125 research outputs found
Acceptability of the transitional wearable companion â+meâ in typical children: a pilot study
This work presents the results of the first experimentation of +me-the first prototype of
Transitional Wearable Companionârun on 15 typically developed (TD) children with ages
between 8 and 34 months. +me is an interactive device that looks like a teddy bear that
can be worn around the neck, has touch sensors, can emit appealing lights and sounds,
and has input-output contingencies that can be regulated with a tablet via Bluetooth.
The participants were engaged in social play activities involving both the device and
an adult experimenter. +me was designed with the objective of exploiting its intrinsic
allure as an attractive toy to stimulate social interactions (e.g., eye contact, turn taking,
imitation, social smiles), an aspect potentially helpful in the therapy of Autism Spectrum
Disorders (ASD) and other Pervasive Developmental Disorders (PDD). The main purpose
of this preliminary study is to evaluate the general acceptability of the toy by TD children,
observing the elicited behaviors in preparation for future experiments involving children
with ASD and other PDD. First observations, based on video recording and scoring,
show that +me stimulates good social engagement in TD children, especially when their
age is higher than 24 months
A Mock Data and Science Challenge for Detecting an Astrophysical Stochastic Gravitational-Wave Background with Advanced LIGO and Advanced Virgo
The purpose of this mock data and science challenge is to prepare the data
analysis and science interpretation for the second generation of
gravitational-wave experiments Advanced LIGO-Virgo in the search for a
stochastic gravitational-wave background signal of astrophysical origin. Here
we present a series of signal and data challenges, with increasing complexity,
whose aim is to test the ability of current data analysis pipelines at
detecting an astrophysically produced gravitational-wave background, test
parameter estimation methods and interpret the results. We introduce the
production of these mock data sets that includes a realistic observing scenario
data set where we account for different sensitivities of the advanced detectors
as they are continuously upgraded toward their design sensitivity. After
analysing these with the standard isotropic cross-correlation pipeline we find
that we are able to recover the injected gravitational-wave background energy
density to within for all of the data sets and present the results
from the parameter estimation. The results from this mock data and science
challenge show that advanced LIGO and Virgo will be ready and able to make a
detection of an astrophysical gravitational-wave background within a few years
of operations of the advanced detectors, given a high enough rate of compact
binary coalescing events
Feasibility and cost analysis of implementing high intensity aphasia clinics within a sub-acute setting
The current study explored the clinical feasibility and costs of embedding three different intensive service delivery models for aphasia treatment (computer, group therapy, and therapy with a speech pathology therapy assistant) within three sub-acute facilities. The study employed a two cohort comparison design, with the first cohort (n = 22) receiving the standard service of treatment currently offered. This treatment was delivered by a speech-language pathologist and involved on average 3 hours of treatment/week over 8 weeks. Participants in the second cohort (n = 31) received one of the three intensive treatment models providing up to 9 hours of therapy/week for 11 weeks. Organizational data was collected throughout treatment, with participant, caregiver, and clinician satisfaction with the intensive models also being measured. Participants completed the spoken language production sub-tests and the Disability Questionnaire of the Comprehensive Aphasia Test (CAT) pre- and post-treatment. All intensive models yielded high participant attendance, satisfaction, and significant improvements to the CAT sub-tests. The pro-rata cost of providing treatment per hour per client for the computer and group therapy models was found to be Ì 30% cheaper compared to the standard service. The outcomes support the potential feasibility of embedding the different models into sub-acute facilities to enhance client access to intensive treatment for aphasia
Optimal combination of signals from co-located gravitational wave interferometers for use in searches for a stochastic background
This article derives an optimal (i.e., unbiased, minimum variance) estimator
for the pseudo-detector strain for a pair of co-located gravitational wave
interferometers (such as the pair of LIGO interferometers at its Hanford
Observatory), allowing for possible instrumental correlations between the two
detectors. The technique is robust and does not involve any assumptions or
approximations regarding the relative strength of gravitational wave signals in
the detector pair with respect to other sources of correlated instrumental or
environmental noise. An expression is given for the effective power spectral
density of the combined noise in the pseudo-detector. This can then be
introduced into the standard optimal Wiener filter used to cross-correlate
detector data streams in order to obtain an optimal estimate of the stochastic
gravitational wave background. In addition, a dual to the optimal estimate of
strain is derived. This dual is constructed to contain no gravitational wave
signature and can thus be used as on "off-source" measurement to test
algorithms used in the "on-source" observation.Comment: 14 pages, 4 figures, submitted to Physical Review D Resubmitted after
editing paper in response to referee comments. Removed appendices A, B and
edited text accordingly. Improved legibility of figures. Corrected several
references. Corrected reference to science run number (S1 vs. S2) in text and
figure caption
Outcomes of Abrupt Switch to Bevacizumab of Patients Undergoing Aflibercept Intravitreal Injections for Neovascular Age-Related Macular Degeneration in a Tertiary Center in Lombardy, Italy: A Real-Life Retrospective Analysis
To assess real-life anatomical and functional outcomes of switch to bevacizumab in patients undergoing aflibercept intravitreal injections for nAMD
Trans-Scleral Plugs Fixated FIL SSF IOL: A Review of the Literature and Comparison with Other Secondary IOL Implants
Purpose. To revise the current literature on FIL SSF (Carlevale) intraocular lens, previously known as Carlevale lens, and to compare their outcomes with those from other secondary IOL implants. Methods. We performed a peer review of the literature regarding FIL SSF IOLs until April 2021 and analyzed the results only of articles with a minimum of 25 cases and a follow-up of at least 6 months. The searches yielded 36 citations, 11 of which were abstracts of meeting presentations that were not included in the analysis because of their limited data. The authors reviewed 25 abstracts and selected six articles of possible clinical relevance to review in full text. Of these, four were considered to be sufficiently clinically relevant. Particularly, we extrapolated data regarding the pre- and postoperative best corrected visual acuities (BCVA) and the complications related to the procedure. The complication rates were then compared with those from a recently published Ophthalmic Technology Assessment by the American Academy of Ophthalmology (AAO) on secondary IOL implants. Results. Four studies with a total of 333 cases were included for results analysis. The BCVA improved in all cases after surgery, as expected. Cystoid macular edema (CME) and increased intraocular pressure were the most common complications, with an incidence of up to 7.4% and 16.5%, respectively. Other IOL types from the AAO report included anterior chamber IOLs, iris fixation IOLs, sutured iris fixation IOLs, sutured scleral fixation IOLs, and sutureless scleral fixation IOLs. There was no statistically significant difference in the rates of postoperative CME (p = 0.20), and vitreous hemorrhage (p = 0.89) between other secondary implants and the FIL SSF IOL, whereas the rate of retinal detachment was significantly less with FIL SSF IOLs (p = 0.04). Conclusion. The results of our study suggest the implantation of FIL SSF IOLs is an effective and safe surgical strategy in cases where there is a lack of capsular support. In fact, their outcomes seem to be comparable to those obtained with the other available secondary IOL implants. According to published literature, the FIL SSF (Carlevale) IOL provides favorable functional results with a low rate of postoperative complications
Response of serum proteome in patients undergoing infrarenal aortic aneurysm repair.
