Individual perceptions of physical activity in a community-level initiative in North Queensland, Australia

Introduction: Community-level health initiatives advertise the benefits of physical activity, however, it is unknown how personally relevant these promoted benefits are to those who take part. The purpose of this study was to describe the personal experience of participation in the health programs, and to identify how appropriate the participants felt the programs were. Methods: Participants were rural North Queensland residents participating in Australian federal government funded health initiative programs offered by their local council. There were 25 participants (10 males, 15 females) whose ages ranged from 47 to 79. Twenty-one were in the 12-week Diabetes Australia Beat It program, and four participants were in a 10-week water aerobics program. Qualitative data was provided by participants during semi-structured interviews which asked about current exercise habits, reason for taking part in the program and opinions about the program and facilitators. Results: Thematic Analysis was used to analyze the data. It was an inductive analysis that assessed semantic themes from a realist perspective. The themes fond detail the personal definition of exercise (Exercise to me), the physical benefits of exercise (Keep yourself, Future fitness, Observed changes), and the psychological benefits of exercise (socializing, challenging oneself, sense of achievement). Conclusions: The benefits that participants felt they gained from the physical fitness program, and their reasons for attending were different to the programs' expected outcomes. Programs should aim to appeal and cater to the needs of a wide group of people who have limited access to exercise facilities and health behaviour programs

Individual perceptions of physical activity in a community-level initiative in North Queensland, Australia

Introduction: Community-level health initiatives advertise the benefits of physical activity, however, it is unknown how personally relevant these promoted benefits are to those who take part. The purpose of this study was to describe the personal experience of participation in the health programs, and to identify how appropriate the participants felt the programs were. Methods: Participants were rural North Queensland residents participating in Australian federal government funded health initiative programs offered by their local council. There were 25 participants (10 males, 15 females) whose ages ranged from 47 to 79. Twenty-one were in the 12-week Diabetes Australia Beat It program, and four participants were in a 10-week water aerobics program. Qualitative data was provided by participants during semi-structured interviews which asked about current exercise habits, reason for taking part in the program and opinions about the program and facilitators. Results: Thematic Analysis was used to analyze the data. It was an inductive analysis that assessed semantic themes from a realist perspective. The themes fond detail the personal definition of exercise (Exercise to me), the physical benefits of exercise (Keep yourself, Future fitness, Observed changes), and the psychological benefits of exercise (socializing, challenging oneself, sense of achievement). Conclusions: The benefits that participants felt they gained from the physical fitness program, and their reasons for attending were different to the programs' expected outcomes. Programs should aim to appeal and cater to the needs of a wide group of people who have limited access to exercise facilities and health behaviour programs

Enzymatic enhancement of the free monoterpenol content of a Portuguese wine from a single, native grape variety; “Trajadura”

Three important monoterpene aroma releasing activities contained in an Aspergillus niger preparation were investigated for effects of pH, alcohol, SO2, temperature and concentration of glucose. Application of the enzyme preparation during microvinification or wine maturation of a Portuguese white wine from Trajadura grapes, increased monoterpene content roughly 2-fold and 3-fold respectively

Frequentist Analysis of the Parameter Space of Minimal Supergravity

We make a frequentist analysis of the parameter space of minimal supergravity (mSUGRA), in which, as well as the gaugino and scalar soft supersymmetry-breaking parameters being universal, there is a specific relation between the trilinear, bilinear and scalar supersymmetry-breaking parameters, A_0 = B_0 + m_0, and the gravitino mass is fixed by m_{3/2} = m_0. We also consider a more general model, in which the gravitino mass constraint is relaxed (the VCMSSM). We combine in the global likelihood function the experimental constraints from low-energy electroweak precision data, the anomalous magnetic moment of the muon, the lightest Higgs boson mass M_h, B physics and the astrophysical cold dark matter density, assuming that the lightest supersymmetric particle (LSP) is a neutralino. In the VCMSSM, we find a preference for values of m_{1/2} and m_0 similar to those found previously in frequentist analyses of the constrained MSSM (CMSSM) and a model with common non-universal Higgs masses (NUHM1). On the other hand, in mSUGRA we find two preferred regions: one with larger values of both m_{1/2} and m_0 than in the VCMSSM, and one with large m_0 but small m_{1/2}. We compare the probabilities of the frequentist fits in mSUGRA, the VCMSSM, the CMSSM and the NUHM1: the probability that mSUGRA is consistent with the present data is significantly less than in the other models. We also discuss the mSUGRA and VCMSSM predictions for sparticle masses and other observables, identifying potential signatures at the LHC and elsewhere.Comment: 18 pages 27 figure

