Unconventional critical activated scaling of two-dimensional quantum spin-glasses

We study the critical behavior of two-dimensional short-range quantum spin glasses by numerical simulations. Using a parallel tempering algorithm, we calculate the Binder cumulant for the Ising spin glass in a transverse magnetic field with two different short-range bond distributions, the bimodal and the Gaussian ones. Through an exhaustive finite-size scaling analysis, we show that the universality class does not depend on the exact form of the bond distribution but, most important, that the quantum critical behavior is governed by an infinite randomness fixed point.Comment: 6 pages, 6 figure

Determination of oscillator strength of confined excitons in a semiconductor microcavity

We have achieved a significant experimental Rabi-splitting (3.4 meV) for confined polaritons in a planar semiconductor $\lambda$ microcavity for only a single quantum well (SQW) of GaAs (10 nm) placed at the antinode. The Rabi-splitting phenomena are discussed in detail based on the semiclassical theory, where two coupled harmonic oscillators (excitons and photons) are used to describe the system. In this way, we can obtain the dispersion curve of polaritons, the minimum value for the cavity reflectance and the oscillator strength to reach the strong coupling regime. This approach describes an ensemble of excitons confined in a SQW and includes a dissipation component. The results present a weak coupling regime, where an enhanced spontaneous emission takes place, and a strong coupling regime, where Rabi-splitting in the dispersion curve can be observed. The theoretical results are confronted with experimental data for the reflectance behavior in resonant and off-resonant conditions and present a great accuracy. This allows us to determine the oscillator strength of the confined excitons in the SQW with great precision.Comment: 11 pages, 7 figure

Lattice Gauge Fixing for Parameter Dependent Covariant Gauges

We propose a non-perturbative procedure to fix generic covariant gauges on the lattice. Varying the gauge parameter, this gauge fixing provides a concrete method to check numerically the gauge dependence of correlators measured on the lattice. The new algorithm turns out to converge with a good efficiency. As a preliminary physical result, we find a sensitive dependence of the gluon propagator on the gauge parameter.Comment: 10 pages (LaTeX2e), 5 eps figure

Effects of novel prostaglandin analogues on platelet function

Thromboxane A2 (TXA2) is a potent platelet aggregating agent and constrictor of coronary, vascular, and bronchial smooth muscle. This Thesis is concerned with the actions on human platelets of 5 endoperoxide analogues, EP035, EP037, EP043, EP045 and EP092. These analogues show competitive receptor blockade of TXA2 action on smooth muscle: it was of particular interest to determine whether additional modes of action contributed to their anti-aggregatory effects in platelets. The purification of a binding protein from sheep muscle and the development of a protein binding assay for the measurement of platelet cAMP levels are described. EP035 increases platelet cAMP levels markedly; this is thought to be due to a partial agonist effect on the PGI2 receptor of human platelets. EP092 is the only other analogue to raise basal cAMP levels. Although this effect is very weak, it may be sufficient to augment the action of EP092 when high con¬ centrations are used. The development of a GC-MS assay for the measurement of platelet TXB2 levels is described. EP043 was found to inhibit the biosynthesis of TXB2 from arachidonic acid (AA) added exogenously to platelets. EP092 shows a slight inhibitory effect but at ten-fold higher concentra¬ tions. The inhibition of AA metabolism by EP035 is suggested to result from its action to increase platelet cAMP levels. The development of a binding assay for 3H 9,11-epoxymethano PGH2 to whole platelets is described. Total binding appears to be the sum of binding to a non-specific saturable site, uptake of the lipo¬ philic ligand and binding to a stereospecific, saturable site. The specific saturable component of binding can be displaced by TXA

Optimal Path to Epigenetic Switching

We use large deviation methods to calculate rates of noise-induced transitions between states in multistable genetic networks. We analyze a synthetic biochemical circuit, the toggle switch, and compare the results to those obtained from a numerical solution of the master equation.Comment: 5 pages. 2 figures, uses revtex 4. PR-E reviewed for publicatio

Influence of the Ground-State Topology on the Domain-Wall Energy in the Edwards-Anderson +/- J Spin Glass Model

We study the phase stability of the Edwards-Anderson spin-glass model by analyzing the domain-wall energy. For the bimodal distribution of bonds, a topological analysis of the ground state allows us to separate the system into two regions: the backbone and its environment. We find that the distributions of domain-wall energies are very different in these two regions for the three dimensional (3D) case. Although the backbone turns out to have a very high phase stability, the combined effect of these excitations and correlations produces the low global stability displayed by the system as a whole. On the other hand, in two dimensions (2D) we find that the surface of the excitations avoids the backbone. Our results confirm that a narrow connection exists between the phase stability of the system and the internal structure of the ground-state. In addition, for both 3D and 2D we are able to obtain the fractal dimension of the domain wall by direct means.Comment: 4 pages, 3 figures. Accepted for publication in Rapid Communications of Phys. Rev.

Anxiety Associated With Increased Risk for Emergency Department Recidivism in Patients With Low-Risk Chest Pain

Anxiety contributes to the chest pain symptom complex in 30% to 40% of patients with low-risk chest pain seen in the emergency department (ED). The validated Hospital Anxiety Depression Scale-Anxiety subscale (HADS-A) has been used as an anxiety screening tool in this population. The objective was to determine the prevalence of abnormal HADS-A scores in a cohort of low-risk chest pain patients and test the association of HADS-A score with subsequent healthcare utilization and symptom recurrence. In a single-center, prospective, observational cohort study of adult ED subjects with low-risk chest pain, the HADS-A was used to stratify participants into 2 groups: low anxiety (score <8) and high anxiety (score ≥8). At 45-day follow-up, chest pain recurrence was assessed by patient report, whereas ED utilization was assessed through chart review. Of the 167 subjects enrolled, 78 (47%) were stratified to high anxiety. The relative risk for high anxiety being associated with at least one 30-day ED return visit was 2.6 (95% confidence interval 1.4 to 4.7) and this relative risk increased to 9.1 (95% confidence interval 2.18 to 38.6) for 2 or more ED return visits. Occasional chest pain recurrence was reported by more subjects in the high anxiety group, 68% vs 47% (p = 0.029). In conclusion, 47% of low-risk chest pain cohort had abnormal levels of anxiety. These patients were more likely to have occasional recurrence of their chest pain and had an increased risk multiple ED return visits