Rediscovery of the Badegoule 5 skeletal remains (Badegoule, Le Lardin-Saint-Lazare, Dordogne, France)

International audienceIn 1910 at the site of Badegoule (Dordogne), O. Hauser discovered cranial remains of a juvenile specimen labelled Badegoule 5. No other information about this specimen or its future was available after 1910. However, unpublished German archives confirm that Badegoule 5 had not been lost or destroyed. In fact, Badegoule 5 is preserved in the collections of the Field Museum of Natural History, Chicago (Illinois) (inventory number is 199559), although it was labelled that it could have derived from Le Moustier (O. Hauser excavations). One of us has had the chance to restore the specimen, and the nature of the sediment which contained these remains confirms our interpretation of the archives. Considering data from excavations of A. Cheynier and J. Couchard of different loci of Badegoule, we infer that the human remains belong to the Badegoulian levels.Redécouverte des vestiges humains «Badedgoule 5» (Badegoule, commune du Lardin-Saint-Lazare, Dordogne, France). Dans le gisement de Badegoule (Dordogne), O. Hauser mis au jour, en 1910, des vestiges crâniens d'un sujet immature (Badegoule 5). Aucune autre information sur ce spécimen n'était disponible tout comme son devenir. Des archives allemandes inédites nous assurent que Badegoule 5 n'a pas été perdu et qu'il fait actuellement partie des collections du Field Museum of Natural History à Chicago (Illinois) où il a été restauré par l'un de nous. Il y est inventorié sous le numéro 199559 et il est mentionné comme provenant du Moustier (fouilles Hauser). La nature du sédiment qui contenait ces vestiges confirme nos investigations sur les archives et nous permet, en fonction des résultats des fouilles de A. Cheynier et J. Couchard (de différents locus de Badegoule), de supposer qu'ils se rapportent aux niveaux badegouliens

Rediscovery of the Badegoule 5 skeletal remains (Badegoule, le Lardin-Saint-Lazare, Dordogne, France)

In 1910 at the site of Badegoule (Dordogne), O. Hauser discovered cranial remains of a juvenile specimen labelled Badegoule 5. No other information about this specimen or its future was available after 1910. However, unpublished German archives confirm that Badegoule 5 had not been lost or destroyed. In fact, Badegoule 5 is preserved in the collections of the Field Museum of Natural History, Chicago (Illinois) (inventory number is 199559), although it was labelled that it could have derived from Le Moustier (O. Hauser excavations). One of us has had the chance to restore the specimen, and the nature of the sediment which contained these remains confirms our interpretation of the archives. Considering data from excavations of A. Cheynier and J. Couchard of different loci of Badegoule, we infer that the human remains belong to the Badegoulian levels.Dans le gisement de Badegoule (Dordogne), O. Hauser mis au jour, en 1910, des vestiges crâniens d’un sujet immature (Badegoule 5). Aucune autre information sur ce spécimen n’était disponible tout comme son devenir. Des archives allemandes inédites nous assurent que Badegoule 5 n’a pas été perdu et qu’il fait actuellement partie des collections du Field Museum of Natural History à Chicago (Illinois) où il a été restauré par l’un de nous. Il y est inventorié sous le numéro 199559 et il est mentionné comme provenant du Moustier (fouilles Hauser). La nature du sédiment qui contenait ces vestiges confirme nos investigations sur les archives et nous permet, en fonction des résultats des fouilles de A. Cheynier et J. Couchard (de différents locus de Badegoule), de supposer qu’ils se rapportent aux niveaux badegouliens.1910 entdeckte O. Hauser in der Fundstelle Badegoule (Dordogne) Schädelfragmente eines Kindes, die unter der Bezeichnung «Badegoule 5» geführt werden. Nähere Informationen zu diesem Fund und seinem Verbleib nach 1910 lagen bisher nicht vor. Unveröffentlichte Dokumente aus Archiven in Deutschland belegen nun, dass die Reste «Badegoule 5» nicht verlorengegangen oder zerstört sind, sondern in den Sammlungen des Field Museum of Natural History in Chicago (Illinois) liegen. Sie werden dort mit der Inventarnummer 199559 und dem Fundstellenbezug «Le Moustier (Ausgrabung O. Hauser)» geführt. Einem der Autoren war es möglich die Schädelreste näher zu untersuchen. Die Charakteristik der Sedimente, in welchen die Schädelfragmente eingebettet waren, bestätigt die Zuweisung des Fundes über die Archivunterlagen nach Badegoule. Die Ergebnisse der von A. Cheynier and J. Couchard an verschiedenen Stellen in Badegoule durchgeführten Ausgrabungen zeigen, dass das Sediment mit den Schädelfragmenten wahrscheinlich aus einer Badegoulien-Schicht stammt

Feasibility of performance-based and self-reported outcomes in self-managed falls prevention exercise interventions for independent older adults living in the community

