2,305 research outputs found
Expected and Predicted Realignments: The FF/DM Exchange Rate During the EMS
An empirical model of time-varying realignment risk in an exchange rate target zone is developed. Expected rates of devaluation are estimated as the difference between interest race differentials and estimated expected rates of depreciation within the exchange rate band, using French Franc/Deutsche Mark data during the European Monetary System. The behavior of estimated expected rates of depreciation accord well with the theoretical model of Bertola-Svensson (1990) . We are also able to predict actual realignments with some success.
Significant advances towards a reproducible, clinically relevant large animal model of acetaminophen-induced acute liver failure
Glycine and hyperammonemia : potential target for the treatment of hepatic encephalopathy
Hepatic encephalopathy (HE) is a neuropsychiatric
disorder caused by hepatic dysfunction. Numerous studies
dictate that ammonia plays an important role in the pathogenesis of HE, and hyperammonemia can lead to alterations in
amino acid homeostasis. Glutamine and glycine are both
ammoniagenic amino acids that are increased in liver failure.
Modulating the levels of glutamine and glycine has shown to
reduce ammonia concentration in hyperammonemia.
Ornithine Phenylacetate (OP) has consistently been shown to
reduce arterial ammonia levels in liver failure by modulating
glutamine levels. In addition to this, OP has also been found to
modulate glycine concentration providing an additional ammonia removing effect. Data support that glycine also serves
an important role in N-methyl D-aspartate (NMDA) receptor
mediated neurotransmission in HE. This potential important
role for glycine in the pathogenesis of HE merits further
investigations
The use of model cellulose gel beads to clarify flame-retardant characteristics of layer-by-layer nanocoatings.
Layer-by-Layer (LbL) assembled nanocoatings are exploited to impart flame-retardant properties to cellulosic substrates. A model cellulose material can make it possible to investigate an optimal bilayer (BL) range for the deposition of coating while elucidating the main flame-retardant action thus allowing for an efficient design of optimized LbL formulations. Model cellulose gel beads were prepared by dissolving cellulose-rich fibers followed by precipitation. The beads were LbL-treated with chitosan (CH) and sodium hexametaphosphate (SHMP). The char forming properties were studied using thermal gravimetric analysis. The coating increased the char yield in nitrogen to up to 29 % and showed a distinct pattern of micro intumescent behavior upon heating. An optimal range of 10-20 BL is observed. The well-defined model cellulose gel beads hence introduce a new scientific route both to clarify the fundamental effects of different film components and to optimize the composition of the films
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