Cyclosporine A, an alternative to the oral lichen planus erosive treatment

We present a double blind study in two groups afflicted with Oral Lichen Planus erythematous of long evolution and resistant to other treatments. We tested on it a treatment with Cyclosporine A (CyA) which had been successfully used before by many dermatologists.In the group A we used mouthwashes with a 5 ml Cyclosporine A solution to a 10% in olive oil of 0.4° of acidity for five minutes, three times a day for eight weeks. In the control group we used acetonide of triamcinolone 0,1% in aqueous solution. Patients in group A improved considerably in their symptomatology in a 90 % against a 60 % in group B. In group A we could appreciate a disappearance of the symptomatology after two weeks of treatment in 60% of patients against 30% in group B.CyA can be an alternative to the conventional treatments in the acute period of lichen planus although it can not be considered as a first option drug because of the high cost of the treatment. For long term, results are not so good and we consider that extensive studies are necessary.Nous présentons une étude en double aveugle qui a porté sur deux groupes de malades porteurs d’un lichen plan buccal de longue évolution et résistant aux traitements classiques. Nous avons essayé un traitement avec la Ciclosporine ® qui avait réussi auparavant chez plusieurs dermatologues.Le groupe A a essayé des rinçages avec 5 ml de solution Ciclosporine A à 10 % dans de l’huile d’olive de 0,4°d’acidité, pendant 5 minutes, 3 fois par jour, pendant 8 semaines. Le groupe de contrôle a utilisé une solution de triamcinolone acetonide à 0,1%. A peu près 90% des malades du groupe étudié ont présenté une considérable amélioration de la symptomatologie, contre seulement 60% pour le groupe B. Après 2 semaines les symptômes ont disparu chez 60% des malades du groupe A, contre seulement 30% des malades du groupe B.La Ciclosporine A peut être une alternative aux traitements conventionnels dans les périodes aigues du lichen plan. Cependant elle ne peut pas être considérée comme une drogue de premier choix étant donné son coût élevé. Pour évaluer les résultats à long terme il sera nécessaire d’entreprendre des études plus étendues

Perinatal Loss at Term: The Role of Uteroplacental and Fetal Doppler Assessment.

OBJECTIVE: To examine the association of uterine artery (UtA) Doppler indices and cerebroplacental ratio (CPR) on perinatal outcome at term. METHODS: This retrospective cohort study conducted in a single tertiary referral centre included all singleton pregnancies undergoing ultrasound assessment in the third trimester, which subsequently delivered at term. Fetal biometry and Dopplers including the umbilical artery (UA), middle cerebral artery (MCA) and uterine artery were recorded. Data was corrected for gestational age and CPR was calculated as a ratio between the MCA pulsatility index (PI) and UA PI. Logistic regression analysis was conducted to examine for independent predictors of adverse perinatal outcome. RESULTS: The study included 7013 pregnancies; 12 were complicated by perinatal death. When compared to pregnancies resulting in live birth, pregnancies complicated by perinatal death had significantly more small for gestational age (SGA) infants (27.3% vs 5%, p = 0.001) and a higher incidence of low CPR (16.7% vs 4.5%, p = 0.041). A subgroup analysis comparing 1527 low risk pregnancies demonstrated that the UtA PI MoM, CPR <5(th) centile and estimated fetal weight (EFW) centile were all significantly associated with the risk of perinatal death at term (all p < 0.05). After adjusting for confounding variables, only EFW (OR 0.96, 95% CI 0.93-0.99; p = 0.003) and UtA PI MoM (OR 13.10, 95%CI 1.95-87.89; p = 0.008) remained independent predictors of perinatal death in the low risk cohort. CONCLUSION: High uterine artery PI at term is independently associated with increased risk of adverse perinatal outcome regardless of fetal size. These results suggest that perinatal mortality at term is related, not only to EFW and fetal redistribution (CPR), but also to indices of uterine perfusion

