Control estadístico para el monitoreo del proceso de corte de pastillas de jabón

This study aims to apply the methodology of statistical process control charts in the monitoring of the net weight of soap bars of a production line, with the objective of evaluating the evolution of this variable as a characteristic of product quality; the results of traditional charts are compared to EWMA memory charts. In manufacturing processes where the misalignments are minimal, Shewhart charts may be less sensitive to these mismatches, which may take a long time to be detected. In this study are applied EWMA control charts that are more appropriate than traditional ones to detect small mismatches more quickly. Having the CEP charts for the monitoring and subsequent analysis of the process variables will enable timely detection of changes in product quality, evaluation of quality aspects of the manufacturing process and continuous improvement in the processes.Este estudio tiene como propósito aplicar la metodología de las cartas de control estadístico de procesos en el monitoreo del peso neto de pastillas de jabones de una línea de producción, con el objetivo de evaluar la evolución de esta variable como característica de calidad del producto; se comparan los resultados de las cartas tradicionales respecto a cartas con memoria EWMA. En los procesos fabriles en donde los desajustes que se presentan son mínimos, los gráficos Shewhart pueden ser poco sensibles a estos desajustes que pueden tardar mucho tiempo en ser detectados. En este estudio se aplican cartas de control EWMA que son más apropiadas que las tradicionales para detectar pequeños desajustes con más rapidez. Disponer de las cartas CEP para el monitoreo y posterior análisis de las variables de proceso, permitirá detectar oportunamente los cambios en la calidad del producto, evaluar aspectos de la calidad del proceso de manufactura y ejercer mejoras continuas en los mismos.

Entrenamiento pliométrico en la activación neuromuscular de tobillo en sujetos físicamente activos con inestabilidad crónica: una revisión de la literatura

48 p.Introducción: los esguinces laterales de tobillo son unas de las lesiones más comunes en la población general y la más frecuente en jóvenes físicamente activos. Se ha establecido que un 40% de las personas que sufren de esta lesión desarrollan Inestabilidad Crónica de Tobillo. Dentro de los desafíos en las disfunciones de tobillo ha aparecido la pliometría como una posible estrategia de rehabilitación. Objetivo: revisar el efecto de un programa de entrenamiento pliométrico sobre la actividad neuromuscular de tobillo en personas físicamente activas que presentan inestabilidad crónica de tobillo. Metodología: esta revisión de la literatura se obtuvo de las bases de datos Pubmed, Web of Science, Scopus y EBSCO, que incluyó ensayos controlados aleatorizados que han analizado el entrenamiento pliométrico en base a la actividad neuromuscular en sujetos físicamente activos con inestabilidad crónica de tobillo durante los últimos 5 años. Conclusión: si bien la información es limitada, el uso de una intervención basada en saltos pliométricos podría ser una herramienta terapéutica capaz de generar mejoras en la activación neuromuscular de los músculos del tobillo con ICT. // ABSTRACT: Introduction: Lateral ankle sprains are one of the most common injuries in general population, and the most frequent in physically active young people. It has been established that 40% of people who suffer from this injury develop Chronic Ankle Instability. Within the challenges in ankle dysfunctions, plyometrics has emerged as a possible rehabilitation strategy. Objective: To check the effect of a plyometric training program on ankle neuromuscular activity in physically active individuals with chronic ankle instability. Methodology: The literature review is based on PubMed, Web of Science, Scopus and EBSCO data, including randomized controlled trials that have analyzed the plyometric training based on ankle neuromuscular activity in physical active individuals with chronic ankle instability over the last five years. Conclusion: Even tough information its limitated the use of an intervention based on plyometric jumps could be a therapeutic tool capable of generating improvements in the neuromuscular activation of ankle muscles with CT

Mucosal immune defence polymorphisms: relevant players in IgA vasculitis?

Congresos y Comunicaciones: Comunicación, Congreso - póster

IgAV and IgAN: a single entity regarding CD40, BLK and BANK1 polymorphisms.

