1,771 research outputs found
Ti‑based robust MOFs in the combined photocatalytic degradation of emerging organic contaminants
Photocatalysis process is a promising technology for environmental remediation. In the continuous
search of new heterogeneous photocatalysts, metal–organic frameworks (MOFs) have recently
emerged as a new type of photoactive materials for water remediation. Particularly, titaniumbased
MOFs (Ti-MOFs) are considered one of the most appealing subclass of MOFs due to their
promising optoelectronic and photocatalytic properties, high chemical stability, and unique structural
features. However, considering the limited information of the reported studies, it is a hard task to
determine if real-world water treatment is attainable using Ti-MOF photocatalysts. In this paper,
via a screening with several Ti-MOFs, we originally selected and described the potential of a Ti-MOF
in the photodegradation of a mixture of relevant Emerging Organic Contaminants (EOCs) in real
water. Initially, two challenging drugs (i.e., the β-blocker atenolol (At) and the veterinary antibiotic
sulfamethazine (SMT)) and four water stable and photoactive Ti-MOF structures have been rationally
selected. From this initial screening, the mesoporous Ti-trimesate MIL-100(Ti) was chosen as the
most promising photocatalyst, with higher At or SMT individual photodegradation (100% of At and
SMT photodegradation in 2 and 4 h, respectively). Importantly, the safety of the formed by-products
from the At and SMT photodegradation was confirmed. Finally, the At and SMT photodegradation
capacity of MIL-100(Ti) was confirmed under realistic conditions, by using a mixture of contaminants
in tap drinking water (100% of At and SMT photodegradation in 4 h), proven in addition its potential
recyclability, which reinforces the potential of MIL-100(Ti) in water remediation.Regional Madrid 2017-T2/IND-5149Juan de la Cierva incorporation JC2019-038894-I
MCIN/AEI RED2018-102471-TLa Caixa Foundation 100010434
LCF/BQ/PR20/ 11770014Center for Forestry Research & Experimentation (CIEF)European Commission SEJIGENT/2021/059
PROMETEU/2021/054
PID2019-104228RB-I00
PID2020-118117RB-I00
RTC2019-007254-
Pushing the Limits on the Intestinal Crossing of Metal−Organic Frameworks: An Ex Vivo and In Vivo Detailed Study
Biocompatible nanoscaled metal−organic frameworks
(nanoMOFs) have been widely studied as drug delivery systems
(DDSs), through different administration routes, with rare examples in
the convenient and commonly used oral administration. So far, the
main objective of nanoMOFs as oral DDSs was to increase the
bioavailability of the cargo, without considering the MOF intestinal
crossing with potential advantages (e.g., increasing drug availability,
direct transport to systemic circulation). Thus, we propose to address
the direct quantification and visualization of MOFs’ intestinal bypass.
For that purpose, we select the microporous Fe-based nanoMOF, MIL-
127, exhibiting interesting properties as a nanocarrier (great
biocompatibility, large porosity accessible to different drugs, green
and multigram scale synthesis, outstanding stability along the
gastrointestinal tract). Additionally, the outer surface of MIL-127
was engineered with the biopolymer chitosan (CS@MIL-127) to improve the nanoMOF intestinal permeation. The
biocompatibility and intestinal crossing of nanoMOFs is confirmed using a simple and relevant in vivo model, Caenorhabditis
elegans; these worms are able to ingest enormous amounts of nanoMOFs (up to 35 g per kg of body weight). Finally, an ex vivo
intestinal model (rat) is used to further support the nanoMOFs’ bypass across the intestinal barrier, demonstrating a fast
crossing (only 2 h). To the best of our knowledge, this report on the intestinal crossing of intact nanoMOFs sheds light on the
safe and efficient application of MOFs as oral DDSs.Ramon Areces Foundation project H+MOFsM-ERA-NET CMOF.cell project - MCIN/AEI PCI2020-111998European Union NextGenerationEU/PRTR)Comunidad de MadridEuropean Regional Development Fund-FEDER 2014-2020-OE REACT-UE 1MCIN/AEI/FEDER "Una manera de hacer Europa" RTI2018-096273-B-I00
MCIN/AEI PID2019-104228RB-I00
PID2020-112848RB-C21Generalitat de Catalunya 2017SGR765"Severo Ochoa" Programme for Centres of Excellence in RD SEV-2015-0496
CEX2019-000917-SRegional Madrid funding 2017-T2/IND-5149Juan de la Cierva incorporation JC2019-038894-IEuropean Union NextGenerationEU/PRTR, Multifunctional Metallodrugs in Diagnosis and Therapy Network (MICIU) RED2018-102471-
Influential factors in motivation and learning strategies in grade students
Analizando los diferentes procesos mentales que se dan durante el aprendizaje desde diferentes paradigmas, donde el docente pasa de ser el protagonista y responsable del aprendizaje del alumno a ser quien planifica la enseñanza y la organiza para que sus alumnos realicen un aprendizaje significativo. En el aprendizaje autorregulado los aprendices son los que eligen y deciden sobre su conducta, siendo los artífices y promotores de sus aprendizajes. A través de este estudio sobre una muestra de estudiantes universitarios, utilizando el instrumento CEAM II (Cuestionario de Estrategias de Aprendizaje y Motivación), formado por preguntas sobre la motivación y las estrategias de aprendizaje pretendemos conocer la implicaciones de las diferentes dimensiones que lo forman. El análisis de las diferentes variables nos lleva a conocer qué valores son los más empleados por los estudiantes dentro de los factores de motivación (metas intrínsecas, valor de la tarea y autoeficacia) y de las