BACKGROUND: Little is known about associations between performance-based measurements and self-reported scales, nor about ceiling effects or sensitivity to change to evaluate effects in the target population for self-managed exercise interventions. This study aimed to explore the feasibility of using performance-based outcomes for gait speed, functional leg strength and balance, and self-reported outcomes of falls-efficacy and functional ability in two self-managed falls prevention exercise interventions for community dwelling older adults. METHODS: Independent living, community-dwelling older adults (n = 67) exercised with one of two self-managed falls prevention exercise programmes, a digital programme (DP) or a paper booklet (PB) in a 4-month participant preference trial. Pre- and post-assessments, by blinded assessors, included Short Physical Performance Battery (SPPB) and 30s Chair stand test (30s CST). Participants completed self-reported questionnaires: Activities-specific and Balance Confidence scale (ABC), Iconographical Falls Efficacy Scale (Icon-FES), Late-Life Function and Disability Instrument Function Component (LLFDI-FC). In addition, improvement in balance and leg strength was also self-rated at post-assessment. Participants' mean age was 76 ± 4 years and 72% were women. RESULTS: Ceiling effects were evident for the balance sub-component of the SPPB, and also indicated for ABC and Icon-FES in this high functioning population. In SPPB, gait speed, 30s CST, and LLFDI-FC, 21-56% of participants did not change their scores beyond the Minimal Clinically Important Difference (MCID). At pre-assessment all performance-based tests correlated significantly with the self-reported scales, however, no such significant correlations were seen with change-scores. Improvement of performance-based functional leg strength with substantial effect sizes and significant correlations with self-reported exercise time was shown. There were no differences in outcomes between the exercise programmes except that DP users reported improved change of leg strength to a higher degree than PB users. CONCLUSION: The LLFDI-FC and sit-to-stand tests were feasible and sensitive to change in this specific population. The balance sub-component of SPPB and self-reported measures ABC and Icon-FES indicated ceiling effects and might not be suitable as outcome measures for use in a high functioning older population. Development and evaluation of new outcome measures are needed for self-managed fall-preventive interventions with high functioning community-dwelling older adults

Recruitment strategies and reach of a digital fall-prevention intervention for community-dwelling older adults

Background: To have an impact on the population's health, preventive interventions have to reach a large proportion of the intended population. Digital solutions show potential for providing wider access to fall preventive exercise. However, there is a lack of knowledge about how to reach the target group. The aim of this study was to describe the recruitment process used in the Safe Step randomised controlled trial and the characteristics of the participants reached. Methods: Several recruitment methods, both digital and non-digital, were adopted to reach the intended sample size. Sociodemographic parameters from the baseline questionnaire were used to describe participant characteristics. The characteristics were also compared to a representative sample of older adults in the Swedish population. Results: In total, 1628 older adults were recruited. Social media proved to be the most successful recruitment strategy, through which 76% of the participants were recruited. The participants reached had a mean age of 75.9 years, lived in both urban and rural locations, were already frequent users of the Internet and applications (smartphone/tablet) (79.9%), had higher education (71.9%), and a large proportion were women (79.4%). In comparison with the general population participants in the Safe Step study were more highly educated (p &lt; 0.001), women in the study more frequently lived alone (p &lt; 0.001) and men more often reported poorer self-rated health (p = 0.04). Within the study, men reported a faster deteriorating balance (p = 0.003) and more prescribed medication (p &lt; 0.001) than women. Conclusion: Recruitment via social media is a useful strategy for reaching older adults, especially women and frequent users of the Internet, for a fully self-managed and digital fall prevention exercise intervention. This study underlines that a range of interventions must be available to attract and suit older adults with different functional statuses and digital skills.Originally included in thesis in manuscript form.</p

Effectiveness of a self-managed digital exercise programme to prevent falls in older community-dwelling adults -study protocol for the Safe Step randomized controlled trial

INTRODUCTION: Exercise interventions have a strong evidence base for falls prevention. However, exercise can be challenging to implement and often has limited reach and poor adherence. Digital technology provides opportunities for both increased access to the intervention and support over time. Further knowledge needs to be gained regarding the effectiveness of completely self-managed digital exercise interventions. The main objective of this study is to compare the effectiveness of a self-managed digital exercise programme, Safe Step, in combination with monthly educational videos with educational videos alone, on falls over 1 year in older community-dwelling adults.METHODS AND ANALYSIS: A two-arm parallel randomised controlled trial will be conducted with at least 1400 community-living older adults (70+ years) who experience impaired balance. Participants will be recruited throughout Sweden with enrolment through the project website. They will be randomly allocated to either the Safe Step exercise programme with additional monthly educational videos about healthy ageing and fall prevention, or the monthly education videos alone. Participants receiving the exercise intervention will be asked to exercise at home for at least 30 min, 3 times/week with support of the Safe Step application. The primary outcome will be rate of falls (fall per person year). Participants will keep a fall calendar and report falls at the end of each month through a digital questionnaire. Further assessments of secondary outcomes will be made through self-reported questionnaires and a self-test of 30 s chair stand test at baseline and 3, 6, 9 and 12 months after study start. Data will be analysed according to the intention-to-treat principle.ETHICS AND DISSEMINATION: Ethical approval was obtained by The Regional Ethical Review Board in Umeå (Dnr 2018/433-31). Findings will be disseminated through the project web-site, peer-reviewed journals, national and international conferences and through senior citizen organisations' newsletters.TRIAL REGISTRATION NUMBER: NCT03963570

The RIPI-f (Reporting Integrity of Psychological Interventions delivered face-to-face) checklist was developed to guide reporting of treatment integrity in face-to-face psychological interventions.

