Propuesta metodologica en el ambito de la mecatronica: vehículos de competicion de alta eficiencia

El principal interés de la presente tesis consiste en el estudio de un método para el diseño y fabricación de un vehículo prototipo de alta eficiencia para la participación en competiciones de nivel internacional. El método descrito se aplicará como ejemplo a la forma exterior del vehículo. En el diseño y fabricación de estos vehículos se deben cumplir unos principios básicos de eficiencia y seguridad. En este trabajo se ha procedido a realizar las siguientes acciones: - Estudio de la reglamentación en cuanto a medidas de seguridad. - Estudio de la restricciones de diseño impuestas por nuestro tipo de vehículo (dirección delantera, motor de combustión, etc.). - Establecimiento de la metodología. - Diseño en 2D del perfil aerodinámico óptimo. - Diseño de la carrocería en 3D y su posterior, perfeccionamiento del diseño a partir de un estudio CFD (Computation Fluid Dynamics). - Proceso de Fabricación de la carrocería.Colomer Romero, V. (2013). Propuesta metodologica en el ambito de la mecatronica: vehículos de competicion de alta eficiencia [Tesis doctoral]. Editorial Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/34512TESI

When should we order a next generation sequencing test in a patient with cancer?

Technical advances in genome sequencing and the implementation of next-generation sequencing (NGS) in clinical oncology have paved the way for individualizing cancer patient therapy based on molecular profiles. When and how to use NGS testing in the clinic is at present an unsolved issue, although new research results provide evidence favoring this approach in some types of advanced cancer. Clinical research is evolving rapidly, from basket and umbrella trials to adaptative design precision oncology clinical studies, and genomic and molecular data often displace the classical clinical validation procedures of biomarkers. In this context, physicians must be aware of the clinical evidence behind these new biomarkers and NGS tests available, in order to use them in the right moment, and with a critical point of view. This review will present the status of currently available targeted drugs that can be effective based on actionable molecular alterations, and the NGS tests that are currently available, offering a practical guide for the application of Clinical Precision Oncology in the real world routine practice.probability of identifying a targetable mutation is low[62], the canceris in early stages with recognized and effective forms of standardtreatment, or the patient has an irreversible disease with very shortlife-expectancy. As with any other laboratory test, doctors andpatients must be sure before ordering an NGS test that its result willhave an impact of the therapeutic plan. In any case, standard single-gene molecular testing must always be performed when indicated,since important therapeutic targets might be potentially missed if nomolecular analyses were performed.Clinical trials are showing that NGS testing can have an impact inthe response rate and progression-free survival of patients, and cantherefore be a very useful strategy leading to new molecularly-tar-geted treatment indications. Key factors responsible for improvedresults in precision-oriented clinical research, include refining themolecular pathways studied, developing molecular testing that inte-grates standarised genomic tests with transcriptomic analysis andimmunohistochemistry, selecting more active targeted agents,designing combinations of targeted agents -also with other forms oftherapy, and providing early treatment recommendations with avail-able Molecular Multidisciplinary Boards. Interdisciplinary discussionare very important to help with the interpretation of unclear molecu-lar results that are oftentimes seen with NGS testing.Important unsolved issues that will need to be addressed in thefuture include deciding which is the best tissue to perform NGS (pri-mary tumor vs metastasis, tumor DNA vs circulating tumor DNA),when is the right moment to test (atfirst diagnosis of advanced dis-ease or when the disease is refractory), and whether there are NGSclinical trial designs that allow for the use of control groups. Finally,using a complete informed consent before NGS testing and communi-cating NGS reports to patients are two very important aspects of theprocedure that have raised ethical concerns, and that must be alwaysaddressed by the practicing oncologists when ordering a NGS test.Search strategy and selection criteriaWe identified references through PubMed with the search terms“cancer AND NGS,”“cancer AND next generation sequencing,”“can-cer AND genomics,”for articles published to March 30, 2020. Thefinalreference list was generated on the basis of originality and relevanceto the broad scope of this Review.FundingThis Review was funded in part by research funds from projectsPIE15/00068andPI17/01865(Instituto de Salud Carlos III) awardedto RC, projectsJR17/00007andPI17/008(Instituto de Salud CarlosIII), awarded to NR-L,PI15/01491andPI19/00549(Instituto de SaludCarlos III) awarded to AA, projectsSAF2017 82886-R(Ministerio deEconomía y Competitividad), INDISNET-S2011/BMD-2332(Fundaci on Ram on Areces), andHR17-00016("La Caixa" Foundation)awarded to FS-M, and projectsPI16/00354(Instituto de Salud CarlosIII) andB2017/BMD-3733from the Consejería de Educaci on, Juventudy Deporte, Comunidad de Madrid, awarded to MQ-F. The manuscriptis part of the activities of the endowed Chair of Personalised PrecisionOncology, Universidad Aut onoma de Madrid (UAM-Fundaci on Insti-tuto Roche)S

