1,663 research outputs found
Effects of lowering body temperature via hyperhydration, with and without glycerol ingestion and practical precooling on cycling time trial performance in hot and humid conditions
Background
Hypohydration and hyperthermia are factors that may contribute to fatigue and impairment of endurance performance. The purpose of this study was to investigate the effectiveness of combining glycerol hyperhydration and an established precooling technique on cycling time trial performance in hot environmental conditions.
Methods
Twelve well-trained male cyclists performed three 46.4-km laboratory-based cycling trials that included two climbs, under hot and humid environmental conditions (33.3 ± 1.1°C; 50 ± 6% r.h.). Subjects were required to hyperhydrate with 25 g.kg-1 body mass (BM) of a 4°C beverage containing 6% carbohydrate (CON) 2.5 h prior to the time trial. On two occasions, subjects were also exposed to an established precooling technique (PC) 60 min prior to the time trial, involving 14 g.kg-1 BM ice slurry ingestion and applied iced towels over 30 min. During one PC trial, 1.2 g.kg-1 BM glycerol was added to the hyperhydration beverage in a double-blind fashion (PC+G). Statistics used in this study involve the combination of traditional probability statistics and a magnitude-based inference approach.
Results
Hyperhydration resulted in large reductions (−0.6 to −0.7°C) in rectal temperature. The addition of glycerol to this solution also lowered urine output (330 ml, 10%). Precooling induced further small (−0.3°C) to moderate (−0.4°C) reductions in rectal temperature with PC and PC+G treatments, respectively, when compared with CON (0.0°C, P<0.05). Overall, PC+G failed to achieve a clear change in cycling performance over CON, but PC showed a possible 2% (30 s, P=0.02) improvement in performance time on climb 2 compared to CON. This improvement was attributed to subjects’ lower perception of effort reported over the first 10 km of the trial, despite no clear performance change during this time. No differences were detected in any other physiological measurements throughout the time trial.
Conclusions
Despite increasing fluid intake and reducing core temperature, performance and thermoregulatory benefits of a hyperhydration strategy with and without the addition of glycerol, plus practical precooling, were not superior to hyperhydration alone. Further research is warranted to further refine preparation strategies for athletes competing in thermally stressful events to optimize health and maximize performance outcomes
The interplay of intrinsic and extrinsic bounded noises in genetic networks
After being considered as a nuisance to be filtered out, it became recently
clear that biochemical noise plays a complex role, often fully functional, for
a genetic network. The influence of intrinsic and extrinsic noises on genetic
networks has intensively been investigated in last ten years, though
contributions on the co-presence of both are sparse. Extrinsic noise is usually
modeled as an unbounded white or colored gaussian stochastic process, even
though realistic stochastic perturbations are clearly bounded. In this paper we
consider Gillespie-like stochastic models of nonlinear networks, i.e. the
intrinsic noise, where the model jump rates are affected by colored bounded
extrinsic noises synthesized by a suitable biochemical state-dependent Langevin
system. These systems are described by a master equation, and a simulation
algorithm to analyze them is derived. This new modeling paradigm should enlarge
the class of systems amenable at modeling.
We investigated the influence of both amplitude and autocorrelation time of a
extrinsic Sine-Wiener noise on: the Michaelis-Menten approximation of
noisy enzymatic reactions, which we show to be applicable also in co-presence
of both intrinsic and extrinsic noise, a model of enzymatic futile cycle
and a genetic toggle switch. In and we show that the
presence of a bounded extrinsic noise induces qualitative modifications in the
probability densities of the involved chemicals, where new modes emerge, thus
suggesting the possibile functional role of bounded noises
Analytic Lifshitz black holes in higher dimensions
We generalize the four-dimensional R^2-corrected z=3/2 Lifshitz black hole to
a two-parameter family of black hole solutions for any dynamical exponent z and
for any dimension D. For a particular relation between the parameters, we find
the first example of an extremal Lifshitz black hole. An asymptotically
Lifshitz black hole with a logarithmic decay is also exhibited for a specific
critical exponent depending on the dimension. We extend this analysis to the
more general quadratic curvature corrections for which we present three new
families of higher-dimensional D>=5 analytic Lifshitz black holes for generic
z. One of these higher-dimensional families contains as critical limits the z=3
three-dimensional Lifshitz black hole and a new z=6 four-dimensional black
hole. The variety of analytic solutions presented here encourages to explore
these gravity models within the context of non-relativistic holographic
correspondence.Comment: 14 page
Bridging Time Scales in Cellular Decision Making with a Stochastic Bistable Switch
Cellular transformations which involve a significant phenotypical change of
the cell's state use bistable biochemical switches as underlying decision
systems. In this work, we aim at linking cellular decisions taking place on a
time scale of years to decades with the biochemical dynamics in signal
transduction and gene regulation, occuring on a time scale of minutes to hours.
