Search literacy: learning to search to learn

People can often find themselves out of their depth when they face knowledge-based problems, such as faulty technology, or medical concerns. This can also happen in everyday domains that users are simply inexperienced with, like cooking. These are common exploratory search conditions, where users don’t quite know enough about the domain to know if they are submitting a good query, nor if the results directly resolve their need or can be translated to do so. In such situations, people turn to their friends for help, or to forums like StackOverflow, so that someone can explain things to them and translate information to their specific need. This short paper describes work-in-progress within a Google-funded project focusing on Search Literacy in these situations, where improved search skills will help users to learn as they search, to search better, and to better comprehend the results. Focusing on the technology-problem domain, we present initial results from a qualitative study of questions asked and answers given in StackOverflow, and present plans for designing search engine support to help searchers learn as they search

Emissionsmessungen im Frequenzbereich von 6 GHz bis 40 GHz

[no abstract available

Better Together: Unifying Datalog and Equality Saturation

We present egglog, a fixpoint reasoning system that unifies Datalog and equality saturation (EqSat). Like Datalog, it supports efficient incremental execution, cooperating analyses, and lattice-based reasoning. Like EqSat, it supports term rewriting, efficient congruence closure, and extraction of optimized terms. We identify two recent applications--a unification-based pointer analysis in Datalog and an EqSat-based floating-point term rewriter--that have been hampered by features missing from Datalog but found in EqSat or vice-versa. We evaluate egglog by reimplementing those projects in egglog. The resulting systems in egglog are faster, simpler, and fix bugs found in the original systems.Comment: PLDI 202

Rückwirkung von Positioniersystemen auf die Feldverteilung in einer GTEM-Zelle

Eine GTEM-Zelle (Gigahertz Transverse Electromagnetic Cell) ist eine standardisierte Mess- und Prüfumgebung für elektromagnetische Verträglichkeit (EMV). Sie zeichnet sich durch die Erzeugung homogener elektromagnetischer Felder über ein breites Frequenzspektrum aus [1]. Für die Untersuchung feldgebundener EMV-Probleme ist neben der analytischen und numerischen Betrachtung, die präzise Messung [2] elektromagnetischer Felder von großer Bedeutung. Automatisierte Positioniersysteme für Feldsonden [3, 4] ermöglichen dabei eine Reduzierung der benötigten Messzeit und eine Erhöhung der Reproduzierbarkeit, wobei das verwendete System möglichst keinen Einfluss auf das Feld haben sollte. In dieser Arbeit werden die Rückwirkungen von zwei verschiedenartigen Positioniersystemen auf das zu messende Feld in einer GTEM-Zelle untersucht und aufgezeigt. Dazu werden ein automatisierter Kreuztisch und ein Positioniersystem mit einer hängenden Feldsonde in die Zelle eingesetzt

Hoosiers’ Health in a Changing Climate: A Report from the Indiana Climate Change Impacts Assessment

In the coming decades, Indiana’s changing climate will bring with it higher temperatures, longer heat waves, more extremely hot days and more frequent extreme storm events. Those changes will affect the health of Hoosiers in every part of the state. This report from the Indiana Climate Change Impacts Assessment (IN CCIA) describes historical and future climate-related health impacts that affect Hoosiers

Within-household clustering of genetically related Plasmodium falciparum infections in a moderate transmission area of Uganda.

BACKGROUND: Evaluation of genetic relatedness of malaria parasites is a useful tool for understanding transmission patterns, but patterns are not easily detectable in areas with moderate to high malaria transmission. To evaluate the feasibility of detecting genetic relatedness in a moderate malaria transmission setting, relatedness of Plasmodium falciparum infections was measured in cohort participants from randomly selected households in the Kihihi sub-county of Uganda (annual entomological inoculation rate of 27 infectious bites per person). METHODS: All infections detected via microscopy or Plasmodium-specific loop mediated isothermal amplification from passive and active case detection during August 2011-March 2012 were genotyped at 26 microsatellite loci, providing data for 349 samples from 230 participants living in 80 households. Pairwise genetic relatedness was calculated using identity by state (IBS). RESULTS: As expected, genetic diversity was high (mean heterozygosity [He] = 0.73), and the majority (76.5 %) of samples were polyclonal. Despite the high genetic diversity, fine-scale population structure was detectable, with significant spatiotemporal clustering of highly related infections. Although the difference in malaria incidence between households at higher (mean 1127 metres) versus lower elevation (mean 1015 metres) was modest (1.4 malaria cases per person-year vs. 1.9 per person-year, respectively), there was a significant difference in multiplicity of infection (2.2 vs. 2.6, p = 0.008) and, more strikingly, a higher proportion of highly related infections within households (6.3 % vs. 0.9 %, p = 0.0005) at higher elevation compared to lower elevation. CONCLUSIONS: Genetic data from a relatively small number of diverse, multiallelic loci reflected fine scale patterns of malaria transmission. Given the increasing interest in applying genetic data to augment malaria surveillance, this study provides evidence that genetic data can be used to inform transmission patterns at local spatial scales even in moderate transmission areas

Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal.

The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, TRACERx Renal. We observe up to 30 driver events per tumor and show that subclonal diversification is associated with known prognostic parameters. By resolving the patterns of driver event ordering, co-occurrence, and mutual exclusivity at clone level, we show the deterministic nature of clonal evolution. ccRCC can be grouped into seven evolutionary subtypes, ranging from tumors characterized by early fixation of multiple mutational and copy number drivers and rapid metastases to highly branched tumors with >10 subclonal drivers and extensive parallel evolution associated with attenuated progression. We identify genetic diversity and chromosomal complexity as determinants of patient outcome. Our insights reconcile the variable clinical behavior of ccRCC and suggest evolutionary potential as a biomarker for both intervention and surveillance

EGFR-targeted fluorescence molecular imaging for intraoperative margin assessment in oral cancer patients: a phase II trial

Inadequate surgical margins occur frequently in oral squamous cell carcinoma surgery. Fluorescence molecular imaging (FMI) has been explored for intraoperative margin assessment, but data are limited to phase-I studies. In this single-arm phase-II study (NCT03134846), our primary endpoints were to determine the sensitivity, specificity and positive predictive value of cetuximab-800CW for tumor-positive margins detection. Secondary endpoints were safety, close margin detection rate and intrinsic cetuximab-800CW fluorescence. In 65 patients with 66 tumors, cetuximab-800CW was well-tolerated. Fluorescent spots identified in the surgical margin with signal-to-background ratios (SBR) of ≥2 identify tumor-positive margins with 100% sensitivity, 85.9% specificity, 58.3% positive predictive value, and 100% negative predictive value. An SBR of ≥1.5 identifies close margins with 70.3% sensitivity, 76.1% specificity, 60.5% positive predictive value, and 83.1% negative predictive value. Performing frozen section analysis aimed at the fluorescent spots with an SBR of ≥1.5 enables safe, intraoperative adjustment of surgical margins