160 research outputs found
Reseña de la tesis de Carla Traglia “Ahora tenemos Salario: Transformación de las familias tareferas de Jardín América a partir del acceso a la Asignación Universal por Hijo para la protección social”. En: LaRivada, V. 2, n° 2
El trabajo aborda la situación que atraviesa la fracción más importante de trabajadores
de la actividad rural de la Provincia de Misiones; los trabajadores y trabajadoras
de la cosecha de la Yerba Mate (tareferos), una de las actividades económicas más
importantes y distributivas de la zona, y con mayor utilización de mano de obra rural.
La Tarefa es una emblemática actividad por la histórica explotación que han sufrido
estos trabajadores. Ha sido reflejada en numerosas novelas, películas y canciones,
como por ejemplo “El mensú” de Ramón Ayala.
La autora realiza en su tesis una sucinta descripción de la evolución histórica de la Protección Social en Argentina, con sus avances y retrocesos, incluyendo los recientes años de desregulación y flexibilización vinculados a la época de los noventas y la llamada “globalización” neoliberal
Ariel - Volume 9 Number 3
Executive Editor
Emily Wofford
Business Manager
Fredric Jay Matlin
University News
John Patrick Welch
World News
George Robert Coar
Editorials Editor
Steve Levine
Features
Mark Rubin
Brad Feldstein
Photo
Rick Spaide
Circulation
Victor Onufreiczuk
Lee Wugofski
Graphics and Art
Steve Hulkower
Commons Editor
Brenda Peterso
Geant4 simulation model of electromagnetic processes in oriented crystals for the accelerator physics
Electromagnetic processes of charged particles interaction with oriented
crystals provide a wide variety of innovative applications such as beam
steering, crystal-based extraction/collimation of leptons and hadrons in an
accelerator, a fixed-target experiment on magnetic and electric dipole moment
measurement, X-ray and gamma radiation source for radiotherapy and nuclear
physics and a positron source for lepton and muon colliders, a compact
crystalline calorimeter as well as plasma acceleration in the crystal media.
One of the main challenges is to develop an up-to-date, universal and fast
simulation tool to simulate these applications.
We present a new simulation model of electromagnetic processes in oriented
crystals implemented into Geant4, which is a toolkit for the simulation of the
passage of particles through matter. We validate the model with the
experimental data as well as discuss the advantages and perspectives of this
model for the applications of oriented crystals mentioned above.Comment: 18 pages, 9 figure
Loss-of-function mutations in Lysyl-tRNA synthetase cause various leukoencephalopathy phenotypes
Objective: To expand the clinical spectrum of lysyl-tRNA synthetase (KARS) gene–related diseases, which so far includes Charcot-Marie-Tooth disease, congenital visual impairment and microcephaly, and nonsyndromic hearing impairment.
Methods: Whole-exome sequencing was performed on index patients from 4 unrelated families with leukoencephalopathy. Candidate pathogenic variants and their cosegregation were confirmed by Sanger sequencing. Effects of mutations on KARS protein function were examined by aminoacylation assays and yeast complementation assays.
Results: Common clinical features of the patients in this study included impaired cognitive ability, seizure, hypotonia, ataxia, and abnormal brain imaging, suggesting that the CNS involvement is the main clinical presentation. Six previously unreported and 1 known KARS mutations were identified and cosegregated in these families. Two patients are compound heterozygous for missense mutations, 1 patient is homozygous for a missense mutation, and 1 patient harbored an insertion mutation and a missense mutation. Functional and structural analyses revealed that these mutations impair aminoacylation activity of lysyl-tRNA synthetase, indicating that de- fective KARS function is responsible for the phenotypes in these individuals.
Conclusions: Our results demonstrate that patients with loss-of-function KARS mutations can manifest CNS disorders, thus broadening the phenotypic spectrum associated with KARS-related disease
Organizaciones Agrarias y Cooperativas: Transformaciones en trabajo, producción, y acceso a la tierra en Misiones. 16H351
Las actividades agropecuarias en Misiones, vienen sufriendo profundas transformaciones
que impactan de manera diferencial sobre los trabajadores y sobre los productores agrarios,
pero también en el proceso manufacturero y de comercialización.
Con el objetivo de identificar y analizar éstas transformaciones recientes, intentaremos
generar conocimiento sobre cambios productivos y en la organización del trabajo en
encadenamientos agroindustriales del té y la yerba mate, relevar las estrategias económicas
de las cooperativas agroindustriales, identificando sus particularidades respecto a la
organización del trabajo, a las modalidades de incorporación de tecnologías y normas de
calidad, y en relación con las políticas públicas. También investigaremos la incidencia de
organizaciones de productores agrarios sobre los cambios en la implementación de políticas
agropecuarias, en especial respecto a la producción, comercialización de alimentos y
acceso a la tierra.
