Философско-антропологический подход в риторике. Случай Кассирера

В этой статье мы утверждаем, что философия символических форм Эрнста Кассирера является незаменимым философско-антропологическим партнером риторики. Мы предполагаем, что освоение риторикой теории символических форм Кассирера позволит вывести риторику за пределы её доминирующей трактовки как теории, ориентированной на языковое выражение, и позволит ей полностью соответствовать широкому пониманию риторики как учения о том, каким образом создаётся, утверждается и изменяется социальное значение. Чтобы сделать наше расширенное понимание риторико-философско-антропологического подхода более ясным, мы построили наше рассуждение частично на критике недавней попытки Томаса А. Дишенны (Discenna, Rhetorica 32/3, 2014) включить Кассирера в риторическую традицию в ходе анализа давосских дебатов между Кассирером и М. Хайдеггером 1929 года; и частично на разъяснении тех аспектов мысли Кассирера, которые мы считаем наиболее важными для развития риторико-философской антропологии социального значения. Основным выводом проведенного исследования является тезис о том, что философия символических форм Кассирера создает теоретические основы современной риторической философской антропологии как учения о формировании социального значения

К вопросу о doxa: эпистемология “новой риторики”

M. Rosengren developed doxology as an 'other' take on epistemology, as teaching about how we actually do create the knowledge that we need. He has chosen to call his epistemic stance doxological in order to emphasise that all knowledge is doxic knowledge, thus turning the seminal Platonic distinction between doxa (beliefs, opinions) and episteme (objective, eternal knowledge) upside down

Человек как мера. Беседа с Матсом Розенгреном о контексте возникновения доксологии

A subject of a conversation is the social context for the emergence of a doxology as a project of the naturalised theory of knowledge. The Swedish philosopher Mats Rosengren developed the doxology. From his point of view, human knowledge has never been and will never be epistemic (in the Platonic sense). It is always cultural and historical determined, situational and changeable. During the conversation, Rosengren discusses the specifics of the doxological understanding of the constructive nature of scientific knowledge. He speaks about the importance of reception of the French philosophy of the 20th century for the emergence of a doxology. Mats Rosengren gave an interview on June 14, 2018, in Stockholm in the House of the Union of the Swedish writers. Mikael Nydahl did the simultaneous translation from Swedish. Further, Dmitry Vorobev made the transcript and editing of the conversation written text. The paper allows better to understand what the doxology is – as a modern version of the Protagorean theory of knowledge – and what is not. Предметом беседы стал социальный контекст возникновения доксологии – натурализованной теории познания, предложенной шведским философом Матсом Розенгреном. С его точки зрения человеческое знание никогда не было и не будет эпистемическим (в платоновском смысле). Оно всегда культурно-исторически обусловлено, ситуативно, изменчиво. В ходе беседы Розенгрен говорит о специфике доксологического понимания конструктивного характера научного познания, о значении рецепции французской философии XX века для возникновения доксологии. Профессор Розенгрен дал интервью 14 июня 2018 года в Стокгольме в доме Союза шведских писателей. Синхронный перевод с шведского сделал Микаэль Нюдаль. В дальнейшем на базе аудиозаписи беседы Дмитрием Воробьевым был создан и отредактирован текст интервью. Новизна данной работы заключается в том, что она позволяет лучше понять, чем является и чем не является доксология, заявленная ее автором как современный вариант протагорейской теории познания

Тезис Протагора: доксологическая перспектива

The paper presents doxological interpretation of homo-measure set. Traditionally this thesis is seen as an expression of the impermanent human doxa as the only possible truth. Using the approach of analytic philosophy to the interpretation of the famous speech, the author refuses treatment of man as an individual in favor of a generic understanding of the man. Generic feature of human in ancient world-view is the logos, which is coming to be seen as a measure of all things, including man himself

Тезис Протагора: доксологическая перспектива

The paper presents doxological interpretation of homo-measure set. Traditionally this thesis is seen as an expression of the impermanent human doxa as the only possible truth. Using the approach of analytic philosophy to the interpretation of the famous speech, the author refuses treatment of man as an individual in favor of a generic understanding of the man. Generic feature of human in ancient world-view is the logos, which is coming to be seen as a measure of all things, including man himself

Overweight, obesity and the risk of LADA : results from a Swedish case-control study and the Norwegian HUNT Study

Aims/hypothesis Excessive weight is a risk factor for type 2 diabetes, but its role in the promotion of autoimmune diabetes is not clear. We investigated the risk of latent autoimmune diabetes in adults (LADA) in relation to overweight/obesity in two large population-based studies. Methods Analyses were based on incident cases of LADA (n = 425) and type 2 diabetes (n = 1420), and 1704 randomly selected control participants from a Swedish case-control study and prospective data from the Norwegian HUNT Study including 147 people with LADA and 1,012,957 person-years of follow-up (1984-2008). We present adjusted ORs and HRs with 95% CI. Results In the Swedish data, obesity was associated with an increased risk of LADA (OR 2.93, 95% CI 2.17, 3.97), which was even stronger for type 2 diabetes (OR 18.88, 95% CI 14.29, 24.94). The association was stronger in LADA with low GAD antibody (GADA; Conclusions/interpretation Overweight/obesity is associated with increased risk of LADA, particularly when in combination with FHD. These findings support the hypothesis that, even in the presence of autoimmunity, factors linked to insulin resistance, such as excessive weight, could promote onset of diabetes.Peer reviewe

Mutational and gene fusion analyses of primary large cell and large cell neuroendocrine lung cancer.