Chandra X-Ray Observations of Two Unusual BAL Quasars

We report sensitive Chandra X-ray non-detections of two unusual, luminous Iron Low-Ionization Broad Absorption Line Quasars (FeLoBALs). The observations do detect a non-BAL, wide-binary companion quasar to one of the FeLoBAL quasars. We combine X-ray-derived column density lower limits (assuming solar metallicity) with column densities measured from ultraviolet spectra and CLOUDY photoionization simulations to explore whether constant density slabs at broad line region densities can match the physical parameters of these two BAL outflows, and find that they cannot. In the "overlapping-trough" object SDSS J0300+0048, we measure the column density of the X-ray absorbing gas to be N_H >= 1.8 x 1024 cm-2. From the presence of Fe II UV78 absorption but lack of Fe II UV195/UV196 absorption, we infer the density in that part of the absorbing region to be n_e ~ 106 cm-3. We do find that a slab of gas at that density might be able to explain this object's absorption. In the Fe III-dominant object SDSS J2215-0045, the X-ray absorbing column density of N_H >= 3.4 x 1024 cm-2 is consistent with the Fe III-derived N_H >= 2 x 1022 cm-2 provided the ionization parameter is log U > 1.0 for both the n_e = 1011 cm-3 and n_e = 1012 cm-3 scenarios considered (such densities are required to produce Fe III absorption without Fe II absorption). However, the velocity width of the absorption rules out its being concentrated in a single slab at these densities. Instead, this object's spectrum can be explained by a low density, high ionization and high temperature disk wind that encounters and ablates higher density, lower ionization Fe III-emitting clumps.Comment: 18 pages, 6 figure

CEO pay, shareholder returns, and accounting profits

We assess the impact on CEO pay (including salary, cash bonus, and benefits in kind) of changes in both accounting and shareholder returns in 99 British companies in the years 1972-89. After correcting for heterogeneity biases inherent in the standard specifications of the problem, we find a strong positive relationship between CEO pay and within-company changes in shareholder returns, and no statistically significant relationship between CEO pay and within-company changes in accounting returns. Differences between firms in long-term average profitability do appear to have a substantial effect on CEO pay, while differences between firms in shareholder returns add nothing to the within-firm pay dynamics.These findings call into question the rationale for explicitly share-based incentive schemes

Diagnostic comparison of malaria infection in peripheral blood, placental blood and placental biopsies in Cameroonian parturient women

<p>Abstract</p> <p>Background</p> <p>In sub-Saharan Africa, <it>Plasmodium falciparum </it>malaria in pregnancy presents an enormous diagnostic challenge. The epidemiological and clinical relevance of the different types of malaria diagnosis as well as risk factors associated with malaria infection at delivery were investigated.</p> <p>Method</p> <p>In a cross-sectional survey, 306 women reporting for delivery in the Mutenegene maternity clinic, Fako division, South West province, Cameroon were screened for <it>P. falciparum </it>in peripheral blood, placental blood and placental tissue sections by microscopy. Information relating to the use of intermittent preventive treatment in pregnancy with sulphadoxine/pyrimethamine, history of fever attack, infant birth weights and maternal anaemia were recorded.</p> <p>Results</p> <p>Among these women, <it>P. falciparum </it>infection was detected in 5.6%, 25.5% and 60.5% of the cases in peripheral blood, placental blood and placental histological sections respectively. Placental histology was more sensitive (97.4%) than placental blood film (41.5%) and peripheral blood (8.0%) microscopy. In multivariate analysis, age (≤ 20 years old) (OR = 4.61, 95% CI = 1.47 – 14.70), history of fever attack (OR = 2.98, 95% CI = 1.58 – 5.73) were significant risk factors associated with microscopically detected parasitaemia. The use of ≥ 2 SP doses (OR = 0.18, 95% CI = 0.06 – 0.52) was associated with a significant reduction in the prevalence of microscopic parasitaemia at delivery. Age (>20 years) (OR = 0.34, 95% CI = 0.15 – 0.75) was the only significant risk factor associated with parasitaemia diagnosed by histology only in univariate analysis. Microscopic parasitaemia (OR = 2.74, 95% CI = 1.33–5.62) was a significant risk factor for maternal anaemia at delivery, but neither infection detected by histology only, nor past infection were associated with increased risk of anaemia.</p> <p>Conclusion</p> <p>Placenta histological examination was the most sensitive indicator of malaria infection at delivery. Microscopically detected parasitaemia was associated with increased risk of maternal anaemia at delivery, but not low-grade parasitaemia detected by placental histology only.</p

Proposed therapeutic range of treosulfan in reduced toxicity pediatric allogeneic hematopoietic stem cell transplant conditioning: results from a prospective trial

Treosulfan is given off‐label in pediatric allogeneic hematopoietic stem cell transplant. This study investigated treosulfan's pharmacokinetics (PKs), efficacy, and safety in a prospective trial. Pediatric patients (n = 87) receiving treosulfan‐fludarabine conditioning were followed for at least 1 year posttransplant. PKs were described with a two‐compartment model. During follow‐up, 11 of 87 patients died and 12 of 87 patients had low engraftment (≤ 20% myeloid chimerism). For each increase in treosulfan area under the curve from zero to infinity (AUC(0‐∞)) of 1,000 mg hour/L the hazard ratio (95% confidence interval) for mortality increase was 1.46 (1.23–1.74), and the hazard ratio for low engraftment was 0.61 (0.36–1.04). A cumulative AUC(0‐∞) of 4,800 mg hour/L maximized the probability of success (> 20% engraftment and no mortality) at 82%. Probability of success with AUC(0‐∞) between 80% and 125% of this target were 78% and 79%. Measuring PK at the first dose and individualizing the third dose may be required in nonmalignant disease