Lepto-hadronic model for the broadband emission of Cygnus X-1

Cygnus X-1 is a well observed microquasar. Broadband observations at all wavelengths have been collected over the years. The origin of the MeV tail observed with COMPTEL and INTEGRAL is still under debate and it has mostly been attributed to the corona, although its high degree of polarization suggests it is synchrotron radiation from a jet. The origin of the transient emission above $\sim 100$ GeV is also unclear. We aim to disentangle the origin of the broadband spectral energy distribution (SED) of Cygnus X-1, focusing particularly on the gamma-ray emission, and to gain information on the physical conditions inside the jets. We develop and apply a lepto-hadronic, inhomogeneous jet model to the non-thermal SED of Cygnus X-1. We calculate the contributions to the SED of both protons and electrons accelerated in an extended region of the jet. We also estimate the radiation of charged secondaries produced in hadronic interactions, through several radiative processes. Absorption effects are considered. We produce synthetic maps of the jets at radio wavelengths. We find two sets of model parameters that lead to good fits of the SED. One of the models fits all the observations, including the MeV tail. This model also predicts hadronic gamma-ray emission slightly below the current upper limits. The flux predicted at 8.4 GHz is in agreement with the observations available in the literature, although the synthetic source is more compact than the imaged radio jet. Our results show that the MeV emission in Cygnus X-1 may be jet synchrotron radiation. This depends mainly on the strength of the jet magnetic field and the location of the injection region of the relativistic particles. Our calculations show that there must be energetic electrons in the jets quite far from the black hole.Comment: Accepted for publication in A&

Spinal anesthesia in ambulatory patients.

PURPOSE OF THIS REVIEW To assess current practice in the use of spinal anesthesia in major ambulatory surgery, highlighting its advantages over general anesthesia and identifying potential areas for improvement to facilitate a transition to a sustainable healthcare system. RECENT FINDINGS Spinal anesthesia might be preferred in selected populations when compared to general anesthesia providing the highest standards of healthcare quality.The use of local anesthetics with short half-life has proven to be efficient in achieving high anesthesia success rates. Spinal anesthesia does not increase perioperative complications; instead, it has shown a reduction in postoperative nausea and vomiting, an improvement in patient comfort, and a favorable economic impact when compared to general anesthesia. SUMMARY Spinal anesthesia is an appropriate method for anesthesia in ambulatory patients, offering advantages over general anesthesia in selected populations.The use of spinal anesthesia is expanding to meet surgical needs. Therefore, it is crucial to plan ahead and anticipate organizational failures in the ambulatory setting to maintain safety and efficiency during outpatient procedures and surgeries

Cultural Framing and the Impact On Acute Pain and Pain Services.

PURPOSE OF REVIEW Optimal treatment requires a thorough understanding of all factors contributing to pain in the individual patient. In this review, we investigate the influence of cultural frameworks on pain experience and management. RECENT FINDINGS The loosely defined concept of culture in pain management integrates a predisposing set of diverse biological, psychological and social characteristics shared within a group. Cultural and ethnic background strongly influence the perception, manifestation, and management of pain. In addition, cultural, racial and ethnic differences continue to play a major role in the disparate treatment of acute pain. A holistic and culturally sensitive approach is likely to improve pain management outcomes, will better cover the needs of diverse patient populations and help reduce stigma and health disparities. Mainstays include awareness, self-awareness, appropriate communication, and training

Estudio preliminar de la combinación de vitaminas y bisfosfonatos en hueso maxilar de ratas

El balance óseo está mediado por una regulación inmunoendócrina, siendo éste un complejo proceso. Entre las acciones llevadas a cabo para mantener la densidad y estructura del esqueleto son variadas las farmacoterapias utilizadas. Diversos estudios han demostrado que tanto Alendronato, Vitamina D3 y Vitamina E contribuyen a la inhibición de la reabsorción ósea. Objetivo: Estudiar el efecto de la administración combinada de alendronato y vitamina D por vía subcutánea y de vitamina E por vía oral sobre la regeneración ósea. Materiales y métodos: La dosificación fue 0,5 mg/kg de peso corporal de AL, 50 mg/kg de vitamina D y 20 mg/kg de vitamina E. El efecto se evaluó en ratas machos Wistar (n=108), de 90 ± 20 g, divididas en 6 grupos. Se realizó la exodoncia de los primeros molares inferiores. La droga se inyectó en forma subcutánea en tiempos 0, 7, 15 y 30 días post cirugía. Se tomaron radiografías de las mandíbulas, en cada tiempo experimental y se analizaron con el Software Image ProPlus versión 4,1 de Media Cibernetics. Los estudios estadísticos se realizaron a través del análisis de la variancia. Resultados: Los estudios radiográficos demostraron un incremento en la densidad mineral ósea promedio (DMO) conforme avanza el tiempo en los grupos problemas analizados con respecto al control, siendo más evidentes los tratamientos con vitamina D a los 30 días. Conclusiones: Los datos evaluados sirven para mostrar una tendencia, pero son insuficientes como para detectar diferencias significativas al contrastar las drogas, si se observan cambios significativos entre etapas, como era previsible. Se continuará con la investigación para poder obtener resultados que permitan emitir conclusiones que avalen nuestra hipótesis de trabajo.Fil: Moro, Cecilia. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica A; Argentina.Fil: Aguzzi, Alejandra. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica A; Argentina.Fil: Virga, María Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica B; Argentina.Fil: Romero, S. Universidad Nacional de Tucumán. Facultad de Odontología; Argentina.Fil: Basualdo, MM. Universidad Nacional de Tucumán; Argentina.Otras Ciencias Médica

