central authority matches applicants to posts. It does so using one of the
rank-maximal matchings. Since there may be more than one rank- maximal matching
of , we assume that the central authority chooses any one of them randomly.
Let  be a manipulative applicant, who knows the preference lists of all
the other applicants and wants to falsify his preference list so that he has a
chance of getting better posts than if he were truthful. In the first problem
addressed in this paper the manipulative applicant  wants to ensure that
he is never matched to any post worse than the most preferred among those of
rank greater than one and obtainable when he is truthful. In the second problem
the manipulator wants to construct such a preference list that the worst post
he can become matched to by the central authority is best possible or in other
words,  wants to minimize the maximal rank of a post he can become matched
to
Donor binding energy and thermally activated persistent photoconductivity in high mobility (001) AlAs quantum wells
A doping series of AlAs (001) quantum wells with Si delta-modulation doping
on both sides reveals different dark and post-illumination saturation
densities, as well as temperature dependent photoconductivity. The lower dark
two-dimensional electron density saturation is explained assuming deep binding
energy of Delta_DK = 65.2 meV for Si-donors in the dark. Persistent
photoconductivity (PPC) is observed upon illumination, with higher saturation
density indicating shallow post-illumination donor binding energy. The
photoconductivity is thermally activated, with 4 K illumination requiring
post-illumination annealing to T = 30 K to saturate the PPC. Dark and
post-illumination doping efficiencies are reported.Comment: The values of binding energy changed from previous versions because
  of a better understanding for the dielectric permittivity. Also, the Gamma -
  X donor states are better explaine
Paired and altruistic kidney donation in the UK: algorithms and experimentation
We study the computational problem of identifying optimal
sets of kidney exchanges in the UK. We show how to expand an integer
programming-based formulation [1, 19] in order to model the criteria that
constitute the UK definition of optimality. The software arising from this
work has been used by the National Health Service Blood and Transplant
to find optimal sets of kidney exchanges for their National Living Donor
Kidney Sharing Schemes since July 2008.We report on the characteristics
of the solutions that have been obtained in matching runs of the scheme
since this time. We then present empirical results arising from the real
datasets that stem from these matching runs, with the aim of establishing
the extent to which the particular optimality criteria that are present
in the UK influence the structure of the solutions that are ultimately
computed. A key observation is that allowing 4-way exchanges would be
likely to lead to a significant number of additional transplants
Experimentally exploring compressed sensing quantum tomography
In the light of the progress in quantum technologies, the task of verifying
the correct functioning of processes and obtaining accurate tomographic
information about quantum states becomes increasingly important. Compressed
sensing, a machinery derived from the theory of signal processing, has emerged
as a feasible tool to perform robust and significantly more resource-economical
quantum state tomography for intermediate-sized quantum systems. In this work,
we provide a comprehensive analysis of compressed sensing tomography in the
regime in which tomographically complete data is available with reliable
statistics from experimental observations of a multi-mode photonic
architecture. Due to the fact that the data is known with high statistical
significance, we are in a position to systematically explore the quality of
reconstruction depending on the number of employed measurement settings,
randomly selected from the complete set of data, and on different model
assumptions. We present and test a complete prescription to perform efficient
compressed sensing and are able to reliably use notions of model selection and
cross-validation to account for experimental imperfections and finite counting
statistics. Thus, we establish compressed sensing as an effective tool for
quantum state tomography, specifically suited for photonic systems.Comment: 12 pages, 5 figure
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