Archaeological/Anthropological-Native American Coordination, An Example of Sharing the Research on the Northwest Coast of North America

The conflict, almost a panic for some archaeologists, over who "owns" the past--scientists or tribes--does not need to exist. Both groups have equal validity (legal or otherwise) in being involved. With shared scientific technical and tribal cultural expertise, an equal partnership produces results not possible otherwise. Here is one example of a formalized 50/50 sharing of the research that expands scientific and cultural understanding n the Pacific Northwest of North America. In this case, the Squaxin Island Tribe and a College signed a formal cooperative agreement that helped set the stage for developing (1) a tribal cultural resource management office, (2) the first full-scale investigation of a site in this region (which contains a wet component, (3) outreach cultural resource Management training through online classes, and (4) public interpretation in a new tribal museum. Working together, equally respecting each other's needs, archaeologists and tribes can create the scientific/cultural results they both require

Visualization Support for Cognitive Sciences

The science of computer graphics and visualization is intertwined in many ways with Cognitive Sciences. On the one hand, computer graphics can lead to virtual environments in which a person is exposed to a virtual scenario. Typically, 3D-capable display technology combined with tracking systems, which are capable of identifying where the person is located at, are deployed to achieve maximal immersion in that the persons point of view is recreated in the virtual scenario. As a result, an impressive experience is created such that that person is navigating the virtual scenario as if it was real. On the other hand, visualization techniques can be utilized to present the results from a cognitive science experiment to the user such that it provides easier access to the data. This could range from simple plots to more sophisiticated approaches, such as parallel coordinates. In addition, results from cognitive sciences can feed back into the visualization to make the visualization more user-friendly. For example, more intuitive input devices, such as cyber gloves which track the position of a users fingers, could be used to intuitively make selections or view modifications. The Appenzeller Visualization Laboratory is in a perfect position to enable research in all of these areas mentioned above. Sophisticated display systems are available which provide full immersion, ranging from single screens and head-mounted displays to full-size CAVE-type displays. This presentation will illustrate some examples for visualizations of data from the cognitive science realm and showcase display systems and some of their use cases

Qwu?gwes - A Squaxin Island tribal heritage wet site, Puget Sound, USA

The Qwu?gwes wet site is located at the very head of Puget Sound in Washington State, USA (fig 1). Puget Sound has been referred to as an inland sea, but is better termed as a large glacially cut fjord that is approximately 145km long, running north to south, where the ocean salt water from the Pacific mixes with fresh water draining from the surrounding watersheds. Puget Sound was formed into the north–south fjord it is today by glaciers that advanced from the north at least four times, scouring and carving it for millions of years (Waitt & Thorson 1983). The Vashon Stade was the last major advance, reaching its maximum about 18,000 years ago, covering everything between the Olympic and the Cascade mountains and spreading as far south as our specific region of study. As the Vashon Stade retreated, its melting ice created a massive fresh water lake that released through the Black Lake spillway at the head of Eld Inlet, our site location, and down the Chehalis River drainage to the Pacific Ocean. Once the glaciers melted far enough north, the Straits of Juan de Fuca were open and salt water from the Pacific Ocean entered Puget Sound, making it the salt water ‘inland sea’ it is today (fig 1). Our research area encompasses the southern reaches of the traditional territory of the Lushootseed-speaking Coast Salish People and language family, sometimes referred to as Puget [Sound] Salish (Suttles & Lane 1990, 485–502; Thompson & Kinkade 1990, 38; fig 1). Few systematic archaeological investigations have occurred in this region, especially in the southern section of Lushootseed traditional territory, so this paper should be considered a much needed synthesis of a well-preserved waterlogged site. Qwu?gwes forms the main reference point for our synthesized presentations, and this work is based on the original papers presented by the authors at the 11th International Wetland Archaeology Research Project (WARP) conference in Edinburgh (21–24 September 2005). This joint investigation of the Squaxin Island Tribe and South Puget Sound Community College has been ongoing for several years and provides both a scientific and cultural perspective of the many findings. Earlier publications stress the basis of this joint co-operative effort and the need for co-ordinated scientific and Native cultural understandings and explanations (Foster & Croes 2002, 2004)

Study of Natural Health Product Adverse Reactions (SONAR): Active Surveillance of Adverse Events Following Concurrent Natural Health product and Prescription Drug Use in Community Pharmacies