estrategias de aprendizaje (elaboración, organización y metacognición), así como aquellos ítems más y menos valorados por los mismos. Los docentes debemos trasmitir a los estudiantes los contenidos de las diferentes asignaturas a través de una metodología que les resulte atractiva, así les facilitaremos la adquisición de los mismosAnalyzing the different mental processes that occur during learning from different paradigms, where the teacher happens to be the protagonist and responsible for student learning to be who plans and organizes teaching for their students make significant learning. It should motivate, highlighting the importance of the matter and its implications for acredentar interest in it. Self-regulated learning learners are those who choose and decide on their conduct, being the architects and promoters of their learning.. Through this study on a sample of university students using the CEAM II (Learning Strategies Questionnaire and Motivation) instrument, consisting of questions about motivation and learning strategies we tried to understand the implications of different dimensions that form. The analysis of the different variables leads us to know which values are the most used by students in motivational factors (intrinsic goals, task value and self-efficacy) and learning strategies (preparation, organization and metacognition) as well as those items most and least valued by them. Teachers must convey to students the contents of different subjects through a methodology that is attractive to them, so we will provide the acquisition thereo
Renal lithiasis in children
Justification and objective: Renal lithiasis is due to the precipitation of crystals due to an imbalance in the urine between promoting substances and inhibitory substances. It is a pathology with a prevalence between 2–10% in the pediatric population, with an incidence that has increased in the last 25 years; for this reason this study aims to know the prevalence, clinical and metabolic manifestations of renal lithiasis in the pediatric population of the National Children's Hospital of Costa Rica. Methods: Tthis is a retrospective, descriptive and observational study, through the review of records of patients under 18 years of age with the diagnosis of renal lithiasis, attended at the National Children's Hospital, in the period from January 2000 to 2018. Results: A total of 106 patients were included. The average age at diagnosis was 6.6 ± 3.8 years; the frequency of cases has increased 5.5 times in the last 5 years. Risk factors detected: urinary tract abnormalities 22.6% and family history of lithiasis 17.9%. Metabolic analysis showed low urine output in 74.3%, hyperphosphaturia in 43.2%, hypomagnesuria 39.2% and hypercalciuria 37.8%. Etiologies determined: metabolic 54.7%, urinary tract malformations 16% and idiopathic in 30.9%. Intracorporeal lithotripsy was applied in 61.2%. Recurrence was observed in 28.5% of cases, and a relationship was found between the incidence of recurrence and the size of the lithotripsy (p = 0.001) and surgical treatment (p = 0.010). Conclusions: There is an increase in the frequency of cases of pediatric lithiasis with a multifactorial etiology at the National Children's Hospital of Costa Rica
Review of the ship accidents investigations presented at the STAB
The safety of seafarers and passengers and the protection of the marine environment can be enhanced by timely and accurate reports identifying the circumstances and causes of marine casualties and incidents. These reports can lead to greater awareness of casualty causation and result in remedial measures for the purpose of enhancing safety of life at sea and protection of the marine environment. This “review paper” collects several contributions presented through the years in different STAB events
Suicidal Risk and Depression in Pregnant Women in Times of Pandemic
PurposePregnancy is a risk period for the development of mental disorders. About 10% of pregnant women worldwide experience a mental disorder, mainly depression, and this percentage has been aggravated by the COVID-19 pandemic. This study aims to understand the impact of COVID-19 on the mental health of pregnant women.MethodsThree hundred and one pregnant women in the week 21.85 +/- 9.9 were recruited through social media and pregnant women forums from September 2020 to December 2020. A multiple-choice questionnaire was administered to evaluate the sociodemographic characteristics of the women, the care provided, and different aspects related to COVID-19. A Beck Depression Inventory was also delivered.ResultsOf the pregnant women 23.5% had seen or had considered seeing a mental health professional during pregnancy. Predictive models using multivariate logistic regression found that this fact was associated with an increased risk of depression (OR = 4.22; CI 95% 2.39-7.52; P < 0.001). Among women with moderate-severe depression, it was associated with an increased risk of having suicidal thoughts (OR = 4.99; CI 95% 1.11-27.9; P = 0.044) and age was found to be a protective variable (OR = 0.86; CI 95% 0.72-0.98; P = 0.053).ConclusionsThe COVID-19 pandemic represents a major mental health challenge for pregnant women. Despite the decrease in face-to-face visits, there are opportunities for health professionals to identify the existence of psycho-pathological alterations and suicidal ideation by asking the patient if she is seeing or considering seeing a mental health professional. Therefore, it is necessary to develop tools for early identification to ensure correct detection and care.