Probabilistic Guarded P Systems, A New Formal Modelling Framework

Multienvironment P systems constitute a general, formal framework for modelling the dynamics of population biology, which consists of two main approaches: stochastic and probabilistic. The framework has been successfully used to model biologic systems at both micro (e.g. bacteria colony) and macro (e.g. real ecosystems) levels, respectively. In this paper, we extend the general framework in order to include a new case study related to P. Oleracea species. The extension is made by a new variant within the probabilistic approach, called Probabilistic Guarded P systems (in short, PGP systems). We provide a formal definition, a simulation algorithm to capture the dynamics, and a survey of the associated software.Ministerio de Economía y Competitividad TIN2012- 37434Junta de Andalucía P08-TIC-0420

Comparison of Mechanical Properties of Hemp-Fibre Biocomposites Fabricated with Biobased and Regular Epoxy Resins

[EN] Bio- and green composites are mainly used in non-structural automotive elements like interior panels and vehicle underpanels. Currently, the use of biocomposites as a worthy alternative to glass fibre-reinforced plastics (GFRPs) in structural applications still needs to be fully evaluated. In the current study, the development of a suited biocomposites started with a thorough review of the available raw materials, including both reinforcement fibres and matrix materials. Based on its specific properties, hemp appeared to be a very suitable fibre. A similar analysis was conducted for the commercially available biobased matrix materials. Greenpoxy 55 (with a biocontent of 55%) and Super Sap 100 (with a biocontent of 37%) were selected and compared with a standard epoxy resin. Tensile and three-point bending tests were conducted to characterise the hemp-based biocomposite.The authors acknowledge financial support from the Spanish Government, Project PID2019-108807RB-I00.Colomer Romero, V.; Rogiest, D.; García Manrique, JA.; Crespo, J. (2020). Comparison of Mechanical Properties of Hemp-Fibre Biocomposites Fabricated with Biobased and Regular Epoxy Resins. Materials. 13(24):1-8. https://doi.org/10.3390/ma13245720181324Mohanty, A. K., Misra, M., & Hinrichsen, G. (2000). Biofibres, biodegradable polymers and biocomposites: An overview. Macromolecular Materials and Engineering, 276-277(1), 1-24. doi:10.1002/(sici)1439-2054(20000301)276:13.0.co;2-wLa Mantia, F. P., & Morreale, M. (2011). Green composites: A brief review. Composites Part A: Applied Science and Manufacturing, 42(6), 579-588. doi:10.1016/j.compositesa.2011.01.017Hansen, O., Habermann, C., & Endres, H.-J. (2019). BIO-BASED MATERIALS FOR EXTERIOR APPLICATIONS – PROJECT BIOHYBRIDCAR. Zukunftstechnologien für den multifunktionalen Leichtbau, 189-200. doi:10.1007/978-3-662-58206-0_18Gholampour, A., & Ozbakkaloglu, T. (2019). A review of natural fiber composites: properties, modification and processing techniques, characterization, applications. Journal of Materials Science, 55(3), 829-892. doi:10.1007/s10853-019-03990-yPatil, N. V., Rahman, M. M., & Netravali, A. N. (2017). «Green» composites using bioresins from agro‐wastes and modified sisal fibers. Polymer Composites, 40(1), 99-108. doi:10.1002/pc.24607Verma, D., & Senal, I. (2019). Natural fiber-reinforced polymer composites. Biomass, Biopolymer-Based Materials, and Bioenergy, 103-122. doi:10.1016/b978-0-08-102426-3.00006-0Adekomaya, O. (2020). Adaption