800 research outputs found
Evaluation of wind tunnel performance testings of an advanced 45 deg swept 8-bladed propeller at Mach numbers from 0.45 to 0.85
The increased emphasis of fuel conservation in the world and the rapid increase in the cost of jet fuel has stimulated a series of studies of both conventional and unconventional propulsion systems for commercial aircraft. The results of these studies indicate that a fuel saving of 15 to 30 percent may be realized by the use of an advanced high-speed turboprop (Prop-Fan) compared to aircraft equipped with high bypass turbofan engines of equivalent technology. The Prop-Fan propulsion system is being investigated as part of the NASA Aircraft Energy Efficient Program. This effort includes the wind tunnel testing of a series of 8 and 10-blade Prop-Fan models incorporate swept blades. Test results indicate efficiency levels near the goal of 80 percent at Mach 0.8 cruise and an altitude of 10.67 km (35,000 ft). Each successive swept model has shown improved efficiency relative to the straight blade model. The fourth model, with 45 deg swept blades reported herein, shows a net efficiency of 78.2 at the design point with a power loading of 301 kW/sq meter and a tip speed of 243.8 m/sec (800 ft/sec.)
Conditional Image-Text Embedding Networks
This paper presents an approach for grounding phrases in images which jointly
learns multiple text-conditioned embeddings in a single end-to-end model. In
order to differentiate text phrases into semantically distinct subspaces, we
propose a concept weight branch that automatically assigns phrases to
embeddings, whereas prior works predefine such assignments. Our proposed
solution simplifies the representation requirements for individual embeddings
and allows the underrepresented concepts to take advantage of the shared
representations before feeding them into concept-specific layers. Comprehensive
experiments verify the effectiveness of our approach across three phrase
grounding datasets, Flickr30K Entities, ReferIt Game, and Visual Genome, where
we obtain a (resp.) 4%, 3%, and 4% improvement in grounding performance over a
strong region-phrase embedding baseline.Comment: ECCV 2018 accepted pape
The exit velocity of a compressed air cannon
The use of compressed air cannons in an undergraduate lab provides a way to
illustrate the cooperation of diverse physics concepts, such as conservation of
momentum, the work-kinetic energy theorem, expansion of gas, air drag, and
elementary Newtonian mechanics. However, recent proposals have disagreed as to
whether the expansion of the gas in the cannon should be modeled as an
adiabatic or an isothermal process. We built an air cannon that utilized a
diaphragm valve to release our pressurized gas and found that neither model
accurately predicted the exit velocity of our projectile. We present a new
model, based on the flow of air through the valve, that is in much better
agreement with our data
Chimeric carrier proteins for targeted delivery of tumor antigens to professional antigen presenting cells
An optically actuated surface scanning probe
We demonstrate the use of an extended, optically trapped probe that is capable of imaging surface topography with nanometre precision, whilst applying ultra-low, femto-Newton sized forces. This degree of precision and sensitivity is acquired through three distinct strategies. First, the probe itself is shaped in such a way as to soften the trap along the sensing axis and stiffen it in transverse directions. Next, these characteristics are enhanced by selectively position clamping independent motions of the probe. Finally, force clamping is used to refine the surface contact response. Detailed analyses are presented for each of these mechanisms. To test our sensor, we scan it laterally over a calibration sample consisting of a series of graduated steps, and demonstrate a height resolution of ∼ 11 nm. Using equipartition theory, we estimate that an average force of only ∼ 140 fN is exerted on the sample during the scan, making this technique ideal for the investigation of delicate biological samples
Ondansetron does not reduce the shivering threshold in healthy volunteers
Background. Ondansetron, a serotonin-3 receptor antagonist, reduces postoperative shivering. Drugs that reduce shivering usually impair central thermoregulatory control, and may thus be useful for preventing shivering during induction of therapeutic hypothermia. We determined, therefore, whether ondansetron reduces the major autonomic thermoregulatory response thresholds (triggering core temperatures) in humans. Methods. Control (placebo) and ondansetron infusions at the target plasma concentration of 250 ng ml−1 were studied in healthy volunteers on two different days. Each day, skin and core temperatures were increased to provoke sweating; then reduced to elicit peripheral vasoconstriction and shivering. We determined the core-temperature sweating, vasoconstriction and shivering thresholds after compensating for changes in mean-skin temperature. Data were analysed using t-tests and presented as means (sds); P<0.05 was taken as significant. Results. Ondensetron plasma concentrations were 278 (57), 234 (55) and 243 (58) ng ml−1 at the sweating, vasoconstriction and shivering thresholds, respectively; these corresponded to ≈50 mg of ondansetron which is approximately 10 times the dose used for postoperative nausea and vomiting. Ondansetron did not change the sweating (control 37.4 (0.4)°C, ondansetron 37.6 (0.3)°C, P=0.16), vasoconstriction (37.0 (0.5)°C vs 37.1 (0.3)°C; P=0.70), or shivering threshold (36.3 (0.5)°C vs 36.3 (0.6)°C; P=0.76). No sedation was observed on either study day. Conclusions. Ondansetron appears to have little potential for facilitating induction of therapeutic hypothermi