Toxicological assessment of mesoporous silica particles in the nematode Caenorhabditis elegans

[EN] Here we report the toxicological evaluation of mesoporous silica particles (MSPs) in the nematode C. elegans. Specifically, we have investigated the effect of bare micro- (M0) and nano-sized (N0) MSPs, and their corresponding functionalized particles with a starch derivative (Glu-N) (M1 and N1, respectively) on C. elegans ageing parameters. The toxicity of MSPs, their impact on C. elegans lifespan, movement capacity, progeny and ability to survive upon exposure to acute oxidative stress were assessed. This study demonstrated that both size particles assayed (M0 and N0), labeled with rhodamine and monitored through fluorescence microscopy, are ingested by the nematode. Moreover, toxicity assays indicated that bare nano-sized particles (N0) have a negative impact on the C. elegans lifespan, reducing mobility and progeny production. By contrast, micro-sized particles (M0) proved innocuous for the nematodes. Furthermore, functionalization of nanoparticles with starch derivative reduced their toxicity in C. elegans. Thus, oral intake of N1 comparatively increased the mean lifespan and activity rates as well as resistance to oxidative stress. The overall findings presented here demonstrate the influence of MSP size and surface on their potential toxicity in vivo and indicate the silica-based mesoporous particles to be a potential support for encapsulation in oral delivery applications. Furthermore, the good correlation obtained between healthy aging variables and viability (mean lifespan) validates the use of C. elegans as a multicellular organism for nanotoxicology studies of MSPs.The authors wish to express their gratitude to the Spanish Government (MINECO Projects AGL2012-39597-C02-01, AGL2012-39597-C02-02, AGL2015-70235-C2-1, MAT2012-38429-C04-01 and MAT2015-64139-C4-1), the Generalitat Valenciana (Project PROMETEOII/2014/047) and Colombian Administrative Department of Science, Technology and Research which supported Ms. Acosta Scholarship. We would also like to thank the Institut de Ciencia dels Materials (ICMUV), the Microscopy Service of the Universitat Politecnica de Valencia and the microscopy service of IATA for technical support. We thank Roquette for the Glucidex samples.Acosta-Romero, C.; Barat Baviera, JM.; Martínez-Máñez, R.; Sancenón Galarza, F.; Llopis Llopis, S.; Gonzalez, N.; Genovés, S.... (2018). Toxicological assessment of mesoporous silica particles in the nematode Caenorhabditis elegans. Environmental Research. 166:61-70. https://doi.org/10.1016/j.envres.2018.05.018S617016

Apnoeic oxygenation during paediatric tracheal intubation: a systematic review and meta-analysis

