PENGARUH METODE JIGSAW DISERTAI MEDIA LKS DAN POWER POINTPADA PEMBELAJARAN KIMIA DITINJAU DARI KREATIVITAS TERHADAP PRESTASI BELAJAR SISWA PADA MATERI POKOK HIDROKARBON KELAS X SEMESTER GENAP DI SMA NEGERI 1 PONOROGO T.A. 2011/2012

Tujuan penelitian ini untuk mengetahui pengaruh pembelajaran dengan metode Jigsaw disertai LKS dan power point terhadap prestasi belajar, prestasi belajar ditinjau dari kreativitas, dan interaksi antara media pembelajaran dengan kreativitas terhadap prestasi belajar di kelas X semester genap SMAN I Ponorogo. Materi yang diambil adalah hidrokarbon. Rancangan penelitian menggunakan “Desain Faktorial 2 x 2 “. Sampel penelitian yaitu kelas X.2 dan X.3 SMA N 1 Ponorogo tahun pelajaran 2011/2012 yang diambil dengan teknik cluster random sampling. Analisis data keadaan awal siswa dalam penelitian ini menggunakan uji normalitas dengan metode Liliefors, uji homogenitas dengan metode Bartlet (Uji Chi Kuadrat), dan uji keseimbangan dengan uji t dua pihak . Uji hipotesis menggunakan uji analisis variansi (anava) dua jalan dengan sel tak sama. Hasil penelitian ini adalah prestasi belajar siswa pada pembelajaran kimia melalui metode jigsaw disertai LKS dan power point memberikan pengaruh yang sama terhadap prestasi belajar kognitif maupun afektif, dimana F hitung 3,002 (kognitif) dan 2,382 (afektif) < F tabel (4,004), kreativitas tidak mempengaruhi prestasi belajar kognitif, di mana F hitung < F tabel yaitu 0,049 < 4,004, sedangkan prestasi belajar afektif siswa yang memiliki kreativitas tinggi lebih tinggi daripada siswa dengan kreativitas rendah, di mana F hitung > F tabel yaitu 5,368 > 4,004, dan tidak ada interaksi antara pembelajaran kimia melalui metode jigsaw disertai LKS dan power point dengan kreativitas terhadap prestasi belajar, F hitung (1,243) < F tabel (4,004), sedangkan pada aspek afektif, nilai F hitung (0,204) < Ftabel (4,004). Kata kunci: Jigsaw, kreativitas, LKS, power point, prestasi belajar , hidrokarbo

Development and validation of a NanoString BASE47 bladder cancer gene classifier

Background Recent molecular characterization of urothelial cancer (UC) has suggested potential pathways in which to direct treatment, leading to a host of targeted therapies in development for UC. In parallel, gene expression profiling has demonstrated that high-grade UC is a heterogeneous disease. Prognostic basal-like and luminal-like subtypes have been identified and an accurate transcriptome BASE47 classifier has been developed. However, these phenotypes cannot be broadly investigated due to the lack of a clinically viable diagnostic assay. We sought to develop and evaluate a diagnostic classifier of UC subtype with the goal of accurate classification from clinically available specimens. Methods Tumor samples from 52 patients with high-grade UC were profiled for BASE47 genes concurrently by RNAseq as well as NanoString. After design and technical validation of a BASE47 NanoString probeset, results from the RNAseq and NanoString were used to translate diagnostic criteria to the Nanostring platform. Evaluation of repeatability and accuracy was performed to derive a final Nanostring based classifier. Diagnostic classification resulting from the NanoString BASE47 classifier was validated on an independent dataset (n = 30). The training and validation datasets accurately classified 87% and 93% of samples, respectively. Results Here we have derived a NanoString-platform BASE47 classifier that accurately predicts basal-like and luminal-like subtypes in high grade urothelial cancer. We have further validated our new NanoString BASE47 classifier on an independent dataset and confirmed high accuracy when compared with our original Transcriptome BASE47 classifier. Conclusions The NanoString BASE47 classifier provides a faster turnaround time, a lower cost per sample to process, and maintains the accuracy of the original subtype classifier for better clinical implementation

Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD

Objective To develop a resource of systematically collected, longitudinal clinical data and biospecimens for assisting in the investigation into neuromyelitis optica spectrum disorder (NMOSD) epidemiology, pathogenesis, and treatment. Methods To illustrate its research-enabling purpose, epidemiologic patterns and disease phenotypes were assessed among enrolled subjects, including age at disease onset, annualized relapse rate (ARR), and time between the first and second attacks. Results As of December 2017, the Collaborative International Research in Clinical and Longitudinal Experience Study (CIRCLES) had enrolled more than 1,000 participants, of whom 77.5% of the NMOSD cases and 71.7% of the controls continue in active follow-up. Consanguineous relatives of patients with NMOSD represented 43.6% of the control cohort. Of the 599 active cases with complete data, 84% were female, and 76% were anti-AQP4 seropositive. The majority were white/Caucasian (52.6%), whereas blacks/African Americans accounted for 23.5%, Hispanics/ Latinos 12.4%, and Asians accounted for 9.0%. The median age at disease onset was 38.4 years, with a median ARR of 0.5. Seropositive cases were older at disease onset, more likely to be black/African American or Hispanic/Latino, and more likely to be female. Conclusions Collectively, the CIRCLES experience to date demonstrates this study to be a useful and readily accessible resource to facilitate accelerating solutions for patients with NMOSD

PENGARUH METODE JIGSAW DISERTAI MEDIA LKS DAN POWER POINT PADA PEMBELAJARAN KIMIA DITINJAU DARI KREATIVITAS TERHADAP PRESTASI BELAJAR SISWA PADA MATERI POKOK HIDROKARBON KELAS X SEMESTER GENAP DI SMA NEGERI 1 PONOROGO T.A. 2011/2012

Tujuan penelitian ini untuk mengetahui pengaruhpembelajaran dengan metode Jigsaw disertai LKS dan power point terhadap prestasi belajar, prestasi belajar ditinjau dari kreativitas, dan interaksi antara media pembelajaran dengan kreativitas terhadap prestasi belajar di kelas X semester genap SMAN I Ponorogo. Materi yang diambil adalah hidrokarbon. Rancangan penelitian menggunakan “Desain Faktorial 2 x 2 “. Sampel penelitian yaitu kelas X.2 dan X.3 SMA N 1 Ponorogo tahun pelajaran 2011/2012 yang diambil dengan teknik cluster random sampling. Analisis data keadaan awal siswa dalam penelitian ini menggunakan uji normalitas dengan metode Liliefors, uji homogenitas dengan metode Bartlet (Uji Chi Kuadrat), dan uji keseimbangan dengan uji t dua pihak. Uji hipotesis menggunakan uji analisis variansi (anava) dua jalan dengan sel tak sama. Hasil penelitian ini adalahprestasi belajar siswa pada pembelajaran kimia melalui metode jigsaw disertai LKS dan power point memberikan pengaruh yang sama terhadap prestasi belajar kognitif maupun afektif, dimana Fhitung 3,002 (kognitif) dan 2,382 (afektif) &lt; Ftabel (4,004), kreativitas tidak mempengaruhi prestasi belajar kognitif, di mana Fhitung&lt; Ftabel yaitu 0,049 &lt; 4,004, sedangkan prestasi belajar afektif siswa yang memiliki kreativitas tinggi lebih tinggi daripada siswa dengan kreativitas rendah, di mana Fhitung&gt; Ftabel yaitu 5,368 &gt; 4,004, dan tidak ada interaksi antara pembelajaran kimia melalui metode jigsaw disertai LKS dan power point dengan kreativitas terhadap prestasi belajar, Fhitung (1,243) &lt; Ftabel (4,004), sedangkan pada aspek afektif, nilai Fhitung (0,204) &lt; Ftabel (4,004).Kata kunci: Jigsaw, kreativitas,LKS, power point, prestasi belajar ,hidrokarbo

A Carmen, del Port de la Selva

Publicat a El Periódico

PENGARUH METODE JIGSAW DISERTAI MEDIA LKS DAN POWER POINT PADA PEMBELAJARAN KIMIA DITINJAU DARI KREATIVITAS TERHADAP PRESTASI BELAJAR SISWA PADA MATERI POKOK HIDROKARBON KELAS X SEMESTER GENAP DI SMA NEGERI 1 PONOROGO T.A. 2011/2012

