U-Pn geochronology of deformed metagranites in central Sutherland, Scotland: evidence for widespread late Silurian metamorphism and ductile deformation of the Moine Supergroup during the Caledonian orogeny

Within the Caledonides of central Sutherland, Scotland, the Neoproterozoic metasedimentary rocks of the Moine Supergroup record NW-directed D2 ductile thrusting and nappe assembly, accompanied by widespread tight-to-isoclinal folding and amphibolite-facies metamorphism. A series of metagranite sheets which were emplaced and penetratively deformed during D2 have been dated using SHRIMP UâPb geochronology. Zircon ages of 424 8 Ma (Vagastie Bridge granite), 420 6 Ma (Klibreck granite) and 429 11 Ma (Strathnaver granite) are interpreted to date emplacement, and hence regional D2 deformation, during mid- to late Silurian time. Titanite ages of 413 3 Ma (Vagastie Bridge granite) and 416 3 Ma (Klibreck granite) are thought to date post-metamorphic cooling through a blocking temperature of c. 550â 500 8C. A mid- to late Silurian age for D2 deformation supports published models that have viewed the internal ductile thrusts of this part of the orogen as part of the same kinematically linked system of forelandpropagating thrusts as the marginal Moine Thrust Zone. The new data contrast with previous interpretations that have viewed the dominant structures and metamorphic assemblages within the Moine Supergroup as having formed during the early to mid-Ordovician Grampian arcâcontinent orogeny. The mid-to late Silurian D2 nappe stacking event in Sutherland is probably a result of the collision of Baltica with the Scottish segment of Laurentia

The harmonization of animal protection during transport in the European Union : analysis of the sanctioning systems in Italy, Romania and Spain

In the last sixty years, countries in Europe developed a common legal framework for the protection of so-called "farmed" Animals: on farms, during transport and at the time of their killing. This document describes the most relevant aspects of the sanctioning systems implementing the legislation on the protection of Animals during transport in three countries: Italy, Spain and Romania. These nations were chosen in connection with the author's collaboration with the German non-governmental organization, Animals' Angels. The association has been investigating animal transports at the international level since 1998, with particular attention to these three countries. The article draws on findings collected from the organization's field experience as well as perspectives that have emerged over time during the analysis of the various countries. This document aims to lay out the positive and the negative points of each penalty system, as a basis for a wider analysis, and to formulate proposals for a better and uniform application of a dissuasive sanctioning system in Europe. The fact that penalties are left to the competence of the member states, which are culturally different and have different legal systems, has led to an alarmingly irregular implementation. From another perspective, with protection being put in second place, this leads to competitive distortion in the territory of the European Union. The article examines efforts made by European institutions and member states to improve the harmonisation of the application of Regulation (EC) No. 1/2005. It also offers practical inputs that can be used in future negotiations of the existing laws on animal transport.En los últimos sesenta años, los países europeos desarrollaron un marco legal común para la protección de los animales "de granja": en las granjas, durante el transporte y en el momento de su matanza. Este documento pretende describir los aspectos más relevantes de los sistemas de sanción que aplican la legislación sobre la protección de los animales durante el transporte en tres países: Italia, España y Rumanía. La razón por la que elegí estas naciones reside en mi colaboración con la organización no gubernamental alemana Animals' Angels. Esta asociación lleva investigando los transportes de animales desde 1998, a nivel internacional, con especial atención a estos tres países. Me gustaría utilizar algunos de los hallazgos recogidos de nuestra experiencia directa en el campo y las opiniones consolidadas durante el análisis de los distintos países. El presente documento tiene por objeto extrapolar lo positivo y lo negativo de cada sistema de sanciones, como punto de partida para un análisis más amplio, a fin de formular propuestas para una aplicación mejor y más uniforme de un sistema de sanciones disuasivas en Europa. El hecho de que las sanciones se dejen a la competencia de los Estados miembros, que son culturalmente diferentes y tienen sistemas jurídicos distintos, da lugar a una preocupante falta de homogeneidad en la aplicación en la actualidad. Desde otra perspectiva, en relación a la necesidad de protección, esto lleva a una distorsión de la competencia en el territorio de la Unión Europea. Examinaré los esfuerzos realizados por las instituciones europeas y los Estados Miembros, para mejorar la armonización de la aplicación del Reglamento (CE) Nº 1/2005. Además, tengo la intención de ofrecer algunas aportaciones prácticas que espero sean tomadas en serio en caso de futuras negociaciones de las actuales leyes sobre transporte de animales