Considerando las interacciones complejas en las transformaciones en curso, al mismo
tiempo las limitaciones contextuales y las estrategias de los actores, exploraremos canales
de circulación de insumos y de productos, mecanismos de fijación de precios, para analizar
relaciones económicas y de poder, así como transferencias entre los distintos sectores.
Desde una perspectiva metodológica cualitativa, tomaremos algunas experiencias de
producción y comercialización, por parte de pequeños productores en forma asociativa,
como referencia empírica para reflexionar sobre las posibilidades y dificultades de las
organizaciones agrarias
Flavonoids from the Brazilian plant Croton betulaster inhibit the growth of human glioblastoma cells and induce apoptosis
This study investigated the effects of the flavonoids 5-hydroxy-7,4′-dimethoxyflavone, casticin, and penduletin, isolated from Croton betulaster Müll Arg., Euphorbiaceae, a plant utilized in popular medicine in Brazil, on the growth and viability of the human glioblastoma cell line GL-15. We observed that 5-hydroxy-7,4′-dimethoxyflavone and casticin were not toxic to GL-15 cells after 24 h of exposure. However, casticin and penduletin inhibited the metabolic activity of glioblastoma cells significantly at a concentration of 10 μM (p ≤ 0.05). Flavonoids casticin and penduletin also induced a significant and dose-dependent growth inhibition beginning at 24 h of exposure, and the most potent flavonoid was penduletin. It was also observed that penduletin and casticin induced an enlargement of the cell body and a reduction of cellular processes, accompanied by changes in the pattern of expression of the cytoskeletal protein vimentin. Signs of apoptosis, such as the externalization of membrane phosphatidyl serine residues, nuclear condensation, and fragmentation, were also detected in cells treated with 50–100 μM flavonoids. Our results indicate that flavonoids extracted from C. betulaster present antitumoral activity to glioblastoma cells, with penduletin proving to be the most potent of the tested flavonoids. Our results also suggest that these molecules may be promising supplementary drugs for glioblastoma treatment
An Information Theoretic, Microfluidic-Based Single Cell Analysis Permits Identification of Subpopulations among Putatively Homogeneous Stem Cells
An incomplete understanding of the nature of heterogeneity within stem cell populations remains a major impediment to the development of clinically effective cell-based therapies. Transcriptional events within a single cell are inherently stochastic and can produce tremendous variability, even among genetically identical cells. It remains unclear how mammalian cellular systems overcome this intrinsic noisiness of gene expression to produce consequential variations in function, and what impact this has on the biologic and clinical relevance of highly ‘purified’ cell subgroups. To address these questions, we have developed a novel method combining microfluidic-based single cell analysis and information theory to characterize and predict transcriptional programs across hundreds of individual cells. Using this technique, we demonstrate that multiple subpopulations exist within a well-studied and putatively homogeneous stem cell population, murine long-term hematopoietic stem cells (LT-HSCs). These subgroups are defined by nonrandom patterns that are distinguishable from noise and are consistent with known functional properties of these cells. We anticipate that this analytic framework can also be applied to other cell types to elucidate the relationship between transcriptional and phenotypic variation
The association between environmental exposures during childhood and the subsequent development of Crohn's Disease: A score analysis approach
Background Environmental factors during childhood are thought to play a role in the aetiology of Crohn's Disease (CD). In South Africa, recently published work based on an investigation of 14 childhood environmental exposures during 3 age intervals (0-5, 6-10 and 11-18 years) has provided insight into the role of timing of exposure in the future development of CD. The 'overlapping' contribution of the investigated variables however, remains unclear. The aim of this study was to perform a post hoc analysis using this data and investigate the extent to which each variable contributes to the subsequent development of CD relative to each aforementioned age interval, based on a score analysis approach. Methods Three methods were used for the score analysis. Two methods employed the subgrouping of one or more (similar) variables (methods A and B), with each subgroup assigned a score value weighting equal to one. For comparison, the third approach (method 0) involved no grouping of the 14 variables. Thus, each variable held a score value of one. Results Results of the score analysis (Method 0) for the environmental exposures during 3 age intervals (0-5, 6-10 and 11-18 years) revealed no significant difference between the case and control groups. By contrast, results from Method A and Method B revealed a significant difference during all 3 age intervals between the case and control groups, with cases having significantly lower exposure scores (approximately 30% and 40% lower, respectively). Conclusion Results from the score analysis provide insight into the 'compound' effects from multiple environmental exposures in the aetiology of CD.IS
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