Tujuan penelitian ini untuk mengetahui pengaruhpembelajaran dengan metode Jigsaw disertai LKS dan power point terhadap prestasi belajar, prestasi belajar ditinjau dari kreativitas, dan interaksi antara media pembelajaran dengan kreativitas terhadap prestasi belajar di kelas X semester genap SMAN I Ponorogo. Materi yang diambil adalah hidrokarbon. Rancangan penelitian menggunakan “Desain Faktorial 2 x 2 “. Sampel penelitian yaitu kelas X.2 dan X.3 SMA N 1 Ponorogo tahun pelajaran 2011/2012 yang diambil dengan teknik cluster random sampling. Analisis data keadaan awal siswa dalam penelitian ini menggunakan uji normalitas dengan metode Liliefors, uji homogenitas dengan metode Bartlet (Uji Chi Kuadrat), dan uji keseimbangan dengan uji t dua pihak. Uji hipotesis menggunakan uji analisis variansi (anava) dua jalan dengan sel tak sama. Hasil penelitian ini adalahprestasi belajar siswa pada pembelajaran kimia melalui metode jigsaw disertai LKS dan power point memberikan pengaruh yang sama terhadap prestasi belajar kognitif maupun afektif, dimana Fhitung 3,002 (kognitif) dan 2,382 (afektif) &lt; Ftabel (4,004), kreativitas tidak mempengaruhi prestasi belajar kognitif, di mana Fhitung&lt; Ftabel yaitu 0,049 &lt; 4,004, sedangkan prestasi belajar afektif siswa yang memiliki kreativitas tinggi lebih tinggi daripada siswa dengan kreativitas rendah, di mana Fhitung&gt; Ftabel yaitu 5,368 &gt; 4,004, dan tidak ada interaksi antara pembelajaran kimia melalui metode jigsaw disertai LKS dan power point dengan kreativitas terhadap prestasi belajar, Fhitung (1,243) &lt; Ftabel (4,004), sedangkan pada aspek afektif, nilai Fhitung (0,204) &lt; Ftabel (4,004).Kata kunci: Jigsaw, kreativitas,LKS, power point, prestasi belajar ,hidrokarbo

SIGMA: Scala Internal Domain-Specific Languages for Model Manipulations

International audienceModel manipulation environments automate model operations such as model consistency checking and model transformation. A number of external model manipulation Domain-Specific Languages (DSL) have been proposed, in particular for the Eclipse Modeling Framework (EMF). While their higher levels of abstraction result in gains in expressiveness over general-purpose languages, their limitations in versatility, performance, and tool support together with the need to learn new languages may significantly contribute to accidental complexities. In this paper, we present Sigma, a family of internal DSLs embedded in Scala for EMF model consistency checking, model-to-model and model-to-text transformations. It combines the benefits of external model manipulation DSLs with general-purpose programming taking full advantage of Scala versatility, performance and tool support. The DSLs are compared to the state-of-the-art Epsilon languages in non-trivial model manipulation tasks that resulted in 20% to 70% reduction in code size and significantly better performance

The evolution of manufacturing SPECIES

This research aims to develop hierarchical and cladistic classifications of manufacturing system evolution, incorporating evolving and interacting product, process and production system features. The objectives then are to systematically organise manufacturing systems and their characteristics in classifications Forty-six candidate species of manufacturing systems have been identified and organised in a 4th generation hierarchical classification with 14 ‘genera’, 6 ‘families’ 3 ‘orders’ and 1 ‘class’ of discrete manufacturing. The accompanying cladistic classification hypothesises the evolutionary history of manufacturing, using ‘descriptors’ drawn from a library of 12 characters and 66 states. These are consistent and synthesise many of the established typologies in the literature

The Net Global Effects of Alternative U.S. Biofuel Mandates

One of the declared objectives of U.S. biofuel policy is the reduction of greenhouse gas (GHG) emissions from fossil fuel combustion, but many studies have questioned whether such a reduction would actually occur and, if so, how large it would be. This report describes the global market, land use, GHG emissions, and nitrogen use impacts of the U.S. Renewable Fuel Standard (RFS2) and several alternative biofuel policy designs, which differ in terms of mandate magnitude and feedstock composition, over the 2010-2030 period