A framework for assessing product innovation strategies in a competitive context

The development of new products capable of satisfying customer demands on a timely basis has become a priority for firms seeking to improve their competitive advantage in a global context. However, this challenge has become highly complex due to a growing diversity of both products and processes, higher costs, and unprecedented considerations for quality and service. Despite knowing a great deal about both the characteristics of successful firms and new product development processes, little is known regarding requisite guidelines for successful strategies in product development

Detection of selection signatures in farmed coho salmon (Oncorhynchus kisutch) using dense genome-wide information

Animal domestication and artificial selection give rise to gradual changes at the genomic level in populations. Subsequent footprints of selection, known as selection signatures or selective sweeps, have been traced in the genomes of many animal livestock species by exploiting variation in linkage disequilibrium patterns and/or reduction of genetic diversity. Domestication of most aquatic species is recent in comparison with land animals, and salmonids are one of the most important fish species in aquaculture. Coho salmon (Oncorhynchus kisutch), cultivated primarily in Chile, has been subjected to breeding programs to improve growth, disease resistance traits, and flesh color. This study aimed to identify selection signatures that may be involved in adaptation to culture conditions and traits of productive interest. To do so, individuals of two domestic populations cultured in Chile were genotyped with 200 thousand SNPs, and analyses were conducted using iHS, XP-EHH and CLR. Several signatures of selection on different chromosomal regions were detected across both populations. Some of the identified regions under selection contained genes such anapc2, alad, chp2 and myn, which have been previously associated with body weight in Atlantic salmon, or sec24d and robo1, which have been associated with resistance to Piscirickettsia salmonis in coho salmon. Findings in our study can contribute to an integrated genome-wide map of selection signatures, to help identify the genetic mechanisms of phenotypic diversity in coho salmon

Multiresidue Analysis of Multiclass Pesticides in Lavandin Essential Oil by LC/MS/MS Using the Scheduled Selected Reaction Monitoring Mode

In this paper we describe the development of the first multiclass pesticide residue method applied to essential oils. A total of 70 pesticides covering a wide range of polarity and currently used on essential oil crops have been included in the method. The procedure consists of a 10-fold dilution of lavandin essential oil followed by a direct injection analysis by liquid chromatography/tandem mass spectrometry. The system used is an API 4000 QTrap equipped with an electrospray ionization interface and operating in scheduled selected reaction monitoring acquisition mode. Matrix effects were evaluated by comparing the slopes of matrix-matched and solvent-based calibration curves. Weak signal suppression or enhancement (<20%) was observed for most of the compounds. Method sensitivity was determined statistically by the injection of five matrix-matched calibration curves with the distribution’s normality and the variance’s homogeneity checked before establishment of a suitable regression model. Limits of detection (LODs) and quantification (LOQs) were then determined using the blank standard’s deviation and the slope of the mean curve. The analytical method has been validated for 67 of the 70 pesticides and meets the following LOQs: ≤1 μg/L for 9 pesticides, ≤5 μg/L for 44, ≤10 μg/L for 9, and ≤20 μg/L for

Seeps, springs and wetlands: San Juan Basin, Colorado. Social-ecological climate resilience project

Prepared for: North Centeral Climate Adaptation Science Center.Social-Ecological Climate Resilience Project, 2016.Includes bibliographical references

