Tafazzin regulates human conjunctiva epithelial cell proliferation via inhibiting TGFβ signaling pathway

Molecular Vision181402-1410MVEP

Instabilities and Clumping in Type Ia Supernova Remnants

We present two-dimensional high-resolution hydrodynamical simulations in spherical polar coordinates of a Type Ia supernova interacting with a constant density interstellar medium. The ejecta are assumed to be freely expanding with an exponential density profile. The interaction gives rise to a double-shocked structure susceptible to hydrodynamic instabilities. The Rayleigh-Taylor instability initially grows, but the Kelvin-Helmholtz instability takes over, producing vortex rings. The nonlinear instability initially evolves toward longer wavelengths and eventually fades away when the reverse shock front is in the flatter part of the supernova density distribution. Based on observations of X-ray knots and the protrusion in the southeast outlin of Tycho's supernova remnant, we include clumping in the ejecta. The clump interaction with the reverse shock induces Rayleigh-Taylor and Kelvin-Helmholtz instabilities on the clump surface that facilitate fragmentation. In order to survive crushing and to have a bulging effect on the forward shock, the clump's initial density ratio to the surrounding ejecta must be at least 100 for the conditions in Tycho's remnant. The 56Ni bubble effect may be important for the development of clumpiness in the ejecta. The observed presence of an Fe clump would then require a non-radioactive origin for this Fe, possibly 54Fe. The large radial distance of the X-ray emitting Si and S ejecta from the remnant center indicates that they were initially in clumps.Comment: 27 pages, 4 postscript figures, 5 GIF figures submitted to Astrophysical Journa

Effect of intracameral injection of fibrin tissue sealant on the rabbit anterior segment

Molecular Vision161087-1097MVEP

Genetic diversity of Asian water buffalo (Bubalus bubalis): mitochondrial DNA D-loop and cytochrome b sequence variation

Swamp and river buffalo mitochondrial DNA (mtDNA) was sequenced for 303 bp of the cytochrome b gene for 54 animals from 14 populations, and for 158 bp of the D-loop region for 80 animals from 11 populations. Only one cytochrome b haplotype was found in river buffalo. Of the four haplotypes identified in swamp buffalo, one found in all populations is apparently ancestral both to the other swamp haplotypes and to the river haplotype. The phylogenetic relationships among the 33 D-loop haplotypes, with a cluster of 11 found in swamp buffalo only, also support the evolution of domesticated swamp and river buffalo from an ancestral swamp-like animal, most likely represented today by the wild Asian buffalo (Bubalus arnee). The time of divergence of the swamp and river types, estimated from the D-loop data, is 28 000 to 87 000 years ago. We hypothesise that the species originated in mainland south-east Asia, and that it spread north to China and west to the Indian subcontinent, where the rive type evolved and was domesticated. Following domestication in China, the domesticated swamp buffalo spread through two separate routes, through Taiwan and the Philippines to the eastern islands of Borneo and Sulawesi, and south through mainland southeast Asia and then to the western islands of Indonesia

Analysis of conjunctival fibroblasts from a proband with Schnyder corneal dystrophy

Molecular Vision141277-128

The Mesozoic along-strike tectono-metamorphic segmentation of Longmen Shan (eastern Tibetan plateau)

The Longmen Shan belt (eastern border of the Tibetan plateau) constitutes a tectonically active region as demonstrated by the occurrence of the unexpected 2008 Mw 7.9 Wenchuan and 2013 Mw 6.6 Lushan earthquakes in the central and southern parts of the belt respectively. These events revealed the necessity of a better understanding of the long‐term geological evolution of the belt and its effect on the present dynamics and crustal structure. New structural and thermobarometric data offer a comprehensive dataset of the paleo‐temperatures across the belt and P‐T estimates for low‐grade metamorphic domains. In the central Longmen Shan, two metamorphic jumps of 150‐200°C, 5‐6 kbar and ~50 °C, 3‐5 kbar acquired during the Early Mesozoic are observed across the Wenchuan and Beichuan faults respectively, attesting to their thrusting movement and unrevealing a major decollement between the allochtonous Songpan‐Garze metasedimentary cover (at T > 500°C) and the autochtonous units and the basement (T < 400°C). In the southern Longmen Shan, the only greenschist‐facies metamorphism is observed both in the basement (360 ± 30°C, 6 ± 2 kbar) and in the metasedimentary cover (350 ± 30°C, 3 ± 1 kbar). Peak conditions were reached at c. 80‐60 Ma in the basement and c. 55‐33 Ma in the cover, c. 50 Ma after the greenschist‐facies metamorphic overprint observed in the central Longmen Shan (c. 150‐120 Ma). This along‐strike metamorphic segmentation coincides well with the present fault segmentation and reveals that the central and southern Longmen Shan experienced different tectono‐metamorphic histories since the Mesozoic

Green and brown bridges between weeds and crops reveal novel Diaporthe species in Australia

Diaporthe (syn. Phomopsis) species are well-known saprobes, endophytes or pathogens on a range of plants. Several species have wide host ranges and multiple species may sometimes colonise the same host species. This study describes eight novel Diaporthe species isolated from live and/or dead tissue from the broad acre crops lupin, maize, mungbean, soybean and sunflower, and associated weed species in Queensland and New South Wales, as well as the environmental weed bitou bush (Chrysanthemoides monilifera subsp. rotundata) in eastern Australia. The new taxa are differentiated on the basis of morphology and DNA sequence analyses based on the nuclear ribosomal internal transcribed spacer region, and part of the translation elongation factor-1α and ß-tubulin genes. The possible agricultural significance of live weeds and crop residues ('green bridges') as well as dead weeds and crop residues ('brown bridges') in aiding survival of the newly described Diaporthe species is discussed