of green composite in automotive part replacements: discussions on material modification and future patronage. Environmental Science and Pollution Research, 27(8), 8807-8813. doi:10.1007/s11356-019-07557-xKim, Y. K., & Chalivendra, V. (2020). Natural fibre composites (NFCs) for construction and automotive industries. Handbook of Natural Fibres, 469-498. doi:10.1016/b978-0-12-818782-1.00014-6Potluri, R., & Chaitanya Krishna, N. (2020). Potential and Applications of Green Composites in Industrial Space. Materials Today: Proceedings, 22, 2041-2048. doi:10.1016/j.matpr.2020.03.218Mann, G. S., Singh, L. P., Kumar, P., & Singh, S. (2018). Green composites: A review of processing technologies and recent applications. Journal of Thermoplastic Composite Materials, 33(8), 1145-1171. doi:10.1177/0892705718816354Standard Test Method for Tensile Properties of Polymer Matrix Composite Materials https://www.astm.org/Standards/D3039https://www.pecepoxy.co.uk/data-sheets/TDS_100_1000_v4.pdfhttp://www.matrix-composites.co.uk/prod-data-sheet/old/greenpoxy-55-ft-uk.pdfCzłonka, S., Strąkowska, A., & Kairytė, A. (2020). The Impact of Hemp Shives Impregnated with Selected Plant Oils on Mechanical, Thermal, and Insulating Properties of Polyurethane Composite Foams. Materials, 13(21), 4709. doi:10.3390/ma13214709Madhu, P., Mavinkere Rangappa, S., Khan, A., Al Otaibi, A., Al‐Zahrani, S. A., Pradeep, S., … Siengchin, S. (2020). Experimental investigation on the mechanical and morphological behavior of Prosopis juliflora bark fibers/E‐glass/carbon fabrics reinforced hybrid polymeric composites for structural applications. Polymer Composites, 41(12), 4983-4993. doi:10.1002/pc.2576

Training intensity-dependent increases in corticospinal but not intracortical excitability after acute strength training

The purpose of this study was to determine whether the increases in corticospinal excitability (CSE) observed after one session of unilateral isometric strength training (ST) are related to changes in intracortical excitability measured by magnetic brain stimulation (TMS) in the trained and the contralateral untrained biceps brachii (BB) and whether such changes scale with training intensity. On three separate days, 15 healthy young men performed one ST session of 12 sets of eight isometric contractions of the right elbow flexors at 0% (control session), 25%, or 75% of the maximal voluntary contraction (MVC) in a random order. Before and after each session separated at least by 1 week, motor evoked potential (MEP) amplitude, short-interval intracortical inhibition (SICI), contralateral silent period (SP), and intracortical facilitation (ICF) generated by TMS were measured in the trained and the untrained BBs. Compared with baseline, MEPs recorded from the trained BB increased by similar to 47% after training at 75% of MVC (P .05). MEPs in the untrained BB and SICI, SP, and ICF in either BB did not change. Therefore, acute high-intensity but not low-intensity unilateral isometric ST increases CSE in the trained BB without modifications in intracortical inhibition or facilitation. Thus, increases in corticospinal neurons or alpha-alpha-motoneuron excitability could underlie the increases in CSE. Regardless of contraction intensity, acute isometric ST did not modify the excitability of the ipsilateral primary motor cortex measured by TMS

Does Heavy-Resistance Training Improve Mobility and Perception of Quality of Life in Older Women?