BACKGROUND: Postoperative organ dysfunction in conventional surgery for abdominal aortic aneurysm (AAA) is associated with a complex inflammatory reaction, with activation of coagulation and fibrinolysis. A prospective,observational study was performed to define the complex plasma proteomic changes after AAA repair and to identify factor(s) that may affect myocardial function in uncomplicated procedures. METHODS: Ten patients undergoing infrarenal AAA repair were investigated. Eight subjects subjected to major abdominal surgery served as controls. Hemodynamic changes were continuously monitored by using the pressure recording analytical method technique. The time course of plasma proteins was investigated after induction of anesthesia and at different times after surgery (6 h, 12 h, 24 h, 36 h) by using two-dimensional difference gel electrophoresis, matrix-assisted laser desorption/ionization-time of flight mass spectrometry, and Western blot. The effects of plasma on the functional properties of isolated rat ventricular myocytes were also investigated. RESULTS: In AAA patients alone, 18 spots were found to change more than two-fold in expression level, spot identification revealing an increased thrombin generation 6 h after surgery. At the same time cardiac cycle efficiency significantly reduced versus baseline (-0.5 +/- 0.9 vs. 0.18 +/- 0.3 in AAA patients, P < 0.01; 0.4 +/- 0.1 vs. 0.2 +/- 0.3 in control surgery, not significant; P < 0.01 group x time interaction at ANOVA). Plasma obtained 6 h after AAA surgery dose-dependently inhibited contractile function of control rat myocytes (percent shortening fell by 51% with 10% of AAA plasma and was abolished with 20% of AAA plasma, P < 0.001 for both). The inhibitory response was abolished by thrombin antagonism. CONCLUSIONS: These findings show for the first time the possible role of thrombin generation within the complex activation of inflammatory response in causing hemodynamic instability in the early postoperative period after AAA surger
Zika virus infection among symptomatic patients from two healthcare centers in Sao Paulo State, Brazil: prevalence, clinical characteristics, viral detection in body fluids and serodynamics.
Zika virus (ZIKV) clinical presentation and frequency/duration of shedding need further clarification. Symptomatic ZIKV-infected individuals identified in two hospitals in Sao Paulo State, Brazil, were investigated regarding clinical characteristics, shedding in body fluids, and serodynamics. Ninety-four of 235 symptomatic patients (Site A: 58%; Site B: 16%) had Real-Time PCR-confirmed ZIKV infection; fever, headache and gastrointestinal symptoms were less frequent, and rash was more frequent compared to ZIKV-negative patients. Real-Time PCR in serum had worse performance compared to plasma, while urine had the highest sensitivity. Shedding in genital fluids and saliva was rare. IgM positivity was the highest 28 days (24%); IgG positivity increased >14 days (96%) remaining positive in 94% of patients >28 days. ZIKV prevalence varied importantly in two neighboring cities during the same transmission season. Urine Real-Time PCR can improve diagnostic sensitivity; serum testing is less useful. Accurate serological tests are needed to improve diagnosis and surveillance
Zika virus infection among symptomatic patients from two healthcare centers in Sao Paulo State, Brazil: prevalence, clinical characteristics, viral detection in body fluids and serodynamics
Zika virus (ZIKV) clinical presentation and frequency/duration of shedding need further clarification. Symptomatic ZIKV-infected individuals identified in two hospitals in Sao Paulo State, Brazil, were investigated regarding clinical characteristics, shedding in body fluids, and serodynamics. Ninety-four of 235 symptomatic patients (Site A: 58%; Site B: 16%) had Real-Time PCR-confirmed ZIKV infection; fever, headache and gastrointestinal symptoms were less frequent, and rash was more frequent compared to ZIKV-negative patients. Real-Time PCR in serum had worse performance compared to plasma, while urine had the highest sensitivity. Shedding in genital fluids and saliva was rare. IgM positivity was the highest <14 days after the symptoms onset (86%), decreasing >28 days (24%); IgG positivity increased >14 days (96%) remaining positive in 94% of patients >28 days. ZIKV prevalence varied importantly in two neighboring cities during the same transmission season. Urine Real-Time PCR can improve diagnostic sensitivity; serum testing is less useful. Accurate serological tests are needed to improve diagnosis and surveillance
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