S100A expression in normal corneal-limbal epithelial cells and ocular surface squamous cell carcinoma tissue

Molecular Vision172263-2271MVEP

Multicore implementation of a fixed-complexity tree-search detector for MIMO communications

[EN] Multicore systems allow the efficient implementation of signal processing algorithms for communication systems due to their high parallel processing capabilities. In this paper, we present a high-throughput multicore implementation of a fixed-complexity tree-search-based detector interesting for MIMO wireless communication systems. Experimental results confirm that this implementation allows to accelerate the data detection stage for different constellation sizes and number of subcarriers.This work was supported by the TEC2009-13741 project of the Spanish Ministry of Science, by the PROMETEO/2009/013 project and ACOMP/2012/076 of the Generalitat Valenciana, and the Vicerrectorado de Investigacion de la UPV through Programa de Apoyo a la Investigacion y desarrollo (PAID-05-11-2898).Ramiro Sánchez, C.; Roger Varea, S.; Gonzalez, A.; Almenar Terré, V.; Vidal Maciá, AM. (2013). Multicore implementation of a fixed-complexity tree-search detector for MIMO communications. The Journal of Supercomputing (Online). 65(3):1010-1019. https://doi.org/10.1007/s11227-012-0839-xS10101019653Paulraj AJ, Gore DA, Nabar RU, Bölcskei H (2004) An overview of MIMO communications—a key to gigabit wireless. Proc IEEE 92(2):198–218Jiang M, Hanzo L (2007) Multiuser MIMO-OFDM for next-generation wireless systems. Proc IEEE 95(7):1430–14693GPP TS 36.201, V10.0.0, Evolved Universal Terrestrial Radio Access (E-UTRA); Physical layer—general description, December 2010Lin Y, Lee H, Woh M, Harel Y, Mahlke S, Mudge T, Chakrabarti C, Flautner K (2007) SODA: a high-performance DSP architecture for software-defined radio. IEEE MICRO 27(1):114–123Yang C-H, Markovic D (2008) A multi-core sphere decoder VLSI architecture for MIMO communications. In: Global telecommunications conference, November, pp 1–6Wu D, Eilert J, Liu D (2011) Implementation of a high-speed MIMO soft-output symbol detector for software defined radio. J Signal Process Syst 63(1):27–37Tan K, Liu H, Zhang J, Zhang Y, Fang J, Voelker GM (2011) Sora: high-performance software radio using general-purpose multi-core processors. Communun ACM 54(1):99–107Roger S, Ramiro C, Gonzalez A, Almenar V, Vidal AM (2012) An efficient GPU implementation of fixed-complexity sphere decoders for MIMO wireless systems. Integr Comput-Aided Eng 19(4):341–350Chen Y-K et al (2009) Signal processing on platforms with multiple cores: Part 1-Overview and methodologies. IEEE Signal Proc Mag 6:24–25Karam LJ, AlKamal I, Gatherer A, Frantz GA, Anderson DV, Evans BL (2009) Trends in multicore DSP platforms. IEEE Signal Process Mag 26(6):38–49Barbero LG, Thompson JS (2008) Fixing the complexity of the sphere decoder for MIMO detection. IEEE Trans Wirel Commun 7(6):2131–2142Hassibi B, Vikalo H (2005) On sphere decoding algorithm. Part I, The expected complexity. IEEE Trans Signal Process 54(5):2806–2818Agrell E, Eriksson T, Vardy A, Zeger K (2002) Closest point search in lattices. IEEE Trans Inf Theory 48(8):2201–2214OpenMP v3.0, http://www.openmp.org/mp-documents/spec30.pdf , May 200

Pituitary apoplexy following shoulder arthroplasty: a case report

<p>Abstract</p> <p>Introduction</p> <p>Pituitary apoplexy following a major surgical procedure is a catastrophic event and the diagnosis can be delayed in a previously asymptomatic patient. The decision on thromboprophylaxis in shoulder replacements in the absence of definite guidelines, rests on a careful clinical judgment.</p> <p>Case presentation</p> <p>A previously healthy 62-year-old Caucasian male patient who underwent shoulder arthroplasty developed hyponatremia resistant to correction with saline replacement. The patient had a positive family history of deep vein thrombosis and pulmonary embolism and heparin thromboprophylaxis was considered on clinical grounds. The patient developed hyponatremia resistant to conventional treatment and later developed ocular localizing signs with oculomotor nerve palsy. The diagnosis was delayed due to other confounding factors in the immediate post-operative period. Subsequent workup confirmed a pituitary adenoma with features of pituitary insufficiency. The patient was managed successfully on conservative lines with a multidisciplinary approach.</p> <p>Conclusions</p> <p>A high index of suspicion is required in the presence of isolated post-operative hyponatremia resistant to medical correction. A central cause, in particular pituitary adenoma, should be suspected early. Thromboprophylaxis in shoulder replacements needs careful consideration as it may be a contributory factor in precipitating this life-threatening condition.</p