Relationship between atypical sexual fantasies, behaviour, and pornography consumption

Paraphilia is a condition in which the sexual excitement rely on fantasizing and/or participating in unusual sexual behaviours although the line between “normal” and “abnormal” has been disputed. The project aimed to explore which sexual fantasies and behaviours are common and uncommon in the general population. Furthermore, the relationship between sexual fantasies, sexual behaviours and problematic pornography consumption was examined. Finally, the impact of gender was assessed. Analyses were conducted on a sample of 139 participants. Correlations were found between fantasies, behaviours and problematic pornography consumption. Furthermore, gender differences were found for both sexual fantasies and problematic pornography consumption. Finally, multiple regression revealed that age, gender [Men], fantasies and behaviours were significant predictor of problematic pornography consumption. Those findings are in-line with previous studies which highlighted that the threshold to consider a sexual practice as being abnormal needs to be reconsidered on the basis of self-reported fantasies and behaviours in the general population

B-cell responses to vaccination at the extremes of age

Infants and the elderly share a high vulnerability to infections and therefore have specific immunization requirements. Inducing potent and sustained B-cell responses is as challenging in infants as it is in older subjects. Several mechanisms to explain the decreased B-cell responses at the extremes of age apply to both infants and the elderly. These include intrinsic B-cell limitations as well as numerous microenvironmental factors in lymphoid organs and the bone marrow. This Review describes the mechanisms that shape B-cell responses at the extremes of age and how they could be taken into account to design more effective immunization strategies for these high-risk age groups