Human endogenous retrovirus K106 (HERV-K106) was infectious after the emergence of anatomically modern humans.

HERV-K113 and HERV-K115 have been considered to be among the youngest HERVs because they are the only known full-length proviruses that are insertionally polymorphic and maintain the open reading frames of their coding genes. However, recent data suggest that HERV-K113 is at least 800,000 years old, and HERV-K115 even older. A systematic study of HERV-K HML2 members to identify HERVs that may have infected the human genome in the more recent evolutionary past is lacking. Therefore, we sought to determine how recently HERVs were exogenous and infectious by examining sequence variation in the long terminal repeat (LTR) regions of all full-length HERV-K loci. We used the traditional method of inter-LTR comparison to analyze all full length HERV-Ks and determined that two insertions, HERV-K106 and HERV-K116 have no differences between their 5' and 3' LTR sequences, suggesting that these insertions were endogenized in the recent evolutionary past. Among these insertions with no sequence differences between their LTR regions, HERV-K106 had the most intact viral sequence structure. Coalescent analysis of HERV-K106 3' LTR sequences representing 51 ethnically diverse individuals suggests that HERV-K106 integrated into the human germ line approximately 150,000 years ago, after the emergence of anatomically modern humans

Expansión rápida del maxilar superior y su impacto a nivel de la vía aérea superior: revisión bibliográfica

Maxillary expansion, whether rapid or slow, has been a procedure used for years to correct transverse malocclusions. Its benefits and effects at the dental aspect, such as the middle palatal suture are well known. Lately, however, its repercussion and effects at the airway aspect, have been studied and established as a point of interest; especially during the treatment of patients with respiratory problems. According to current bibliography, rapid maxillary expansion is associated with an increase in the upper airway volume. Nowadays, with the high development of techniques based on 3D images and with the inception of Cone Beam computed tomography, it is possible to perform quantitative analysis and evaluate the effects of maxillary expansion on the upper airway in a three dimensional way. With the use of imagenology, it is possible to visualize the increase in the upper airway dimensions, however, there is no evidence that this increase somehow, improves the respiratory function.La expansión del maxilar ya sea rápida o lenta, ha sido un procedimiento utilizado durante años para la corrección de maloclusiones transversales. Sus beneficios y efectos a nivel dentario, como de sutura palatina media son conocidos. Sin embargo, en los últimos años la repercusión y sus efectos a nivel de vía aérea han sido estudiados y se han establecido como un punto de interés sobre todo durante el tratamiento de pacientes con problemas respiratorios. Según la bibliografía actual, la expansión rápida del maxilar induce un aumento significativo del volumen de la vía aérea superior. Hoy en día, con el alto desarrollo de técnicas basadas en imágenes 3D y con el advenimiento de la tomografía computarizada Cone Beam, es posible realizar análisis cuantitativos y evaluar los efectos de la expansión maxilar a nivel de la vía aérea superior en los tres sentidos del espacio. Mediante el uso de imagenología es posible visualizar la ganancia en la vía aérea superior pero aún no es posible evidenciar si este aumento se correlaciona con una mejora en la función respiratoria

Unified Supersymmetric Model of Naturally Small Dirac Neutrino Masses and the Axionic Solution of the Strong CP Problem

Using the particle content of the fundamental {27} supermultiplet of E_6, naturally small Dirac neutrino masses are obtained in the context of SU(3)_C times SU(2)_L times U(1)_Y times U(1)_{chi}, where U(1)_{chi} comes from the decomposition E_6 to SO(10) times U(1)_{psi}, then SO(10) to SU(5) times U(1)_{chi}. New observable consequences are predicted at the TeV scale. An axionic solution of the strong CP problem may be included at no extra cost.Comment: 10 pages, no figure, Eqs.(16)-(20) are correcte

Preservation of the metabolic rate of oxygen in preterm infants during indomethacin therapy for closure of the ductus arteriosus

Background:The aim of this study was to assess and quantify the effects of indomethacin on cerebral blood flow (CBF), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO 2) in preterm infants undergoing treatment for a patent ductus arteriosus (PDA).Methods:CBF and CMRO 2 were measured before and after the first dose of a 3-d course of indomethacin to close hemodynamically significant PDA in preterm neonates. Indocyanine-green (ICG) concentration curves were acquired before and after indomethacin injection to quantify CBF and CMRO 2.Results:Eight preterm neonates (gestational age, 27.6 ± 0.5 wk; birth weight, 992 ± 109 g; 6 males:2 females) were treated at a median age of 4.5 d (range, 4-21 d). Indomethacin resulted in an average CBF decrease of 18% (pre- and post-CBF = 12.9 ± 1.3 and 10.6 ± 0.8 ml/100 g/min, respectively) and an OEF increase of 11% (pre- and post-OEF = 0.38 ± 0.02 and 0.42 ± 0.02, respectively) but no significant change in CMRO 2 (pre- and post-CMRO 2 = 0.83 ± 0.07 and 0.76 ± 0.07 ml O 2 /100 g/min, respectively). Corresponding mean blood pressure (BP), arterial oxygen saturation (S a O 2), heart rate, and end-tidal carbon dioxide tension levels remained unchanged.Conclusion:Indomethacin resulted in significant reduction in CBF but did not alter CMRO 2 because of a compensatory increase in OEF. Copyright © 2013 International Pediatric Research Foundation, Inc

Human Endogenous Retrovirus K106 (HERV-K106) Was Infectious after the Emergence of Anatomically Modern Humans

HERV-K113 and HERV-K115 have been considered to be among the youngest HERVs because they are the only known full-length proviruses that are insertionally polymorphic and maintain the open reading frames of their coding genes. However, recent data suggest that HERV-K113 is at least 800,000 years old, and HERV-K115 even older. A systematic study of HERV-K HML2 members to identify HERVs that may have infected the human genome in the more recent evolutionary past is lacking. Therefore, we sought to determine how recently HERVs were exogenous and infectious by examining sequence variation in the long terminal repeat (LTR) regions of all full-length HERV-K loci. We used the traditional method of inter-LTR comparison to analyze all full length HERV-Ks and determined that two insertions, HERV-K106 and HERV-K116 have no differences between their 5′ and 3′ LTR sequences, suggesting that these insertions were endogenized in the recent evolutionary past. Among these insertions with no sequence differences between their LTR regions, HERV-K106 had the most intact viral sequence structure. Coalescent analysis of HERV-K106 3′ LTR sequences representing 51 ethnically diverse individuals suggests that HERV-K106 integrated into the human germ line approximately 150,000 years ago, after the emergence of anatomically modern humans.</p

Time Out of Joint: Hamlet and the Pure Form of Time

The aim of this paper is to explore why Deleuze takes up Hamlet’s claim that ‘time is out of joint’. In the first part of this paper, I explore this claim by looking at how Deleuze relates it to Plato’s Timaeus and its conception of the relationship between movement and time. Once we have seen how time functions when it is ‘in joint’, I explore what it would mean for time to no longer be understood in terms of an underlying rational structure. The claim can be understood as about a relationship between time and action. In the second part of this paper, I want to relate this new understanding of time to Hamlet itself, in order to see how temporality operates within the play. I will conclude by relating these two different conceptions of time out of joint to one another through Nietzsche’s Eternal Return

The zooarchaeological application of quantifying cranial shape differences in wild boar and domestic pigs (Sus scrofa) using 3D geometric morphometrics

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