Demographic responses to the manipulation of adult females in corn mouse populations

Variation in population abundance is a consequence of changes in demographic parameters such as survival and recruitment. These demographic parameters can be affected by intraspecifi c competition, thus adults may play an important role influencing the survival and/or reproduction of juvenile individuals in many species of small mammals. We present an analysis of Calomys musculinus populations using capturemark- recapture models in order to evaluate the effect of female removal on their demography. The study was carried out in four enclosures during two different periods: a reference period and a treatment period, with the removal of adult females. Reference period was analyzed to describe population demography without manipulations. In treatment period, two control enclosures maintained both parents remained with their offspring whereas other two enclosures had their adult females removed. Seven monthly trapping sessions were carried out (spring to autumn). We estimated apparent survival, recruitment, population growth rates and recapture probabilities. Models considered these parameters constrained to vary as a function of time, enclosure, sex and/or treatment. During the reference period survival and recruitment showed sex and time effects, survival was higher in females and decreased towards June; recruitment showed a peak in February with a higher number of recruited males; population growth rates peaked in February and decreased towards June. During the treatment period survival showed time effect whereas recruitment showed time and treatment effects. Survival was higher at the beginning of the breeding period and decreased afterwards, and recruitment was higher in control enclosures; population growth rates showed a similar pattern than in reference period. There were not differences in growth rates and abundances between control and experimental enclosures. Under our experimental and methodological conditions, the results would indicate that the absence of females in experimental enclosures was not enough to cause a clear impact on final population size.Fil: Gomez, Maria Daniel. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente; ArgentinaFil: Steinmann, Andrea Rosa. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente; Argentina. Universidad Nacional de Río Cuarto; ArgentinaFil: Priotto, Jose Waldemar. Universidad Nacional de Río Cuarto; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente; Argentin

Demographic responses to the manipulation of adult females in corn mouse populations

Variation in population abundance is a consequence of changes in demographic parameters such as survival and recruitment. These demographic parameters can be affected by intraspecifi c competition, thus adults may play an important role influencing the survival and/or reproduction of juvenile individuals in many species of small mammals. We present an analysis of Calomys musculinus populations using capturemark- recapture models in order to evaluate the effect of female removal on their demography. The study was carried out in four enclosures during two different periods: a reference period and a treatment period, with the removal of adult females. Reference period was analyzed to describe population demography without manipulations. In treatment period, two control enclosures maintained both parents remained with their offspring whereas other two enclosures had their adult females removed. Seven monthly trapping sessions were carried out (spring to autumn). We estimated apparent survival, recruitment, population growth rates and recapture probabilities. Models considered these parameters constrained to vary as a function of time, enclosure, sex and/or treatment. During the reference period survival and recruitment showed sex and time effects, survival was higher in females and decreased towards June; recruitment showed a peak in February with a higher number of recruited males; population growth rates peaked in February and decreased towards June. During the treatment period survival showed time effect whereas recruitment showed time and treatment effects. Survival was higher at the beginning of the breeding period and decreased afterwards, and recruitment was higher in control enclosures; population growth rates showed a similar pattern than in reference period. There were not differences in growth rates and abundances between control and experimental enclosures. Under our experimental and methodological conditions, the results would indicate that the absence of females in experimental enclosures was not enough to cause a clear impact on final population size.Fil: Gomez, Maria Daniel. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente; ArgentinaFil: Steinmann, Andrea Rosa. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente; Argentina. Universidad Nacional de Río Cuarto; ArgentinaFil: Priotto, Jose Waldemar. Universidad Nacional de Río Cuarto; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente; Argentin

Optimization of plates reinforced with different initial slope and variable number of carbon fibers

Optimization methods for curvilinear reinforcements placement aims to improve mechanical response of structure. Whenever a gradient-based method is used to optimization, it is necessary arbitrate an initial placement for the fibers. This initial guess has influence on the result. This work aims to observe the influence of the initial positioning of straight carbon fiber in epoxy resin plates, which had their compliance minimized by Sequential Linear Programming. The maximum displacement is observed too, even if it is not an objective function. The case studies were carried out on the same structure and the number of fibers and its slope were changed. Variation of the force slope was also evaluated. The results confirmed an influence of the initial slope in results. The addition of a greater number of fibers does not always cause a better performance in the design. To achieve the best results, it is essential that the initial arrangement be configured in such a way as to provide proximity of the ends of the fibers and the forces and supports. It's important to try to place the fibers with axial directions close to the axial direction of the force

Normal faulting in the 1923 Berdún earthquake and postorogenic extension in the Pyrenees