Abstract Background Supplemental oxygen administration by apnoeic oxygenation during laryngoscopy for tracheal intubation is intended to prolong safe apnoea time, reduce the risk of hypoxaemia, and increase the success rate of first-attempt tracheal intubation under general anaesthesia. This systematic review examined the efficacy and effectiveness of apnoeic oxygenation during tracheal intubation in children. Methods This systematic review and meta-analysis included randomised controlled trials and non-randomised studies in paediatric patients requiring tracheal intubation, evaluating apnoeic oxygenation by any method compared with patients without apnoeic oxygenation. Searched databases were MEDLINE, Embase, Cochrane Library, CINAHL, ClinicalTrials.gov, International Clinical Trials Registry Platform (ICTRP), Scopus, and Web of Science from inception to March 22, 2023. Data extraction and risk of bias assessment followed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) recommendation. Results After initial selection of 40 708 articles, 15 studies summarising 9802 children were included (10 randomised controlled trials, four pre-post studies, one prospective observational study) published between 1988 and 2023. Eight randomised controlled trials were included for meta-analysis (n=1070 children; 803 from operating theatres, 267 from neonatal intensive care units). Apnoeic oxygenation increased intubation first-pass success with no physiological instability (risk ratio [RR] 1.27, 95% confidence interval [CI] 1.03–1.57, P=0.04, I2=0), higher oxygen saturation during intubation (mean difference 3.6%, 95% CI 0.8–6.5%, P=0.02, I2=63%), and decreased incidence of hypoxaemia (RR 0.24, 95% CI 0.17–0.33, P<0.01, I2=51%) compared with no supplementary oxygen administration. Conclusion This systematic review with meta-analysis confirms that apnoeic oxygenation during tracheal intubation of children significantly increases first-pass intubation success rate. Furthermore, apnoeic oxygenation enables stable physiological conditions by maintaining oxygen saturation within the normal range. Clinical trial registration Protocol registered prospectively on PROSPERO (registration number: CRD42022369000) on December 2, 2022

Personality Factors as Predictors in Burnout Level Changes for Surgical Area Nurses

Surgical area nurses provide comprehensive care to patients throughout the surgical process. Increases in life expectancy lead to the appearance and development of diseases, translating into an increase in the number of necessary interventions. Increases in the workload can be another risk factor for the development of burnout in professionals in this area. Knowledge of psychological and personality-related variables provides relevant information of level changes in the dimensions of burnout syndrome. Three logistic regression models, based on a cross-sectional study with 214 nurses working in the surgical area in the Andalusian Health Service, Spain, were built for each dimension. These models included different variables related to depression and personality, with some being significant at the population level and consequently true risk or protection factors. Friendliness, responsibility and extraversion are protection factors for the personal accomplishment dimension, whilst neuroticism is a risk factor for this dimension. Friendliness is also a protection factor for depersonalization, whilst depression is a risk factor. Finally, neuroticism, responsibility and depression are risk factors for the emotional exhaustion dimension of burnout. These findings provide relevant information that makes anticipation of this syndrome in this group easier

RESILIENCIA Y SU RELACIÓN CON ESTILOS DE VIDA DE LOS ADULTOS MAYORES AUTOVALENTES

Objetivo. Relacionar la capacidad de resiliencia de un grupo de adultos mayores autovalentes de la comuna de Chillán Viejo (Chile) respecto a sus estilos de vida. Material y métodos: Estudio de tipo correlacional y de corte transversal de 176 adultos mayores autovalentes de ambos sexos entre 65 y 85 años de edad asistentes a un centro de salud primaria de la comuna de Chillán Viejo Región del Bío-Bío, Chile. Se aplicó la escala Resiliencia de Wagnild y young adaptada por las autoras del estudio; empleándose la prueba de &#967;2 o la prueba exacta de Fischer, cuando correspondiera, considerándose como significancia estadística p<0,05. Resultados. El 82,4% de los participantes del estudio poseen una alta capacidad de resiliencia. Se observó que la capacidad de resiliencia depende significativamente de la situación de pareja (p=0,002), la mantención de actividad sexual (p=0,008), las actividades recreativas (p=0,015) y el estado de ánimo (p=0,001). Conclusión. Existen características de sus estilos de vida que se relacionan en mayor medida a su nivel de resiliencia, que le permite enfrentar cambios propios del proceso natural de envejecimiento de los adultos mayores

Effect of energy sources on the apparent total tract digestibility and excretion of nutrients by bovine cattle

ABSTRACT Objective. To evaluate the effect of three energy sources on the intake, total apparent digestibility and excretion of nutrients in cattle diet. Materials and methods. Six ruminally cannulated cows (730 ± 70 kg) were distributed into three treatments in a replicated 3x3 Latin square experimental design, where: (I) Control: Low ether extract diet (3.50% EE); (II) Soybean: High ether extract diet (5.30% EE) with inclusion of 15% soybean and (III) Citrus pulp: Low ether extract diet (3.00% EE) and high pectin involvement with inclusion of 15% citrus pulp. To determine the digestibility of DM and its fractions, chromic oxide was used as a marker. Nutrient excretion was calculated from the digestibility coefficient of each fraction. Results. The soybean treatment reduced (p0.05) of the energy source on the digestibility coefficients of DM, CP, NDF, EE, NFE or OM. The TDN value was higher for the soybean treatment. The excretion of DM, NFE and OM was lower (p<0.05) for the soybean treatment. All energy sources influenced the excretion of crude protein. Conclusions. The energy sources used did not affect the digestibility of the diets and are indicated as high potential sources to be used in cattle