Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with Alprazolam

Introduction: Allostatic Load (AL) index proposes indicators for the functioningof the main potentially stress-affected systems. Sex differences instress response and stress-related diseases susceptibility have been describedfor the general population. In this observational study we describe the effectsof sex and age on allostatic load variables, in a cohort of patients with generalanxiety disorders and neuroticism treated with alprazolam during 12 weeks,before and after treatment. Methods: Patients with general (DSM IV) anxietydisorders with >6 in Hamilton scale, Allostatic load (>1 Crimmins and SeemanAL modified criteria) and neuroticism >18 (NEO-FFI inventory), wereincluded. All patients completed psychiatric assessment, allostatic load indexdetermination before (−1 week) and after 12 weeks of treatment with alprazolam(0.25 - 1 mg/t.i.d). Allostatic load parameters comprised cardiovascular,metabolic and inflammatory variables. Univariate analysis (two-wayANOVA), Student?s t-test (related variables) and Pearson correlations weredetermined. Results: Fifty-four patients, 35 females (48.6 ± 11.7 years) and 19males (44.2 ± 12.8 years) with general anxiety disorder were included; 28 patientswith <50 years (60.7% females), and 26 with ≥50 years (69.2% females).Younger patients (<50 years) (two-way ANOVA, p = 0.02) were significantlyassociated with lower allostatic load index after treatment. However, womenshowed higher anxiety levels in both, before (Two-way ANOVA, p = 0.059)and after treatment (two-way ANOVA, p = 0.005), with a significantly betterprofile than men in many individual AL variables, particularly cardiovascular(systolic blood pressure), obesity (body mass index), and lipids (higher HDLlevels). After treatment a higher reduction of fibrinogen levels was found inmen (two-way ANOVA, p = 0.02). Conclusions: In this preliminary analysiswe described sex and age differences in psychiatry aspects and allostatic loadindexes in patients with general anxiety disorders in the short-term treatmentwith alprazolam. These considerations remark the need of pondering sex andage differences during the use of drugs for protracted periods.Fil: D`Alessio, Luciana. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Soria, Carlos A.. Henri Laborit Institute Of Biosciences; ArgentinaFil: Remedi, Carolina. Henri Laborit Institute Of Biosciences; Argentina; ArgentinaFil: Roldán, Emilio J. A.. Instituto de Neurobiología IDNEU; Argentin

Rigidity analysis of protein structures and rapid simulations of protein motion

It is a common goal in biophysics to understand protein structural properties and their relationship to protein function. I investigated protein structural properties using three coarse graining methods: a rigidity analysis method First, a geometric simulation method Froda and normal mode analysis as implemented in Elnemo to identify the protein directions of motion. Furthermore, I also compared the results between the coarse graining methods with the results from molecular dynamics and from experiments that I carried out. The results from the rigidity analysis across a set of protein families presented in chapter 3 highlighted two different patterns of protein rigidity loss, i.e. "sudden" and "gradual". It was found that theses characteristic patterns were in line with the rigidity distribution of glassy networks. The simulations of protein motion by merging flexibility, rigidity and normal mode analyses presented in chapter 4 were able to identify large conformational changes of proteins using minimal computational resources. I investigated the use of RMSD as a measure to characterise protein motion and showed that, despite it is a good measure to identify structural differences when comparing the same protein, the use of extensive RMSD better captures the extend of motion of a protein structure. The in-depth investigation of yeast PDI mobility presented in chapter 5 confirmed former experimental results that predicted a large conformational change for this enzyme. Furthermore, the results predicted: a characteristic rigidity distribution for yeast PDI, a minimum and a maximum active site distance and a relationship between the energy cutoff, i.e. the number of hydrogen bonds part of the network of bonds, and protein mobility. The results obtained were tested against molecular dynamics simulations in chapter 6. The MD simulation also showed a large conformational change for yeast PDI but with a slightly different minimum and maximum inter-cysteine distance. Furthermore, MD was able to reveal new data, i.e. the most likely inter-cysteine distance. In order to test the accuracy of the coarse graining and MD simulations I carried out cross-linking experiments to test the minimum inter-cysteine distance predictions. The results presented in chapter 7 show that human PDI minimum distance is below 12Å whereas the yeast PDI minimum distance must be above 12Å as no cross-linking structures where found with the available (12Å long) cross-linkers

Proceso de Desarrollo de Productos (PDP). Desarrollo de guía para la elaboración de nuevos productos y servicios en el Instituto de Capacitación e Investigación del Plástico y del Caucho (ICIPC)