[Abstract] Regular physical exercise has shown great benefits in preventing age-related functional losses and in improving the perception of health-related quality of life (HRQoL) in older people. To optimize these benefits, it would be interesting to evaluate what type of exercise is better. Therefore, the purpose of this study was to assess the effects of heavy-resistance training on mobility and HRQoL in older women. Forty healthy, untrained older women (60–75 years) were randomly assigned to three groups: circuit resistance training (CRT, n = 15), traditional resistance training (TRT, n = 15) or the control group (CG, n = 10). During the 12-week training period, both experimental groups performed training with heavy loads, twice a week. Before and after the training period, the Timed Up and Go test, as a proxy of mobility, and the perception of HRQoL were evaluated. TRT and CRT resulted in a statistically significant improvement in the Timed Up and Go test (−5.4 and −10.3%, respectively; p < 0.05), but only the improvement after CRT was significantly greater than changes in the CG (p < 0.001). Only CRT elicited improvements in several dimensions of the perception of the HRQoL questionnaire, such as: physical functioning (13%, p < 0.001), general health (8.1%; p = 0.048), vitality (17.7%; p < 0.001), role emotional (6.7%; p = 0.044) and physical component summary (6.3%; p = 0.001). The change in the CRT group was greater than in the CG (p < 0.001) in the physical functioning score. The present findings show that CRT might be a time- (and hence cost-) effective alternative to trigger multiple positive functional and psychological adaptations in older women.This work was supported by the grants from Fundación San Antonio, reference n: PMAFI-10/21Fundación Universitaria San Antonio (Murcia); PMAFI-10/2

Training load but not fatigue affects cross-education of maximal voluntary force

The purpose of this study was to determine the effects of training load (25% vs. 75% of one repetition maximum [1RM]) and fatigue (failure vs. non-failure) during four weeks of unilateral knee extension resistance training (RT) on maximal voluntary force in the trained and the untrained knee extensors. Healthy young adults (n = 42) were randomly assigned to control (CON, n = 9, 24 +/- 4.3 years), low-load RT to failure (LLF, n = 11, 21 +/- 1.3 years, three sets to failure at 25% of 1RM), high-load RT to failure (HLF, n = 11, 21 +/- 1.4 years, three sets to failure at 75% of 1RM), and high-load RT without failure (HLNF, n = 11, 22 +/- 1.5 years, six sets of five repetitions at 75% of 1RM) groups. Before and after the four weeks of training, 1RM, maximal voluntary isometric force, and corticospinal excitability (CSE) were measured. 1RM in the trained (20%, d = 0.70, 15%, d = 0.61) and the untrained knee extensors (5%, d = 0.27, 6%, d = 0.26) increased only in the HLF and HLNF groups, respectively. MVIC force increased only in the trained leg of the HLF (5%, d = 0.35) and HLNF groups (12%, d = 0.67). CSE decreased in the VL of both legs in the HLNF group (-19%, d = 0.44) and no changes occurred in the RF. In conclusion, high- but not low-load RT improves maximal voluntary force in the trained and the untrained knee extensors and fatigue did not further enhance these adaptations. Voluntary force improvements were unrelated to CSE changes in both legs

Implementation of Project-Based Learning at a Multidisciplinary Level of the Specialization in Design and Manufacture of Machines and Prototypes in the Degree of Mechanical Engineering

