Improving the quality of pork and pork products for the consumer : development of innovative, integrated, and sustainable food production chains of high quality pork products matching consumer demands

Improving the quality of pork and pork products for the consumer: development of innovative, integrated, and sustainable food production chains of high quality pork products matching consumer demands

Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl-CoA binding protein

Acyl-CoA binding protein (ACBP) maintains a pool of fatty acyl-CoA molecules in the cell and plays a role in fatty acid metabolism. The biochemical properties of Plasmodium falciparum ACBP are described together with the 2.0 AÊ resolution crystal structures of a P. falciparum ACBP-acyl-CoA complex and of bovine ACBP in two crystal forms. Overall, the bovine ACBP crystal structures are similar to the NMR structures published previously; however, the bovine and parasite ACBP structures are less similar. The parasite ACBP is shown to have a different ligand-binding pocket, leading to an acyl-CoA binding speci®city different from that of bovine ACBP. Several non-conservative differences in residues that interact with the ligand were identi®ed between the mammalian and parasite ACBPs. These, together with measured bindingspeci®city differences, suggest that there is a potential for the design of molecules that might selectively block the acyl-CoA binding site. # 2001 Academic Pres

From Logics to Procedures : Arguing within International Environmental Negociations

Mainstream literature in international relations understands negotiations in terms of power politics and/or bargaining processes between rival national interests to account for states' negotiating stands. Using definitions and questions initially defined by Thomas Risse, this study of processes at work in the biodiversity regime underlines instead their deliberative dimension and its contribution to positive negotiation outcomes. However, the article also challenges the dominant understanding of deliberation in global environmental politics that focuses on the participation of non-governmental organizations and other interest groups in the 'public space'. Instead it identifies deliberative elements in the negotiation process proper, stressing in particular the importance of the relationships developed between governmental delegations through series of closed meetings of selected participants. This contribution uses for illustration the negotiations leading to the Cartagena Protocol on Biosafety and to the Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from their Utilization