Objectives: Intervention integrity is the degree to which the study intervention is delivered as intended. This article presents the RIPI-f checklist (Reporting Integrity of Psychological Interventions delivered face-to-face) and summarizes its development methods. RIPI-f proposes guidance for reporting intervention integrity in evaluative studies of face-to-face psychological interventions. Study Design and Setting: We followed established procedures for developing reporting guidelines. We examined 56 documents (reporting guidelines, bias tools, and methodological guidance) for relevant aspects of face-to-face psychological intervention integrity. Eighty four items were identified and grouped as per the template for intervention description and replication (TIDieR) domains. Twenty nine experts from psychology and medicine and other scholars rated the relevance of each item in a single-round Delphi survey.Amultidisciplinary panel of 11 experts discussed the survey results in three online consensus meetings and drafted the final version of the checklist. Results: We propose RIPI-f, a checklist with 50 items. Our checklist enhances TIDieR with important extensions, such as therapeutic alliance, provider’s allegiance, and the adherence of providers and participants. Conclusion: RIPI-f can improve the reporting of face-to-face psychological interventions. The tool can help authors, researchers, systematic reviewers, and guideline developers. We suggest using RIPI-f alongside other reporting guidelines.post-print504 K

The RIPI-f (Reporting Integrity of Psychological Interventions delivered face-to-face) checklist was developed to guide reporting of treatment integrity in face-to-face psychological interventions

Objective: Intervention integrity is the degree to which the study intervention is delivered as intended. This article presents the RIPI-f checklist (Reporting Integrity of Psychological Interventions delivered face-to-face) and summarizes its development methods. RIPI-f proposes guidance for reporting intervention integrity in evaluative studies of face-to-face psychological interventions. Study design and setting: We followed established procedures for developing reporting guidelines. We examined 56 documents (reporting guidelines, bias tools, and methodological guidance) for relevant aspects of face-to-face psychological intervention integrity. Eighty-four items were identified and grouped according to the template for intervention description and replication (TIDieR) domains. Twenty-nine experts from psychology and medicine and other scholars rated the relevance of each item in a single-round Delphi survey. A multidisciplinary panel of 11 experts discussed the survey results in three online consensus meetings and drafted the final version of the checklist. Results: We propose RIPI-f, a checklist with 50 items. Our checklist enhances TIDieR with important extensions, such as therapeutic alliance, provider's allegiance, and the adherence of providers and participants. Conclusion: RIPI-f can improve the reporting of face-to-face psychological interventions. The tool can help authors, researchers, systematic reviewers, and guideline developers. We suggest using RIPI-f alongside other reporting guidelines

Hormone references for ultrasound breast staging and endocrine profiling to detect female onset of puberty

Context - Application of ultrasound (US) to evaluate attainment and morphology of glandular tissue provides a new rationale for evaluating onset and progression of female puberty, but currently no hormone references complement this method. Furthermore, previous studies have not explored the predictive value of endocrine profiling to determine female puberty onset. Objective - To integrate US breast staging with hypothalamic-pituitary-gonadal hormone references and test the predictive value of an endocrine profile to determine thelarche. Design Setting and Participants - Cross-sectional sample of 601 healthy Norwegian girls, ages 6 to 16 years. Main Outcome Measures - Clinical and ultrasound breast evaluations were performed for all included girls. Blood samples were analyzed by immunoassay and ultrasensitive liquid chromatography–tandem mass spectrometry (LC-MS/MS) to quantify estradiol (E2) and estrone (E1) from the subpicomolar range. Results - References for E2, E1, luteinizing hormone, follicle-stimulating hormone, and sex hormone–binding globulin were constructed in relation to chronological age, Tanner stages, and US breast stages. An endocrine profile index score derived from principal component analysis of these analytes was a better marker of puberty onset than age or any individual hormone, with receiver-operating characteristic area under the curve 0.91 (P < 0.001). Ultrasound detection of nonpalpable glandular tissue in 14 out of 264 (5.3%) girls with clinically prepubertal presentation was associated with significantly higher median serum levels of E2 (12.5 vs 4.9 pmol/L; P < 0.05) and a distinct endocrine profile (arbitrary units; P < 0.001). Conclusions - We provide the first hormone references for use with US breast staging and demonstrate the application of endocrine profiling to improve detection of female puberty onset