Congresos y conferencias: Comunicación de congreso - oral

Surrogate indices of insulin resistance using the Matsuda index as reference in adult men—a computational approach

Background: Overweight and obesity, high blood pressure, hyperglycemia, hyperlipidemia, and insulin resistance (IR) are strongly associated with non-communicable diseases (NCDs), including type 2 diabetes, cardiovascular disease, stroke, and cancer. Different surrogate indices of IR are derived and validated with the euglycemic–hyperinsulinemic clamp (EHC) test. Thus, using a computational approach to predict IR with Matsuda index as reference, this study aimed to determine the optimal cutoff value and diagnosis accuracy for surrogate indices in non-diabetic young adult men. Methods: A cross-sectional descriptive study was carried out with 93 young men (ages 18–31). Serum levels of glucose and insulin were analyzed in the fasting state and during an oral glucose tolerance test (OGTT). Additionally, clinical, biochemical, hormonal, and anthropometric characteristics and body composition (DEXA) were determined. The computational approach to evaluate the IR diagnostic accuracy and cutoff value using difference parameters was examined, as well as other statistical tools to make the output robust. Results: The highest sensitivity and specificity at the optimal cutoff value, respectively, were established for the Homeostasis model assessment of insulin resistance index (HOMA-IR) (0.91; 0.98; 3.40), the Quantitative insulin sensitivity check index (QUICKI) (0.98; 0.96; 0.33), the triglyceride-glucose (TyG)-waist circumference index (TyG-WC) (1.00; 1.00; 427.77), the TyG-body mass index (TyG-BMI) (1.00; 1.00; 132.44), TyG-waist-to-height ratio (TyG-WHtR) (0.98; 1.00; 2.48), waist-to-height ratio (WHtR) (1.00; 1.00; 0.53), waist circumference (WC) (1.00; 1.00; 92.63), body mass index (BMI) (1.00; 1.00; 28.69), total body fat percentage (TFM) (%) (1.00; 1.00; 31.07), android fat (AF) (%) (1.00; 0.98; 40.33), lipid accumulation product (LAP) (0.84; 1.00; 45.49), leptin (0.91; 1.00; 16.08), leptin/adiponectin ratio (LAR) (0.84; 1.00; 1.17), and fasting insulin (0.91; 0.98; 16.01). Conclusions: The computational approach was used to determine the diagnosis accuracy and the optimal cutoff value for IR to be used in preventive healthcare.Fil: Malagón Soriano, Víctor Antonio. Universidad Nacional de Colombia; ColombiaFil: Ledezma Forero, Andres Julian. Universidad Nacional de Colombia; ColombiaFil: Espinel Pachon, Cristian Felipe. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Burgos Cárdenas, Álvaro Javier. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Garces, Maria Fernanda. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Ortega Ramírez, Gustavo Eduardo. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Franco Vega, Roberto. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Peralta Franco, Jhon Jairo. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Maldonado Acosta, Luis Miguel. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Rubio Romero, Jorge Andres. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Mercado Pedroza, Manuel Esteban. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Caminos Cepeda, Sofia Alexandra. Universitat Pompeu Fabra; EspañaFil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Rivera Moreno, Carlos Armando. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Darghan Contreras, Aquiles Enrique. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Ruiz Parra, Ariel Iván. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Caminos, Jorge E.. Universidad Nacional de Colombia. Facultad de Medicina; Colombi

Surrogate indices of insulin resistance using the Matsuda index as reference in adult men—a computational approach

