Adventures in Malley Country: Concerning Peter Carey's My Life as a Fake

Contemporary anxieties around cloning and genetic modification have deep roots in a nineteenth- and twentieth-century tradition of narrative thought-experiments about the artificial reproduction of human life. In the ‘strange wickedness’ to which HG Wells’s narrator refers—as good a condensation of the tradition’s topic as any—strangeness has always been as prominent as wickedness. In that tradition the myths of Prometheus and Faust, of the golem and the doppelgänger, together with fables and fictions concerning automata and scientifically produced monsters and/or reflections on the real and the illusory, have con- verged to define a problematics of the sorcerer’s apprentice. We will see that such a problematics reflects a powerful fear of artifice, or more accurately a phobia: a fear of artifice as great as the attraction it also exerts

Alkylimidotungsten Fluorides and Related Compounds

In this work, tungsten hexafluoride derivatives have been prepared containing the strong pi -donor ligands, the oxo, the imido and the alkylimido groups, with the main emphasis of the work being on the alkylimido derivatives. The compounds WF4X(MeCN) , where X = O or NH, have been prepared by the reaction of WF6 with (Me3Si)2X in acetonitrile. When X = NH, the product is unstable to further reaction. The reactions of primary amines and their trimethyl- silyl analogues with tungsten hexafluoride have been investigated. This has resulted in the identification of compounds of the type, WF4NMe(L), where L = MeCN, EtCN, (MeO)2SO, EtOC(O)CH3 and (MeO)P(O)Me, and the salts RNH3+ WF5NR -, where R = Me, Et and Bu n. The reaction of the amine, Me3SiNHMe, with WF6 gave salts of the anion WF5NMe - and W2F9(NMe)2. In addition the compound, WF3(OMe) (NMe) [(MeO)2 P(O) Me] , has been identified. The reaction of WF6 with BuNH2 gave a very insoluble 1:3 adduct. The following techniques have been used in the study of these compounds; elemental analyses, low and high resolution mass spectrometry, infra red spectrometry Raman spectrometry and n. m. r. spectrometry. The n. m. r. spectra of these compounds have been extensively studied. The n. m. r. evidence shows that the W = N - C skeleton is linear or nearly linear. This is explained in terms of the lone pair of electrons on the nitrogen being fed into empty d-orbitals on the tungsten atom. The reaction of T1WF7 with (Me3Si)2NMe was investigated. The products were Me3SiF and an insoluble cream solid of the composition, T1WF4NMe. The structure was not found, but i. r. and low temperature Raman evidence suggested that it contains the WF4NMe moiety. Related reactions were also investigated, X-Ray powder diffraction was used in these investigations along with the previously mentioned techniques. The reactions of WF6 with Me3SnCF3 and Me3SnC6F5 gave charge transfer complexes. The reactions of MoF6 with Me4Sn or Me3SnCF3 in acetonitrile gave insoluble white solids and MeF, or MeF and CF4

Opportunities for epidemiologists in implementation science: A primer

The field of epidemiology has been defined as the study of the spread and control of disease. However, epidemiology frequently focuses on studies of etiology and distribution of disease at the cost of understanding the best ways to control disease. Moreover, only a small fraction of scientific discoveries are translated into public health practice, and the process from discovery to translation is exceedingly slow. Given the importance of translational science, the future of epidemiologic training should include competency in implementation science, whose goal is to rapidly move evidence into practice. Our purpose in this paper is to provide epidemiologists with a primer in implementation science, which includes dissemination research and implementation research as defined by the National Institutes of Health. We describe the basic principles of implementation science, highlight key components for conducting research, provide examples of implementation studies that encompass epidemiology, and offer resources and opportunities for continued learning. There is a clear need for greater speed, relevance, and application of evidence into practice, programs, and policies and an opportunity to enable epidemiologists to conduct research that not only will inform practitioners and policy-makers of risk but also will enhance the likelihood that evidence will be implemented

Vernacular cinema, self-concept and the perceptual–conceptual shift:exploring conversations between film education and developmental psychology

Co-authored by film education practitioners and developmental psychologists, this article seeks to establish an interdisciplinary dialogue between the emergent discourses of film education and developmental psychology. In particular, it explores the possible implications for our understandings of film education of recent psychological research into: (1) the cognitive and social consequences for young people of developing a sense of self; and (2) understandings of children’s development of visual cognition. Seeking areas of commonality and mutual resonance between different disciplinary vocabularies and methodologies, ultimately we present a series of proposals for how film education may benefit from further interface with developmental psychology

Models in dissemination and implementation research: useful tools in public health services and systems research