[EN] Since the implementation of the Bologna Process, universities have been incorporating into the European Higher Education Area, adapting and unifying educational criteria for all the European centers. Although mobility and bilingualism have been clearly promoted in universities by increasing performance in certain areas, it is necessary to improve other areas such as the implementation of novel active learning methodologies to promote deep learning. For this reason, Universitat Politècnica de València is putting faith in the implementation of active methodologies that integrate the development and acquisition of competences making the students the center of the learning-teaching process. Moreover, the lack of coordination among different subjects of the specialization in design and manufacture of machines and prototypes in the degree of Mechanical Engineering, is another important issue to be considered as it makes students to find difficulties in solving real problems. In light of all these identified difficulties, the objective of this work is to design a project-based learning (PBL) model among the different subjects of the aforementioned specialization. The use of PBL will make students to actively participate in higher-level of cognitive processes. The most important premise when designing the project, in this case a gearbox casing, is the multidisciplinary aspects as the same project will have continuity and will cover different contents throughout the different subjects in the specialization. The methodology used for defining and implementing the PBL model consists of: (i) the identification of the current main difficulties; (ii) the definition of the PBL model; (iii) the identification of the necessary contents per subject to be applied in the solving process of the PBL model; and (iv) the evaluation/assessment of the PBL model implementation. Finally, both the project and the different activities to be carried out in the different subjects involved in the PBL model are presented. In addition, the results obtained through a satisfaction survey performed by the students to collect their opinion will be also analysed to provide feedback for further improvement of the PBL model.This article has been supported by Universitat Politècnica de València, particularly by the Vice-rectorate for Digital Resources and Documentation (Vicerrectorado de Recursos Digitales y Documentación) and Vice-Rectorate for Studies, Quality and Accreditation (Vicerrectorado de Estudios, Calidad y Acreditación) under the Call for Learning + Teaching (Convocatoria A+D2019: Aprendizaje + Docencia. Proyectos de Innovación y Mejora Educativa) and Project Code: A157. The authors would like to acknowledge the support of the Institute of Educational Sciences (Instituto de Ciencias de la Educación), the Evaluation and Monitoring Commission for Educational Innovation and Improvement Projects (Comisión de Evaluación y Seguimiento de Proyectos de Innovación y Mejora Educativa (CESPIME) and Escuela Politécnica Superior de AlcoyMontava-Jorda, S.; Colomer Romero, V.; Martínez Sanz, AV.; Reig-Pérez, MJ.; López Esteve, FM. (2021). Implementation of Project-Based Learning at a Multidisciplinary Level of the Specialization in Design and Manufacture of Machines and Prototypes in the Degree of Mechanical Engineering. EDULEARN Proceedings (Internet). 7477-7483. https://doi.org/10.21125/edulearn.2021.1518S7477748

Does ipsilateral corticospinal excitability play a decisive role in the cross-education effect caused by unilateral resistance training?:A systematic review

INTRODUCTION: Unilateral resistance training has been shown to improve muscle strength in both the trained and the untrained limb. One of the most widely accepted theories is that this improved performance is due to nervous system adaptations, specifically in the primary motor cortex. According to this hypothesis, increased corticospinal excitability (CSE), measured with transcranial magnetic stimulation, is one of the main adaptations observed following prolonged periods of training. The principal aim of this review is to determine the degree of adaptation of CSE and its possible functional association with increased strength in the untrained limb. DEVELOPMENT: We performed a systematic literature review of studies published between January 1970 and December 2016, extracted from Medline (via PubMed), Ovid, Web of Science, and Science Direct online databases. The search terms were as follows: (transcranial magnetic stimulation OR excitability) AND (strength training OR resistance training OR force) AND (cross transfer OR contralateral limb OR cross education). A total of 10 articles were found. CONCLUSION: Results regarding increased CSE were inconsistent. Although the possibility that the methodology had a role in this inconsistency cannot be ruled out, the results appear to suggest that there may not be a functional association between increases in muscle strength and in CSE

Membrane Computing as a Modelling Tool: Looking Back and Forward from Sevilla

This paper is a tribute to Prof. Mario de Jesús Pérez- Jiménez. An overview of modelling applications in membrane computing has been compiled, trying to narrate it from a historical perspective and including numerous bibliographical references. Since being exhaustive was obviously out of scope, this quick tour on almost two decades of applications is biased, paying special attention to the contributions in which Prof. Pérez-Jiménez and members of his research group were involved.Ministerio de Economía y Competitividad TIN2017-89842-