BackgroundOverweight and obesity, high blood pressure, hyperglycemia, hyperlipidemia, and insulin resistance (IR) are strongly associated with non-communicable diseases (NCDs), including type 2 diabetes, cardiovascular disease, stroke, and cancer. Different surrogate indices of IR are derived and validated with the euglycemic–hyperinsulinemic clamp (EHC) test. Thus, using a computational approach to predict IR with Matsuda index as reference, this study aimed to determine the optimal cutoff value and diagnosis accuracy for surrogate indices in non-diabetic young adult men.MethodsA cross-sectional descriptive study was carried out with 93 young men (ages 18–31). Serum levels of glucose and insulin were analyzed in the fasting state and during an oral glucose tolerance test (OGTT). Additionally, clinical, biochemical, hormonal, and anthropometric characteristics and body composition (DEXA) were determined. The computational approach to evaluate the IR diagnostic accuracy and cutoff value using difference parameters was examined, as well as other statistical tools to make the output robust.ResultsThe highest sensitivity and specificity at the optimal cutoff value, respectively, were established for the Homeostasis model assessment of insulin resistance index (HOMA-IR) (0.91; 0.98; 3.40), the Quantitative insulin sensitivity check index (QUICKI) (0.98; 0.96; 0.33), the triglyceride-glucose (TyG)-waist circumference index (TyG-WC) (1.00; 1.00; 427.77), the TyG-body mass index (TyG-BMI) (1.00; 1.00; 132.44), TyG-waist-to-height ratio (TyG-WHtR) (0.98; 1.00; 2.48), waist-to-height ratio (WHtR) (1.00; 1.00; 0.53), waist circumference (WC) (1.00; 1.00; 92.63), body mass index (BMI) (1.00; 1.00; 28.69), total body fat percentage (TFM) (%) (1.00; 1.00; 31.07), android fat (AF) (%) (1.00; 0.98; 40.33), lipid accumulation product (LAP) (0.84; 1.00; 45.49), leptin (0.91; 1.00; 16.08), leptin/adiponectin ratio (LAR) (0.84; 1.00; 1.17), and fasting insulin (0.91; 0.98; 16.01).ConclusionsThe computational approach was used to determine the diagnosis accuracy and the optimal cutoff value for IR to be used in preventive healthcare

5to. Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad. Memoria académica

El V Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad, CITIS 2019, realizado del 6 al 8 de febrero de 2019 y organizado por la Universidad Politécnica Salesiana, ofreció a la comunidad académica nacional e internacional una plataforma de comunicación unificada, dirigida a cubrir los problemas teóricos y prácticos de mayor impacto en la sociedad moderna desde la ingeniería. En esta edición, dedicada a los 25 años de vida de la UPS, los ejes temáticos estuvieron relacionados con la aplicación de la ciencia, el desarrollo tecnológico y la innovación en cinco pilares fundamentales de nuestra sociedad: la industria, la movilidad, la sostenibilidad ambiental, la información y las telecomunicaciones. El comité científico estuvo conformado formado por 48 investigadores procedentes de diez países: España, Reino Unido, Italia, Bélgica, México, Venezuela, Colombia, Brasil, Estados Unidos y Ecuador. Fueron recibidas un centenar de contribuciones, de las cuales 39 fueron aprobadas en forma de ponencias y 15 en formato poster. Estas contribuciones fueron presentadas de forma oral ante toda la comunidad académica que se dio cita en el Congreso, quienes desde el aula magna, el auditorio y la sala de usos múltiples de la Universidad Politécnica Salesiana, cumplieron respetuosamente la responsabilidad de representar a toda la sociedad en la revisión, aceptación y validación del conocimiento nuevo que fue presentado en cada exposición por los investigadores. Paralelo a las sesiones técnicas, el Congreso contó con espacios de presentación de posters científicos y cinco workshops en temáticas de vanguardia que cautivaron la atención de nuestros docentes y estudiantes. También en el marco del evento se impartieron un total de ocho conferencias magistrales en temas tan actuales como la gestión del conocimiento en la universidad-ecosistema, los retos y oportunidades de la industria 4.0, los avances de la investigación básica y aplicada en mecatrónica para el estudio de robots de nueva generación, la optimización en ingeniería con técnicas multi-objetivo, el desarrollo de las redes avanzadas en Latinoamérica y los mundos, la contaminación del aire debido al tránsito vehicular, el radón y los riesgos que representa este gas radiactivo para la salud humana, entre otros

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research