Dissemination and implementation (D&I) science seeks to understand how to systematically facilitate utilization of evidence. Theories and frameworks (hereafter called models) augment D&I research by enhancing efforts to spread evidence-based interventions (EBIs). D&I models are relevant for public health services and systems research, which also explores the uses of evidence. This report: 1) develops an inventory of models; 2) synthesizes this information; and 3) provides guidance on how to select a model. The research team used snowball sampling to collect models. This article uses three author-defined variables: construct flexibility, focus on dissemination and/or implementation activities, and socio-ecological framework level to categorize models. Models that addressed policy are noted. Public health researchers and practitioners can use this inventory to identify models to guide D&I research and/or efforts

Glacial Aerodynamic Roughness Estimates:Uncertainty, Sensitivity, and Precision in Field Measurements

Calculation of the sensible and latent heat (turbulent) fluxes is required in order to close the surface energy budget of glaciers and model glacial melt. The aerodynamic roughness length, z0, is a key parameter in the bulk approach to calculating sensible heat flux; yet, z0 is commonly considered simply as a tuning parameter or generalized between surfaces and over time. Spatially and temporally distributed observations of z0 over ice are rare. Both direct (from wind towers and sonic anemometers) and indirect (from microtopographic surveys) measurements of z0 are subject to sensitivities and uncertainties that are often unstated or overlooked. In this study, we present a quantitative evaluation of aerodynamic profile-based and microtopographic methods and their effect on z0 using data collected from Storglaciären and Sydöstra Kaskasatjäkkaglaciären, Tarfala Valley, Arctic Sweden. Aggressive data filters discard most of the wind tower data but still produce realistic z0 values of 1.9 mm and 2 mm. Despite uncertainty introduced by scale and resolution dependence, microtopographic methods produced estimates of z0 comparable to wind tower values and those found on similar surfaces. We conclude that (1) in the absence of direct turbulent flux measurements from sonic anemometers, the profile and microtopographic methods provide realistic z0 values, (2) both 2D and 3D microtopographic methods are dependent on scale, resolution, and the chosen detrending method, and (3) careful calibration of these parameters could enable glacier-wide investigations of z0 from remotely sensed data, including those increasingly available from satellite platforms

BAF180 promotes cohesion and prevents genome instability and aneuploidy

BAF180, a subunit of the PBAF chromatin remodeling complex, is frequently mutated in cancer. Although PBAF regulates transcription, it remains unclear whether this is what drives tumorigenesis in cells lacking BAF180. Based on data from yeast, we hypothesized that BAF180 may prevent tumorigenesis by promoting cohesion. Here, we show BAF180 is required for centromeric cohesion in mouse and human cells. Mutations identified in tumor samples are unable to support this activity, and also compromise cohesion-dependent functions in yeast. We provide evidence of genome instability in line with loss of cohesion, and importantly, we find dynamic chromosome instability following DNA damage in cells lacking BAF180. These data demonstrate a function for BAF180 in promoting genome stability that is distinct from its well-characterized role in transcriptional regulation, uncovering a potent mechanism for its tumor-suppressor activity

Dissemination and implementation science training needs: Insights from practitioners and researchers

INTRODUCTION: Dissemination and implementation research training has great potential to improve the impact and reach of health-related research; however, research training needs from the end user perspective are unknown. This paper identifies and prioritizes dissemination and implementation research training needs. METHODS: A diverse sample of researchers, practitioners, and policymakers was invited to participate in Concept Mapping in 2014–2015. Phase 1 (Brainstorming) gathered participants' responses to the prompt: To improve the impact of research evidence in practice and policy settings, a skill in which researchers need more training is… The resulting statement list was edited and included subsequent phases. Phase 2 (Sorting) asked participants to sort each statement into conceptual piles. In Phase 3 (Rating), participants rated the difficulty and importance of incorporating each statement into a training curriculum. A multidisciplinary team synthesized and interpreted the results in 2015–2016. RESULTS: During Brainstorming, 60 researchers and 60 practitioners/policymakers contributed 274 unique statements. Twenty-nine researchers and 16 practitioners completed sorting and rating. Nine concept clusters were identified: Communicating Research Findings, Improve Practice Partnerships, Make Research More Relevant, Strengthen Communication Skills, Develop Research Methods and Measures, Consider and Enhance Fit, Build Capacity for Research, and Understand Multilevel Context. Though researchers and practitioners had high agreement about importance (r =0.93) and difficulty (r =0.80), ratings differed for several clusters (e.g., Build Capacity for Research). CONCLUSIONS: Including researcher and practitioner perspectives in competency development for dissemination and implementation research identifies skills and capacities needed to conduct and communicate contextualized, meaningful, and relevant research