The induction of obesity in the rat with bipiperidyl mustard

Lesions in the ventromedial region of the hypothalamus were shown by Hetherington & Ranson (1940) to produce hyperphagia and obesity in the rat. The chemical agents gold thioglucose (GTG; Brecher & Waxler, 1949) and bipiperidyl mustard (BPM; Rutman et al. 1966) which are widely used to induce obesity in mice also produce lesions in this region of the hypothalamus (Marshall et al. 1955; Rutman et al. 1966). The use of GTG to induce obesity in the rat has proved to be unsuitable for widespread use and would be very expensive (Mayer & Marshall, 1956; Wagner & de Groot 1963). Bunyan et al. (1976) have shown that monosodium glutamate administered to newborn rats and mice produces obesity without hyperphagia. Miller (1979) has recently reviewed non-genetic models of obesity and has summarized methods which produce a high proportion of obese mice, with low mortality, using monosodium glutamate or gold thioglucose, but although he mentions the use of BPM in mice he does not recommend it because it is carcinogenic and difficult to obtain. He concludes that in all the models of obesity efficiency of energy utilization is the most important factor in the aetiology of the obesity. We now report an experiment in which obesity has been induced in the rat without mortality and inexpensively using BPM

Origin and evolution of the light nuclides

After a short historical (and highly subjective) introduction to the field, I discuss our current understanding of the origin and evolution of the light nuclides D, He-3, He-4, Li-6, Li-7, Be-9, B-10 and B-11. Despite considerable observational and theoretical progress, important uncertainties still persist for each and every one of those nuclides. The present-day abundance of D in the local interstellar medium is currently uncertain, making it difficult to infer the recent chemical evolution of the solar neighborhood. To account for the observed quasi-constancy of He-3 abundance from the Big Bang to our days, the stellar production of that nuclide must be negligible; however, the scarce observations of its abundance in planetary nebulae seem to contradict this idea. The observed Be and B evolution as primaries suggests that the source composition of cosmic rays has remained quasi-constant since the early days of the Galaxy, a suggestion with far reaching implications for the origin of cosmic rays; however, the main idea proposed to account for that constancy, namely that superbubbles are at the source of cosmic rays, encounters some serious difficulties. The best explanation for the mismatch between primordial Li and the observed "Spite-plateau" in halo stars appears to be depletion of Li in stellar envelopes, by some yet poorly understood mechanism. But this explanation impacts on the level of the recently discovered early ``Li-6 plateau'', which (if confirmed), seriously challenges current ideas of cosmic ray nucleosynthesis.Comment: 18 pages, 9 figs. Invited Review in "Symposium on the Composition of Matter", honoring Johannes Geiss on the occasion of his 80th birthday (Grindelwald, Switzerland, Sept. 2006), to be published in Space Science Series of ISS

An Empirical Comparison of Consumer Innovation Adoption Models: Implications for Subsistence Marketplaces

So called “pro-poor” innovations may improve consumer wellbeing in subsistence marketplaces. However, there is little research that integrates the area with the vast literature on innovation adoption. Using a questionnaire where respondents were asked to provide their evaluations about a mobile banking innovation, this research fills this gap by providing empirical evidence of the applicability of existing innovation adoption models in subsistence marketplaces. The study was conducted in Bangladesh among a geographically dispersed sample. The data collected allowed an empirical comparison of models in a subsistence context. The research reveals the most useful models in this context to be the Value Based Adoption Model and the Consumer Acceptance of Technology model. In light of these findings and further examination of the model comparison results the research also shows that consumers in subsistence marketplaces are not just motivated by functionality and economic needs. If organizations cannot enhance the hedonic attributes of a pro-poor innovation, and reduce the internal/external constraints related to adoption of that pro-poor innovation, then adoption intention by consumers will be lower

The Cholecystectomy As A Day Case (CAAD) Score: A Validated Score of Preoperative Predictors of Successful Day-Case Cholecystectomy Using the CholeS Data Set

Background Day-case surgery is associated with significant patient and cost benefits. However, only 43% of cholecystectomy patients are discharged home the same day. One hypothesis is day-case cholecystectomy rates, defined as patients discharged the same day as their operation, may be improved by better assessment of patients using standard preoperative variables. Methods Data were extracted from a prospectively collected data set of cholecystectomy patients from 166 UK and Irish hospitals (CholeS). Cholecystectomies performed as elective procedures were divided into main (75%) and validation (25%) data sets. Preoperative predictors were identified, and a risk score of failed day case was devised using multivariate logistic regression. Receiver operating curve analysis was used to validate the score in the validation data set. Results Of the 7426 elective cholecystectomies performed, 49% of these were discharged home the same day. Same-day discharge following cholecystectomy was less likely with older patients (OR 0.18, 95% CI 0.15–0.23), higher ASA scores (OR 0.19, 95% CI 0.15–0.23), complicated cholelithiasis (OR 0.38, 95% CI 0.31 to 0.48), male gender (OR 0.66, 95% CI 0.58–0.74), previous acute gallstone-related admissions (OR 0.54, 95% CI 0.48–0.60) and preoperative endoscopic intervention (OR 0.40, 95% CI 0.34–0.47). The CAAD score was developed using these variables. When applied to the validation subgroup, a CAAD score of ≤5 was associated with 80.8% successful day-case cholecystectomy compared with 19.2% associated with a CAAD score >5 (p < 0.001). Conclusions The CAAD score which utilises data readily available from clinic letters and electronic sources can predict same-day discharges following cholecystectomy