We show that a stochastic bistable switch forms a viable biochemical mechanism
to implement decision processes on long time scales. As a case study, the
mechanism is applied to model the initiation of follicle growth in mammalian
ovaries, where the physiological time scale of follicle pool depletion is on
the order of the organism's lifespan. We construct a simple mathematical model
for this process based on experimental evidence for the involved genetic
mechanisms. Despite the underlying stochasticity, the proposed mechanism turns
out to yield reliable behavior in large populations of cells subject to the
considered decision process. Our model explains how the physiological time
constant may emerge from the intrinsic stochasticity of the underlying gene
regulatory network. Apart from ovarian follicles, the proposed mechanism may
also be of relevance for other physiological systems where cells take binary
decisions over a long time scale.Comment: 14 pages, 4 figure
Finite Temperature Aging Holography
We construct the gravity background which describes the dual field theory
with aging invariance. We choose the decay modes of the bulk scalar field in
the internal spectator direction to obtain the dissipative behavior of the
boundary correlation functions of the dual scalar fields. In particular, the
two-time correlation function at zero temperature has the characteristic
features of the aging system: power law decay, broken time translation and
dynamical scaling. We also construct the black hole backgrounds with asymptotic
aging invariance. We extensively study characteristic behavior of the finite
temperature two-point correlation function via analytic and numerical methods.Comment: 38 pages and 5 figures, expanded discussions on correlator, one
mistake is fixed, modified discussion on shear viscosity, to appear in JHE
A continuous mapping of sleep states through association of EEG with a mesoscale cortical model
Here we show that a mathematical model of the human sleep cycle can be used to obtain a detailed description of electroencephalogram (EEG) sleep stages, and we discuss how this analysis may aid in the prediction and prevention of seizures during sleep. The association between EEG data and the cortical model is found via locally linear embedding (LLE), a method of dimensionality reduction. We first show that LLE can distinguish between traditional sleep stages when applied to EEG data. It reliably separates REM and non-REM sleep and maps the EEG data to a low-dimensional output space where the sleep state changes smoothly over time. We also incorporate the concept of strongly connected components and use this as a method of automatic outlier rejection for EEG data. Then, by using LLE on a hybrid data set containing both sleep EEG and signals generated from the mesoscale cortical model, we quantify the relationship between the data and the mathematical model. This enables us to take any sample of sleep EEG data and associate it with a position among the continuous range of sleep states provided by the model; we can thus infer a trajectory of states as the subject sleeps. Lastly, we show that this method gives consistent results for various subjects over a full night of sleep and can be done in real time
Vacuum Ambiguity in de Sitter Space at Strong Coupling
It is well known that in the weak coupling regime, quantum field theories in
de Sitter space do not have a unique vacuum, but a class of vacua parametrized
by a complex parameter , i.e., the so-called -vacua. In this
article, using gauge/gravity duality, we calculate the symmetric two-point
function of strongly coupled supersymmetric Yang-Mills theory on
. We find that there is a class of de Sitter invariant vacua,
parametrized by a set of complex parameters .Comment: 17 pages in JHEP style, references adde
Charged, conformal non-relativistic hydrodynamics
We embed a holographic model of an U(1) charged fluid with Galilean
invariance in string theory and calculate its specific heat capacity and
Prandtl number. Such theories are generated by a R-symmetry twist along a null
direction of a N=1 superconformal theory. We study the hydrodynamic properties
of such systems employing ideas from the fluid-gravity correspondence.Comment: 31 pages, 1 figure, JHEP3 style, refs added, typos corrected, missing
terms in spatial charge current and field corrections added, to be published
in JHE
Black holes and black branes in Lifshitz spacetimes
We construct analytic solutions describing black holes and black branes in
asymptotically Lifshitz spacetimes with arbitrary dynamical exponent z and for
arbitrary number of dimensions. The model considered consists of Einstein
gravity with negative cosmological constant, a scalar, and N U(1) gauge fields
with dilatonic-like couplings. We study the phase diagrams and thermodynamic
instabilities of the solution, and find qualitative differences between the
cases with 12.Comment: 27 pages, 10 figures; v2 references added, minor comments adde
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