The 10 July 1923 earthquake near Berdún (Spain) is the largest instrumentally recorded event in the Pyrenees. We recover old analog seismograms and use 20 hand-digitized waveforms for regional moment tensor inversion. We estimate moment magnitude Mw 5.4, centroid depth of 8 km, and a pure normal faulting source with strike parallel to the mountain chain (N292°E), dip of 66° and rake of -88°. The new mechanism fits into the general predominance of normal faulting in the Pyrenees and extension inferred from Global Positioning System data. The unique location of the 1923 earthquake, near the south Pyrenean thrust front, shows that the extensional regime is not confined to the axial zone where high topography and the crustal root are located. Together with seismicity near the northern mountain front, this indicates that gravitational potential energy in the western Pyrenees is not extracted locally but induces a wide distribution of postorogenic deformation.Peer ReviewedPostprint (published version

Case Studies:

Adaptive building envelopes can provide improvements in building energy efficiency and economics, through their capability to change their behaviour in real time according to indooroutdoor parameters. This may be by means of materials, components or systems. As such, adaptive façades can make a significant and viable contribution to meeting the EU´s 2020 targets. Several different adaptive façade concepts have already been developed, and an increase in emerging, innovative solutions is expected in the near future. In this context the EU initiative COST Action TU 1403 aims to harmonize, share and disseminate technological knowledge on adaptive facades at a European level. According to the definition given by this COST Action, an adaptive façade is a building envelope consisting of multifunctional and highly adaptive systems that is able to change its functions, features, or behaviour over time in response to transient performance requirements and boundary conditions, with the aim of improving the overall building performance. In order to explore the available and emerging technologies focusing on adaptive façades, Working Group 1 of the COST Action undertook research to form a database of adaptive façade case studies and projects structured in accordance with a simple classification – materials, components and systems. In addition to this, details of the purpose of the systems/components/materials with adaptive features and the working principle of each technology were also collected together with data regarding design practice, technology readiness, and economical aspects, among others. The information was collected with the help of a specific online survey (structured in the following main sections: detailed description - metrics- characterization- economic aspects – references). The database includes 165 cases of adaptive façade systems, components, and materials that allowed a variety of analyses to be carried out. According to the classification adopted within WG1 (materials, components, systems), each of the classification terms are introduced together with examples from the case study database in the following sections. This volume ends with a section dedicated to future developments, where different issues are addressed such as embedded functionality and efficiency amd biomimetic inspirations. The importance of adaptive façades through their flexibility, and intelligent design within the context of smart cities is also discussed. The work within Working Group 1 - Adaptive technologies and products was developed within four distinct sub-groups (SG) in order to provide outputs according to the objectives of this WG and the COST Action: SG1 – Database, SG2 – Educational Pack, SG3 – Publications and Reports and SG4 – Short Term Scientific Missions (STSM). This work was possible due to the strong commitment and work of all WG1 members: Laura Aelenei, Aleksandra Krstić-Furundžić, Daniel Aelenei, Marcin Brzezicki, Tillmann Klein, Jose Miguel Rico-Martínez, Theoni Karlessi, Christophe Menezo, Susanne Gosztonyi, Nikolaus Nestle, Jerry Eriksson, Mark Alston, Rosa Romano, Maria da Glória Gomes, Enrico Sergio Mazzucchelli, Sandra Persiani, Claudio Aresta, Nitisha Vedula, Miren Juaristi

The Process of Digital Transformation in Education During the COVID-19 Pandemic

Purpose: This document seeks to delve into the digital transformation of education during the COVID-19 pandemic, aiming to provide a comprehensive understanding of this evolving phenomenon's purpose and significance.   Design/Methodology/Approach: The research approach undertaken is characterized by a non-experimental, documentary, exploratory, and descriptive study methodology, which involves an extensive examination of existing literature and data to gain insights into the digital transformation in education during the pandemic.   Findings: The study's key findings revolve around the consensus in existing literature regarding the swift acceleration of the transformation of education from traditional face-to-face classes to virtual learning environments. It also highlights the implications of this transformation, particularly in reshaping teaching models and advocating for a hybrid approach encompassing both face-to-face and virtual learning.   Research, Practical & Social implications: The implications of this research extend to informing educational institutions about the need for digital adaptation, guiding policymakers in supporting adaptable learning models, and empowering educators with a deeper understanding of the changing educational landscape. Moreover, it considers the broader societal impact, including equity and access issues in education.   Originality/Value: This research is unique in its contribution to understanding the profound impact of the COVID-19 pandemic on education. It emphasizes the significance of adaptability and hybrid learning models while providing a foundation for future educational research and policy development

Molecular Characterization of Imported and Autochthonous Dengue in Northeastern Spain