Social Ecological Climate Resilience Project - 2016

Prepared for: North Central Climate Science Center, Fort Collins, Colorado.February 2017.Includes bibliographical references.Climate change is already having impacts on nature, ecosystem services and people in southwestern Colorado and is likely to further alter our natural landscapes in the coming decades. Understanding the potential changes and developing adaptation strategies can help ensure that natural landscapes and human communities remain healthy in the face of a changing climate. An interdisciplinary team consisting of social, ecological and climate scientists developed an innovative climate planning framework and worked with the Social‐Ecological Climate Resilience Project (SECR) and other stakeholders in Colorado’s San Juan River watershed to develop adaptation strategies for two significant landscapes, pinyon juniper woodlands and seeps, springs, and wetland resources under three climate scenarios between 2035 and 2050. This report summarizes the planning framework and results for the pinyon‐juniper landscape (the seeps, springs and wetlands results will be provided separately). This framework can be utilized to develop strategies for other landscapes at local, state, and national scales. Diagrams, narrative scenarios, and maps that depict climate scenarios and the social‐ecological responses help us portray the climate impact in the face of an uncertain future. Interviews and focus group workshops with agency staff and stakeholders who are users of public lands identified several important opportunities to improve the adaptation planning process for developing strategies that meet both social and ecological needs. Planning techniques that include or directly relate to specific resources, such as water and forage, or to activities, such as recreation or grazing, provide avenues for engaging diverse stakeholders into the process. Utilizing the scenarios to understand the impacts to our social and ecological landscapes, three overarching landscape‐scale adaptation strategies were developed. Each of these strategies has a suite of potential actions required to reach a desired future condition. The three key strategies are: 1) identify and protect persistent ecosystems as refugia, 2) proactively manage for resilience, and 3) accept, assist, and allow for transformation in non‐climate refugia sites. If the framework and strategies from this project are adopted by the local community, including land managers, owners, and users, the climate change impacts can be reduced, allowing for a more sustainable human and natural landscape

Sagebrush landscape: Upper Gunnison River Basin, Colorado Social-Ecological Climate Resilience Project

Prepared with: The Gunnison Climate Working Group and Stakeholders in Gunnison, Colorado for: the North Central Climate Science Center, Ft. Collins, Colorado.April 30, 2017.Includes bibliographical references.Utilizing climate stories to understand the social and ecological impacts to the sagebrush landscape, the team worked with stakeholders to develop three overarching landscape‐scale adaptation strategies. Each of the strategies has a suite of potential actions required to reach a desired future condition. The three key strategies are: 1) identify and protect climate refugia sites (persistent areas), 2) maintain or enhance the resilience of the climate refugia sites, and 3) accept, assist and allow for transformation in non‐climate refugia sites. If adopted by the local community, including land managers and landowners, the framework and strategies resulting from this project can help to reduce the adverse impacts of climate change, allowing for a more sustainable human and natural landscape

Loose abrasive slurries for optical glass lapping

International audienceLoose abrasive lapping is widely used to prepare optical glass before its final polishing. We carried out a comparison of 20 different slurries from four different vendors. Slurry particle sizes and morphologies were measured. Fused silica samples were lapped with these different slurries on a single side polishing machine and characterized in terms of surface roughness and depth of subsurface damage (SSD). Effects of load, rotation speed, and slurry concentration during lapping on roughness, material removal rate, and SSD were investigated

Saguache County, closed basin biological inventory. Volume I: Natural heritage assessment final report

Prepared for: The Nature Conservancy, San Luis Valley program, Saguache, Colorado.February 1998.Includes bibliographical references

A new prescription model for regional citrate anticoagulation in therapeutic plasma exchanges.

Regional citrate anticoagulation (RCA) is proposed for various extracorporeal purification techniques to overcome the risk of bleeding that might result from systemic anticoagulation. Yet, no individualized treatment protocol has been proposed for therapeutic plasma exchange (TPE) so far. The objective of this study was to assess the determinants of blood citrate concentration needed and to develop an individualized RCA protocol useful for clinical practice. The study population included 14 patients who underwent a total of 47 TPE sessions. Citrate was infused pre-plasmafilter. Post-plasmafilter and systemic plasma ionized calcium concentrations were measured at standardized time intervals. An algorithm was proposed for the supplementation of calcium. During the discovery phase, citrate was infused at a fixed starting rate, and adapted accordingly to obtained post-plasmafilter ionized calcium levels. Using a mathematical approach, an algorithm was thereafter developed for individualized prescriptions of citrate. Pre-treatment values of hematocrit and plasma ionized calcium were the main determinants of the required rate of citrate infusion. These can be integrated into a final equation enabling to individualize the prescription. A prefilter ionized calcium concentration between 0.24 and 0.33 mmol/l prevented coagulation of the extracorporeal circuit. Significant hypocalcemia occurred in 8.5% of treatments. There were no significant acid-base disturbances. We propose a new protocol, which enables for the first time to individualize the prescription of regional citrate anticoagulation during TPE, in an efficient manner. The immediately obtained regional anticoagulation protects against both the risk of coagulation of the membrane and the exposure to an excess of citrate