Background: Many consumers use natural health products (NHPs) concurrently with prescription medications. As NHP-related harms are under-reported through passive surveillance, the safety of concurrent NHP-drug use remains unknown. To conduct active surveillance in participating community pharmacies to identify adverse events related to concurrent NHP-prescription drug use. Methodology/Principal Findings: Participating pharmacists asked individuals collecting prescription medications about (i) concurrent NHP/drug use in the previous three months and (ii) experiences of adverse events. If an adverse event was identified and if the patient provided written consent, a research pharmacist conducted a guided telephone interview to gather additional information after obtaining additional verbal consent and documenting so within the interview form. Over a total of 112 pharmacy weeks, 2615 patients were screened, of which 1037 (39.7%; 95% CI: 37.8% to 41.5%) reported concurrent NHP and prescription medication use. A total of 77 patients reported a possible AE (2.94%; 95% CI: 2.4% to 3.7%), which represents 7.4% of those using NHPs and prescription medications concurrently (95%CI: 6.0% to 9.2%). Of 15 patients available for an interview, 4 (26.7%: 95% CI: 4.3% to 49.0%) reported an AE that was determined to be “probably” due to NHP use. Conclusions/Significance: Active surveillance markedly improves identification and reporting of adverse events associated with concurrent NHP-drug use. Although not without challenges, active surveillance is feasible and can generate adverse event data of sufficient quality to allow for meaningful adjudication to assess potential harms

Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb

Nemaline myopathy (NM) caused by mutations in the gene encoding nebulin (NEB) accounts for at least 50% of all NM cases worldwide, representing a significant disease burden. Most NEB-NM patients have autosomal recessive disease due to a compound heterozygous genotype. Of the few murine models developed for NEB-NM, most are Neb knockout models rather than harbouring Neb mutations. Additionally, some models have a very severe phenotype that limits their application for evaluating disease progression and potential therapies. No existing murine models possess compound heterozygous Neb mutations that reflect the genotype and resulting phenotype present in most patients. We aimed to develop a murine model that more closely matched the underlying genetics of NEB-NM, which could assist elucidation of the pathogenetic mechanisms underlying the disease. Here, we have characterised a mouse strain with compound heterozygous Neb mutations; one missense (p.Tyr2303His), affecting a conserved actin-binding site and one nonsense mutation (p.Tyr935*), introducing a premature stop codon early in the protein. Our studies reveal that this compound heterozygous model, Neb(Y2303H, Y935X), has striking skeletal muscle pathology including nemaline bodies. In vitro whole muscle and single myofibre physiology studies also demonstrate functional perturbations. However, no reduction in lifespan was noted. Therefore, Neb(Y2303H,Y935X) mice recapitulate human NEB-NM and are a much needed addition to the NEB-NM mouse model collection. The moderate phenotype also makes this an appropriate model for studying NEB-NM pathogenesis, and could potentially be suitable for testing therapeutic applications.Peer reviewe

Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb

Nemaline myopathy (NM) caused by mutations in the gene encoding nebulin (NEB) accounts for at least 50% of all NM cases worldwide, representing a significant disease burden. Most NEB-NM patients have autosomal recessive disease due to a compound heterozygous genotype. Of the few murine models developed for NEB-NM, most are Neb knockout models rather than harbouring Neb mutations. Additionally, some models have a very severe phenotype that limits their application for evaluating disease progression and potential therapies. No existing murine models possess compound heterozygous Neb mutations that reflect the genotype and resulting phenotype present in most patients. We aimed to develop a murine model that more closely matched the underlying genetics of NEB-NM, which could assist elucidation of the pathogenetic mechanisms underlying the disease. Here, we have characterised a mouse strain with compound heterozygous Neb mutations; one missense (p.Tyr2303His), affecting a conserved actin-binding site and one nonsense mutation (p.Tyr935*), introducing a premature stop codon early in the protein. Our studies reveal that this compound heterozygous model, Neb(Y2303H, Y935X), has striking skeletal muscle pathology including nemaline bodies. In vitro whole muscle and single myofibre physiology studies also demonstrate functional perturbations. However, no reduction in lifespan was noted. Therefore, Neb(Y2303H,Y935X) mice recapitulate human NEB-NM and are a much needed addition to the NEB-NM mouse model collection. The moderate phenotype also makes this an appropriate model for studying NEB-NM pathogenesis, and could potentially be suitable for testing therapeutic applications.Peer reviewe