High-fidelity ion-trap quantum computing with hyperfine clock states

We propose the implementation of a geometric-phase gate on magnetic-field-insensitive qubits with $\hat{\sigma}^z$-dependent forces for trapped ion quantum computing. The force is exerted by two laser beams in a Raman configuration. Qubit-state dependency is achieved by a small frequency detuning from the virtually-excited state. Ion species with excited states of long radiative lifetimes are used to reduce the chance of a spontaneous photon emission to less than 10$^{-8}$ per gate-run. This eliminates the main source of gate infidelity of previous implementations. With this scheme it seems possible to reach the fault tolerant threshold.Comment: 4 pages, 1 figur

Automated operation of a home made torque magnetometer using LabVIEW

In order to simplify and optimize the operation of our home made torque magnetometer we created a new software system. The architecture is based on parallel, independently running instrument handlers communicating with a main control program. All programs are designed as command driven state machines which greatly simplifies their maintenance and expansion. Moreover, as the main program may receive commands not only from the user interface, but also from other parallel running programs, an easy way of automation is achieved. A program working through a text file containing a sequence of commands and sending them to the main program suffices to automatically have the system conduct a complex set of measurements. In this paper we describe the system's architecture and its implementation in LabVIEW.Comment: 6 pages, 7 figures, submitted to Rev. Sci. Inst

Weighted Bergman kernels and virtual Bergman kernels

We introduce the notion of "virtual Bergman kernel" and apply it to the computation of the Bergman kernel of "domains inflated by Hermitian balls", in particular when the base domain is a bounded symmetric domain.Comment: 12 pages. One-hour lecture for graduate students, SCV 2004, August 2004, Beijing, P.R. China. V2: typo correcte

Quantum Simulation of Quantum Field Theories in Trapped Ions

We propose the quantum simulation of a fermion and an antifermion field modes interacting via a bosonic field mode, and present a possible implementation with two trapped ions. This quantum platform allows for the scalable add-up of bosonic and fermionic modes, and represents an avenue towards quantum simulations of quantum field theories in perturbative and nonperturbative regimes.Comment: To be published in Physical Review Letter

An experimental study of transonic flow about a supercritical airfoil. Static pressure and drag data obtained from tests of a supercritical airfoil and an NACA 0012 airfoil at transonic speeds, supplement

Surface static-pressure and drag data obtained from tests of two slightly modified versions of the original NASA Whitcomb airfoil and a model of the NACA 0012 airfoil section are presented. Data for the supercritical airfoil were obtained for a free-stream Mach number range of 0.5 to 0.9, and a chord Reynolds number range of 2 x 10 to the 6th power to 4 x 10 to the 6th power. The NACA 0012 airfoil was tested at a constant chord Reynolds number of 2 x 10 to the 6th power and a free-stream Mach number range of 0.6 to 0.8

A 16-channel Digital TDC Chip with internal buffering and selective readout for the DIRC Cherenkov counter of the BABAR experiment

A 16-channel digital TDC chip has been built for the DIRC Cherenkov counter of the BaBar experiment at the SLAC B-factory (Stanford, USA). The binning is 0.5 ns, the conversion time 32 ns and the full-scale 32 mus. The data driven architecture integrates channel buffering and selective readout of data falling within a programmable time window. The time measuring scale is constantly locked to the phase of the (external) clock. The linearity is better than 80 ps rms. The dead time loss is less than 0.1% for incoherent random input at a rate of 100 khz on each channel. At such a rate the power dissipation is less than 100 mw. The die size is 36 mm2.Comment: Latex, 18 pages, 13 figures (14 .eps files), submitted to NIM

Geometric phase gate on an optical transition for ion trap quantum computation

We propose a geometric phase gate of two ion qubits that are encoded in two levels linked by an optical dipole-forbidden transition. Compared to hyperfine geometric phase gates mediated by electric dipole transitions, the gate has many interesting properties, such as very low spontaneous emission rates, applicability to magnetic field insensitive states, and use of a co-propagating laser beam geometry. We estimate that current technology allows for infidelities of around 10$^{-4}$.Comment: 4 pages, 2 figure

Irreversible nucleation in molecular beam epitaxy: From theory to experiments

Recently, the nucleation rate on top of a terrace during the irreversible growth of a crystal surface by MBE has been determined exactly. In this paper we go beyond the standard model usually employed to study the nucleation process, and we analyze the qualitative and quantitative consequences of two important additional physical ingredients: the nonuniformity of the Ehrlich-Schwoebel barrier at the step-edge, because of the existence of kinks, and the steering effects, due to the interaction between the atoms of the flux and the substrate. We apply our results to typical experiments of second layer nucleation.Comment: 11 pages. Table I corrected and one appendix added. To be published in Phys. Rev. B (scheduled issue: 15 February 2003

Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs

BACKGROUND: A key focus in cancer research is the discovery of biomarkers that accurately diagnose early lesions in non-invasive tissues. Several studies have identified malignancy-associated DNA methylation changes in blood, yet no general cancer biomarker has been identified to date. Here, we explore the potential of blood DNA methylation as a biomarker of pan-cancer (cancer of multiple different origins) in 41 female cancer discordant monozygotic (MZ) twin-pairs sampled before or after diagnosis using the Illumina HumanMethylation450 BeadChip. RESULTS: We analysed epigenome-wide DNA methylation profiles in 41 cancer discordant MZ twin-pairs with affected individuals diagnosed with tumours at different single primary sites: the breast, cervix, colon, endometrium, thyroid gland, skin (melanoma), ovary, and pancreas. No significant global differences in whole blood DNA methylation profiles were observed. Epigenome-wide analyses identified one novel pan-cancer differentially methylated position at false discovery rate (FDR) threshold of 10 % (cg02444695, P = 1.8 × 10(-7)) in an intergenic region 70 kb upstream of the SASH1 tumour suppressor gene, and three suggestive signals in COL11A2, AXL, and LINC00340. Replication of the four top-ranked signals in an independent sample of nine cancer-discordant MZ twin-pairs showed a similar direction of association at COL11A2, AXL, and LINC00340, and significantly greater methylation discordance at AXL compared to 480 healthy concordant MZ twin-pairs. The effects at cg02444695 (near SASH1), COL11A2, and LINC00340 were the most promising in biomarker potential because the DNA methylation differences were found to pre-exist in samples obtained prior to diagnosis and were limited to a 5-year period before diagnosis. Gene expression follow-up at the top-ranked signals in 283 healthy individuals showed correlation between blood methylation and gene expression in lymphoblastoid cell lines at PRL, and in the skin tissue at AXL. A significant enrichment of differential DNA methylation was observed in enhancer regions (P = 0.03). CONCLUSIONS: We identified DNA methylation signatures in blood associated with pan-cancer, at or near SASH1, COL11A2, AXL, and LINC00340. Three of these signals were present up to 5 years prior to cancer diagnosis, highlighting the potential clinical utility of whole blood DNA methylation analysis in cancer surveillance