Notas sobre la brioflora balear, 5

The following bryophytes are quoted for the first time in the flora of the Balearic Islands: Marchantia paleacea Bertol., Sphaerocarpos texanus Aust., Bryum pseudotriquetrum (Hedw.) Gaertn. et al., Orthotrichum affine Brid., Pseudoleskeella catenulata (Schrad.) Kindb.and Sematophyllum substrumulosum (Hampe)Britt. Some species are new for the flora of Ibiza (9), Formentera (1) and Mallorca 0).Se citan algunos briófitos que son novedad para el catálogo florístico balear: Marchantia paleacea Bertol., Sphaerocarpos texanus Aust., Bryum pseudotriquetrum (Hedw.) Gaertnetal.,OrthotrichumaffineBrid.,Pseudoleskeellacatenulata(Schrad.)Kindb.y Sematophyllum substrumulosum (Hampe)Britt. Se mencionan especies que no habían sido indicadas en la flora de Ibiza (9), Formentera (1) y Mallorca (1)

Notas sobre la brioflora balear. 4

The following bryophytes are quoted for the first time in the bryological flora of the Balearic Islands: Isothecium alopecuroides (Dubois) Isov., Neckera complanata Hüb., Phascus cuspidatum Hedw. var. piliferum (Hedw.) Hook. S Tayl., Timmia bawarica Hessl. Nine species are newfor the flora of Menorca. Plagiomnium cuspidatum (Hedw.) T. Kop. is excluded from the flora of the Balearic Islands.Se citan cuatro briófitos nuevos para la flora balear: Isothecium alopecuroides (Dubois) Isov., Neckera complanata Hüb., Phascum cuspidatum Hedw. var. piliferum (Hedw.) Hook. E. Tayl., Timmia bavarica Hessl. Se señalan nueve especies que constituyen novedad para la flora de la isla de Menorca. Se excluye el Plagiomnium cuspidatum (Hedw.)T. Kop.del catálogo floristico balear

Catalytic dehydrocoupling of amine-boranes and amines into diaminoboranes: isolation of a Pt(II), Shimoi-type, η1-BH complex

The platinum complex [Pt(IBu′)(IBu)][BAr] is a very efficient catalyst in the synthesis of diaminoboranes through dehydrocoupling of amine-boranes and amines. Shimoi-type, η-BH complexes are key intermediates in the process.Financial support (FEDER contribution) from the MINECO (Projects CTQ2013-45011-P and CTQ2014-51912-REDC) and the Junta de Andalucía (Project FQM-2126) is gratefully acknowledged.We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI).Peer Reviewe

Computing option pricing models under transaction costs

AbstractThis paper deals with the Barles–Soner model arising in the hedging of portfolios for option pricing with transaction costs. This model is based on a correction volatility function Ψ solution of a nonlinear ordinary differential equation. In this paper we obtain relevant properties of the function Ψ which are crucial in the numerical analysis and computing of the underlying nonlinear Black–Scholes equation. Consistency and stability of the proposed numerical method are detailed and illustrative examples are given

Nuevo endemismo marroquí: Sideritis cirujanoi, sp. nov.

4 p., il.[EN]A new species, Sideritis cirujanoi Romo, Stübing, Roselló & Peris (Lamiaceae), from the Riff range (northern Morocco), is described[ES]Se describe una nueva eSfecie, Sideritis cirujanoi Romo, Stübing, Roselló & Peris (Lamiaceae), de las montañas del Rif (norte de Marruecos).Peer reviewe

Accuracy of the fetal cerebroplacental ratio for the detection of intrapartum compromise in nonsmall fetuses.