SignificanceAmong women with moderate-severe depression, considered seeing a mental health professional during pregnancy was associated with an increased risk of having suicidal thoughts and age was found to be a protective variable. Despite the decrease in face-to-face visits during COVID-19 pandemic, there are opportunities for health professionals to identify the existence of psycho-pathological alterations and suicidal ideation by asking the patient if she is seeing or considering seeing a mental health professional. Asking about their intention to seek specialized assistance can help to identify those women at risk of suffering affective disorders such as depression and suicidal ideation and to individually plan future medical visits.Universidad de Granada/
CBU
SegNeRF: 3D Part Segmentation with Neural Radiance Fields
Recent advances in Neural Radiance Fields (NeRF) boast impressive
performances for generative tasks such as novel view synthesis and 3D
reconstruction. Methods based on neural radiance fields are able to represent
the 3D world implicitly by relying exclusively on posed images. Yet, they have
seldom been explored in the realm of discriminative tasks such as 3D part
segmentation. In this work, we attempt to bridge that gap by proposing SegNeRF:
a neural field representation that integrates a semantic field along with the
usual radiance field. SegNeRF inherits from previous works the ability to
perform novel view synthesis and 3D reconstruction, and enables 3D part
segmentation from a few images. Our extensive experiments on PartNet show that
SegNeRF is capable of simultaneously predicting geometry, appearance, and
semantic information from posed images, even for unseen objects. The predicted
semantic fields allow SegNeRF to achieve an average mIoU of \textbf{30.30%}
for 2D novel view segmentation, and \textbf{37.46%} for 3D part segmentation,
boasting competitive performance against point-based methods by using only a
few posed images. Additionally, SegNeRF is able to generate an explicit 3D
model from a single image of an object taken in the wild, with its
corresponding part segmentation.Comment: Fixed abstract typ
Coup-TFII expression defines two different septum transversum cell compartments crucial to cardiac septation and compact ventricular wall growth
COUP-TFII encodes for an orphan nuclear receptor expressed by multiple embryonic tissues. COUP-TFII functions include the regulation of mesodermal progenitor differentiation and cell fate specification, and is required for completion of cardiovascular development as shown by the early death (E9.5) of COUP-TFII-null mice. In this study, we show that COUP-TFII, which is strongly expressed in the atrial myocardium, is also expressed in two different compartments of the septum transversum (ST, E9.5), a mesodermal folding adjacent to cardiac inflow myocardium. The first ST compartment is COUP-TFII+/Isl1+; cells in this compartment concentrate in the posterior part of the ST, overlap with SHF, and are continuous with the dorsal mesenchymal protrusion (DMP, also known as spina vestibuli). The second compartment is characteristically COUP-TFII+/Isl1-, and comprises the majority of proepicardial cells. To dissect the role of COUP-TFII+ ST cells in cardiac development, we conditionally deleted COUP-TFII in the ST using two different Cre constructs (Wt1Cre; G2-Gata4Cre). We show that COUP-TFII deletion in the ST is most severe in G2-Gata4Cre;COUP-TFII-/- mice, containing various cardiovascular progenitor lineages. Mutant mice display atrial septation and atrioventricular septal defects as well as a severe disruption of compact ventricular myocardial growth and coronary vascularization. We conclude that COUP-TFII plays critical, pleiotropic, tissue-dependent roles during cardiac septation, growth and vascularization.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII
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