Large cell carcinoma with or without neuroendocrine features (LCNEC and LC, respectively) constitutes 3-9% of non-small cell lung cancer but is poorly characterized at the molecular level. Herein we analyzed 41 LC and 32 LCNEC (including 15 previously reported cases) tumors using massive parallel sequencing for mutations in 26 cancer-related genes and gene fusions in ALK, RET, and ROS1. LC patients were additionally subdivided into three immunohistochemistry groups based on positive expression of TTF-1/Napsin A (adenocarcinoma-like, n = 24; 59%), CK5/P40 (squamous-like, n = 5; 12%), or no marker expression (marker-negative, n = 12; 29%). Most common alterations were TP53 (83%), KRAS (22%), MET (12%) mutations in LCs, and TP53 (88%), STK11 (16%), and PTEN (13%) mutations in LCNECs. In general, LCs showed more oncogene mutations compared to LCNECs. Immunomarker stratification of LC revealed oncogene mutations in 63% of adenocarcinoma-like cases, but only in 17% of marker-negative cases. Moreover, marker-negative LCs were associated with inferior overall survival compared with adenocarcinoma-like tumors (p = 0.007). No ALK, RET or ROS1 fusions were detected in LCs or LCNECs. Together, our molecular analyses support that LC and LCNEC tumors follow different tumorigenic paths and that LC may be stratified into molecular subgroups with potential implications for diagnosis, prognostics, and therapy decisions

Novel subgroups of adult-onset diabetes and their association with outcomes : a data-driven cluster analysis of six variables

Background Diabetes is presently classified into two main forms, type 1 and type 2 diabetes, but type 2 diabetes in particular is highly heterogeneous. A refined classification could provide a powerful tool to individualise treatment regimens and identify individuals with increased risk of complications at diagnosis. Methods We did data-driven cluster analysis (k-means and hierarchical clustering) in patients with newly diagnosed diabetes (n=8980) from the Swedish All New Diabetics in Scania cohort. Clusters were based on six variables (glutamate decarboxylase antibodies, age at diagnosis, BMI, HbA(1c), and homoeostatic model assessment 2 estimates of beta-cell function and insulin resistance), and were related to prospective data from patient records on development of complications and prescription of medication. Replication was done in three independent cohorts: the Scania Diabetes Registry (n=1466), All New Diabetics in Uppsala (n=844), and Diabetes Registry Vaasa (n=3485). Cox regression and logistic regression were used to compare time to medication, time to reaching the treatment goal, and risk of diabetic complications and genetic associations. Findings We identified five replicable clusters of patients with diabetes, which had significantly different patient characteristics and risk of diabetic complications. In particular, individuals in cluster 3 (most resistant to insulin) had significantly higher risk of diabetic kidney disease than individuals in clusters 4 and 5, but had been prescribed similar diabetes treatment. Cluster 2 (insulin deficient) had the highest risk of retinopathy. In support of the clustering, genetic associations in the clusters differed from those seen in traditional type 2 diabetes. Interpretation We stratified patients into five subgroups with differing disease progression and risk of diabetic complications. This new substratification might eventually help to tailor and target early treatment to patients who would benefit most, thereby representing a first step towards precision medicine in diabetes.Peer reviewe

Psychosocial factors during the first year after a coronary heart disease event in cases and referents. Secondary Prevention in Uppsala Primary Health Care Project (SUPRIM)

<p>Abstract</p> <p>Background</p> <p>A large number of studies have reported on the psychosocial risk factor pattern prior to coronary heart disease events, but few have investigated the situation during the first year after an event, and none has been controlled. We therefore performed a case-referent study in which the prevalence of a number of psychosocial factors was evaluated.</p> <p>Methods</p> <p>Three hundred and forty-six coronary heart disease male and female cases no more than 75 years of age, discharged from hospital within the past 12 months, and 1038 referents from the general population, matched to the cases by age, sex and place of living, received a postal questionnaire in which information on lifestyle, psychosocial and quality of life measures were sought.</p> <p>Results</p> <p>The cases were, as expected, on sick leave to a larger extent than the referents, reported poorer fitness, poorer perceived health, fewer leisure time activities, but unexpectedly reported better social support, and more optimistic views of the future than the referents. There were no significant case-referent differences in everyday life stress, stressful life events, vital exhaustion, depressive mood, coping or life orientation test. However, women reported less favourable situations than men regarding stressful life events affecting others, vital exhaustion, depressive mood, coping, self-esteem, sleep, and symptom reporting, and female cases reported the most unfavourable situation of all groups.</p> <p>Conclusion</p> <p>In this first controlled study of the situation during the first year after a CHD event disease and gender status both appeared to be determinants of psychological well-being, with gender status apparently the strongest. This may have implications for cardiac rehabilitation programmes.</p