El presente proyecto surge como una necesidad del ICIPC debido al crecimiento sostenido en los últimos años en su portafolio de servicios ofrecidos a las empresas del sector de plásticos, caucho y afines en Colombia y países vecinos -- El ICIPC atiende aproximadamente 250 empresas al año con los diferentes servicios de su portafolio -- Hoy en día el ICIPC reconoce que la gestión de la experiencia adquirida y las mejores prácticas aplicadas durante el desarrollo de nuevos productos, es algo que debe ser sistémico y unificado en la institución para ser eficientes y eficaces. -- La atención a este gran número de empresas requiere la implementación de una metodología sistémica, unificada y estructurada para el Proceso de Desarrollo de Productos –PDP– (Product Development Process) -- Desde el comienzo de operaciones del ICIPC, sus investigadores han sabido aplicar su conocimiento y experiencia en la realización de proyectos de desarrollo de productos y servicios con alto valor agregado, particularmente, y con mayor éxito, los proyectos liderados por aquellos investigadores de mayor experiencia -- Pero también ha habido proyectos donde se han presentado dificultades de planeación y ejecución, y retos para captar y estandarizar las mejores prácticas -- Esta situación pone en evidencia la necesidad de implementar una metodología estructurada para el proceso de desarrollo de productos -- Por esta razón, con el presente trabajo se ha adaptado en el ICIPC un PDP enmarcado en un contexto de gestión de riesgo de desarrollo, dividiendo estratégicamente el proceso de diseño en etapas, con actividades mandatorias y opcionales según el tipo de producto y el nivel de complejidad asociado -- Las etapas a su vez, son separadas por compuertas en las que se revisan y examinan los entregables o resultados de la etapa -- En las compuertas se evalúa el nivel de riesgo y se decide sobre la manera de continuar el proceso de desarrollo -- Este trabajo se realizó en el marco del plan de fortalecimiento institucional ICIPC, bajo el proyecto: Fortalecimiento técnico-administrativo del ICIPC a través de: la creación e implementación de una metodología PDP ("Product Development Process") ajustada a las necesidades de la institución, y la creación de nuevos servicios de resistencia al impacto para nuevos materiales poliméricos [1]. Este proyecto contó con el apoyo del recurso financiero de Colciencias “Patrimonio autónomo fondo nacional de financiamiento para la ciencia, la tecnología y la innovación, Francisco José de Caldas” -- Con base en la nueva filosofía PDP, se han desarrollado productos nuevos y mejoras a existentes para clientes del ICIPC, y se han implementado en el ICIPC nuevos servicios de evaluación de resistencia al impacto en materiales poliméricos que permiten atender la necesidad de empresas del sector -- El informe final de desarrollo e implementación del nuevo servicio de laboratorio, y su procedimiento de realización, ha sido entregado a Colciencias [1] junto con la presente Guía PDP -- El presente documento es dicha Guía PDP –el segundo objetivo del proyecto de fortalecimiento Colciencias– que a su vez, se presenta a la Universidad EAFIT como el trabajo de grado del autor para optar al título de Máster en Ingeniería Aplicad

El fraude en la ciencia: reflexiones a partir del caso Hwang

In 2006 Hwang's fraudulent papers published in Science on stem cell research re-opened the debate on scientific misconduct. Taking this as a starting point, some reflections are put forward on the dimension of fraud in science. The singularity of Hwang's case, due to its scientific, social and media impact, is examined as a consequence of the persuasion mechanisms systematised in the so-called Routes of Scholarly Lying. Furthermore, the reasons for publishing fraudulent research, the inefficiency of peer review for detecting it, and the various mechanisms for managing and eradicating it, are presented

Deficit sustainability and fiscal theory of price level: the case of Italy, 1861–2020

We test sustainability of the Italian government deficit over the period 1861–2020 using the fiscal theory of the price level (FTPL). This approach takes into account monetary and fiscal policy interactions and assumes that fiscal policy may determine the price level even if monetary authorities pursue an inflation-targeting strategy. We consider a cointegrated model with multiple structural changes to characterize the sustainability of public finances and the prevalence of monetary or fiscal dominance during subperiods. We also use recursive unit root tests for explosiveness to test fiscal sustainability and to detect episodes of potential explosive behaviour in Italian public debt. We find two structural changes for the public debt and one change in the primary budget surplus, the alternation of monetary and fiscal dominant regimes, as well as evidence of bubbles related to three episodes of the Italian fiscal performance. Our results reveal the sensitiveness of the primary balance and the debt paths to shocks hitting fiscal, macroeconomic, and financial variables.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. The Project is funded by Ministerio de Ciencia e Innovación, Grant No. PID2020-114646RB-C42, Ministerio de Ciencia e Innovación Grant no. PID2020-115183RB-C22, and EPIT SEJ-487

All-pass-filter-based active damping for VSCs with LCL filters connected to weak grids

