219 research outputs found
DeepLOC: Deep Learning-based Bone Pathology Localization and Classification in Wrist X-ray Images
In recent years, computer-aided diagnosis systems have shown great potential
in assisting radiologists with accurate and efficient medical image analysis.
This paper presents a novel approach for bone pathology localization and
classification in wrist X-ray images using a combination of YOLO (You Only Look
Once) and the Shifted Window Transformer (Swin) with a newly proposed block.
The proposed methodology addresses two critical challenges in wrist X-ray
analysis: accurate localization of bone pathologies and precise classification
of abnormalities. The YOLO framework is employed to detect and localize bone
pathologies, leveraging its real-time object detection capabilities.
Additionally, the Swin, a transformer-based module, is utilized to extract
contextual information from the localized regions of interest (ROIs) for
accurate classification.Comment: AIST-2023 accepted pape
RESEARCH OF LINEAR AND NONLINEAR PROCESSES AT FEMTOSECOND LASER RADIATION PROPAGATION IN THE MEDIUM SIMULATING THE HUMAN EYE VITREOUS
The paper deals with mathematical model of linear and nonlinear processes occurring at the propagation of femtosecond laser
pulses in the vitreous of the human eye. Methods of computing modeling are applied for the nonlinear spectral equation
solution describing the dynamics of a two-dimensional TE-polarized radiation in a homogeneous isotropic medium with
cubic fast-response nonlinearity without the usage of slowly varying envelope approximation. Environments close to the
optical media parameters of the eye were used for the simulation. The model of femtosecond radiation propagation takes into
account the process dynamics for dispersion broadening of pulses in time and the occurence of the self-focusing near the retina when passing through the vitreous body of the eye. Dependence between the pulse duration on the retina has been
revealed and the duration of the input pulse and the values of power density at which there is self-focusing have been found.
It is shown that the main mechanism of radiation damage with the use of titanium-sapphire laser is photoionization. The
results coincide with those obtained by the other scientists, and are usable for creation Russian laser safety standards for
femtosecond laser systems
HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa
The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing. The pro-autophagic molecule AMBRA1 (autophagy/beclin-1 regulator-1) has been defined as a novel regulator of mitophagy in both PINK1/PARKIN-dependent and -independent systems. Here, we identified the E3 ubiquitin ligase HUWE1 as a key inducing factor in AMBRA1-mediated mitophagy, a process that takes place independently of the main mitophagy receptors. Furthermore, we show that mitophagy function of AMBRA1 is post-translationally controlled, upon HUWE1 activity, by a positive phosphorylation on its serine 1014. This modification is mediated by the IKKα kinase and induces structural changes in AMBRA1, thus promoting its interaction with LC3/GABARAP (mATG8) proteins and its mitophagic activity. Altogether, these results demonstrate that AMBRA1 regulates mitophagy through a novel pathway, in which HUWE1 and IKKα are key factors, shedding new lights on the regulation of mitochondrial quality control and homoeostasis in mammalian cells
Considerable enhancement of the critical current in a superconducting film by magnetized magnetic strip
We show that a magnetic strip on top of a superconducting strip magnetized in
a specified direction may considerably enhance the critical current in the
sample. At fixed magnetization of the magnet we observed diode effect - the
value of the critical current depends on the direction of the transport
current. We explain these effects by a influence of the nonuniform magnetic
field induced by the magnet on the current distribution in the superconducting
strip. The experiment on a hybrid Nb/Co structure confirmed the predicted
variation of the critical current with a changing value of magnetization and
direction of the transport current.Comment: 6 pages, 7 figure
Autophagy mediates degradation of nuclear lamina
Z.D. is supported by a fellow award from the Leukemia & Lymphoma Society. B.C.C. is supported by career development awards from the Dermatology Foundation, Melanoma Research Foundation, and American Skin Association. S.L.B., P.D.A. and R.M. are supported by NIA P01 grant (P01AG031862). S.L.B. is also supported by NIH R01 CA078831. R.D.G. is supported by R01 GM106023 and the Progeria Research Foundation
Feasibility studies of the time-like proton electromagnetic form factor measurements with PANDA at FAIR
The possibility of measuring the proton electromagnetic form factors in the
time-like region at FAIR with the \PANDA detector is discussed. Detailed
simulations on signal efficiency for the annihilation of into a
lepton pair as well as for the most important background channels have been
performed. It is shown that precision measurements of the differential cross
section of the reaction can be obtained in a wide
angular and kinematical range. The individual determination of the moduli of
the electric and magnetic proton form factors will be possible up to a value of
momentum transfer squared of (GeV/c). The total cross section will be measured up to (GeV/c).
The results obtained from simulated events are compared to the existing data.
Sensitivity to the two photons exchange mechanism is also investigated.Comment: 12 pages, 4 tables, 8 figures Revised, added details on simulations,
4 tables, 9 figure
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