Development of a primary care-based complex care management intervention for chronically ill patients at high risk for hospitalization: a study protocol

Background: Complex care management is seen as an approach to face the challenges of an ageing society with increasing numbers of patients with complex care needs. The Medical Research Council in the United Kingdom has proposed a framework for the development and evaluation of complex interventions that will be used to develop and evaluate a primary care-based complex care management program for chronically ill patients at high risk for future hospitalization in Germany. Methods and design: We present a multi-method procedure to develop a complex care management program to implement interventions aimed at reducing potentially avoidable hospitalizations for primary care patients with type 2 diabetes mellitus, chronic obstructive pulmonary disease, or chronic heart failure and a high likelihood of hospitalization. The procedure will start with reflection about underlying precipitating factors of hospitalizations and how they may be targeted by the planned intervention (pre-clinical phase). An intervention model will then be developed (phase I) based on theory, literature, and exploratory studies (phase II). Exploratory studies are planned that entail the recruitment of 200 patients from 10 general practices. Eligible patients will be identified using two ways of 'case finding': software based predictive modelling and physicians' proposal of patients based on clinical experience. The resulting subpopulations will be compared regarding healthcare utilization, care needs and resources using insurance claims data, a patient survey, and chart review. Qualitative studies with healthcare professionals and patients will be undertaken to identify potential barriers and enablers for optimal performance of the complex care management program. Discussion: This multi-method procedure will support the development of a primary care-based care management program enabling the implementation of interventions that will potentially reduce avoidable hospitalizations

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19

Festreden gehalten beim Festgottesdienst zum 25jährigen Amtsjubiläum des Herrn Rabbiner Dr. Jacob Cohn in Kattowitz, 6. Januar 1897 : Beigeg. ist d. Wortlaut d. d. Jubilar v. d. Gemeindevertretung überreichten Adresse

von [Ferdinand] Rosenthal u. d. Jubilar

Ferdinand Rosenthal Collection. 1891-1911

This collection primarily contains essays and speeches by Dr. Ferdinand Rosenthal. There are two handwritten documents, likely speeches, entitled "Der Parabel der drei Ringe" (1891) and "Zur feier der 200 jährigen Jubilismus der preussischen Konigstum" (1901); also several printed essays by Dr. Rosenthal entitled "Elila ben Abuia" (1895), "Die Kritik des Mainmonidischen 'Buches der Gesetze' Durch Nachmanides" (1908), "Was War, was ist und was soll der Rabbiner sein?" (1911), six typescripts of speeches (1895-1900), and two programs of events honoring Dr. Rosenthal (1891-1908). There is also an undated copy of a portrait of Dr. Rosenthal in his later years.Photo; pamphlets; sermon manuscripts; brochures on festivities.Addenda: Copies of speeches and sermons held by Rabbi Rosenthal (between 1895-1901) at Storch Synagogue in Breslau.Rabbi in Breslau, born 1839 in Kenese, died 1921 in Breslau. Rabbi of the Storchsynagogue of Breslau, 1887-1921.The original German language inventory is available in the folder.Processed for digitizationSent for digitizationReturned from digitizationLinked to online manifestationdigitize