LCL filters are commonly used to connect Voltage Sourced Converters (VSCs) to the grid. This type of filter is cheaper than a single inductor for the same current THD, but it generates resonance problems if no active or passive damping method is applied. Active damping methods are becoming popular in the literature because they improve efficiency, but they are sometimes difficult to implement and additional measurements are required. This paper proposes an active damping method for VSCs connected to weak grids that is based on making zero the open-loop phase at the resonance frequency. It will be shown that this strategy provides adequate damping of oscillations and that it can be achieved in two different ways: at the design stage (if the design constraints make it possible) or with an all-pass filter in series with the current controller. Two methods to design the all-pass filter are proposed. Also, the proposed active damping technique is compared with three alternatives already proposed in the literature. All the control algorithms are verified by simulation and in a 15 kW prototype of a three-phase VSC connected to a configurable weak grid via a LCL filter

Semantic and Phonemic Verbal Fluency Performance in Patients with General Anxiety Disorders and Allostatic Load under Alprazolam Treatment

Purpose: Anxiety disorders are frequently associated with chronic stress with possible cognitive consequences. The aim of this study was to determine the verbal fluency performance in a cohort of patients with anxiety disorders and allostatic load, treated with alprazolam during 12 weeks. Methods: Patients with GAD (general anxiety disorders, DSM IV), with >6 in Hamilton Anxiety Rating Scale (HAM-A), neuroticism > 18 (NEO-FFI inventory), and normal Mini-Mental State Examination were included. Clinical and Psychiatric examination, Allostatic Load Index and cognitive assessment were analyzed before and after 12 weeks of treatment. The phonemic and semantic verbal fluency tests were determined in all patients. The scoring for each fluency task was determined by counting the number of correct words. The total score from each semantic and phonemic verbal task was analyzed comparing the individual score with normal data controlled by age and sex. Patients with scores > −2 standard deviation (SD) from normative data were considered impaired. Results: Fifty-four patients completed the semantic verbal fluency test before treatment and fifty patients completed after treatment. According to the z-scores before treatment 7 patients of 54 (12.9%) had verbal fluency impairments. After treatment none patients showed semantic verbal fluency deficits but 3 patients of 50 (6%) showed phonemic impairments. Impaired group was significantly associated with an older age before treatment (p = 0.033) and with a similar tendency but not significant (p = 0.09) after treatment (Student t test). Conclusion: In this study older age factor was associated with verbal fluency impairment in GAD patients. Stratified treatments.Fil: Soria, Carlos Alberto. Institute of Biosciences Henri Laborit; ArgentinaFil: Remedi, Carolina. Institute of Biosciences Henri Laborit; ArgentinaFil: D`alessio, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Roldán, Emilio J. A.. Dirección Científica Gador S. A.; Argentin

Deficit sustainability and the Fiscal Theory of the Price Level: the case of Italy, 1861-2020

47 p.We address a test for sustainability of the Italian government deficit over the period 1861-2020, using the fiscal theory of the price level (FTPL). This approach takes into account monetary and fiscal policy interactions and assumes that fiscal policy may determine the price level, even if monetary authorities pursue an inflation targeting strategy. We use a cointegrated model with multiple structural changes to characterize the sustainability of public finances and the prevalence of monetary versus fiscal dominance for sub-periods. We also use the recursive unit root tests for explosiveness to test fiscal sustainability and to detect episodes of potential explosive behavior in Italian public debt

Toward Reliable Compact Modeling of Multilevel 1T-1R RRAM Devices for Neuromorphic Systems

The authors would like to thank the financial support by Deutsche Forschungsgemeinschaft (German Research Foundation) with Project-ID SFB1461 and by the Federal Ministry of Education and Research of Germany under grant numbers 16ES1002, 16FMD01K, 16FMD02 and 16FMD03. The authors also gratefully acknowledge the support of the Spanish Ministry of Science, Innovation and Universities and the FEDER program through project TEC2017-84321-C4-3-R and project A.TIC.117.UGR18 funded by the government of Andalusia (Spain) and the FEDER program. The publication of this article was funded by the Open Access Fund of the Leibniz Association.The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.In this work, three different RRAM compact models implemented in Verilog-A are analyzed and evaluated in order to reproduce the multilevel approach based on the switching capability of experimental devices. These models are integrated in 1T-1R cells to control their analog behavior by means of the compliance current imposed by the NMOS select transistor. Four different resistance levels are simulated and assessed with experimental verification to account for their multilevel capability. Further, an Artificial Neural Network study is carried out to evaluate in a real scenario the viability of the multilevel approach under study.German Research Foundation (DFG) SFB1461Federal Ministry of Education & Research (BMBF) 16ES1002 16FMD01K 16FMD02 16FMD03Spanish Ministry of Science, Innovation and UniversitiesEuropean Commission TEC2017-84321-C4-3-Rgovernment of Andalusia (Spain) A.TIC.117.UGR18Leibniz Associatio