Whole body interaction

In this workshop we explore the notation of whole body interaction. We bring together different disciplines to create a new research direction for study of this emerging form of interaction

Microquasar models for 3EG J1828+0142 and 3EG J1735-1500

Microquasars are promising candidates to emit high-energy gamma-rays. Moreover, statistical studies show that variable EGRET sources at low galactic latitudes could be associated with the inner spiral arms. The variable nature and the location in the Galaxy of the high-mass microquasars, concentrated in the galactic plane and within 55 degrees from the galactic center, give to these objects the status of likely counterparts of the variable low-latitude EGRET sources. We consider in this work the two most variable EGRET sources at low-latitudes: 3EG J1828+0142 and 3EG J1735-1500, proposing a microquasar model to explain the EGRET data in consistency with the observations at lower energies (from radio frequencies to soft gamma-rays) within the EGRET error box.Comment: (1)Universitat de Barcelona, (2)Instituto Argentino de Radioastronomia (3) Facultad de Ciencias Astronomicas y Geofisicas (4)Lawrence Livermore National Laboratory 6 pages, 2 figures. Presented as a poster at the V Microquasar Workshop, Beijing, June 2004. Accepted for publication in the Chinese Journal of Astronomy & Astrophysic

Parity-dependent State Engineering and Tomography in the ultrastrong coupling regime

Reaching the strong coupling regime of light-matter interaction has led to an impressive development in fundamental quantum physics and applications to quantum information processing. Latests advances in different quantum technologies, like superconducting circuits or semiconductor quantum wells, show that the ultrastrong coupling regime (USC) can also be achieved, where novel physical phenomena and potential computational benefits have been predicted. Nevertheless, the lack of effective decoupling mechanism in this regime has so far hindered control and measurement processes. Here, we propose a method based on parity symmetry conservation that allows for the generation and reconstruction of arbitrary states in the ultrastrong coupling regime of light-matter interactions. Our protocol requires minimal external resources by making use of the coupling between the USC system and an ancillary two-level quantum system.Comment: Improved version. 9 pages, 5 figure

General integral relations for the description of scattering states using the hyperspherical adiabatic basis

In this work we investigate 1+2 reactions within the framework of the hyperspherical adiabatic expansion method. To this aim two integral relations, derived from the Kohn variational principle, are used. A detailed derivation of these relations is shown. The expressions derived are general, not restricted to relative $s$ partial waves, and with applicability in multichannel reactions. The convergence of the ${\cal K}$-matrix in terms of the adiabatic potentials is investigated. Together with a simple model case used as a test for the method, we show results for the collision of a $^4$He atom on a \dimer dimer (only the elastic channel open), and for collisions involving a $^6$Li and two $^4$He atoms (two channels open).Comment: Accepted for publication in Physical Review

Variational description of continuum states in terms of integral relations

Two integral relations derived from the Kohn Variational Principle (KVP) are used for describing scattering states. In usual applications the KVP requires the explicit form of the asymptotic behavior of the scattering wave function. This is not the case when the integral relations are applied since, due to their short range nature, the only condition for the scattering wave function $\Psi$ is that it be the solution of $(H-E)\Psi=0$ in the internal region. Several examples are analyzed for the computation of phase-shifts from bound state type wave functions or, in the case of the scattering of charged particles, it is possible to obtain phase-shifts using free asymptotic conditions. As a final example we discuss the use of the integral relations in the case of the Hyperspherical Adiabatic method.Comment: 34 pages, 7 figures, accepted in Phys. Rev.

Models for gamma-ray production in low-mass microquasars

Unlike high-mass gamma-ray binaries, low-mass microquasars lack external sources of radiation and matter that could produce high-energy emission through interactions with relativistic particles. In this work we consider the synchrotron emission of protons and leptons that populate the jet of a low-mass microquasar. In our model photohadronic and inverse Compton (IC) interactions with synchrotron photons produced by both protons and leptons result in a high-energy tail of the spectrum. We also estimate the contribution from secondary pairs injected through photopair production. The high-energy emission is dominated by radiation of hadronic origin, so we can call these objects proton microquasars.Comment: 4 pages, 2 figures, accepted for publication in the International Journal of Modern Physics D, proceedings of HEPRO meeting, held in Dublin, in September 200

The therapeutic promise of disrupting the PD-1/PD-L1 immune checkpoint in cancer: unleashing the CD8 T cell mediated anti-tumor activity results in significant, unprecedented clinical efficacy in various solid tumors.

The role of immune checkpoints in modulating the magnitude as well as the functional profile of T cell responses is increasingly understood in molecular detail. Antibody-mediated blockade of co-inhibitory receptors has been shown to restore T cell function in both chronic viral infections and cancer. The latter has been successfully translated to new therapeutic options in the treatment of cancer. Indeed, monoclonal antibodies blocking either CTLA-4 or PD-1 have recently been approved for the treatment of metastatic melanoma in the United States, Europe and Japan. In this commentary, we summarize and put into perspective five letters recently published back to back in the November 27 (2014) issue of Nature reporting on different immunological and clinical aspects of blockade of the PD-1/PD-L1 pathway in tumor bearing hosts. Notably, treatment with anti-PD-L1 blocking antibody was shown result in profound clinical responses in patients with several solid tumor including bladder, lung and head and neck carcinomas among others. These five simultaneous publications highlight the tremendous therapeutic potential of targeting the PD-1/PD-L1 immune checkpoint and emphasize the need to identify appropriate biomarkers to guide their optimal clinical application