Minimally invasive application of botulinum toxin A in patients with idiopathic rhinitis
<p>Abstract</p> <p>Background</p> <p>Nasal hypersecretion due to idiopathic rhinitis can often not be treated sufficiently by conventional medication. Botulinum toxin A (BTA) has been injected into the nasal mucosa in patients with nasal hypersecretion with a reduction of rhinorrhea lasting for about 4 to 8 weeks. Since the nasal mucosa is well supplied with glands and vessels, the aim of this study was to find out if the distribution of BTA in the nasal mucosa and a reduction of nasal hypersecretion can also be reached by a minimally invasive application by sponges without an injection.</p> <p>Methods</p> <p>Patients were randomly divided into two groups. The effect of BTA (group A, C, D) or saline as placebo (group B) was investigated in 20 patients with idiopathic rhinitis by applying it with a sponge soaked with BTA (40 units each nostril) or saline. Subgroups C and D contained these patients of group A and B who did not improve in symptoms one week after the original treatment (either BTA or saline) who then received the alternative medication. Changes of symptoms (rhinorrhea, nasal obstruction) were scored by the patients in a four point scale and counted (consumption of tissues, sneezing) in a diary. The patients were followed up weeks 1, 2, 4, 8 and 12.</p> <p>Results</p> <p>There was a clear reduction of the amount of secretion in group A compared to group B, C and D. This did not correlate with the tissue consumption, which was comparably reduced in group A and B, but reduced less in group C and D. Sneezing was clearly reduced in group A but comparably unchanged in group B and C and increased in group D. Nasal congestion remained unchanged.</p> <p>Conclusion</p> <p>In some patients with therapy-resistant idiopathic rhinitis BTA applied with a sponge is a long-lasting and minimal invasive therapy to reduce nasal hypersecretion.</p
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Non-stoichiometric oxide and metal interfaces and reactions
We have employed a combination of experimental surface science techniques and density functional calculations to study the reduction of TiO2(110) surfaces through the doping with submonolayer transition metals. We concentrate on the role of Ti adatoms in self doping of rutile and contrast the behaviour to that of Cr. DFT+U calculations enable identification of probable adsorption structures and their spectroscopic characteristics. Adsorption of both metals leads to a broken symmetry and an asymmetric charge transfer localised around the defect site of a mixed localised/delocalised character. Charge transfer creates defect states with Ti 3d character in the band gap at similar to 1-eV binding energy. Cr adsorption, however, leads to a very large shift in the valence-band edge to higher binding energy and the creation of Cr 3d states at 2.8-eV binding energy. Low-temperature oxidation lifts the Ti-derived band-gap states and modifies the intensity of the Cr features, indicative of a change of oxidation state from Cr3+ to Cr4+. Higher temperature processing leads to a loss of Cr from the surface region, indicative of its substitution into the bulk
Guidelines for Planning Local Seed System Interventions
Mozambique implemented the project 'Improving the efficiency of seed distribution in emergency situations: linking seed distribution to market development' with the following objectives: to gain a detailed understanding of the present procedures for assessing seed requirements in emergency situations and to propose a new needs assessment methodology which takes into account farmers' knowledge, attitudes and local practices in the process of obtaining seeds without upsetting normal market behaviour. As part of this project, ICRISAT-Mozambique carried out a study that led to the production of the Guidelines for Planning Local Seed System Interventions, which you have in your hands. The Guidelines are based on experiences in the field and comments made by Ministry of Agriculture and Rural Development (MADER) staff from district to central level. Initial drafts of the Manual were tested in three districts: in Panda and Massinga Districts (Inhambane Province) and in Chibuto District (Gaza Province). The lessons learned during these tests have been integrated into this first edition, although there is still room for improvement and we welcome your suggestions. These Guidelines present a methodology to gain a better and more realistic understanding of the seed systems used by farmers in their districts. The methodology includes procedures to better define 'what, when and how' to act in the event of natural disasters such as droughts and floods which affect the normal unctioning of the seed system. Thus, interventions should only be planned and implemented after the problem has been clearly defined so that they really meet the needs of those who are genuinely affected
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