Autochthonous transmission; Dengue; Molecular epidemiologyTransmissió autòctona; Dengue; Epidemiologia molecularTransmisión autóctona; Dengue; Epidemiología molecularDengue is the most significant arbovirus worldwide and a public health threat to non-endemic areas in which Aedes vectors are present. Autochthonous dengue transmission has been reported in several European countries in the last decade. Infected travelers from endemic regions arriving to areas colonized by Aedes albopictus in Europe need to be monitored in surveillance and control programs. We aimed to perform molecular characterization of RT-PCR-positive dengue cases detected in Catalonia, northeastern Spain, from 2013 to 2018. The basic demographic information and the geographical regions of importation were also analyzed. One-hundred four dengue cases were studied (103 imported infections and the first autochthonous case in our region). The dengue virus strains detected were serotyped and genotyped using molecular methods, and phylogenetic analyses were conducted. All four dengue serotypes were detected in travelers, including up to 10 different genotypes, reflecting the global circulation of dengue in endemic areas. The primary travel-related case of the 2018 autochthonous transmission was not identified, but the molecular analysis revealed dengue serotype 1, genotype I of Asian origin. Our results highlight the diversity of imported dengue virus strains and the role of molecular epidemiology in supporting arbovirus surveillance programs

Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea.

Stress-activated protein kinases (SAPK) are associated with sensorineural hearing loss (SNHL) of multiple etiologies. Their activity is tightly regulated by dual-specificity phosphatase 1 (DUSP1), whose loss of function leads to sustained SAPK activation. Dusp1 gene knockout in mice accelerates SNHL progression and triggers inflammation, redox imbalance and hair cell (HC) death. To better understand the link between inflammation and redox imbalance, we analyzed the cochlear transcriptome in Dusp1-/- mice. RNA sequencing analysis (GSE176114) indicated that Dusp1-/- cochleae can be defined by a distinct profile of key cellular expression programs, including genes of the inflammatory response and glutathione (GSH) metabolism. To dissociate the two components, we treated Dusp1-/- mice with N-acetylcysteine, and hearing was followed-up longitudinally by auditory brainstem response recordings. A combination of immunofluorescence, Western blotting, enzymatic activity, GSH levels measurements and RT-qPCR techniques were used. N-acetylcysteine treatment delayed the onset of SNHL and mitigated cochlear damage, with fewer TUNEL+ HC and lower numbers of spiral ganglion neurons with p-H2AX foci. N-acetylcysteine not only improved the redox balance in Dusp1-/- mice but also inhibited cytokine production and reduced macrophage recruitment. Our data point to a critical role for DUSP1 in controlling the cross-talk between oxidative stress and inflammation

Bronchiectasis-COPD Overlap Syndrome: Role of Peripheral Eosinophil Count and Inhaled Corticosteroid Treatment

Both chronic obstructive pulmonary disease and bronchiectasis are highly prevalent diseases. In both cases, inhaled corticosteroids (ICs) are associated with a decrease in exacerbations in patients with a high peripheral blood eosinophil count (BEC), but it is still not known what occurs in bronchiectasis-COPD overlap syndrome (BCOS). The present study aimed to assess the effect of ICs on various outcomes in patients with BCOS, according to BEC values. We undertook a post-hoc analysis of a cohort of 201 GOLD II-IV COPD patients with a long-term follow-up (median 74 [IQR: 40-106] months). All participants underwent computerized tomography and 115 (57.2%) had confirmed BCOS. A standardized clinical protocol was followed and two sputum samples were collected at each medical visit (every 3-6 months), whenever possible. During follow-up, there were 68 deaths (59.1%), and the mean rate of exacerbations and hospitalizations per year was 1.42 (1.2) and 0.57 (0.83), respectively. A total of 44.3% of the patients presented at least one pneumonic episode per year. The mean value of eosinophils was 402 (112) eosinophils/mu L, with 27 (23.5%), 63 (54.8%), and 25 patients (21.7%) presenting, respectively, less than 100, 101-300, and more than 300 eosinophils/mu L. A total of 84 patients (73.1%) took ICs. The higher the BEC, the higher the annual rate of exacerbations and hospitalizations. Patients with less than 100 eosinophils/mu L presented more infectious events (incident exacerbations, pneumonic episodes, and chronic bronchial infection via pathogenic bacteria). Only those patients with eosinophilia (>300 eosinophils/mu L) treated with ICs decreased the number (1.77 (1.2) vs. 1.08 (0.6), p < 0.001) and the severity (0.67 (0.8) vs. 0.35 (0.5), p = 0.011) of exacerbations, without any changes in the other infectious outcomes or mortality. In conclusion, ICs treatment in patients with BCOS with increased BEC decreased the number and severity of incident exacerbations without any negative influence on other infectious outcomes (incidence of pneumonia or chronic bronchial infection)