An efficient P-KCCA algorithm for 2D-3D face recognition using SVM

In this paper, a novel face recognition system for face recognition and identification based on a combination of Principal Component Analysis and Kernel Canonical Correlation Analysis (P-KCCA) using Support Vector Machine (SVM) is proposed. First, the P-KCCA method is utilized to detect and extract the important features from the input images. This method makes it possible to match the 2D face image with enrolled 3D face data. The resulting features are then classified using the SVM method. The proposed methods were tested on TEXAS database with 200 subjects. The experimental results in the TEXAS face database produce interesting results from the point of view of recognition success, rate, and robustness of the face recognition algorithm. We compare the performance of our proposed face recognition method to other commonly-used methods. The experimental results show that the combination of P-KCCA method using SVM achieves a higher performance compared to the alone PCA, CCA and KCCA algorithms

miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)

Computational prediction of miRNA candidates for human PINK1. a Computation prediction of miRNAs expressed in human midbrain with putative binding sites in the 3′UTR of human PINK1 mRNA. We first searched miRNAs that have putative binding sites in the 3′UTR of human PINK1 mRNA by utilizing several miRNA-target prediction algorithms, such as miRanda [67], miRWalk [68], RNAhybrid [37], and Targetscan [69]. Among 49 miRNAs commonly predicted by different algorithms, 7 miRNAs were known to be expressed in human midbrain [34]. miR-27a/b are predicted to have 2 putative binding sites in the 3′UTR of human PINK1 mRNA, while all other miRNAs are predicted to have 1 putative binding site. b Computational binding prediction of miR-27a/b and their binding sites in the 3′UTR of human PINK1 mRNA. The binding free energies were determined by the RNAhybrid algorithm. (PDF 68 kb

Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli

Huntington's disease (HD), a genetic neurodegenerative disease caused by a polyglutamine expansion in the Huntingtin (Htt) protein, is accompanied by multiple mitochondrial alterations. Here, we show that mitochondrial fragmentation and cristae alterations characterize cellular models of HD and participate in their increased susceptibility to apoptosis. In HD cells, the increased basal activity of the phosphatase calcineurin dephosphorylates the pro-fission dynamin related protein 1 (Drp1), increasing its mitochondrial translocation and activation, and ultimately leading to fragmentation of the organelle. The fragmented HD mitochondria are characterized by cristae alterations that are aggravated by apoptotic stimulation. A genetic analysis indicates that correction of mitochondrial elongation is not sufficient to rescue the increased cytochrome c release and cell death observed in HD cells. Conversely, the increased apoptosis can be corrected by manoeuvres that prevent fission and cristae remodelling. In conclusion, the cristae remodelling of the fragmented HD mitochondria contributes to their hypersensitivity to apoptosis

Contrast-induced acute kidney injury and its contemporary prevention

The complexity and application range of interventional and diagnostic procedures using contrast media (CM) have recently increased. This allows more patients to undergo procedures that involve CM administration. However, the intrinsic CM toxicity leads to the risk of contrast-induced acute kidney injury (CI-AKI). At present, effective therapy of CI-AKI is rather limited. Effective prevention of CI-AKI therefore becomes crucially important. This review presents an in-depth discussion of CI-AKI incidence, pathogenesis, risk prediction, current preventive strategies, and novel treatment possibilities. The review also discusses the difference between CI-AKI incidence following intraarterial and intravenous CM administration. Factors contributing to the development of CI-AKI are considered in conjunction with the mechanism of acute kidney damage. The need for ultimate risk estimation and the prediction of CI-AKI is stressed. Possibilities of CI-AKI prevention is evaluated within the spectrum of existing preventive measures aimed at reducing kidney injury. In particular, the review discusses intravenous hydration regimes and pre-treatment with statins and N-acetylcysteine. The review further focuses on emerging alternative imaging technologies, alternative intravascular diagnostic and interventional procedures, and new methods for intravenous hydration guidance; it discusses the applicability of those techniques in complex procedures and their feasibility in current practise. We put emphasis on contemporary interventional cardiology imaging methods, with a brief discussion of CI-AKI in non-vascular and non-cardiologic imaging and interventional studies

Preparticipation screening of athletes: The prevalence of positive family history

Sudden cardiac death (SCD) is a leading cause of death among athletes, and those with a positive family history (FH) of SCD and/or cardiovascular disease (CVD) may be at increased risk. The primary objective of this study was to assess the prevalence and predictors of positive FH of SCD and CVD in athletes using four widely used preparticipation screening (PPS) systems. The secondary objective was to compare the functionality of the screening systems. In a cohort of 13,876 athletes, 1.28% had a positive FH in at least one PPS system. Multivariate logistic regression analysis identified the maximum heart rate as significantly associated with positive FH (OR = 1.042, 95% CI = 1.027–1.056, p < 0.001). The highest prevalence of positive FH was found using the PPE-4 system (1.20%), followed by FIFA, AHA, and IOC systems (1.11%, 0.89%, and 0.71%, respectively). In conclusion, the prevalence of positive FH for SCD and CVD in Czech athletes was found to be 1.28%. Furthermore, positive FH was associated with a higher maximum heart rate at the peak of the exercise test. The findings of this study revealed significant differences in detection rates between PPS protocols, so further research is needed to determine the optimal method of FH collection.Web of Science104art. no. 18

Zavádění a příprava na certifikaci systému řízení jakosti podle ISO 3834-2

Import 30/09/2008Prezenční639 - Katedra kontroly a řízení jakostiNeuveden

Opportunities for School Management to Deal with the Decreasing Interest in the Teaching Profession in the Ústí nad Labem Region

Centrum školského managementuPedagogická fakultaFaculty of Educatio

Land units composition of home ranges and changing of winter roosts of long-eared owl <italic>Asio otus</italic>

During the years 2010-2012, we observed the spatial activity of long-eared owls by the radio telemetry in an agricultural land. The average home range size of tracked long-eared owls for 100 and 95% minimum convex polygon (MCP) was 415.93 and 350 ha, respectively. Between the breeding and the non-breeding season, we did not record significant differences in the size of home ranges. Open land units (meadows and arable lands) belonged to the most abundant land units in the home ranges of tracked owls (mean for 100 and 95% MCP was 24.6 and 24.3%, respectively). Forest edges with their ecotone character also represented the abundant land unit (mean for 100 and 95% MCP was 11.4 and 10.6%, respectively). An amount of built-inhabited areas in home ranges (mean for 100 and 95% MCP was 8.2 and 10.1%, respectively) correlated positively with their size (Spearman rank correlation: for 100% MCP: rs = 0.83, p <0.05; for 95% MCP: rs = 0.91, p <0.05) that indicates long-eared owls to be avoiding built-inhabited areas as an area of the food getting. Two individuals of long-eared owl changed the winter roosts during one non-breeding season, which were at a distance of 650 m from each other