OBJECTIVE: To study the accuracy of the cerebroplacental ratio (CPR) for the detection of intrapartum fetal compromise (IFC) in fetuses growing over the 10th centile. METHODS: This was a prospective study of 569 nonsmall fetuses attending the day hospital unit of a tertiary hospital that underwent an ultrasound examination at 36-40 weeks, and were delivered within 4 weeks of examination. IFC was defined as a composite of: abnormal intrapartum fetal heart rate or intrapartum fetal scalp pH < 7.20 requiring cesarean section, neonatal umbilical cord pH < 7.20, 5' Apgar score < 7 and postpartum admission to neonatal or pediatric intensive care units. The accuracy of CPR for the prediction of IFC was calculated alone and in combination with other perinatal parameters using univariate and multivariate logistic regression models, which alternatively included the onset of labor to evaluate the influence of induction of labor (IOL) on IFC and a brief composite adverse outcome of two parameters to prove the strength of the approach. RESULTS: The incidence of IFC was 17.9%. CPR sensitivity was 30.4% for a false positive rate (FFR) of 10 and 14.7% for a FPP of 5% (AUC = 0.62, p < 0.001). The multivariate analysis showed that only fetal gender and parity increased the predictive accuracy of CPR alone, although the improvement was poor (AUC = 0.67, p < 0.001). No differences were observed using any of the alternative models. Finally, IOL had no influence of IFC. CONCLUSION: Despite their apparent normality, a proportion of fetuses growing over the 10th centile suffer IFC. Some of them are suitable for detection by means of CPR

Dissecting a vegetable landrace: Components of variation in Spanish ?Moruno? tomatoes as a case studio

The variability of landraces is dissected and related to farmers' practices through surveys. Spanish 'Moruno' tomatoes, recognised for their excellent flavour, were selected as a case study. For this purpose, 30 populations were characterised in a four-year program. Higher intra-population than inter-population variability was found. Variability is generally reduced in the traits used by farmers as selection criteria. Farmers rarely used flavour as a selection criterion, but it is one of the main characteristics used by them to define the landrace. Seed exchange and growing different landraces simultaneously are commonplace, and outcrossing might occur, thus justifying in part the seed degeneration problems experienced by some farmers. At the same time, farmers select seeds for the next year on a per-fruit basis rather than a per-plant basis, justifying the maintenance of a high level of variability. In such cases, high pressure would be applied to key morphological traits but not to flavour. Accordingly, the sugars, acids and volatiles profiles related to flavour in the landraces' populations are highly variable, though the environment also exercises a high effect. It is necessary to make population selections to offer farmers materials combining the best organoleptic perception and a high stable yield. This would reduce the gap between the price premium received by farmers and the expected fair price. It would also be necessary to develop consumer information campaigns to exploit their willingness to pay for the extra value offered by landraces. Only then long-term on-farm conservation would be economically feasible. Although achieving a trade-off between yield and flavour is difficult, it is possible to identify populations that reach a compromise between them. In germplasm banks, it is impossible to evaluate all the materials in the same year. The use of hybrid controls, with no genetic variation, is helpful in considering the environmental effects. Still, genotype x environment interactions are evident, and using selected control populations of landraces is necessary to evaluate possible performances closer to the type of materials being evaluated

Solving fully randomized higher-order linear control differential equations: Application to study the dynamics of an oscillator

This is the peer reviewed version of the following article: Cortés, J-C, Navarro-Quiles, A, Romero, J-V, Roselló, M-D. Solving fully randomized higher-order linear control differential equations: Application to study the dynamics of an oscillator. Comp and Math Methods. 2021; 3:e1163, which has been published in final form at https://doi.org/10.1002/cmm4.1163. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.[EN] In this work, we consider control problems represented by a linear differential equation assuming that all the coefficients are random variables and with an additive control that is a stochastic process. Specifically, we will work with controllable problems in which the initial condition and the final target are random variables. The probability density function of the solution and the control has been calculated. The theoretical results have been applied to study, from a probabilistic standpoint, a damped oscillator.European Social Fund, Grant/Award Numbers: GJIDI/2018/A/009, GJIDI/2018/A/010; Spanish Ministerio de Economía, Industria y Competitividad (MINECO), the Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER UE), Grant/Award Number: MTM2017-89664-P.Cortés, J.; Navarro-Quiles, A.; Romero, J.; Roselló, M. (2021). Solving fully randomized higher-order linear control differential equations: Application to study the dynamics of an oscillator. Computational and Mathematical Methods. 3(6):1-15. https://doi.org/10.1002/cmm4.1163S1153